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Abnormal circulating creatinine concentration

MedGen UID:
866751
•Concept ID:
C4021101
•
Finding
Synonyms: Abnormal blood creatinine level; Abnormal circulating creatinine level; Creatinine levels abnormal
 
HPO: HP:0012100

Definition

An abnormal concentration of creatinine in the blood. [from HPO]

Conditions with this feature

Primary hyperoxaluria, type II
MedGen UID:
120616
•Concept ID:
C0268165
•
Disease or Syndrome
Primary hyperoxaluria type 2 (PH2), caused by deficiency of the enzyme glyoxylate reductase/hydroxypyruvate reductase (GR/HPR), is characterized by recurrent nephrolithiasis (deposition of calcium oxalate in the renal pelvis/urinary tract), nephrocalcinosis (deposition of calcium oxalate in the renal parenchyma), and end-stage renal disease (ESRD). After ESRD, oxalosis (widespread tissue deposition of calcium oxalate) usually develops. Symptom onset is typically in childhood.
See: Condition Record
Primary hyperoxaluria, type II

Professional guidelines

PubMed

Measuring non-polyaminated lipocalin-2 for cardiometabolic risk assessment.
Yang K, Deng HB, Man AWC, Song E, Zhang J, Luo C, Cheung BMY, Yuen KY, Jensen PS, Irmukhamedov A, Elie AGIM, Vanhoutte PM, Xu A, De Mey JGR, Wang Y
ESC Heart Fail 2017 Nov;4(4):563-575. Epub 2017 Jun 27 doi: 10.1002/ehf2.12183. PMID: 29154418Free PMC Article
Ibuprofen lysine for the prevention and treatment of patent ductus arteriosus.
Pai VB, Sakadjian A, Puthoff TD
Pharmacotherapy 2008 Sep;28(9):1162-82. doi: 10.1592/phco.28.9.1162. PMID: 18752387
Twenty-four hour hormonal and metabolic profiles in uraemic patients before and during treatment with continuous ambulatory peritoneal dialysis.
Heaton A, Johnston DG, Haigh JW, Ward MK, Alberti KG, Kerr DN
Clin Sci (Lond) 1985 Oct;69(4):449-57. doi: 10.1042/cs0690449. PMID: 4042546

Recent clinical studies

Etiology

Usefulness of High-Sensitivity Cardiac Troponin T for the Identification of Outlier Patients With Diffuse Coronary Atherosclerosis and Low-Risk Factors.
Magnoni M, Masson S, Andreini D, Moccetti T, Modena MG, Canestrari M, Berti S, Casolo G, Gabrielli D, Marraccini P, Pontone G, Latini R, Maggioni AP, Maseri A; CAPIRE Study Group
Am J Cardiol 2016 May 1;117(9):1397-404. Epub 2016 Feb 17 doi: 10.1016/j.amjcard.2016.02.002. PMID: 26976791
Association between serum adipocyte fatty-acid binding protein concentrations, left ventricular function and myocardial perfusion abnormalities in patients with coronary artery disease.
Huang CL, Wu YW, Wu CC, Lin L, Wu YC, Hsu PY, Jong YS, Yang WS
Cardiovasc Diabetol 2013 Jul 17;12:105. doi: 10.1186/1475-2840-12-105. PMID: 23866022Free PMC Article
Cerebral microvascular disease predicts renal failure in type 2 diabetes.
Uzu T, Kida Y, Shirahashi N, Harada T, Yamauchi A, Nomura M, Isshiki K, Araki S, Sugimoto T, Koya D, Haneda M, Kashiwagi A, Kikkawa R
J Am Soc Nephrol 2010 Mar;21(3):520-6. Epub 2010 Jan 28 doi: 10.1681/ASN.2009050558. PMID: 20110380Free PMC Article
Cerebral herniation in patients with acute liver failure is correlated with arterial ammonia concentration.
Clemmesen JO, Larsen FS, Kondrup J, Hansen BA, Ott P
Hepatology 1999 Mar;29(3):648-53. doi: 10.1002/hep.510290309. PMID: 10051463
Effect of ultrafiltration on priming solution with preserved blood for extracorporeal circulation in infants.
Shimpo H, Shimamoto A, Miyake Y, Onoda K, Tani K, Shimono T, Yuasa H, Yada I
ASAIO J 1996 Sep-Oct;42(5):M792-4. doi: 10.1097/00002480-199609000-00098. PMID: 8944991

