U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Telangiectasia of the skin

MedGen UID:
867629
Concept ID:
C4022018
Finding
Synonyms: Telangiectasia of skin; Teleangiectasia of the skin
SNOMED CT: Telangiectasia of skin (1197432002)
 
HPO: HP:0100585

Definition

Presence of small, permanently dilated blood vessels near the surface of the skin, visible as small focal red lesions. [from HPO]

Conditions with this feature

Kindler syndrome
MedGen UID:
96060
Concept ID:
C0406557
Disease or Syndrome
Kindler syndrome (KS), a rare subtype of inherited epidermolysis bullosa, is characterized by skin fragility and acral blister formation beginning at birth, diffuse cutaneous atrophy, photosensitivity (most prominent during childhood and usually decreasing after adolescence), poikiloderma, diffuse palmoplantar hyperkeratosis, and pseudosyndactyly. Mucosal manifestations are also common and include hemorrhagic mucositis and gingivitis, periodontal disease, premature loss of teeth, and labial leukokeratosis. Other mucosal findings can include ectropion, urethral stenosis, and severe phimosis. Severe long-term complications of KS include periodontitis, mucosal strictures, and aggressive squamous cell carcinomas. Manifestations can range from mild to severe.
Dilated cardiomyopathy-hypergonadotropic hypogonadism syndrome
MedGen UID:
162901
Concept ID:
C0796031
Disease or Syndrome
This syndrome is characterized by the association of dilated cardiomyopathy and hypergonadotropic hypogonadism (DCM-HH).
Mandibular hypoplasia-deafness-progeroid syndrome
MedGen UID:
811623
Concept ID:
C3715192
Disease or Syndrome
Mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome (MDPL) is an autosomal dominant systemic disorder characterized by prominent loss of subcutaneous fat, a characteristic facial appearance, and metabolic abnormalities including insulin resistance and diabetes mellitus. Sensorineural deafness occurs late in the first or second decades of life (summary by Weedon et al., 2013).
Cataract-growth hormone deficiency-sensory neuropathy-sensorineural hearing loss-skeletal dysplasia syndrome
MedGen UID:
863379
Concept ID:
C4014942
Disease or Syndrome
CAGSSS, which comprises cataracts, growth hormone deficiency, sensory neuropathy, sensorineural hearing loss, and skeletal dysplasia, is an autosomal recessive multisystemic disorder with a highly variable phenotypic spectrum. Not all of these features are always present, and almost all the features may present at different times and/or become more apparent with age. The skeletal features are consistent with spondyloepimetaphyseal dysplasia (SEMD) (summary by Vona et al., 2018). One family had a distinctive presentation with infantile-onset intractable seizures and cortical abnormalities reminiscent of Leigh syndrome (see 256000). The correlation between genotype and phenotype remains unclear, but since the IARS2 gene is involved in mitochondrial function, heterogeneous manifestations can be expected (Takezawa et al., 2018).
Telangiectasia, hereditary hemorrhagic, type 1
MedGen UID:
1643786
Concept ID:
C4551861
Disease or Syndrome
Hereditary hemorrhagic telangiectasia (HHT) is characterized by the presence of multiple arteriovenous malformations (AVMs) that lack intervening capillaries and result in direct connections between arteries and veins. The most common clinical manifestation is spontaneous and recurrent nosebleeds (epistaxis) beginning on average at age 12 years. Telangiectases (small AVMs) are characteristically found on the lips, tongue, buccal and gastrointestinal (GI) mucosa, face, and fingers. The appearance of telangiectases is generally later than epistaxis but may be during childhood. Large AVMs occur most often in the lungs, liver, or brain; complications from bleeding or shunting may be sudden and catastrophic. A minority of individuals with HHT have GI bleeding, which is rarely seen before age 50 years.

Professional guidelines

PubMed

Sharma A, Kroumpouzos G, Kassir M, Galadari H, Goren A, Grabbe S, Goldust M
J Cosmet Dermatol 2022 May;21(5):1895-1904. Epub 2022 Feb 14 doi: 10.1111/jocd.14816. PMID: 35104917
van Zuuren EJ, Arents BWM, van der Linden MMD, Vermeulen S, Fedorowicz Z, Tan J
Am J Clin Dermatol 2021 Jul;22(4):457-465. Epub 2021 Mar 23 doi: 10.1007/s40257-021-00595-7. PMID: 33759078Free PMC Article
van den Hoogen F, Khanna D, Fransen J, Johnson SR, Baron M, Tyndall A, Matucci-Cerinic M, Naden RP, Medsger TA Jr, Carreira PE, Riemekasten G, Clements PJ, Denton CP, Distler O, Allanore Y, Furst DE, Gabrielli A, Mayes MD, van Laar JM, Seibold JR, Czirjak L, Steen VD, Inanc M, Kowal-Bielecka O, Müller-Ladner U, Valentini G, Veale DJ, Vonk MC, Walker UA, Chung L, Collier DH, Ellen Csuka M, Fessler BJ, Guiducci S, Herrick A, Hsu VM, Jimenez S, Kahaleh B, Merkel PA, Sierakowski S, Silver RM, Simms RW, Varga J, Pope JE
Ann Rheum Dis 2013 Nov;72(11):1747-55. doi: 10.1136/annrheumdis-2013-204424. PMID: 24092682

