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EEG with parietal focal spikes

MedGen UID:
868671
•Concept ID:
C4023074
•
Finding
HPO: HP:0012017

Definition

EEG with focal sharp transient waves of a duration less than 80 msec in the parietal region. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEEG with parietal focal spikes

Conditions with this feature

Intellectual developmental disorder, X-linked, syndromic, with pigmentary mosaicism and coarse facies
MedGen UID:
1794140
•Concept ID:
C5561930
•
Disease or Syndrome
X-linked syndromic intellectual developmental disorder with pigmentary mosaicism and coarse facies (MRXSPF) is characterized by a phenotypic triad of severe developmental delay, coarse facial dysmorphisms, and Blaschkoid pigmentary mosaicism. Additional clinical features may include epilepsy, orthopedic abnormalities, hypotonia, and growth abnormalities. The disorder affects both males and females (Villegas et al., 2019; Diaz et al., 2020).
See: Condition Record
Intellectual developmental disorder, X-linked, syndromic, with pigmentary mosaicism and coarse facies

Professional guidelines

PubMed

On the clinical utility of on-scalp MEG: A modeling study of epileptic activity source estimation.
Westin K, Beniczky S, Pfeiffer C, Hämäläinen M, Lundqvist D
Clin Neurophysiol 2023 Dec;156:143-155. Epub 2023 Oct 31 doi: 10.1016/j.clinph.2023.10.006. PMID: 37951041

Recent clinical studies

Etiology

Focality in childhood absence epilepsy.
Yayıcı Köken Ö, Şekeroğlu B, Şanlıdağ B, Sarı Yanartaş M, Yılmaz A
Neurol Res 2024 Jul;46(7):626-633. Epub 2024 Apr 21 doi: 10.1080/01616412.2024.2339114. PMID: 38643974
Intracranial correlates of small sharp spikes.
Epitashvili N, San Antonio-Arce V, Brandt A, Schulze-Bonhage A
Clin Neurophysiol 2021 Sep;132(9):2146-2151. Epub 2021 Jun 15 doi: 10.1016/j.clinph.2021.05.019. PMID: 34284250
Case 284: Posterior Quadrantic Dysplasia.
Klumpp M, Mangla R, Goel A
Radiology 2020 Dec;297(3):733-737. doi: 10.1148/radiol.2020190726. PMID: 33196372
Idiopathic focal epilepsies: the "lost tribe".
Pal DK, Ferrie C, Addis L, Akiyama T, Capovilla G, Caraballo R, de Saint-Martin A, Fejerman N, Guerrini R, Hamandi K, Helbig I, Ioannides AA, Kobayashi K, Lal D, Lesca G, Muhle H, Neubauer BA, Pisano T, Rudolf G, Seegmuller C, Shibata T, Smith A, Striano P, Strug LJ, Szepetowski P, Valeta T, Yoshinaga H, Koutroumanidis M
Epileptic Disord 2016 Sep 1;18(3):252-88. doi: 10.1684/epd.2016.0839. PMID: 27435520
Unusual EEG patterns.
Westmoreland BF, Klass DW
J Clin Neurophysiol 1990 Apr;7(2):209-28. doi: 10.1097/00004691-199004000-00005. PMID: 2187021

Diagnosis

Focality in childhood absence epilepsy.
Yayıcı Köken Ö, Şekeroğlu B, Şanlıdağ B, Sarı Yanartaş M, Yılmaz A
Neurol Res 2024 Jul;46(7):626-633. Epub 2024 Apr 21 doi: 10.1080/01616412.2024.2339114. PMID: 38643974
Visual phenomena and anatomo-electro-clinical correlations in occipital lobe seizures.
Maillard L, Ferrand M, Aron O, Cheval M, Tyvaert L, Jonas J, Vignal JP
Rev Neurol (Paris) 2022 Sep;178(7):644-648. Epub 2022 Jul 26 doi: 10.1016/j.neurol.2022.06.001. PMID: 35906139
Focal Cortical Dysplasia and Generalized Epileptiform Discharges: Case Report and Literature Review.
Algethami H, Poghosyan V, Baksh E, Alhameed M
Med Arch 2021 Dec;75(6):462-466. doi: 10.5455/medarh.2021.75.462-466. PMID: 35169375Free PMC Article
Intracranial correlates of small sharp spikes.
Epitashvili N, San Antonio-Arce V, Brandt A, Schulze-Bonhage A
Clin Neurophysiol 2021 Sep;132(9):2146-2151. Epub 2021 Jun 15 doi: 10.1016/j.clinph.2021.05.019. PMID: 34284250
Current trends in electroencephalography.
Blume WT
Curr Opin Neurol 2001 Apr;14(2):193-7. doi: 10.1097/00019052-200104000-00010. PMID: 11262735

