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Thalamic hypometabolism in FDG PET

MedGen UID:
868402
Concept ID:
C4022796
Finding
HPO: HP:0012660

Definition

Reduced uptake of [18F]-fluorodeoxyglucose (FDG) in the thalamus as measured by positron emission tomography (PET) brain scan. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThalamic hypometabolism in FDG PET

Professional guidelines

PubMed

Martí-Andrés G, van Bommel L, Meles SK, Riverol M, Valentí R, Kogan RV, Renken RJ, Gurvits V, van Laar T, Pagani M, Prieto E, Luquin MR, Leenders KL, Arbizu J
Mov Disord 2020 Nov;35(11):2009-2018. Epub 2020 Aug 21 doi: 10.1002/mds.28217. PMID: 32822512

Recent clinical studies

Etiology

Singh NA, Goodrich AW, Graff-Radford J, Machulda MM, Sintini I, Carlos AF, Robinson CG, Reid RI, Lowe VJ, Jack CR Jr, Petersen RC, Boeve BF, Josephs KA, Kantarci K, Whitwell JL
Neuroimage 2024 Apr 15;290:120564. Epub 2024 Mar 3 doi: 10.1016/j.neuroimage.2024.120564. PMID: 38442778Free PMC Article
Lu C, Wang K, Meng F, Wang Y, Shan Y, Wei P, Zhao G
Front Med 2021 Dec;15(6):913-921. Epub 2021 Nov 23 doi: 10.1007/s11684-021-0874-1. PMID: 34811641
Guedj E, Campion JY, Dudouet P, Kaphan E, Bregeon F, Tissot-Dupont H, Guis S, Barthelemy F, Habert P, Ceccaldi M, Million M, Raoult D, Cammilleri S, Eldin C
Eur J Nucl Med Mol Imaging 2021 Aug;48(9):2823-2833. Epub 2021 Jan 26 doi: 10.1007/s00259-021-05215-4. PMID: 33501506Free PMC Article
Parmera JB, Coutinho AM, Aranha MR, Studart-Neto A, de Godoi Carneiro C, de Almeida IJ, Fontoura Solla DJ, Ono CR, Barbosa ER, Nitrini R, Buchpiguel CA, Brucki SMD
Mov Disord 2021 Mar;36(3):651-661. Epub 2020 Nov 18 doi: 10.1002/mds.28373. PMID: 33206389
Muccioli L, Farolfi A, Pondrelli F, d'Orsi G, Michelucci R, Freri E, Canafoglia L, Licchetta L, Toni F, Bonfiglioli R, Civollani S, Pettinato C, Maietti E, Marotta G, Fanti S, Tinuper P, Bisulli F
Eur J Nucl Med Mol Imaging 2020 Jun;47(6):1576-1584. Epub 2019 Dec 19 doi: 10.1007/s00259-019-04647-3. PMID: 31858178

Diagnosis

Kantarci K, Boeve BF, Przybelski SA, Lesnick TG, Chen Q, Fields J, Schwarz CG, Senjem ML, Gunte JL, Jack CR, Min P, Jain M, Miyagawa T, Savica R, Graff-Radford J, Botha H, Jones DT, Knopman DS, Graff-Radford N, Ferman TJ, Petersen RC, Lowe VJ
Neuroimage Clin 2021;31:102754. Epub 2021 Jul 4 doi: 10.1016/j.nicl.2021.102754. PMID: 34252877Free PMC Article
Guedj E, Campion JY, Dudouet P, Kaphan E, Bregeon F, Tissot-Dupont H, Guis S, Barthelemy F, Habert P, Ceccaldi M, Million M, Raoult D, Cammilleri S, Eldin C
Eur J Nucl Med Mol Imaging 2021 Aug;48(9):2823-2833. Epub 2021 Jan 26 doi: 10.1007/s00259-021-05215-4. PMID: 33501506Free PMC Article
Parmera JB, Coutinho AM, Aranha MR, Studart-Neto A, de Godoi Carneiro C, de Almeida IJ, Fontoura Solla DJ, Ono CR, Barbosa ER, Nitrini R, Buchpiguel CA, Brucki SMD
Mov Disord 2021 Mar;36(3):651-661. Epub 2020 Nov 18 doi: 10.1002/mds.28373. PMID: 33206389
Muccioli L, Farolfi A, Pondrelli F, d'Orsi G, Michelucci R, Freri E, Canafoglia L, Licchetta L, Toni F, Bonfiglioli R, Civollani S, Pettinato C, Maietti E, Marotta G, Fanti S, Tinuper P, Bisulli F
Eur J Nucl Med Mol Imaging 2020 Jun;47(6):1576-1584. Epub 2019 Dec 19 doi: 10.1007/s00259-019-04647-3. PMID: 31858178
Arbizu J, Giuliani A, Gállego Perez-Larraya J, Riverol M, Jonsson C, García-García B, Morales M, Imaz L, Pagani M
Q J Nucl Med Mol Imaging 2017 Dec;61(4):386-404. Epub 2017 Jul 27 doi: 10.23736/S1824-4785.17.03024-2. PMID: 28750498

