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Hyperplastic colonic polyposis

MedGen UID:
868611
•Concept ID:
C4023010
•
Neoplastic Process
HPO: HP:0012183

Definition

Presence of multiple hyperplastic polyps in the colon. Hyperplastic polyps are generally about 5 mm in size and show hyperplastic mucosal proliferation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Hyperplastic colonic polyposis

Conditions with this feature

Polyposis syndrome, hereditary mixed, 2
MedGen UID:
350500
•Concept ID:
C1864730
•
Disease or Syndrome
Hereditary mixed polyposis syndrome-2 (HMPS2) is characterized by colonic polyps of mixed hyperplastic, adenomatous, and occasional juvenile types. Polyposis eventually progresses to colorectal cancer (Cao et al., 2006). For a discussion of genetic heterogeneity of HMPS, see HMPS1 (601228).
See: Condition Record
Polyposis syndrome, hereditary mixed, 2

Professional guidelines

PubMed

Serrated Lesions in Inflammatory Bowel Disease: Genotype-Phenotype Correlation.
Brcic I, Dawson H, Gröchenig HP, Högenauer C, Kashofer K
Int J Surg Pathol 2021 Feb;29(1):46-53. Epub 2020 Oct 8 doi: 10.1177/1066896920963798. PMID: 33030071
Serrated polyps of the large intestine: current understanding of diagnosis, pathogenesis, and clinical management.
Rosty C, Hewett DG, Brown IS, Leggett BA, Whitehall VL
J Gastroenterol 2013 Mar;48(3):287-302. Epub 2012 Dec 4 doi: 10.1007/s00535-012-0720-y. PMID: 23208018Free PMC Article
Sporadic and syndromic hyperplastic polyps and serrated adenomas of the colon: classification, molecular genetics, natural history, and clinical management.
East JE, Saunders BP, Jass JR
Gastroenterol Clin North Am 2008 Mar;37(1):25-46, v. doi: 10.1016/j.gtc.2007.12.014. PMID: 18313538

Recent clinical studies

Etiology

Serrated polyposis syndrome; epidemiology and management.
Carballal S, Balaguer F, IJspeert JEG
Best Pract Res Clin Gastroenterol 2022 Jun-Aug;58-59:101791. Epub 2022 Mar 16 doi: 10.1016/j.bpg.2022.101791. PMID: 35988960
Gastritis, Gastric Polyps and Gastric Cancer.
Waldum H, Fossmark R
Int J Mol Sci 2021 Jun 18;22(12) doi: 10.3390/ijms22126548. PMID: 34207192Free PMC Article
Polypoid disease of colon in children.
Soyer T
Pediatr Surg Int 2020 Apr;36(4):447-455. Epub 2020 Jan 21 doi: 10.1007/s00383-020-04621-3. PMID: 31965250
Hereditary colon cancer syndromes.
Gala M, Chung DC
Semin Oncol 2011 Aug;38(4):490-9. doi: 10.1053/j.seminoncol.2011.05.003. PMID: 21810508
Familial adenomatous polyposis.
Half E, Bercovich D, Rozen P
Orphanet J Rare Dis 2009 Oct 12;4:22. doi: 10.1186/1750-1172-4-22. PMID: 19822006Free PMC Article

Diagnosis

Serrated polyposis syndrome; epidemiology and management.
Carballal S, Balaguer F, IJspeert JEG
Best Pract Res Clin Gastroenterol 2022 Jun-Aug;58-59:101791. Epub 2022 Mar 16 doi: 10.1016/j.bpg.2022.101791. PMID: 35988960
Birt-Hogg-Dubé syndrome with simultaneous hyperplastic polyposis of the gastrointestinal tract: case report and review of the literature.
Balsamo F, Cardoso PAS, do Amaral Junior SA, Theodoro TR, de Sousa Gehrke F, da Silva Pinhal MA, Bianco B, Waisberg J
BMC Med Genet 2020 Mar 14;21(1):52. doi: 10.1186/s12881-020-0991-8. PMID: 32171268Free PMC Article
The endoscopist's guide to serrated polyposis.
La Nauze R, Suzuki N, Saunders B, Clark S, Thomas-Gibson S
Colorectal Dis 2014 Jun;16(6):417-25. doi: 10.1111/codi.12475. PMID: 24702773
Hereditary colon cancer syndromes.
Gala M, Chung DC
Semin Oncol 2011 Aug;38(4):490-9. doi: 10.1053/j.seminoncol.2011.05.003. PMID: 21810508
Familial adenomatous polyposis.
Half E, Bercovich D, Rozen P
Orphanet J Rare Dis 2009 Oct 12;4:22. doi: 10.1186/1750-1172-4-22. PMID: 19822006Free PMC Article