Diagnosis

The imbalance of circulating monocyte subgroups with a higher proportion of the CD14+CD16+CD163+ phenotype in patients with preeclampsia.
Gong F, Wang J, Lu N, Wang J, Wang J, Shi X, Cui M, Cui L
Immunol Lett 2023 Jan;253:1-7. Epub 2022 Nov 29 doi: 10.1016/j.imlet.2022.11.005. PMID: 36460232
Association between serum adipocyte fatty-acid binding protein concentrations, left ventricular function and myocardial perfusion abnormalities in patients with coronary artery disease.
Huang CL, Wu YW, Wu CC, Lin L, Wu YC, Hsu PY, Jong YS, Yang WS
Cardiovasc Diabetol 2013 Jul 17;12:105. doi: 10.1186/1475-2840-12-105. PMID: 23866022Free PMC Article
Cerebral microvascular disease predicts renal failure in type 2 diabetes.
Uzu T, Kida Y, Shirahashi N, Harada T, Yamauchi A, Nomura M, Isshiki K, Araki S, Sugimoto T, Koya D, Haneda M, Kashiwagi A, Kikkawa R
J Am Soc Nephrol 2010 Mar;21(3):520-6. Epub 2010 Jan 28 doi: 10.1681/ASN.2009050558. PMID: 20110380Free PMC Article
Urine free beta hCG and beta core in pregnancies affected by Down's syndrome.
Spencer K, Aitken DA, Macri JN, Buchanan PD
Prenat Diagn 1996 Jul;16(7):605-13. doi: 10.1002/(SICI)1097-0223(199607)16:7<605::AID-PD918>3.0.CO;2-Q. PMID: 8843469
Hepatorenal syndrome following hemihepatectomy.
Epstein M, Oster JR, de Velasco RE
Clin Nephrol 1976 Mar;5(3):129-33. PMID: 1261103

Therapy

Administration of low-dose dopamine to nonoliguric patients with sepsis syndrome does not raise intramucosal gastric pH nor improve creatinine clearance.
Olson D, Pohlman A, Hall JB
Am J Respir Crit Care Med 1996 Dec;154(6 Pt 1):1664-70. doi: 10.1164/ajrccm.154.6.8970352. PMID: 8970352
Effect of ultrafiltration on priming solution with preserved blood for extracorporeal circulation in infants.
Shimpo H, Shimamoto A, Miyake Y, Onoda K, Tani K, Shimono T, Yuasa H, Yada I
ASAIO J 1996 Sep-Oct;42(5):M792-4. doi: 10.1097/00002480-199609000-00098. PMID: 8944991
The nutritional/metabolic and hormonal effects of 8 weeks of continuous ambulatory peritoneal dialysis with a 1% amino acid solution.
Arfeen S, Goodship TH, Kirkwood A, Ward MK
Clin Nephrol 1990 Apr;33(4):192-99. PMID: 2190721
Enhancement of renal function by a long-acting somatostatin analogue in patients with decompensated cirrhosis.
Mountokalakis T, Kallivretakis N, Mayopoulou-Symvoulidou D, Karvountzis G, Tolis G
Nephrol Dial Transplant 1988;3(5):604-7. doi: 10.1093/oxfordjournals.ndt.a091713. PMID: 3146715
Hepatorenal syndrome following hemihepatectomy.
Epstein M, Oster JR, de Velasco RE
Clin Nephrol 1976 Mar;5(3):129-33. PMID: 1261103

