U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Large intestinal polyposis

MedGen UID:
868164
•Concept ID:
C4022556
•
Disease or Syndrome
HPO: HP:0030255

Definition

The presence of multiple polyps in the large intestine. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLarge intestinal polyposis

Conditions with this feature

Birt-Hogg-Dube syndrome 1
MedGen UID:
1051978
•Concept ID:
CN375946
•
Disease or Syndrome
Any Birt-Hogg-Dube (BHD) syndrome in which the cause of the disease is a variation in the FLCN gene.
See: Condition Record
Birt-Hogg-Dube syndrome 1

Professional guidelines

PubMed

Genetic predisposition to gastrointestinal polyposis: syndromes, tumour features, genetic testing, and clinical management.
Valle L, Monahan KJ
Lancet Gastroenterol Hepatol 2024 Jan;9(1):68-82. Epub 2023 Nov 4 doi: 10.1016/S2468-1253(23)00240-6. PMID: 37931640
Nonampullary duodenal adenoma: Current understanding of its diagnosis, pathogenesis, and clinical management.
Lim CH, Cho YS
World J Gastroenterol 2016 Jan 14;22(2):853-61. doi: 10.3748/wjg.v22.i2.853. PMID: 26811631Free PMC Article
Endoscopic management of patients with familial adenomatous polyposis (FAP) following a colectomy.
Saurin JC, Napoleon B, Gay G, Ponchon T, Arpurt JP, Boustiere C, Boyer J, Canard JM, Dalbies PA, Escourrou J, Greff M, Lapuelle J, Laugier R, Letard JC, Marchetti B, Palazzo L, Sautereau D, Vedrenne B; SFED
Endoscopy 2005 May;37(5):499-501. doi: 10.1055/s-2005-861295. PMID: 15844037

Recent clinical studies

Etiology

Juvenile polyposis: Focus on less described manifestations.
Saurin JC, Calavas L, Caillot C
Best Pract Res Clin Gastroenterol 2022 Jun-Aug;58-59:101802. Epub 2022 Aug 4 doi: 10.1016/j.bpg.2022.101802. PMID: 35988968
Dispelling misconceptions in the management of familial adenomatous polyposis.
Chittleborough TJ, Warrier SK, Heriot AG, Kalady M, Church J
ANZ J Surg 2017 Jun;87(6):441-445. Epub 2017 Mar 7 doi: 10.1111/ans.13919. PMID: 28266097
Ileal pouch-anal anastomosis: Points of controversy.
Trigui A, Frikha F, Rejab H, Ben Ameur H, Triki H, Ben Amar M, Mzali R
J Visc Surg 2014 Sep;151(4):281-8. Epub 2014 Jul 3 doi: 10.1016/j.jviscsurg.2014.05.004. PMID: 24999229
Ulcerative colitis and cancer.
Kulaylat MN, Dayton MT
J Surg Oncol 2010 Jun 15;101(8):706-12. doi: 10.1002/jso.21505. PMID: 20512947
Sulindac and polyp regression.
Giardiello FM
Cancer Metastasis Rev 1994 Dec;13(3-4):279-83. doi: 10.1007/BF00666098. PMID: 7712590

Diagnosis

Juvenile polyposis: Focus on less described manifestations.
Saurin JC, Calavas L, Caillot C
Best Pract Res Clin Gastroenterol 2022 Jun-Aug;58-59:101802. Epub 2022 Aug 4 doi: 10.1016/j.bpg.2022.101802. PMID: 35988968
Segmental Polyposis.
Wu S, Yang J, Turner JR
Gastroenterology 2020 Dec;159(6):e1-e2. Epub 2020 Apr 20 doi: 10.1053/j.gastro.2020.04.022. PMID: 32325087
Video capsule endoscopy: perspectives of a revolutionary technique.
Bouchard S, Ibrahim M, Van Gossum A
World J Gastroenterol 2014 Dec 14;20(46):17330-44. doi: 10.3748/wjg.v20.i46.17330. PMID: 25516644Free PMC Article
Ileal pouch-anal anastomosis: Points of controversy.
Trigui A, Frikha F, Rejab H, Ben Ameur H, Triki H, Ben Amar M, Mzali R
J Visc Surg 2014 Sep;151(4):281-8. Epub 2014 Jul 3 doi: 10.1016/j.jviscsurg.2014.05.004. PMID: 24999229
Nutrition considerations surrounding restorative proctocolectomy.
Buckman SA, Heise CP
Nutr Clin Pract 2010 Jun;25(3):250-6. doi: 10.1177/0884533610368708. PMID: 20581318

Therapy

Segmental Polyposis.
Wu S, Yang J, Turner JR
Gastroenterology 2020 Dec;159(6):e1-e2. Epub 2020 Apr 20 doi: 10.1053/j.gastro.2020.04.022. PMID: 32325087
Dispelling misconceptions in the management of familial adenomatous polyposis.
Chittleborough TJ, Warrier SK, Heriot AG, Kalady M, Church J
ANZ J Surg 2017 Jun;87(6):441-445. Epub 2017 Mar 7 doi: 10.1111/ans.13919. PMID: 28266097
Ileal pouch-anal anastomosis: Points of controversy.
Trigui A, Frikha F, Rejab H, Ben Ameur H, Triki H, Ben Amar M, Mzali R
J Visc Surg 2014 Sep;151(4):281-8. Epub 2014 Jul 3 doi: 10.1016/j.jviscsurg.2014.05.004. PMID: 24999229
Nutrition considerations surrounding restorative proctocolectomy.
Buckman SA, Heise CP
Nutr Clin Pract 2010 Jun;25(3):250-6. doi: 10.1177/0884533610368708. PMID: 20581318
Sulindac and polyp regression.
Giardiello FM
Cancer Metastasis Rev 1994 Dec;13(3-4):279-83. doi: 10.1007/BF00666098. PMID: 7712590

