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Fusion of gums

MedGen UID:
868567
•Concept ID:
C4022966
•
Congenital Abnormality
Synonyms: Fusion of the gingiva; Gingival synechia; Partial fusion of the gums; Synechia of the gums; Upper and lower gums fused together
 
HPO: HP:0012292

Definition

A congenital defect with an abnormal joining of the gums of the upper and lower jaw. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFusion of gums

Recent clinical studies

Etiology

Expression Levels of A Disintegrin-like Metalloproteinase with Thrombospondin Motifs-4 and -5 (ADAMTS-4 and ADAMTS-5) in Inflamed and Healthy Gingival Tissues.
Tayman MA, Koyuncu İ, Köklü NÖ
Comb Chem High Throughput Screen 2020;23(2):168-176. doi: 10.2174/1386207323666200218113000. PMID: 32067610
High glucose disrupts autophagy lysosomal pathway in gingival epithelial cells via ATP6V0C.
Huang X, Kuang S, Shen Z, Liang M, Lin Z
J Periodontol 2020 May;91(5):705-714. Epub 2019 Oct 24 doi: 10.1002/JPER.19-0262. PMID: 31471894
Transcriptome Alterations In X-Irradiated Human Gingiva Fibroblasts.
Weissmann R, Kacprowski T, Peper M, Esche J, Jensen LR, van Diepen L, Port M, Kuss AW, Scherthan H
Health Phys 2016 Aug;111(2):75-84. doi: 10.1097/HP.0000000000000419. PMID: 27356049Free PMC Article
A periodontal pathogen Treponema denticola hijacks the Fusobacterium nucleatum-driven host response.
Shin JE, Baek KJ, Choi YS, Choi Y
Immunol Cell Biol 2013 Sep;91(8):503-10. Epub 2013 Jul 30 doi: 10.1038/icb.2013.35. PMID: 23897119
Congenital maxillomandibular fusion: a case report and review of the literature.
Daniels JS
J Craniomaxillofac Surg 2004 Jun;32(3):135-9. doi: 10.1016/j.jcms.2004.01.005. PMID: 15113570

Diagnosis

Expression Levels of A Disintegrin-like Metalloproteinase with Thrombospondin Motifs-4 and -5 (ADAMTS-4 and ADAMTS-5) in Inflamed and Healthy Gingival Tissues.
Tayman MA, Koyuncu İ, Köklü NÖ
Comb Chem High Throughput Screen 2020;23(2):168-176. doi: 10.2174/1386207323666200218113000. PMID: 32067610
Oral manifestations in Apert syndrome: case presentation and a brief review of the literature.
Soancă A, Dudea D, Gocan H, Roman A, Culic B
Rom J Morphol Embryol 2010;51(3):581-4. PMID: 20809043
Melanotic neuroectodermal tumour of infancy: a case report and review of the aetiopathogenic hypotheses.
Madrid C, Aziza J, Hlali A, Bouferrache K, Abarca M
Med Oral Patol Oral Cir Bucal 2010 Sep 1;15(5):e739-42. doi: 10.4317/medoral.15.e739. PMID: 20173714
Congenital maxillomandibular syngnathia: case report.
Parkins GE, Boamah MO
J Craniomaxillofac Surg 2009 Jul;37(5):276-8. Epub 2009 Feb 23 doi: 10.1016/j.jcms.2009.01.001. PMID: 19231229
Small facial haemangioma and supraumbilical raphe--a forme fruste of PHACES syndrome?
Chan YC, Eichenfield LF, Malchiodi J, Friedlander SF
Br J Dermatol 2005 Nov;153(5):1053-7. doi: 10.1111/j.1365-2133.2005.06886.x. PMID: 16225625

