U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormal pigmentation of the oral mucosa

MedGen UID:
866613
•Concept ID:
C4020959
•
Finding
Synonyms: Abnormal color of the oral mucosa; Abnormal colour of the oral mucosa; Abnormal pigmentation of oral cavity; Abnormal pigmentation of oral mucous membrane; Abnormal pigmentation of the oral mucosa/gingivae
 
HPO: HP:0100669

Definition

An abnormality of the pigmentation of the mucosa of the mouth. [from HPO]

Recent clinical studies

Etiology

Oral mucosal color changes as a clinical biomarker for cancer detection.
Latini G, De Felice C, Barducci A, Chitano G, Pignatelli A, Grimaldi L, Tramacere F, Laurini R, Andreassi MG, Portaluri M
Eur J Cancer Prev 2012 Jul;21(4):360-6. doi: 10.1097/CEJ.0b013e328350de51. PMID: 22634938
Actinic cheilitis among agricultural workers in Campinas, Brazil.
Junqueira JL, Bönecker M, Furuse C, Morais Pde C, Flório FM, Cury PR, Araújo VC
Community Dent Health 2011 Mar;28(1):60-3. PMID: 21485236
Fanconi's anemia: clinical and radiographic oral manifestations.
de Araujo MR, de Oliveira Ribas M, Koubik AC, Mattioli T, de Lima AA, França BH
Oral Dis 2007 May;13(3):291-5. doi: 10.1111/j.1601-0825.2006.01282.x. PMID: 17448211
Mucocutaneous adverse effects of hydroxyurea: a prospective study of 30 psoriasis patients.
Kumar B, Saraswat A, Kaur I
Clin Exp Dermatol 2002 Jan;27(1):8-13. doi: 10.1046/j.0307-6938.2001.00947.x. PMID: 11952660
Oral mucosa lesions in Mazahua Indian adolescents.
Banderas JA, Toshikasu O, González M
Acta Odontol Latinoam 1999;12(1):11-20. PMID: 12905912

Diagnosis

Common benign and malignant oral mucosal disease.
Wong T, Yap T, Wiesenfeld D
Aust J Gen Pract 2020 Sep;49(9):568-573. doi: 10.31128/AJGP-02-20-5250-01. PMID: 32864671
Pediatric soft tissue oral lesions.
Pinto A, Haberland CM, Baker S
Dent Clin North Am 2014 Apr;58(2):437-53. Epub 2014 Jan 31 doi: 10.1016/j.cden.2013.12.003. PMID: 24655531
Dyskeratosis congenita: clinical report and review of the literature.
Baran I, Nalcaci R, Kocak M
Int J Dent Hyg 2010 Feb;8(1):68-74. doi: 10.1111/j.1601-5037.2009.00364.x. PMID: 20096085
The normal and pathological pigmentation of oral mucous membrane: a review.
Ciçek Y, Ertaş U
J Contemp Dent Pract 2003 Aug 15;4(3):76-86. PMID: 12937598
Generalized melanoses and nonmelanotic pigmentations of the head and neck.
Marlette RH
J Am Dent Assoc 1975 Jan;90(1):141-7. doi: 10.14219/jada.archive.1975.0031. PMID: 803220

Therapy

Actinic cheilitis among agricultural workers in Campinas, Brazil.
Junqueira JL, Bönecker M, Furuse C, Morais Pde C, Flório FM, Cury PR, Araújo VC
Community Dent Health 2011 Mar;28(1):60-3. PMID: 21485236
Oral squamous cell carcinoma during long-term treatment with hydroxyurea.
De Benedittis M, Petruzzi M, Giardina C, Lo Muzio L, Favia G, Serpico R
Clin Exp Dermatol 2004 Nov;29(6):605-7. doi: 10.1111/j.1365-2230.2004.01586.x. PMID: 15550132
Mucocutaneous adverse effects of hydroxyurea: a prospective study of 30 psoriasis patients.
Kumar B, Saraswat A, Kaur I
Clin Exp Dermatol 2002 Jan;27(1):8-13. doi: 10.1046/j.0307-6938.2001.00947.x. PMID: 11952660
Long-term use of FK 506 in living related liver transplantation.
Uemoto S, Tanaka K, Tokunaga Y, Nishizawa T, Sawada H, Katoh H, Yamamoto E, Yamaoka Y, Ozawa K
Transpl Int 1994;7 Suppl 1:S81-4. doi: 10.1111/j.1432-2277.1994.tb01315.x. PMID: 11271341
Generalized melanoses and nonmelanotic pigmentations of the head and neck.
Marlette RH
J Am Dent Assoc 1975 Jan;90(1):141-7. doi: 10.14219/jada.archive.1975.0031. PMID: 803220

Prognosis

Psammomatous melanotic schwannoma as a component of Carney complex.
Shanmugam S, Ghosh M, Niamathullah S, Ghosh S
Indian J Pathol Microbiol 2015 Jul-Sep;58(3):368-70. doi: 10.4103/0377-4929.162903. PMID: 26275268
Mucocutaneous adverse effects of hydroxyurea: a prospective study of 30 psoriasis patients.
Kumar B, Saraswat A, Kaur I
Clin Exp Dermatol 2002 Jan;27(1):8-13. doi: 10.1046/j.0307-6938.2001.00947.x. PMID: 11952660
Long-term use of FK 506 in living related liver transplantation.
Uemoto S, Tanaka K, Tokunaga Y, Nishizawa T, Sawada H, Katoh H, Yamamoto E, Yamaoka Y, Ozawa K
Transpl Int 1994;7 Suppl 1:S81-4. doi: 10.1111/j.1432-2277.1994.tb01315.x. PMID: 11271341
The oral features of betel nut chewers without submucous fibrosis.
Seedat HA, Van Wyk CW
J Biol Buccale 1988 Sep;16(3):123-8. PMID: 3198584
An approach to the diagnosis and management of oral mucosal abnormalities. II. Evaluation of oral lesions with an intact surface.
Courtney RM
Dent J Malays 1985 Apr;8(2):19-22. PMID: 3917000

Clinical prediction guides

Psammomatous melanotic schwannoma as a component of Carney complex.
Shanmugam S, Ghosh M, Niamathullah S, Ghosh S
Indian J Pathol Microbiol 2015 Jul-Sep;58(3):368-70. doi: 10.4103/0377-4929.162903. PMID: 26275268
Fanconi's anemia: clinical and radiographic oral manifestations.
de Araujo MR, de Oliveira Ribas M, Koubik AC, Mattioli T, de Lima AA, França BH
Oral Dis 2007 May;13(3):291-5. doi: 10.1111/j.1601-0825.2006.01282.x. PMID: 17448211
Mucocutaneous adverse effects of hydroxyurea: a prospective study of 30 psoriasis patients.
Kumar B, Saraswat A, Kaur I
Clin Exp Dermatol 2002 Jan;27(1):8-13. doi: 10.1046/j.0307-6938.2001.00947.x. PMID: 11952660
Long-term use of FK 506 in living related liver transplantation.
Uemoto S, Tanaka K, Tokunaga Y, Nishizawa T, Sawada H, Katoh H, Yamamoto E, Yamaoka Y, Ozawa K
Transpl Int 1994;7 Suppl 1:S81-4. doi: 10.1111/j.1432-2277.1994.tb01315.x. PMID: 11271341
The oral features of betel nut chewers without submucous fibrosis.
Seedat HA, Van Wyk CW
J Biol Buccale 1988 Sep;16(3):123-8. PMID: 3198584

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...