Recent clinical studies

Etiology

Leszczynski R, da Silva CA, Pinto ACPN, Kuczynski U, da Silva EM
Cochrane Database Syst Rev 2022 Sep 26;9(9):CD011642. doi: 10.1002/14651858.CD011642.pub2. PMID: 36161591Free PMC Article
Sales AFS, Pandolfo IL, de Almeida Cruz M, Parisi JR, Garcia LA, Martignago CCS, Renno ACM, Vassão PG
Arch Dermatol Res 2022 Nov;314(9):823-838. Epub 2021 Oct 5 doi: 10.1007/s00403-021-02283-2. PMID: 34609598
Alexis AF, Callender VD, Baldwin HE, Desai SR, Rendon MI, Taylor SC
J Am Acad Dermatol 2019 Jun;80(6):1722-1729.e7. Epub 2018 Sep 19 doi: 10.1016/j.jaad.2018.08.049. PMID: 30240779
Riahi RR, Bush AE, Cohen PR
Am J Clin Dermatol 2016 Jun;17(3):265-76. doi: 10.1007/s40257-016-0185-5. PMID: 26969582
van den Hoogen F, Khanna D, Fransen J, Johnson SR, Baron M, Tyndall A, Matucci-Cerinic M, Naden RP, Medsger TA Jr, Carreira PE, Riemekasten G, Clements PJ, Denton CP, Distler O, Allanore Y, Furst DE, Gabrielli A, Mayes MD, van Laar JM, Seibold JR, Czirjak L, Steen VD, Inanc M, Kowal-Bielecka O, Müller-Ladner U, Valentini G, Veale DJ, Vonk MC, Walker UA, Chung L, Collier DH, Ellen Csuka M, Fessler BJ, Guiducci S, Herrick A, Hsu VM, Jimenez S, Kahaleh B, Merkel PA, Sierakowski S, Silver RM, Simms RW, Varga J, Pope JE
Ann Rheum Dis 2013 Nov;72(11):1747-55. doi: 10.1136/annrheumdis-2013-204424. PMID: 24092682

Diagnosis

Lescoat A, Huang S, Carreira PE, Siegert E, de Vries-Bouwstra J, Distler JHW, Smith V, Del Galdo F, Anic B, Damjanov N, Rednic S, Ribi C, Bancel DF, Hoffmann-Vold AM, Gabrielli A, Distler O, Khanna D, Allanore Y; EUSTAR collaborators
JAMA Dermatol 2023 Aug 1;159(8):837-847. doi: 10.1001/jamadermatol.2023.1729. PMID: 37378994Free PMC Article
Alexis AF, Callender VD, Baldwin HE, Desai SR, Rendon MI, Taylor SC
J Am Acad Dermatol 2019 Jun;80(6):1722-1729.e7. Epub 2018 Sep 19 doi: 10.1016/j.jaad.2018.08.049. PMID: 30240779
Weiss MA, Hsu JT, Neuhaus I, Sadick NS, Duffy DM
Dermatol Surg 2014 Dec;40(12):1309-18. doi: 10.1097/DSS.0000000000000225. PMID: 25418805
van den Hoogen F, Khanna D, Fransen J, Johnson SR, Baron M, Tyndall A, Matucci-Cerinic M, Naden RP, Medsger TA Jr, Carreira PE, Riemekasten G, Clements PJ, Denton CP, Distler O, Allanore Y, Furst DE, Gabrielli A, Mayes MD, van Laar JM, Seibold JR, Czirjak L, Steen VD, Inanc M, Kowal-Bielecka O, Müller-Ladner U, Valentini G, Veale DJ, Vonk MC, Walker UA, Chung L, Collier DH, Ellen Csuka M, Fessler BJ, Guiducci S, Herrick A, Hsu VM, Jimenez S, Kahaleh B, Merkel PA, Sierakowski S, Silver RM, Simms RW, Varga J, Pope JE
Ann Rheum Dis 2013 Nov;72(11):1747-55. doi: 10.1136/annrheumdis-2013-204424. PMID: 24092682
Astner S, Anderson RR
Dermatol Ther 2005 May-Jun;18(3):267-81. doi: 10.1111/j.1529-8019.2005.05025.x. PMID: 16229727

Therapy

Chao JR, Porter JP, Hessler J
Facial Plast Surg 2023 Oct;39(5):496-500. Epub 2023 Aug 9 doi: 10.1055/s-0043-1772197. PMID: 37557909
Leszczynski R, da Silva CA, Pinto ACPN, Kuczynski U, da Silva EM
Cochrane Database Syst Rev 2022 Sep 26;9(9):CD011642. doi: 10.1002/14651858.CD011642.pub2. PMID: 36161591Free PMC Article
Sharma A, Kroumpouzos G, Kassir M, Galadari H, Goren A, Grabbe S, Goldust M
J Cosmet Dermatol 2022 May;21(5):1895-1904. Epub 2022 Feb 14 doi: 10.1111/jocd.14816. PMID: 35104917
Gu Y, Han J, Jiang C, Zhang Y
Ageing Res Rev 2020 May;59:101036. Epub 2020 Feb 24 doi: 10.1016/j.arr.2020.101036. PMID: 32105850
Riahi RR, Bush AE, Cohen PR
Am J Clin Dermatol 2016 Jun;17(3):265-76. doi: 10.1007/s40257-016-0185-5. PMID: 26969582