Therapy

Anlotinib treatment for rapidly progressing pediatric embryonal rhabdomyosarcoma in the maxillary gingiva: a case report.
Ding B, Mai B, Liu T, Liu C, Bao H, Hu J, Qian X, Wang S, Ou Q, Dong X, Lei Z, Yan G
Diagn Pathol 2024 Oct 8;19(1):135. doi: 10.1186/s13000-024-01555-5. PMID: 39379998Free PMC Article
TEGDMA releasing in resin composites with different filler contents and its correlation with mitochondrial mediated cytotoxicity in human gingival fibroblasts.
Liu B, Gan X, Zhao Y, Chen J, Yu H, Gao J, Yu H
J Biomed Mater Res A 2019 Jun;107(6):1132-1142. Epub 2019 Mar 5 doi: 10.1002/jbm.a.36600. PMID: 30597721
Acute myeloid leukemia with new complex t(8;21;22) induced hemophagocytic lymphohistiocytosis: A case report.
Wu Y, Xu J, Shen K, Ji J, Yang C, Liu T, Xiang B
Medicine (Baltimore) 2018 Nov;97(44):e12762. doi: 10.1097/MD.0000000000012762. PMID: 30383631Free PMC Article
I-131 SPECT/CT elucidates cryptic findings on planar whole-body scans and can reduce needless therapy with I-131 in post-thyroidectomy thyroid cancer patients.
Blum M, Tiu S, Chu M, Goel S, Friedman K
Thyroid 2011 Nov;21(11):1235-47. Epub 2011 Oct 18 doi: 10.1089/thy.2011.0010. PMID: 22007920
Recalcitrant cicatricial pemphigoid treated with the anti-TNF-alpha agent etanercept.
Kennedy JS, Devillez RL, Henning JS
J Drugs Dermatol 2010 Jan;9(1):68-70. PMID: 20120429

Prognosis

Congenital Bilateral Zygomatico-Maxillo-Mandibular Fusion Associated With Gum Fusion.
Al-Mahdi AH, Koppel DA, Al-Jumaily HA, Mohammed AA, Boyd D
J Craniofac Surg 2016 Jan;27(1):e20-3. doi: 10.1097/SCS.0000000000002293. PMID: 26703053
Management of serious isolated gingival synechia in a newborn: case report and review of the literature.
Bozdag S, Erdeve O, Konas E, Tuncbilek G, Dilmen U
Int J Oral Maxillofac Surg 2011 Dec;40(12):1428-31. Epub 2011 Jun 8 doi: 10.1016/j.ijom.2011.05.003. PMID: 21652177
Intraosseous ameloblastoma with a prominent extraosseous component: pitfalls in diagnosis.
Ide F, Mishima K, Yamada H, Kikuchi K, Saito I, Kusama K
Head Neck Pathol 2010 Sep;4(3):192-7. Epub 2010 Jun 15 doi: 10.1007/s12105-010-0182-6. PMID: 20549402Free PMC Article
Congenital maxillomandibular fusion: a case report and review of the literature.
Daniels JS
J Craniomaxillofac Surg 2004 Jun;32(3):135-9. doi: 10.1016/j.jcms.2004.01.005. PMID: 15113570
Periodontal plastic surgery in a dystrophic epidermolysis bullosa patient: review and case report.
Brain JH, Paul BF, Assad DA
J Periodontol 1999 Nov;70(11):1392-6. doi: 10.1902/jop.1999.70.11.1392. PMID: 10588504

Clinical prediction guides

N-Acetylcysteine modulates the effects of composites on human gingival keratinocytes.
Siemer K, Husari A, Vach K, Tomakidi P, Hellwig E, Schulz SD, Polydorou O
Dent Mater 2021 Apr;37(4):597-611. Epub 2021 Feb 4 doi: 10.1016/j.dental.2021.01.011. PMID: 33551189
Expression Levels of A Disintegrin-like Metalloproteinase with Thrombospondin Motifs-4 and -5 (ADAMTS-4 and ADAMTS-5) in Inflamed and Healthy Gingival Tissues.
Tayman MA, Koyuncu İ, Köklü NÖ
Comb Chem High Throughput Screen 2020;23(2):168-176. doi: 10.2174/1386207323666200218113000. PMID: 32067610
High glucose disrupts autophagy lysosomal pathway in gingival epithelial cells via ATP6V0C.
Huang X, Kuang S, Shen Z, Liang M, Lin Z
J Periodontol 2020 May;91(5):705-714. Epub 2019 Oct 24 doi: 10.1002/JPER.19-0262. PMID: 31471894
Surgical and orthodontic treatment after incidental radiographic discovery of a severely infraoccluded primary molar.
Caldeira AV, Souza ACA, Miguel MAT, Ribeiro IP, Almeida Júnior LA, Sakai VT, Moretti ABS
Gen Dent 2019 Nov-Dec;67(6):72-75. PMID: 31658030
Congenital maxillomandibular fusion: a case report and review of the literature.
Daniels JS
J Craniomaxillofac Surg 2004 Jun;32(3):135-9. doi: 10.1016/j.jcms.2004.01.005. PMID: 15113570

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