Prognosis

Measuring non-polyaminated lipocalin-2 for cardiometabolic risk assessment.
Yang K, Deng HB, Man AWC, Song E, Zhang J, Luo C, Cheung BMY, Yuen KY, Jensen PS, Irmukhamedov A, Elie AGIM, Vanhoutte PM, Xu A, De Mey JGR, Wang Y
ESC Heart Fail 2017 Nov;4(4):563-575. Epub 2017 Jun 27 doi: 10.1002/ehf2.12183. PMID: 29154418Free PMC Article
Usefulness of High-Sensitivity Cardiac Troponin T for the Identification of Outlier Patients With Diffuse Coronary Atherosclerosis and Low-Risk Factors.
Magnoni M, Masson S, Andreini D, Moccetti T, Modena MG, Canestrari M, Berti S, Casolo G, Gabrielli D, Marraccini P, Pontone G, Latini R, Maggioni AP, Maseri A; CAPIRE Study Group
Am J Cardiol 2016 May 1;117(9):1397-404. Epub 2016 Feb 17 doi: 10.1016/j.amjcard.2016.02.002. PMID: 26976791
Association between serum adipocyte fatty-acid binding protein concentrations, left ventricular function and myocardial perfusion abnormalities in patients with coronary artery disease.
Huang CL, Wu YW, Wu CC, Lin L, Wu YC, Hsu PY, Jong YS, Yang WS
Cardiovasc Diabetol 2013 Jul 17;12:105. doi: 10.1186/1475-2840-12-105. PMID: 23866022Free PMC Article
Cerebral microvascular disease predicts renal failure in type 2 diabetes.
Uzu T, Kida Y, Shirahashi N, Harada T, Yamauchi A, Nomura M, Isshiki K, Araki S, Sugimoto T, Koya D, Haneda M, Kashiwagi A, Kikkawa R
J Am Soc Nephrol 2010 Mar;21(3):520-6. Epub 2010 Jan 28 doi: 10.1681/ASN.2009050558. PMID: 20110380Free PMC Article
Urine free beta hCG and beta core in pregnancies affected by Down's syndrome.
Spencer K, Aitken DA, Macri JN, Buchanan PD
Prenat Diagn 1996 Jul;16(7):605-13. doi: 10.1002/(SICI)1097-0223(199607)16:7<605::AID-PD918>3.0.CO;2-Q. PMID: 8843469

Clinical prediction guides

Usefulness of High-Sensitivity Cardiac Troponin T for the Identification of Outlier Patients With Diffuse Coronary Atherosclerosis and Low-Risk Factors.
Magnoni M, Masson S, Andreini D, Moccetti T, Modena MG, Canestrari M, Berti S, Casolo G, Gabrielli D, Marraccini P, Pontone G, Latini R, Maggioni AP, Maseri A; CAPIRE Study Group
Am J Cardiol 2016 May 1;117(9):1397-404. Epub 2016 Feb 17 doi: 10.1016/j.amjcard.2016.02.002. PMID: 26976791
Association between serum adipocyte fatty-acid binding protein concentrations, left ventricular function and myocardial perfusion abnormalities in patients with coronary artery disease.
Huang CL, Wu YW, Wu CC, Lin L, Wu YC, Hsu PY, Jong YS, Yang WS
Cardiovasc Diabetol 2013 Jul 17;12:105. doi: 10.1186/1475-2840-12-105. PMID: 23866022Free PMC Article
Cerebral microvascular disease predicts renal failure in type 2 diabetes.
Uzu T, Kida Y, Shirahashi N, Harada T, Yamauchi A, Nomura M, Isshiki K, Araki S, Sugimoto T, Koya D, Haneda M, Kashiwagi A, Kikkawa R
J Am Soc Nephrol 2010 Mar;21(3):520-6. Epub 2010 Jan 28 doi: 10.1681/ASN.2009050558. PMID: 20110380Free PMC Article
Urine free beta hCG and beta core in pregnancies affected by Down's syndrome.
Spencer K, Aitken DA, Macri JN, Buchanan PD
Prenat Diagn 1996 Jul;16(7):605-13. doi: 10.1002/(SICI)1097-0223(199607)16:7<605::AID-PD918>3.0.CO;2-Q. PMID: 8843469
Soluble immune complexes in sera of patients with nephritis.
Rossen RD, Reisberg MA, Singer DB, Schloeder FX, Suki WN, Hill LL, Eknoyan G
Kidney Int 1976 Sep;10(3):256-63. doi: 10.1038/ki.1976.105. PMID: 135115

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