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EMG: repetitive nerve stimulation abnormality

MedGen UID:
868287
•Concept ID:
C4022681
•
Pathologic Function
HPO: HP:0030000

Definition

Abnormality observed upon electromyography when nerve studied is electrically stimulated six to ten times at 2 or 3 Hertz. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEMG: repetitive nerve stimulation abnormality

Professional guidelines

PubMed

Neuromuscular junction involvement in inherited motor neuropathies: genetic heterogeneity and effect of oral salbutamol treatment.
McMacken G, Whittaker RG, Wake R, Lochmuller H, Horvath R
J Neurol 2023 Jun;270(6):3112-3119. Epub 2023 Mar 4 doi: 10.1007/s00415-023-11643-z. PMID: 36869887Free PMC Article
Baseline Decrement in Patients with Mild Myasthenia Gravis Predicts Immunomodulation Treatment.
Abraham A, Lovblom LE, Bril V
Can J Neurol Sci 2019 Nov;46(6):762-766. doi: 10.1017/cjn.2019.246. PMID: 31322098
Myasthenia gravis: review of diagnosis and management.
Patten BM
Muscle Nerve 1978 May-Jun;1(3):190-205. doi: 10.1002/mus.880010304. PMID: 86952

Recent clinical studies

Etiology

Direct comparison of median and ulnar repetitive nerve stimulation in generalized myasthenia gravis.
Pike-Lee T, Higginbotham D, Li Y
Muscle Nerve 2021 Oct;64(4):490-493. Epub 2021 Jul 14 doi: 10.1002/mus.27366. PMID: 34196418
Congenital myasthenic syndromes.
Finsterer J
Orphanet J Rare Dis 2019 Feb 26;14(1):57. doi: 10.1186/s13023-019-1025-5. PMID: 30808424Free PMC Article
Study on variation trend of repetitive nerve stimulation waveform in amyotrophic lateral sclerosis.
Fu LL, Yin HX, Liu MS, Cui LY
Chin Med J (Engl) 2019 Mar 5;132(5):542-550. doi: 10.1097/CM9.0000000000000117. PMID: 30807353Free PMC Article
Repetitive Nerve Stimulation in Amyotrophic Lateral Sclerosis.
Sun XS, Liu WX, Chen ZH, Ling L, Yang F, Wang HF, Cui F, Huang XS
Chin Med J (Engl) 2018 Sep 20;131(18):2146-2151. doi: 10.4103/0366-6999.240798. PMID: 30203787Free PMC Article
Repetitive nerve stimulation and jitter measurement with disposable concentric needle electrode in newly diagnosed myasthenia gravis patients.
Sirin NG, Kocasoy Orhan E, Durmus H, Deymeer F, Baslo MB
Neurophysiol Clin 2018 Oct;48(5):261-267. Epub 2018 Feb 25 doi: 10.1016/j.neucli.2018.01.003. PMID: 29490884

Diagnosis

Electrodiagnostic Assessment of Motor Neuron Disease.
Kang X, Quan D
Neurol Clin 2021 Nov;39(4):1071-1081. Epub 2021 Aug 31 doi: 10.1016/j.ncl.2021.06.008. PMID: 34602215
Congenital myasthenic syndromes.
Finsterer J
Orphanet J Rare Dis 2019 Feb 26;14(1):57. doi: 10.1186/s13023-019-1025-5. PMID: 30808424Free PMC Article
Repetitive nerve stimulation test in myasthenic crisis.
Oh SJ, Jeong D, Lee I, Alsharabati M
Muscle Nerve 2019 May;59(5):544-548. Epub 2019 Jan 9 doi: 10.1002/mus.26390. PMID: 30488463
Neurophysiological Assessment of Abnormalities of the Neuromuscular Junction in Children.
Pitt M
Int J Mol Sci 2018 Feb 22;19(2) doi: 10.3390/ijms19020624. PMID: 29470437Free PMC Article
Pearls: myasthenia.
Benatar M
Semin Neurol 2010 Feb;30(1):35-7. Epub 2010 Feb 1 doi: 10.1055/s-0029-1244999. PMID: 20127579

