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Focal T2 hypointense thalamic lesion

MedGen UID:
868381
•Concept ID:
C4022775
•
Finding
HPO: HP:0012691

Definition

A darker than expected T2 signal on magnetic resonance imaging (MRI) of the thalamus. This term refers to a localized hypointensity affecting a particular region of the thalamus. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFocal T2 hypointense thalamic lesion

Recent clinical studies

Etiology

White matter and lesion T1 relaxation times increase in parallel and correlate with disability in multiple sclerosis.
Parry A, Clare S, Jenkinson M, Smith S, Palace J, Matthews PM
J Neurol 2002 Sep;249(9):1279-86. doi: 10.1007/s00415-002-0837-7. PMID: 12242554
Multifocal hypointense cerebral lesions on gradient-echo MR are associated with chronic hypertension.
Chan S, Kartha K, Yoon SS, Desmond DW, Hilal SK
AJNR Am J Neuroradiol 1996 Nov-Dec;17(10):1821-7. PMID: 8933864Free PMC Article
Prognostic value of early MR imaging in term infants with severe perinatal asphyxia.
Kuenzle C, Baenziger O, Martin E, Thun-Hohenstein L, Steinlin M, Good M, Fanconi S, Boltshauser E, Largo RH
Neuropediatrics 1994 Aug;25(4):191-200. doi: 10.1055/s-2008-1073021. PMID: 7824091
MR imaging and CT in three cases of Sturge-Weber syndrome: prospective comparison.
Chamberlain MC, Press GA, Hesselink JR
AJNR Am J Neuroradiol 1989 May-Jun;10(3):491-6. PMID: 2501980Free PMC Article

Diagnosis

High-Grade Astrocytoma with Piloid Features: A Dual Institutional Review of Imaging Findings of a Novel Entity.
Soni N, Agarwal A, Ajmera P, Mehta P, Gupta V, Vibhute M, Gubbiotti M, Mark IT, Messina SA, Mohan S, Bathla G
AJNR Am J Neuroradiol 2024 Apr 8;45(4):468-474. doi: 10.3174/ajnr.A8166. PMID: 38485198Free PMC Article
An atypical presentation of primary central nervous system lymphoma: A case report.
Yuen CA, Mastrianni J, Ali S, Pytel P, Park DM, Rezania K
Medicine (Baltimore) 2020 Sep 18;99(38):e22062. doi: 10.1097/MD.0000000000022062. PMID: 32957327Free PMC Article
Primary Malignant Melanoma in the Pineal Region: Case Report and Literature Review.
Wendel C, Kaech DL, Woodtli M
J Neurol Surg A Cent Eur Neurosurg 2018 Jul;79(4):344-352. Epub 2018 Apr 12 doi: 10.1055/s-0038-1639504. PMID: 29649851
The role of MRI in dementia.
Pantano P, Caramia F, Pierallini A
Ital J Neurol Sci 1999;20(5 Suppl):S250-3. doi: 10.1007/s100729970006. PMID: 10662960
Prognostic value of early MR imaging in term infants with severe perinatal asphyxia.
Kuenzle C, Baenziger O, Martin E, Thun-Hohenstein L, Steinlin M, Good M, Fanconi S, Boltshauser E, Largo RH
Neuropediatrics 1994 Aug;25(4):191-200. doi: 10.1055/s-2008-1073021. PMID: 7824091

Therapy

An atypical presentation of primary central nervous system lymphoma: A case report.
Yuen CA, Mastrianni J, Ali S, Pytel P, Park DM, Rezania K
Medicine (Baltimore) 2020 Sep 18;99(38):e22062. doi: 10.1097/MD.0000000000022062. PMID: 32957327Free PMC Article

Prognosis

High-Grade Astrocytoma with Piloid Features: A Dual Institutional Review of Imaging Findings of a Novel Entity.
Soni N, Agarwal A, Ajmera P, Mehta P, Gupta V, Vibhute M, Gubbiotti M, Mark IT, Messina SA, Mohan S, Bathla G
AJNR Am J Neuroradiol 2024 Apr 8;45(4):468-474. doi: 10.3174/ajnr.A8166. PMID: 38485198Free PMC Article
Primary Malignant Melanoma in the Pineal Region: Case Report and Literature Review.
Wendel C, Kaech DL, Woodtli M
J Neurol Surg A Cent Eur Neurosurg 2018 Jul;79(4):344-352. Epub 2018 Apr 12 doi: 10.1055/s-0038-1639504. PMID: 29649851
Prognostic value of early MR imaging in term infants with severe perinatal asphyxia.
Kuenzle C, Baenziger O, Martin E, Thun-Hohenstein L, Steinlin M, Good M, Fanconi S, Boltshauser E, Largo RH
Neuropediatrics 1994 Aug;25(4):191-200. doi: 10.1055/s-2008-1073021. PMID: 7824091

Clinical prediction guides

White matter and lesion T1 relaxation times increase in parallel and correlate with disability in multiple sclerosis.
Parry A, Clare S, Jenkinson M, Smith S, Palace J, Matthews PM
J Neurol 2002 Sep;249(9):1279-86. doi: 10.1007/s00415-002-0837-7. PMID: 12242554
Prognostic value of early MR imaging in term infants with severe perinatal asphyxia.
Kuenzle C, Baenziger O, Martin E, Thun-Hohenstein L, Steinlin M, Good M, Fanconi S, Boltshauser E, Largo RH
Neuropediatrics 1994 Aug;25(4):191-200. doi: 10.1055/s-2008-1073021. PMID: 7824091

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