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Favorable response of weakness to acetylcholine esterase inhibitors

MedGen UID:: 868189
•Concept ID:: C4022581
•: Finding

Synonym:	Favourable response of weakness to acetylcholine esterase inhibitors

HPO:	HP:0030202

Definition

Improvement of muscle strength in response to administration of an acetylcholine esterase inhibitor. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVFavorable response of weakness to acetylcholine esterase inhibitors

Congenital Systemic Disorder
- Abnormality of the nervous system
  - Abnormal nervous system physiology
    - Abnormal synaptic transmission
      - Abnormal peripheral nervous system synaptic transmission
        Response to drugs acting on neuromuscular transmission
        Favorable response of weakness to acetylcholine esterase inhibitors

Recent clinical studies

Etiology

Clinical manifestations of acetylcholine receptor antibody positive and negative myasthenia gravis.

Pasutharnchat N, Wacharapluesadee S, Hemachudha T
J Med Assoc Thai 2012 Mar;95(3):313-9. PMID: 22550827

Randomized, double-blind, placebo-controlled, multicenter study to evaluate the safety and tolerability of metrifonate in patients with probable Alzheimer disease. The Metrifonate Study Group.

Blass JP, Cyrus PA, Bieber F, Gulanski B
Alzheimer Dis Assoc Disord 2000 Jan-Mar;14(1):39-45. doi: 10.1097/00002093-200001000-00005. PMID: 10718203

Diagnosis

Update on muscle-specific tyrosine kinase antibody positive myasthenia gravis.

Guptill JT, Sanders DB
Curr Opin Neurol 2010 Oct;23(5):530-5. doi: 10.1097/WCO.0b013e32833c0982. PMID: 20613516

Therapy

Randomized, double-blind, placebo-controlled, multicenter study to evaluate the safety and tolerability of metrifonate in patients with probable Alzheimer disease. The Metrifonate Study Group.

Blass JP, Cyrus PA, Bieber F, Gulanski B
Alzheimer Dis Assoc Disord 2000 Jan-Mar;14(1):39-45. doi: 10.1097/00002093-200001000-00005. PMID: 10718203

Clinical prediction guides

Update on muscle-specific tyrosine kinase antibody positive myasthenia gravis.

Guptill JT, Sanders DB
Curr Opin Neurol 2010 Oct;23(5):530-5. doi: 10.1097/WCO.0b013e32833c0982. PMID: 20613516

Randomized, double-blind, placebo-controlled, multicenter study to evaluate the safety and tolerability of metrifonate in patients with probable Alzheimer disease. The Metrifonate Study Group.

Blass JP, Cyrus PA, Bieber F, Gulanski B
Alzheimer Dis Assoc Disord 2000 Jan-Mar;14(1):39-45. doi: 10.1097/00002093-200001000-00005. PMID: 10718203

Supplemental Content

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Clinical resources

ClinicalTrials.gov

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MedlinePlus

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Favorable response of weakness to acetylcholine esterase inhibitors
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