Therapy

Townsend L, Pillinger T, Selvaggi P, Veronese M, Turkheimer F, Howes O
Psychol Med 2023 Aug;53(11):4880-4897. Epub 2022 Jun 22 doi: 10.1017/S003329172200174X. PMID: 35730361Free PMC Article
Hammoud DA, Sinharay S, Steinbach S, Wakim PG, Geannopoulos K, Traino K, Dey AK, Tramont E, Rapoport SI, Snow J, Mehta NN, Smith BR, Nath A
Neurology 2018 Oct 23;91(17):e1591-e1601. Epub 2018 Sep 26 doi: 10.1212/WNL.0000000000006398. PMID: 30258017Free PMC Article
Matthews DC, Lerman H, Lukic A, Andrews RD, Mirelman A, Wernick MN, Giladi N, Strother SC, Evans KC, Cedarbaum JM, Even-Sapir E
Neuroimage Clin 2018;20:572-579. Epub 2018 Aug 10 doi: 10.1016/j.nicl.2018.08.006. PMID: 30186761Free PMC Article
Akdemir ÜÖ, Tokçaer AB, Karakuş A, Kapucu LÖ
Clin Nucl Med 2014 Mar;39(3):e220-6. doi: 10.1097/RLU.0000000000000315. PMID: 24321825
Reed LJ, Lasserson D, Marsden P, Stanhope N, Stevens T, Bello F, Kingsley D, Colchester A, Kopelman MD
Cortex 2003 Sep-Dec;39(4-5):1027-45. doi: 10.1016/s0010-9452(08)70876-1. PMID: 14584565

Prognosis

Parmera JB, Coutinho AM, Aranha MR, Studart-Neto A, de Godoi Carneiro C, de Almeida IJ, Fontoura Solla DJ, Ono CR, Barbosa ER, Nitrini R, Buchpiguel CA, Brucki SMD
Mov Disord 2021 Mar;36(3):651-661. Epub 2020 Nov 18 doi: 10.1002/mds.28373. PMID: 33206389
Lu H, Jing D, Chen Y, Cui C, Gao R, Wang L, Liang Z, Chen K, Wu L
J Alzheimers Dis 2020;77(4):1513-1521. doi: 10.3233/JAD-200576. PMID: 32925055
Jaisani Z, Miletich RS, Ramanathan M, Weinstock AL
J Neuroimaging 2020 Jan;30(1):119-125. Epub 2019 Oct 29 doi: 10.1111/jon.12671. PMID: 31661187
Hammoud DA, Sinharay S, Steinbach S, Wakim PG, Geannopoulos K, Traino K, Dey AK, Tramont E, Rapoport SI, Snow J, Mehta NN, Smith BR, Nath A
Neurology 2018 Oct 23;91(17):e1591-e1601. Epub 2018 Sep 26 doi: 10.1212/WNL.0000000000006398. PMID: 30258017Free PMC Article
Dietmann A, Putzer D, Beer R, Helbok R, Pfausler B, Nordin AJ, Virgolini I, Grams AE, Schmutzhard E
Int J Infect Dis 2016 Oct;51:73-77. Epub 2016 Jul 11 doi: 10.1016/j.ijid.2016.06.022. PMID: 27418580

Clinical prediction guides

Singh NA, Goodrich AW, Graff-Radford J, Machulda MM, Sintini I, Carlos AF, Robinson CG, Reid RI, Lowe VJ, Jack CR Jr, Petersen RC, Boeve BF, Josephs KA, Kantarci K, Whitwell JL
Neuroimage 2024 Apr 15;290:120564. Epub 2024 Mar 3 doi: 10.1016/j.neuroimage.2024.120564. PMID: 38442778Free PMC Article
Tsagkaris S, Yau EKC, McClelland V, Papandreou A, Siddiqui A, Lumsden DE, Kaminska M, Guedj E, Hammers A, Lin JP
Brain 2023 Jun 1;146(6):2512-2523. doi: 10.1093/brain/awac439. PMID: 36445406Free PMC Article
McGonigal A, El Youssef N, Bartolomei F, Giusiano B, Guedj E
Epilepsy Behav 2021 Mar;116:107742. Epub 2021 Jan 23 doi: 10.1016/j.yebeh.2020.107742. PMID: 33493809
Parmera JB, Coutinho AM, Aranha MR, Studart-Neto A, de Godoi Carneiro C, de Almeida IJ, Fontoura Solla DJ, Ono CR, Barbosa ER, Nitrini R, Buchpiguel CA, Brucki SMD
Mov Disord 2021 Mar;36(3):651-661. Epub 2020 Nov 18 doi: 10.1002/mds.28373. PMID: 33206389
Arbizu J, Giuliani A, Gállego Perez-Larraya J, Riverol M, Jonsson C, García-García B, Morales M, Imaz L, Pagani M
Q J Nucl Med Mol Imaging 2017 Dec;61(4):386-404. Epub 2017 Jul 27 doi: 10.23736/S1824-4785.17.03024-2. PMID: 28750498

Recent systematic reviews

Townsend L, Pillinger T, Selvaggi P, Veronese M, Turkheimer F, Howes O
Psychol Med 2023 Aug;53(11):4880-4897. Epub 2022 Jun 22 doi: 10.1017/S003329172200174X. PMID: 35730361Free PMC Article
Muccioli L, Farolfi A, Pondrelli F, d'Orsi G, Michelucci R, Freri E, Canafoglia L, Licchetta L, Toni F, Bonfiglioli R, Civollani S, Pettinato C, Maietti E, Marotta G, Fanti S, Tinuper P, Bisulli F
Eur J Nucl Med Mol Imaging 2020 Jun;47(6):1576-1584. Epub 2019 Dec 19 doi: 10.1007/s00259-019-04647-3. PMID: 31858178

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