Therapy

Effectiveness and safety of cold snare polypectomy and cold endoscopic mucosal resection for nonpedunculated colorectal polyps of 10-19 mm: a multicenter observational cohort study.
Mangira D, Raftopoulos S, Vogrin S, Hartley I, Mack A, Gazelakis K, Nalankilli K, Trinh A, Metz AJ, Appleyard M, Grimpen F, Elliott T, Brown G, Moss A
Endoscopy 2023 Jul;55(7):627-635. Epub 2023 Feb 7 doi: 10.1055/a-2029-9539. PMID: 36750222
The "Studded" Rectum: Phenotypic Evidence of MYH-Associated Polyposis.
Church J, Kravochuck S
Dis Colon Rectum 2016 Jun;59(6):565-9. doi: 10.1097/DCR.0000000000000575. PMID: 27145315
Tobacco smoking and colorectal hyperplastic and adenomatous polyps.
Ji BT, Weissfeld JL, Chow WH, Huang WY, Schoen RE, Hayes RB
Cancer Epidemiol Biomarkers Prev 2006 May;15(5):897-901. doi: 10.1158/1055-9965.EPI-05-0883. PMID: 16702367
Colonic metaplasia in the ileal pouch is associated with inflammation and is not the result of long-term adaptation.
Fruin AB, El-Zammer O, Stucchi AF, O'Brien M, Becker JM
J Gastrointest Surg 2003 Feb;7(2):246-53; discussion 253-4. doi: 10.1016/s1091-255x(02)00191-9. PMID: 12600449
Juvenile polyposis--a precancerous condition.
Jass JR, Williams CB, Bussey HJ, Morson BC
Histopathology 1988 Dec;13(6):619-30. doi: 10.1111/j.1365-2559.1988.tb02093.x. PMID: 2853131

Prognosis

Incidence and natural history of gastric high-grade dysplasia in patients with familial adenomatous polyposis syndrome.
DelSignore M, Jeong T, Denmark G, Feldman D, Shih A, Zukerberg L, Chung DC
Gastrointest Endosc 2023 Jan;97(1):25-34.e6. Epub 2022 Sep 14 doi: 10.1016/j.gie.2022.09.002. PMID: 36113625
Birt-Hogg-Dubé syndrome with simultaneous hyperplastic polyposis of the gastrointestinal tract: case report and review of the literature.
Balsamo F, Cardoso PAS, do Amaral Junior SA, Theodoro TR, de Sousa Gehrke F, da Silva Pinhal MA, Bianco B, Waisberg J
BMC Med Genet 2020 Mar 14;21(1):52. doi: 10.1186/s12881-020-0991-8. PMID: 32171268Free PMC Article
Endoscopic and histologic characteristics of serrated lesions.
Moussata D, Boschetti G, Chauvenet M, Stroeymeyt K, Nancey S, Berger F, Lecomte T, Flourié B
World J Gastroenterol 2015 Mar 14;21(10):2896-904. doi: 10.3748/wjg.v21.i10.2896. PMID: 25780286Free PMC Article
Synchronous colorectal cancer: clinical, pathological and molecular implications.
Lam AK, Chan SS, Leung M
World J Gastroenterol 2014 Jun 14;20(22):6815-20. doi: 10.3748/wjg.v20.i22.6815. PMID: 24944471Free PMC Article
Colonic manifestations of PTEN hamartoma tumor syndrome: case series and systematic review.
Stanich PP, Pilarski R, Rock J, Frankel WL, El-Dika S, Meyer MM
World J Gastroenterol 2014 Feb 21;20(7):1833-8. doi: 10.3748/wjg.v20.i7.1833. PMID: 24587660Free PMC Article

Clinical prediction guides

Effectiveness and safety of cold snare polypectomy and cold endoscopic mucosal resection for nonpedunculated colorectal polyps of 10-19 mm: a multicenter observational cohort study.
Mangira D, Raftopoulos S, Vogrin S, Hartley I, Mack A, Gazelakis K, Nalankilli K, Trinh A, Metz AJ, Appleyard M, Grimpen F, Elliott T, Brown G, Moss A
Endoscopy 2023 Jul;55(7):627-635. Epub 2023 Feb 7 doi: 10.1055/a-2029-9539. PMID: 36750222
Endoscopic and histologic characteristics of serrated lesions.
Moussata D, Boschetti G, Chauvenet M, Stroeymeyt K, Nancey S, Berger F, Lecomte T, Flourié B
World J Gastroenterol 2015 Mar 14;21(10):2896-904. doi: 10.3748/wjg.v21.i10.2896. PMID: 25780286Free PMC Article
Synchronous colorectal cancer: clinical, pathological and molecular implications.
Lam AK, Chan SS, Leung M
World J Gastroenterol 2014 Jun 14;20(22):6815-20. doi: 10.3748/wjg.v20.i22.6815. PMID: 24944471Free PMC Article
Role of the serrated pathway in colorectal cancer pathogenesis.
Leggett B, Whitehall V
Gastroenterology 2010 Jun;138(6):2088-100. doi: 10.1053/j.gastro.2009.12.066. PMID: 20420948
The case for a genetic predisposition to serrated neoplasia in the colorectum: hypothesis and review of the literature.
Young J, Jass JR
Cancer Epidemiol Biomarkers Prev 2006 Oct;15(10):1778-84. doi: 10.1158/1055-9965.EPI-06-0164. PMID: 17035382

Recent systematic reviews

Colonic manifestations of PTEN hamartoma tumor syndrome: case series and systematic review.
Stanich PP, Pilarski R, Rock J, Frankel WL, El-Dika S, Meyer MM
World J Gastroenterol 2014 Feb 21;20(7):1833-8. doi: 10.3748/wjg.v20.i7.1833. PMID: 24587660Free PMC Article

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