Therapy

Modulation index predicts the effect of ethosuximide on developmental and epileptic encephalopathy with spike-and-wave activation in sleep.
Shibata T, Tsuchiya H, Akiyama M, Akiyama T, Kobayashi K
Epilepsy Res 2024 May;202:107359. Epub 2024 Apr 4 doi: 10.1016/j.eplepsyres.2024.107359. PMID: 38582072
Ictal blinking triggered by isolated spikes as the only manifestation of seizures.
Katyal R, Jamal-Omidi S, Kubota T, Garcia-Losarcos N, Luders H
Epileptic Disord 2023 Apr;25(2):131-141. Epub 2023 May 6 doi: 10.1002/epd2.20002. PMID: 37283354
Transcranial direct current stimulation for focal status epilepticus or lateralized periodic discharges in four patients in a critical care setting.
Fisher RS, McGinn RJ, Von Stein EL, Wu TQ, Qing KY, Fogarty A, Razavi B, Venkatasubramanian C
Epilepsia 2023 Apr;64(4):875-887. Epub 2023 Feb 7 doi: 10.1111/epi.17514. PMID: 36661376
Idiopathic focal epilepsies: the "lost tribe".
Pal DK, Ferrie C, Addis L, Akiyama T, Capovilla G, Caraballo R, de Saint-Martin A, Fejerman N, Guerrini R, Hamandi K, Helbig I, Ioannides AA, Kobayashi K, Lal D, Lesca G, Muhle H, Neubauer BA, Pisano T, Rudolf G, Seegmuller C, Shibata T, Smith A, Striano P, Strug LJ, Szepetowski P, Valeta T, Yoshinaga H, Koutroumanidis M
Epileptic Disord 2016 Sep 1;18(3):252-88. doi: 10.1684/epd.2016.0839. PMID: 27435520
The investigation of EEG specificity in epileptic children during Depakine therapy.
Khachidze I, Gugushvili M, Makashvili M, Maloletnev V
Int J Neurosci 2016 Oct;126(10):912-21. Epub 2015 Aug 17 doi: 10.3109/00207454.2015.1083991. PMID: 26290045

Prognosis

Early prediction of encephalopathic transformation in children with benign epilepsy with centro-temporal spikes.
Porat Rein A, Kramer U, Hausman Kedem M, Fattal-Valevski A, Mitelpunkt A
Brain Dev 2021 Feb;43(2):268-279. Epub 2020 Sep 8 doi: 10.1016/j.braindev.2020.08.013. PMID: 32912653
Drug-resistant parietal lobe epilepsy: clinical manifestations and surgery outcome.
Asadollahi M, Sperling MR, Rabiei AH, Asadi-Pooya AA
Epileptic Disord 2017 Mar 1;19(1):35-39. doi: 10.1684/epd.2017.0893. PMID: 28256447
Idiopathic focal epilepsies: the "lost tribe".
Pal DK, Ferrie C, Addis L, Akiyama T, Capovilla G, Caraballo R, de Saint-Martin A, Fejerman N, Guerrini R, Hamandi K, Helbig I, Ioannides AA, Kobayashi K, Lal D, Lesca G, Muhle H, Neubauer BA, Pisano T, Rudolf G, Seegmuller C, Shibata T, Smith A, Striano P, Strug LJ, Szepetowski P, Valeta T, Yoshinaga H, Koutroumanidis M
Epileptic Disord 2016 Sep 1;18(3):252-88. doi: 10.1684/epd.2016.0839. PMID: 27435520
Current trends in electroencephalography.
Blume WT
Curr Opin Neurol 2001 Apr;14(2):193-7. doi: 10.1097/00019052-200104000-00010. PMID: 11262735
Parietal and occipital lobe epilepsy: a review.
Sveinbjornsdottir S, Duncan JS
Epilepsia 1993 May-Jun;34(3):493-521. doi: 10.1111/j.1528-1157.1993.tb02590.x. PMID: 8504783

Clinical prediction guides

Focality in childhood absence epilepsy.
Yayıcı Köken Ö, Şekeroğlu B, Şanlıdağ B, Sarı Yanartaş M, