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Hypothalamic hypometabolism in FDG PET

MedGen UID:
868401
•Concept ID:
C4022795
•
Finding
HPO: HP:0012661

Definition

Reduced uptake of [18F]-fluorodeoxyglucose (FDG) in the hypothalamus as measured by positron emission tomography (PET) brain scan. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHypothalamic hypometabolism in FDG PET

Recent clinical studies

Etiology

(18)F-FDG-PET glucose hypometabolism pattern in patients with epileptogenic hypothalamic hamartoma.
Lu C, Wang K, Meng F, Wang Y, Shan Y, Wei P, Zhao G
Front Med 2021 Dec;15(6):913-921. Epub 2021 Nov 23 doi: 10.1007/s11684-021-0874-1. PMID: 34811641
Brain FDG-PET findings in glutamic acid decarboxylase antibody-associated epilepsy.
Mongay-Ochoa N, Sala-Padró J, Reynés-Llompart G, Rodríguez-Bel L, Jaraba S, Morandeira F, Falip M
J Neuroimaging 2021 Sep;31(5):869-873. Epub 2021 May 6 doi: 10.1111/jon.12874. PMID: 33955107
Reduced glucose metabolism in neocortical network nodes remote from hypothalamic hamartomas reflects cognitive impairment.
Wagner K, Schulze-Bonhage A, Urbach H, Trippel M, Spehl TS, Buschmann F, Metternich B, Ofer I, Meyer PT, Frings L
Epilepsia 2017 Jun;58 Suppl 2:41-49. doi: 10.1111/epi.13757. PMID: 28591477

Diagnosis

Brain FDG-PET findings in glutamic acid decarboxylase antibody-associated epilepsy.
Mongay-Ochoa N, Sala-Padró J, Reynés-Llompart G, Rodríguez-Bel L, Jaraba S, Morandeira F, Falip M
J Neuroimaging 2021 Sep;31(5):869-873. Epub 2021 May 6 doi: 10.1111/jon.12874. PMID: 33955107
(18)F-FDG brain PET hypometabolism in post-SARS-CoV-2 infection: substrate for persistent/delayed disorders?
Guedj E, Million M, Dudouet P, Tissot-Dupont H, Bregeon F, Cammilleri S, Raoult D
Eur J Nucl Med Mol Imaging 2021 Feb;48(2):592-595. Epub 2020 Jul 30 doi: 10.1007/s00259-020-04973-x. PMID: 32728799Free PMC Article
Reduced glucose metabolism in neocortical network nodes remote from hypothalamic hamartomas reflects cognitive impairment.
Wagner K, Schulze-Bonhage A, Urbach H, Trippel M, Spehl TS, Buschmann F, Metternich B, Ofer I, Meyer PT, Frings L
Epilepsia 2017 Jun;58 Suppl 2:41-49. doi: 10.1111/epi.13757. PMID: 28591477
Do the Symptoms of Kleine-Levin Syndrome Correlate With the Hypometabolism of the Thalamus on FDG PET?
Xie H, Guo J, Liu H, Song W
Clin Nucl Med 2016 Mar;41(3):255-6. doi: 10.1097/RLU.0000000000001043. PMID: 26562572

Therapy

(18) F-SynVesT-1 positron emission tomography in a hypothalamic hamartoma with abnormal uptake.
Xiao L, Zhou M, Tang Y, Hu S
Epilepsia 2023 Apr;64(4):e43-e47. Epub 2023 Feb 17 doi: 10.1111/epi.17533. PMID: 36745038
HPA axis normalization, estimated by DEX/CRH test, but less alteration on cerebral glucose metabolism in depressed patients receiving ECT after medication treatment failures.
Yuuki N, Ida I, Oshima A, Kumano H, Takahashi K, Fukuda M, Oriuchi N, Endo K, Matsuda H, Mikuni M
Acta Psychiatr Scand 2005 Oct;112(4):257-65. doi: 10.1111/j.1600-0447.2005.00625.x. PMID: 16156832

Clinical prediction guides

Brain FDG-PET findings in glutamic acid decarboxylase antibody-associated epilepsy.
Mongay-Ochoa N, Sala-Padró J, Reynés-Llompart G, Rodríguez-Bel L, Jaraba S, Morandeira F, Falip M
J Neuroimaging 2021 Sep;31(5):869-873. Epub 2021 May 6 doi: 10.1111/jon.12874. PMID: 33955107
Brain imaging and cognition in young narcoleptic patients.
Huang YS, Liu FY, Lin CY, Hsiao IT, Guilleminault C
Sleep Med 2016 Aug;24:137-144. Epub 2016 Jan 19 doi: 10.1016/j.sleep.2015.11.023. PMID: 27663355
HPA axis dysfunction in unmedicated major depressive disorder and its normalization by pharmacotherapy correlates with alteration of neural activity in prefrontal cortex and limbic/paralimbic regions.
Aihara M, Ida I, Yuuki N, Oshima A, Kumano H, Takahashi K, Fukuda M, Oriuchi N, Endo K, Matsuda H, Mikuni M
Psychiatry Res 2007 Aug 15;155(3):245-56. Epub 2007 Jun 22 doi: 10.1016/j.pscychresns.2006.11.002. PMID: 17587554

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