Prognosis

Anuforo A, Evbayekha E, Agwuegbo C, Okafor TL, Antia A, Adabale O, Ugoala OS, Okorare O, Phagoora J, Alagbo HO, Shamaki GR, Disreal Bob-Manuel T
Ann Vasc Surg 2024 Aug;105:106-124. Epub 2024 Apr 5 doi: 10.1016/j.avsg.2024.01.009. PMID: 38583765
Lescoat A, Huang S, Carreira PE, Siegert E, de Vries-Bouwstra J, Distler JHW, Smith V, Del Galdo F, Anic B, Damjanov N, Rednic S, Ribi C, Bancel DF, Hoffmann-Vold AM, Gabrielli A, Distler O, Khanna D, Allanore Y; EUSTAR collaborators
JAMA Dermatol 2023 Aug 1;159(8):837-847. doi: 10.1001/jamadermatol.2023.1729. PMID: 37378994Free PMC Article
Schaffer JV
Clin Dermatol 2014 Nov-Dec;32(6):772-83. Epub 2014 Mar 1 doi: 10.1016/j.clindermatol.2014.02.017. PMID: 25441471
Paller AS
Clin Dermatol 2005 Jan-Feb;23(1):68-77. doi: 10.1016/j.clindermatol.2004.09.011. PMID: 15708291
Callen JP
Lancet 2000 Jan 1;355(9197):53-7. doi: 10.1016/S0140-6736(99)05157-0. PMID: 10615903

Clinical prediction guides

Anuforo A, Evbayekha E, Agwuegbo C, Okafor TL, Antia A, Adabale O, Ugoala OS, Okorare O, Phagoora J, Alagbo HO, Shamaki GR, Disreal Bob-Manuel T
Ann Vasc Surg 2024 Aug;105:106-124. Epub 2024 Apr 5 doi: 10.1016/j.avsg.2024.01.009. PMID: 38583765
Lescoat A, Huang S, Carreira PE, Siegert E, de Vries-Bouwstra J, Distler JHW, Smith V, Del Galdo F, Anic B, Damjanov N, Rednic S, Ribi C, Bancel DF, Hoffmann-Vold AM, Gabrielli A, Distler O, Khanna D, Allanore Y; EUSTAR collaborators
JAMA Dermatol 2023 Aug 1;159(8):837-847. doi: 10.1001/jamadermatol.2023.1729. PMID: 37378994Free PMC Article
Hyldahl SJ, El-Jaji MQ, Schuster A, Kjeldsen AD
Int J Dermatol 2022 Dec;61(12):1497-1505. Epub 2022 Jul 6 doi: 10.1111/ijd.16320. PMID: 35792874Free PMC Article
Sales AFS, Pandolfo IL, de Almeida Cruz M, Parisi JR, Garcia LA, Martignago CCS, Renno ACM, Vassão PG
Arch Dermatol Res 2022 Nov;314(9):823-838. Epub 2021 Oct 5 doi: 10.1007/s00403-021-02283-2. PMID: 34609598
Pearson DR, Werth VP, Pappas-Taffer L
Clin Dermatol 2018 Jul-Aug;36(4):459-474. Epub 2018 Apr 12 doi: 10.1016/j.clindermatol.2018.04.004. PMID: 30047430

Recent systematic reviews

Leszczynski R, da Silva CA, Pinto ACPN, Kuczynski U, da Silva EM
Cochrane Database Syst Rev 2022 Sep 26;9(9):CD011642. doi: 10.1002/14651858.CD011642.pub2. PMID: 36161591Free PMC Article
Kalantari Y, Dadkhahfar S, Etesami I
J Cosmet Dermatol 2022 Apr;21(4):1379-1392. Epub 2022 Feb 3 doi: 10.1111/jocd.14804. PMID: 35076997
Sales AFS, Pandolfo IL, de Almeida Cruz M, Parisi JR, Garcia LA, Martignago CCS, Renno ACM, Vassão PG
Arch Dermatol Res 2022 Nov;314(9):823-838. Epub 2021 Oct 5 doi: 10.1007/s00403-021-02283-2. PMID: 34609598
Reiter O, Mimouni I, Dusza S, Halpern AC, Leshem YA, Marghoob AA
J Am Acad Dermatol 2021 Sep;85(3):653-664. Epub 2019 Nov 7 doi: 10.1016/j.jaad.2019.11.008. PMID: 31706938Free PMC Article
Thomson J, Hogan S, Leonardi-Bee J, Williams HC, Bath-Hextall FJ
Cochrane Database Syst Rev 2020 Nov 17;11(11):CD003412. doi: 10.1002/14651858.CD003412.pub3. PMID: 33202063Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...