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Abnormal oral mucosa morphology

MedGen UID:
868765
Concept ID:
C4023170
Anatomical Abnormality
Synonyms: Abnormality of lining of mouth; Abnormality of mucosa of mouth; Abnormality of oral mucosa; Abnormality of oral mucous membrane
 
HPO: HP:0011830

Definition

Abnormality of the oral mucosa. [from HPO]

Conditions with this feature

Hypohidrotic X-linked ectodermal dysplasia
MedGen UID:
57890
Concept ID:
C0162359
Disease or Syndrome
Hypohidrotic ectodermal dysplasia (HED) is characterized by hypotrichosis (sparseness of scalp and body hair), hypohidrosis (reduced ability to sweat), and hypodontia (congenital absence of teeth). The cardinal features of classic HED become obvious during childhood. The scalp hair is thin, lightly pigmented, and slow growing. Sweating, although present, is greatly deficient, leading to episodes of hyperthermia until the affected individual or family acquires experience with environmental modifications to control temperature. Only a few abnormally formed teeth erupt, at a later-than-average age. Physical growth and psychomotor development are otherwise within normal limits. Mild HED is characterized by mild manifestations of any or all the characteristic features.

Professional guidelines

PubMed

Chiang CP, Yu-Fong Chang J, Wang YP, Wu YH, Lu SY, Sun A
J Formos Med Assoc 2018 Sep;117(9):756-765. Epub 2018 Feb 19 doi: 10.1016/j.jfma.2018.01.021. PMID: 29472048
Bittermann GK, de Ruiter AP, Janssen NG, Bittermann AJ, van der Molen AM, van Es RJ, Rosenberg AJ, Koole R
Clin Oral Investig 2016 Mar;20(2):207-17. Epub 2015 Sep 16 doi: 10.1007/s00784-015-1589-y. PMID: 26374747Free PMC Article
Madisch A, Morgner A, Stolte M, Miehlke S
Expert Opin Investig Drugs 2008 Dec;17(12):1829-37. doi: 10.1517/13543780802514500. PMID: 19012499

Recent clinical studies

Etiology

Hasegawa T, Ouchi T, Shibukawa Y, Asoda S, Nakagawa T
Front Biosci (Landmark Ed) 2023 Oct 25;28(10):265. doi: 10.31083/j.fbl2810265. PMID: 37919086
Afanasyev DE, Liubarets SF
Probl Radiac Med Radiobiol 2020 Dec;25:18-55. doi: 10.33145/2304-8336-2020-25-18-55. PMID: 33361828
Ganesh D, Sreenivasan P, Öhman J, Wallström M, Braz-Silva PH, Giglio D, Kjeller G, Hasséus B
Anticancer Res 2018 Jun;38(6):3223-3229. doi: 10.21873/anticanres.12587. PMID: 29848669
Tomas C, Soyer P, Dohan A, Dray X, Boudiaf M, Hoeffel C
World J Gastroenterol 2014 Aug 21;20(31):10864-75. doi: 10.3748/wjg.v20.i31.10864. PMID: 25152588Free PMC Article
Warnakulasuriya S, Johnson NW, van der Waal I
J Oral Pathol Med 2007 Nov;36(10):575-80. doi: 10.1111/j.1600-0714.2007.00582.x. PMID: 17944749

Diagnosis

Li R, Zhang R, Shi X, Jiao X, Li Y, Zhao Y, Liu T, Zhang C
Int Dent J 2024 Jun;74(3):581-588. Epub 2024 Jan 26 doi: 10.1016/j.identj.2023.12.011. PMID: 38278714Free PMC Article
Chiang CP, Yu-Fong Chang J, Wang YP, Wu YH, Lu SY, Sun A
J Formos Med Assoc 2018 Sep;117(9):756-765. Epub 2018 Feb 19 doi: 10.1016/j.jfma.2018.01.021. PMID: 29472048
Pinto A, Haberland CM, Baker S
Dent Clin North Am 2014 Apr;58(2):437-53. Epub 2014 Jan 31 doi: 10.1016/j.cden.2013.12.003. PMID: 24655531
Warnakulasuriya S, Johnson NW, van der Waal I
J Oral Pathol Med 2007 Nov;36(10):575-80. doi: 10.1111/j.1600-0714.2007.00582.x. PMID: 17944749
Bozdağ KE, Gül Y, Karaman A
Int J Dermatol 2000 Mar;39(3):203-4. doi: 10.1046/j.1365-4362.2000.00816.x. PMID: 10759961