Prognosis

Low prevalence of serrated polyposis syndrome in screening populations: a systematic review.
van Herwaarden YJ, Verstegen MH, Dura P, Kievit W, Drenth JP, Dekker E, IJspeert JE, Hoogerbrugge N, Nagengast FM, Nagtegaal ID, Bisseling TM
Endoscopy 2015 Nov;47(11):1043-9. Epub 2015 Jun 30 doi: 10.1055/s-0034-1392411. PMID: 26126164
Video capsule endoscopy: perspectives of a revolutionary technique.
Bouchard S, Ibrahim M, Van Gossum A
World J Gastroenterol 2014 Dec 14;20(46):17330-44. doi: 10.3748/wjg.v20.i46.17330. PMID: 25516644Free PMC Article
Ileal pouch-anal anastomosis: Points of controversy.
Trigui A, Frikha F, Rejab H, Ben Ameur H, Triki H, Ben Amar M, Mzali R
J Visc Surg 2014 Sep;151(4):281-8. Epub 2014 Jul 3 doi: 10.1016/j.jviscsurg.2014.05.004. PMID: 24999229
Molecular pathology of colorectal cancer.
Bosman FT
Cytogenet Cell Genet 1999;86(2):112-7. doi: 10.1159/000015362. PMID: 10545700
Familial polyposis coli.
Bülow S
Dan Med Bull 1987 Mar;34(1):1-15. PMID: 3030666

Clinical prediction guides

Genetic predisposition to gastrointestinal polyposis: syndromes, tumour features, genetic testing, and clinical management.
Valle L, Monahan KJ
Lancet Gastroenterol Hepatol 2024 Jan;9(1):68-82. Epub 2023 Nov 4 doi: 10.1016/S2468-1253(23)00240-6. PMID: 37931640
Low prevalence of serrated polyposis syndrome in screening populations: a systematic review.
van Herwaarden YJ, Verstegen MH, Dura P, Kievit W, Drenth JP, Dekker E, IJspeert JE, Hoogerbrugge N, Nagengast FM, Nagtegaal ID, Bisseling TM
Endoscopy 2015 Nov;47(11):1043-9. Epub 2015 Jun 30 doi: 10.1055/s-0034-1392411. PMID: 26126164
Video capsule endoscopy: perspectives of a revolutionary technique.
Bouchard S, Ibrahim M, Van Gossum A
World J Gastroenterol 2014 Dec 14;20(46):17330-44. doi: 10.3748/wjg.v20.i46.17330. PMID: 25516644Free PMC Article
Molecular pathology of colorectal cancer.
Bosman FT
Cytogenet Cell Genet 1999;86(2):112-7. doi: 10.1159/000015362. PMID: 10545700
Ileal pouch-anal anastomosis: state of the art.
Pena JP, Gemlo BT, Rothenberger DA
Baillieres Clin Gastroenterol 1992 Mar;6(1):113-28. doi: 10.1016/0950-3528(92)90022-7. PMID: 1316792

Recent systematic reviews

Complications and functional outcomes after ileo-anal pouch excision-a systematic review of 14 retrospective observational studies.
MacDonald S, Au S, Thornton M, Macdonald A
Int J Colorectal Dis 2021 Apr;36(4):677-687. Epub 2021 Jan 20 doi: 10.1007/s00384-021-03838-5. PMID: 33471205
Lateral pararectal versus transrectal stoma placement for prevention of parastomal herniation.
Hardt J, Meerpohl JJ, Metzendorf MI, Kienle P, Post S, Herrle F
Cochrane Database Syst Rev 2019 Apr 24;4(4):CD009487. doi: 10.1002/14651858.CD009487.pub3. PMID: 31016723Free PMC Article
Low prevalence of serrated polyposis syndrome in screening populations: a systematic review.
van Herwaarden YJ, Verstegen MH, Dura P, Kievit W, Drenth JP, Dekker E, IJspeert JE, Hoogerbrugge N, Nagengast FM, Nagtegaal ID, Bisseling TM
Endoscopy 2015 Nov;47(11):1043-9. Epub 2015 Jun 30 doi: 10.1055/s-0034-1392411. PMID: 26126164
Colonic manifestations of PTEN hamartoma tumor syndrome: case series and systematic review.
Stanich PP, Pilarski R, Rock J, Frankel WL, El-Dika S, Meyer MM
World J Gastroenterol 2014 Feb 21;20(7):1833-8. doi: 10.3748/wjg.v20.i7.1833. PMID: 24587660Free PMC Article
Impact of ileal pouch-anal anastomosis on female fertility: meta-analysis and systematic review.
Rajaratnam SG, Eglinton TW, Hider P, Fearnhead NS
Int J Colorectal Dis 2011 Nov;26(11):1365-74. Epub 2011 Jul 16 doi: 10.1007/s00384-011-1274-9. PMID: 21766164

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...