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Abnormal brain choline/creatine ratio by MRS

MedGen UID:
868366
•Concept ID:
C4022760
•
Anatomical Abnormality
HPO: HP:0012709

Definition

A deviation from normal in the ratio of choline to creatine in the brain identified by magnetic resonance spectroscopy (MRS). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal brain choline/creatine ratio by MRS

Professional guidelines

PubMed

Magnetic resonance spectroscopy and neurocognitive dysfunction in obstructive sleep apnea before and after CPAP treatment.
O'Donoghue FJ, Wellard RM, Rochford PD, Dawson A, Barnes M, Ruehland WR, Jackson ML, Howard ME, Pierce RJ, Jackson GD
Sleep 2012 Jan 1;35(1):41-8. doi: 10.5665/sleep.1582. PMID: 22215917Free PMC Article
Effects of antidepressant treatment on N-acetyl aspartate and choline levels in the hippocampus and thalami of post-stroke depression patients: a study using (1)H magnetic resonance spectroscopy.
Huang Y, Chen W, Li Y, Wu X, Shi X, Geng D
Psychiatry Res 2010 Apr 30;182(1):48-52. Epub 2010 Mar 15 doi: 10.1016/j.pscychresns.2009.11.009. PMID: 20227856

Recent clinical studies

Etiology

Abnormal Thalamic Metabolism in Patients With Lifelong Premature Ejaculation.
Xia JD, Chen F, Zhang QJ, Wang YM, Dai YT, Song NH, Wang ZJ, Zhang B, Yang J
J Sex Med 2021 Feb;18(2):275-283. Epub 2020 Dec 24 doi: 10.1016/j.jsxm.2020.11.014. PMID: 33358559
Cerebral folate deficiency in adults: A heterogeneous potentially treatable condition.
Masingue M, Benoist JF, Roze E, Moussa F, Sedel F, Lubetzki C, Nadjar Y
J Neurol Sci 2019 Jan 15;396:112-118. Epub 2018 Nov 10 doi: 10.1016/j.jns.2018.11.014. PMID: 30448717
Multivoxel proton magnetic resonance spectroscopy in heat stroke.
Li J, Zhang XY, Wang B, Zou ZM, Li HF, Wang PY, Xia JK
Clin Radiol 2015 Jan;70(1):37-41. Epub 2014 Nov 4 doi: 10.1016/j.crad.2014.09.004. PMID: 25443777
Proton MR Spectroscopy of the brain in children with neuronopathic Gaucher's disease.
Razek AA, Abdalla A, Gaber NA, Fathy A, Megahed A, Barakat T, Latif Alsayed MA
Eur Radiol 2013 Nov;23(11):3005-11. Epub 2013 Jun 20 doi: 10.1007/s00330-013-2924-9. PMID: 23783781
Metabolite alterations in autistic children: a 1H MR spectroscopy study.
Kubas B, Kułak W, Sobaniec W, Tarasow E, Lebkowska U, Walecki J
Adv Med Sci 2012 Jun 1;57(1):152-6. doi: 10.2478/v10039-012-0014-x. PMID: 22472469

Diagnosis

Cerebral folate deficiency in adults: A heterogeneous potentially treatable condition.
Masingue M, Benoist JF, Roze E, Moussa F, Sedel F, Lubetzki C, Nadjar Y
J Neurol Sci 2019 Jan 15;396:112-118. Epub 2018 Nov 10 doi: 10.1016/j.jns.2018.11.014. PMID: 30448717
Neurochemical evaluation of brain function with 1H magnetic resonance spectroscopy in patients with fragile X syndrome.
Utine GE, Akpınar B, Arslan U, Kiper PÖ, Volkan-Salancı B, Alanay Y, Aktaş D, Haliloğlu G, Oğuz KK, Boduroğlu K, Alikaşifoğlu M
Am J Med Genet A 2014 Jan;164A(1):99-105. Epub 2013 Nov 20 doi: 10.1002/ajmg.a.36207. PMID: 24259304
Metabolite alterations in autistic children: a 1H MR spectroscopy study.
Kubas B, Kułak W, Sobaniec W, Tarasow E, Lebkowska U, Walecki J
Adv Med Sci 2012 Jun 1;57(1):152-6. doi: 10.2478/v10039-012-0014-x. PMID: 22472469
1H magnetic resonance spectroscopy in preclinical Huntington disease.
van Oostrom JC, Sijens PE, Roos RA, Leenders KL
Brain Res 2007 Sep 7;1168:67-71. Epub 2007 Jul 17 doi: 10.1016/j.brainres.2007.05.082. PMID: 17707354
Magnetic resonance spectroscopy.
Duncan JS
Epilepsia 1996 Jul;37(7):598-605. doi: 10.1111/j.1528-1157.1996.tb00622.x. PMID: 8681890