Therapy

Afanasyev DE, Liubarets SF
Probl Radiac Med Radiobiol 2020 Dec;25:18-55. doi: 10.33145/2304-8336-2020-25-18-55. PMID: 33361828
Baig S, Rubab Z, Farooq W
J Coll Physicians Surg Pak 2018 May;28(5):381-385. doi: 10.29271/jcpsp.2018.05.381. PMID: 29690969
Prescrire Int 2015 Sep;24(163):210-1, 213. PMID: 26417631
Salvatore S, Hauser B, Vandenplas Y
Nestle Nutr Workshop Ser Pediatr Program 2007;59:115-26; discussion 126-31. doi: 10.1159/000098531. PMID: 17245095
Newburger JW, Fulton DR
Curr Opin Pediatr 2004 Oct;16(5):508-14. doi: 10.1097/01.mop.0000137796.23813.64. PMID: 15367843

Prognosis

Cai X, Zhang J, Zhang H, Zhou X, Zhou Z, Jing F, Luo H, Li T
Oral Dis 2024 Jul;30(5):3028-3038. Epub 2023 Nov 20 doi: 10.1111/odi.14809. PMID: 37983891
Zhang X, Gleber-Netto FO, Wang S, Martins-Chaves RR, Gomez RS, Vigneswaran N, Sarkar A, William WN Jr, Papadimitrakopoulou V, Williams M, Bell D, Palsgrove D, Bishop J, Heymach JV, Gillenwater AM, Myers JN, Ferrarotto R, Lippman SM, Pickering CR, Xiao G
Cancer Med 2023 Mar;12(6):7508-7518. Epub 2023 Jan 31 doi: 10.1002/cam4.5478. PMID: 36721313Free PMC Article
Wilder EG, Frieder J, Sulhan S, Michel P, Cizenski JD, Wright JM, Menter MA
J Am Acad Dermatol 2017 Nov;77(5):809-830. doi: 10.1016/j.jaad.2017.02.017. PMID: 29029902
Tomas C, Soyer P, Dohan A, Dray X, Boudiaf M, Hoeffel C
World J Gastroenterol 2014 Aug 21;20(31):10864-75. doi: 10.3748/wjg.v20.i31.10864. PMID: 25152588Free PMC Article
Newburger JW, Fulton DR
Curr Opin Pediatr 2004 Oct;16(5):508-14. doi: 10.1097/01.mop.0000137796.23813.64. PMID: 15367843

Clinical prediction guides

Li R, Zhang R, Shi X, Jiao X, Li Y, Zhao Y, Liu T, Zhang C
Int Dent J 2024 Jun;74(3):581-588. Epub 2024 Jan 26 doi: 10.1016/j.identj.2023.12.011. PMID: 38278714Free PMC Article
Mahmood H, Shephard A, Hankinson P, Bradburn M, Araujo ALD, Santos-Silva AR, Lopes MA, Vargas PA, McCombe KD, Craig SG, James J, Brooks J, Nankivell P, Mehanna H, Rajpoot N, Khurram SA
Br J Cancer 2023 Nov;129(10):1599-1607. Epub 2023 Sep 27 doi: 10.1038/s41416-023-02438-0. PMID: 37758836Free PMC Article
Gonzalez Ballerga E, Pozo MO, Rubatto Birri PN, Kanoore Edul VS, Sorda JA, Daruich J, Dubin A
Microcirculation 2018 May;25(4):e12448. Epub 2018 Apr 16 doi: 10.1111/micc.12448. PMID: 29527776
Sasaki R, Yamamoto T, Ando T
J Craniofac Surg 2016 Jan;27(1):e2-4. doi: 10.1097/SCS.0000000000002247. PMID: 26745198
Reichart PA, Schmidt-Westhausen AM, Khongkhunthian P, Strietzel FP
J Oral Rehabil 2016 May;43(5):388-99. Epub 2015 Dec 21 doi: 10.1111/joor.12373. PMID: 26685871

Recent systematic reviews

Ramani RS, Tan I, Bussau L, Angel CM, McCullough M, Yap T
Oral Dis 2023 Nov;29(8):3003-3015. Epub 2022 Jul 10 doi: 10.1111/odi.14291. PMID: 35765235
Parkin N, Benson PE, Thind B, Shah A, Khalil I, Ghafoor S
Cochrane Database Syst Rev 2017 Aug 21;8(8):CD006966. doi: 10.1002/14651858.CD006966.pub3. PMID: 28828758Free PMC Article
Reichart PA, Schmidt-Westhausen AM, Khongkhunthian P, Strietzel FP
J Oral Rehabil 2016 May;43(5):388-99. Epub 2015 Dec 21 doi: 10.1111/joor.12373. PMID: 26685871
Almeida FT, Pachêco-Pereira C, Porporatti AL, Flores-Mir C, Leite AF, De Luca Canto G, Guerra EN
J Gastroenterol Hepatol 2016 Mar;31(3):527-40. doi: 10.1111/jgh.13149. PMID: 26331960
Parkin N, Benson PE, Thind B, Shah A
Cochrane Database Syst Rev 2008 Oct 8;(4):CD006966. doi: 10.1002/14651858.CD006966.pub2. PMID: 18843740

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