Therapy

Neuromuscular junction involvement in inherited motor neuropathies: genetic heterogeneity and effect of oral salbutamol treatment.
McMacken G, Whittaker RG, Wake R, Lochmuller H, Horvath R
J Neurol 2023 Jun;270(6):3112-3119. Epub 2023 Mar 4 doi: 10.1007/s00415-023-11643-z. PMID: 36869887Free PMC Article
Congenital myasthenic syndromes.
Finsterer J
Orphanet J Rare Dis 2019 Feb 26;14(1):57. doi: 10.1186/s13023-019-1025-5. PMID: 30808424Free PMC Article
Repetitive nerve stimulation as a diagnostic aid for distinguishing cervical spondylotic amyotrophy from amyotrophic lateral sclerosis.
Zheng C, Jin X, Zhu Y, Lu F, Jiang J, Xia X
Eur Spine J 2017 Jul;26(7):1929-1936. Epub 2017 Mar 31 doi: 10.1007/s00586-017-5060-4. PMID: 28364332
Repetitive nerve stimulation in myasthenia gravis--relative sensitivity of different muscles.
Costa J, Evangelista T, Conceição I, de Carvalho M
Clin Neurophysiol 2004 Dec;115(12):2776-82. doi: 10.1016/j.clinph.2004.05.024. PMID: 15546785
Myasthenia gravis: review of diagnosis and management.
Patten BM
Muscle Nerve 1978 May-Jun;1(3):190-205. doi: 10.1002/mus.880010304. PMID: 86952

Prognosis

Incidence and causes of overdiagnosis of myasthenia gravis.
Andrapalliyal N, Claytor B, Li Y
Muscle Nerve 2023 Jun;67(6):464-468. Epub 2022 Dec 30 doi: 10.1002/mus.27774. PMID: 36533968
Neurophysiological patterns of acute and post-acute foodborne botulism.
Boccagni C, Prestandrea C, D'Agostino T, Rubino F, Renda M, Sesti E, Bagnato S
Muscle Nerve 2021 Oct;64(4):435-444. Epub 2021 Jul 29 doi: 10.1002/mus.27370. PMID: 34255868
Repetitive nerve stimulation as a diagnostic aid for distinguishing cervical spondylotic amyotrophy from amyotrophic lateral sclerosis.
Zheng C, Jin X, Zhu Y, Lu F, Jiang J, Xia X
Eur Spine J 2017 Jul;26(7):1929-1936. Epub 2017 Mar 31 doi: 10.1007/s00586-017-5060-4. PMID: 28364332
Muscle-specific receptor tyrosine kinase antibody-positive and seronegative myasthenia gravis.
Muppidi S, Wolfe GI
Front Neurol Neurosci 2009;26:109-119. Epub 2009 Apr 6 doi: 10.1159/000212372. PMID: 19349708
Is exercise necessary with repetitive nerve stimulation in evaluating patients with suspected myasthenia gravis?
Rubin DI, Hentschel K
Muscle Nerve 2007 Jan;35(1):103-6. doi: 10.1002/mus.20667. PMID: 17024676

Clinical prediction guides

Neurophysiological patterns of acute and post-acute foodborne botulism.
Boccagni C, Prestandrea C, D'Agostino T, Rubino F, Renda M, Sesti E, Bagnato S
Muscle Nerve 2021 Oct;64(4):435-444. Epub 2021 Jul 29 doi: 10.1002/mus.27370. PMID: 34255868
Direct comparison of median and ulnar repetitive nerve stimulation in generalized myasthenia gravis.
Pike-Lee T, Higginbotham D, Li Y
Muscle Nerve 2021 Oct;64(4):490-493. Epub 2021 Jul 14 doi: 10.1002/mus.27366. PMID: 34196418
Consideration of repetitive nerve stimulation of the median nerve in patients being evaluated for myasthenia gravis.
Lee TH, Li Y
Muscle Nerve 2019 Dec;60(6):658-661. Epub 2019 Oct 9 doi: 10.1002/mus.26713. PMID: 31531870
Repetitive Nerve Stimulation in Amyotrophic Lateral Sclerosis.
Sun XS, Liu WX, Chen ZH, Ling L, Yang F, Wang HF, Cui F, Huang XS
Chin Med J (Engl) 2018 Sep 20;131(18):2146-2151. doi: 10.4103/0366-6999.240798. PMID: 30203787Free PMC Article
Repetitive nerve stimulation as a diagnostic aid for distinguishing cervical spondylotic amyotrophy from amyotrophic lateral sclerosis.
Zheng C, Jin X, Zhu Y, Lu F, Jiang J, Xia X
Eur Spine J 2017 Jul;26(7):1929-1936. Epub 2017 Mar 31 doi: 10.1007/s00586-017-5060-4. PMID: 28364332

Recent systematic reviews

Clinical features and outcomes of Myasthenia Gravis associated with COVID-19 vaccines: A systematic review and pooled analysis.
Tayebi AH, Samimisedeh P, Jafari Afshar E, Ayati A, Ghalehnovi E, Foroutani L, Abbasi Khoshsirat N, Rastad H
Medicine (Baltimore) 2023 Oct 6;102(40):e34890. doi: 10.1097/MD.0000000000034890. PMID: 37800781Free PMC Article
Congenital myasthenic syndromes.
Finsterer J
Orphanet J Rare Dis 2019 Feb 26;14(1):57. doi: 10.1186/s13023-019-1025-5. PMID: 30808424Free PMC Article

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