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Agenesis of mandibular incisor

MedGen UID:: 867497
•Concept ID:: C4021876
•: Anatomical Abnormality

Synonyms:	Absence of lower front tooth; Absence of lower incisor; Absence of mandibular incisor; Agenesis of lower incisor; Failure of development of mandibular incisor; Missing lower front tooth; Missing lower incisor

HPO:	HP:0200161

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAgenesis of mandibular incisor

Abnormal oral morphology
- Abnormal oral cavity morphology
  - Abnormality of the dentition
    - Abnormal number of teeth
      - Abnormal number of incisors
        Agenesis of incisor
        Agenesis of mandibular incisor
        Agenesis of mandibular central incisor
        Agenesis of permanent mandibular central incisor
        Agenesis of primary mandibular central incisor
        Agenesis of mandibular lateral incisor
        Agenesis of permanent mandibular lateral incisor
        Agenesis of primary mandibular lateral incisor

Professional guidelines

PubMed

Nine Novel PAX9 Mutations and a Distinct Tooth Agenesis Genotype-Phenotype.

Wong SW, Han D, Zhang H, Liu Y, Zhang X, Miao MZ, Wang Y, Zhao N, Zeng L, Bai B, Wang YX, Liu H, Frazier-Bowers SA, Feng H
J Dent Res 2018 Feb;97(2):155-162. Epub 2017 Sep 14 doi: 10.1177/0022034517729322. PMID: 28910570 Free PMC Article

Hypodontia: An Update on Its Etiology, Classification, and Clinical Management.

Al-Ani AH, Antoun JS, Thomson WM, Merriman TR, Farella M
Biomed Res Int 2017;2017:9378325. Epub 2017 Mar 19 doi: 10.1155/2017/9378325. PMID: 28401166 Free PMC Article

Antecedents and correlates of hypoplastic enamel defects of primary incisors.

Needleman HL, Allred E, Bellinger D, Leviton A, Rabinowitz M, Iverson K
Pediatr Dent 1992 May-Jun;14(3):158-66. PMID: 1528784

See all (26)

Recent clinical studies

Etiology

Patterns of nonsyndromic tooth agenesis and sexual dimorphism.

Kanchanasevee C, Chantarangsu S, Pittayapat P, Porntaveetus T
BMC Oral Health 2023 Jan 23;23(1):37. doi: 10.1186/s12903-023-02753-1. PMID: 36691053 Free PMC Article

Influence of mandibular incisor agenesis and growth pattern on symphysis characteristics: A retrospective cephalometric study.

Yoshida S, Ota S, Kobayashi S
Orthod Craniofac Res 2023 Aug;26(3):393-401. Epub 2022 Nov 20 doi: 10.1111/ocr.12621. PMID: 36329568

Skeletal and dentoalveolar characteristics of maxillary lateral incisor agenesis patients: a comparative cross-sectional study.

Tageldin MA, Yacout YM, Marzouk ES
BMC Oral Health 2022 Dec 15;22(1):608. doi: 10.1186/s12903-022-02656-7. PMID: 36522742 Free PMC Article

Symmetry of crown widths in subjects with unilateral maxillary lateral incisor agenesis.

Gorucu-Coskuner H, Atik E, Akarsu-Guven B
J Orofac Orthop 2022 Sep;83(5):325-331. Epub 2021 Apr 14 doi: 10.1007/s00056-021-00293-3. PMID: 33852040

Prevalence of hypodontia and associated factors: a systematic review and meta-analysis.

Khalaf K, Miskelly J, Voge E, Macfarlane TV
J Orthod 2014 Dec;41(4):299-316. doi: 10.1179/1465313314Y.0000000116. PMID: 25404667

See all (328)

Diagnosis

Molar incisor hypomineralization: Analysis of asymmetry of lesions.

Biondi AM, Córtese SG, Babino L, Toscano MA
Acta Odontol Latinoam 2019 Apr 1;32(1):44-48. PMID: 31206574

Prevalence and patterns of permanent tooth agenesis in individuals with Down syndrome: a meta-analysis.

Palaska PK, Antonarakis GS
Eur J Oral Sci 2016 Aug;124(4):317-28. Epub 2016 Jun 17 doi: 10.1111/eos.12282. PMID: 27311636

Prevalence of hypodontia and associated factors: a systematic review and meta-analysis.

Khalaf K, Miskelly J, Voge E, Macfarlane TV
J Orthod 2014 Dec;41(4):299-316. doi: 10.1179/1465313314Y.0000000116. PMID: 25404667

Non-syndromic multiple supernumerary teeth: meta-analysis.

Alvira-González J, Gay-Escoda C
J Oral Pathol Med 2012 May;41(5):361-6. Epub 2011 Nov 18 doi: 10.1111/j.1600-0714.2011.01111.x. PMID: 22092693

Mandibular lateral incisor-canine transposition, concomitant dental anomalies, and genetic control.

Peck S, Peck L, Kataja M
Angle Orthod 1998 Oct;68(5):455-66. doi: 10.1043/0003-3219(1998)068<0455:MLICTC>2.3.CO;2. PMID: 9770104

See all (194)

Therapy

Three-dimensional evaluation of alveolar bone thickness of mandibular anterior teeth in different dentofacial types.

Eraydın F, Germec-Cakan D, Tozlu M, Ozdemir FI
Niger J Clin Pract 2018 Apr;21(4):519-524. doi: 10.4103/njcp.njcp_90_17. PMID: 29607868

Phenotypes of Enamel Hypomineralization and Molar Incisor Hypomineralization in Permanent Dentition: Identification, Quantification and Proposal for Classification.