Therapy

Effects of antidepressant treatment on N-acetyl aspartate and choline levels in the hippocampus and thalami of post-stroke depression patients: a study using (1)H magnetic resonance spectroscopy.
Huang Y, Chen W, Li Y, Wu X, Shi X, Geng D
Psychiatry Res 2010 Apr 30;182(1):48-52. Epub 2010 Mar 15 doi: 10.1016/j.pscychresns.2009.11.009. PMID: 20227856
Prognostic value of 1H-MRS in neonatal encephalopathy.
da Silva LF, Höefel Filho JR, Anés M, Nunes ML
Pediatr Neurol 2006 May;34(5):360-6. doi: 10.1016/j.pediatrneurol.2005.10.011. PMID: 16647995
Early proton magnetic resonance spectroscopy in normal-appearing brain correlates with outcome in patients following traumatic brain injury.
Garnett MR, Blamire AM, Corkill RG, Cadoux-Hudson TA, Rajagopalan B, Styles P
Brain 2000 Oct;123 ( Pt 10):2046-54. doi: 10.1093/brain/123.10.2046. PMID: 11004122
Highly active antiretroviral therapy reverses brain metabolite abnormalities in mild HIV dementia.
Chang L, Ernst T, Leonido-Yee M, Witt M, Speck O, Walot I, Miller EN
Neurology 1999 Sep 11;53(4):782-9. doi: 10.1212/wnl.53.4.782. PMID: 10489041
Proton magnetic resonance spectroscopy to study the metabolic changes in the brain of a patient with Leigh syndrome.
Takahashi S, Oki J, Miyamoto A, Okuno A
Brain Dev 1999 Apr;21(3):200-4. doi: 10.1016/s0387-7604(98)00095-3. PMID: 10372907

Prognosis

Cerebral folate deficiency in adults: A heterogeneous potentially treatable condition.
Masingue M, Benoist JF, Roze E, Moussa F, Sedel F, Lubetzki C, Nadjar Y
J Neurol Sci 2019 Jan 15;396:112-118. Epub 2018 Nov 10 doi: 10.1016/j.jns.2018.11.014. PMID: 30448717
Proton MR Spectroscopy of the brain in children with neuronopathic Gaucher's disease.
Razek AA, Abdalla A, Gaber NA, Fathy A, Megahed A, Barakat T, Latif Alsayed MA
Eur Radiol 2013 Nov;23(11):3005-11. Epub 2013 Jun 20 doi: 10.1007/s00330-013-2924-9. PMID: 23783781
Frontal white matter biochemical abnormalities in first-episode, treatment-naive patients with major depressive disorder: a proton magnetic resonance spectroscopy study.
Wang Y, Jia Y, Xu G, Ling X, Liu S, Huang L
J Affect Disord 2012 Feb;136(3):620-6. Epub 2011 Nov 29 doi: 10.1016/j.jad.2011.10.020. PMID: 22129769
1H magnetic resonance spectroscopy in preclinical Huntington disease.
van Oostrom JC, Sijens PE, Roos RA, Leenders KL
Brain Res 2007 Sep 7;1168:67-71. Epub 2007 Jul 17 doi: 10.1016/j.brainres.2007.05.082. PMID: 17707354
Cerebral metabolism within 18 hours of birth asphyxia: a proton magnetic resonance spectroscopy study.
Hanrahan JD, Sargentoni J, Azzopardi D, Manji K, Cowan FM, Rutherford MA, Cox IJ, Bell JD, Bryant DJ, Edwards AD
Pediatr Res 1996 Apr;39(4 Pt 1):584-90. doi: 10.1203/00006450-199604000-00004. PMID: 8848329

Clinical prediction guides

Abnormal Thalamic Metabolism in Patients With Lifelong Premature Ejaculation.
Xia JD, Chen F, Zhang QJ, Wang YM, Dai YT, Song NH, Wang ZJ, Zhang B, Yang J
J Sex Med 2021 Feb;18(2):275-283. Epub 2020 Dec 24 doi: 10.1016/j.jsxm.2020.11.014. PMID: 33358559
Multivoxel proton magnetic resonance spectroscopy in heat stroke.
Li J, Zhang XY, Wang B, Zou ZM, Li HF, Wang PY, Xia JK
Clin Radiol 2015 Jan;70(1):37-41. Epub 2014 Nov 4 doi: 10.1016/j.crad.2014.09.004. PMID: 25443777
Neurochemical evaluation of brain function with 1H magnetic resonance spectroscopy in patients with fragile X syndrome.
Utine GE, Akpınar B, Arslan U, Kiper PÖ, Volkan-Salancı B, Alanay Y, Aktaş D, Haliloğlu G, Oğuz KK, Boduroğlu K, Alikaşifoğlu M
Am J Med Genet A 2014 Jan;164A(1):99-105. Epub 2013 Nov 20 doi: 10.1002/ajmg.a.36207. PMID: 24259304
Effects of antidepressant treatment on N-acetyl aspartate and choline levels in the hippocampus and thalami of post-stroke depression patients: a study using (1)H magnetic resonance spectroscopy.
Huang Y, Chen W, Li Y, Wu X, Shi X, Geng D
Psychiatry Res 2010 Apr 30;182(1):48-52. Epub 2010 Mar 15 doi: 10.1016/j.pscychresns.2009.11.009. PMID: 20227856
1H magnetic resonance spectroscopy in preclinical Huntington disease.
van Oostrom JC, Sijens PE, Roos RA, Leenders KL
Brain Res 2007 Sep 7;1168:67-71. Epub 2007 Jul 17 doi: 10.1016/j.brainres.2007.05.082. PMID: 17707354

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