Mittal N
J Clin Pediatr Dent 2016;40(5):367-74. doi: 10.17796/1053-4628-40.5.367. PMID: 27617377

Effectiveness of TAD-anchored maxillary protraction in late mixed dentition.

Feng X, Li J, Li Y, Zhao Z, Zhao S, Wang J
Angle Orthod 2012 Nov;82(6):1107-14. Epub 2012 Mar 29 doi: 10.2319/111411-705.1. PMID: 22458766 Free PMC Article

Antecedents and correlates of hypoplastic enamel defects of primary incisors.

Needleman HL, Allred E, Bellinger D, Leviton A, Rabinowitz M, Iverson K
Pediatr Dent 1992 May-Jun;14(3):158-66. PMID: 1528784

Prevalence of hypodontia and developmental malformation of permanent teeth in Saudi Arabian schoolchildren.

al-Emran S
Br J Orthod 1990 May;17(2):115-8. doi: 10.1179/bjo.17.2.115. PMID: 2192761

See all (59)

Prognosis

Interceptive orthodontic management of mandibular lateral incisor-canine transposition using simplified and efficient biomechanical approach: A case report.

Singh H, Mittal T, Sharma P, Kapoor P, Maurya RK, Rastogi S
Int Orthod 2022 Dec;20(4):100690. Epub 2022 Sep 16 doi: 10.1016/j.ortho.2022.100690. PMID: 36123290

Orthodontic treatment of mandibular incisor agenesis with Herbst appliance in a patient with Hanhart syndrome: A 12-year follow-up.

Turri de Castro Ribeiro T, Doneux Van der Laan H, Massaro C, Moura Carvalho Lauris RC, Mizue Kokitsu-Nakata N, Porto Peixoto A
Am J Orthod Dentofacial Orthop 2022 Jun;161(6):866-877. Epub 2022 Feb 3 doi: 10.1016/j.ajodo.2021.01.035. PMID: 35123837

Hypodontia: An Update on Its Etiology, Classification, and Clinical Management.

Al-Ani AH, Antoun JS, Thomson WM, Merriman TR, Farella M
Biomed Res Int 2017;2017:9378325. Epub 2017 Mar 19 doi: 10.1155/2017/9378325. PMID: 28401166 Free PMC Article

Impacted and transmigrant mandibular canines incidence, aetiology, and treatment: a systematic review.

Dalessandri D, Parrini S, Rubiano R, Gallone D, Migliorati M
Eur J Orthod 2017 Apr 1;39(2):161-169. doi: 10.1093/ejo/cjw027. PMID: 27036134

Prevalence and patterns of permanent tooth agenesis in individuals with Down syndrome: a meta-analysis.

Palaska PK, Antonarakis GS
Eur J Oral Sci 2016 Aug;124(4):317-28. Epub 2016 Jun 17 doi: 10.1111/eos.12282. PMID: 27311636

See all (141)

Clinical prediction guides

Patterns of nonsyndromic tooth agenesis and sexual dimorphism.

Kanchanasevee C, Chantarangsu S, Pittayapat P, Porntaveetus T
BMC Oral Health 2023 Jan 23;23(1):37. doi: 10.1186/s12903-023-02753-1. PMID: 36691053 Free PMC Article

Molar incisor hypomineralization: Analysis of asymmetry of lesions.

Biondi AM, Córtese SG, Babino L, Toscano MA
Acta Odontol Latinoam 2019 Apr 1;32(1):44-48. PMID: 31206574

Hypodontia: An Update on Its Etiology, Classification, and Clinical Management.

Al-Ani AH, Antoun JS, Thomson WM, Merriman TR, Farella M
Biomed Res Int 2017;2017:9378325. Epub 2017 Mar 19 doi: 10.1155/2017/9378325. PMID: 28401166 Free PMC Article

Relationship between mandibular incisor irregularity and type of occlusion in ankyloglossia.

Sepet E, Yildiz C, Erdem AP, Ikikarakayali G, Gorken FN, Kuru S
Oral Health Prev Dent 2015;13(1):59-63. doi: 10.3290/j.ohpd.a32135. PMID: 24914432

A study of prevalence and distribution of tooth agenesis.

Bozga A, Stanciu RP, Mănuc D
J Med Life 2014 Oct-Dec;7(4):551-4. PMID: 25713620 Free PMC Article

See all (190)

Recent systematic reviews

Atypical Radicular Anatomy in Permanent Human Teeth: A Systematic Review.

Nino-Barrera J, Alzate-Mendoza D, Olaya-Abril C, Gamboa-Martinez LF, Guamán-Laverde M, Lagos-Rosero N, Romero-Diaz AC, Duran N, Vanegas-Hoyose L
Crit Rev Biomed Eng 2022;50(1):19-34. doi: 10.1615/CritRevBiomedEng.2022043742. PMID: 35997108

Impacted and transmigrant mandibular canines incidence, aetiology, and treatment: a systematic review.

Dalessandri D, Parrini S, Rubiano R, Gallone D, Migliorati M
Eur J Orthod 2017 Apr 1;39(2):161-169. doi: 10.1093/ejo/cjw027. PMID: 27036134

Prevalence of hypodontia and associated factors: a systematic review and meta-analysis.

Khalaf K, Miskelly J, Voge E, Macfarlane TV
J Orthod 2014 Dec;41(4):299-316. doi: 10.1179/1465313314Y.0000000116. PMID: 25404667

See all (3)

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Agenesis of mandibular incisor

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

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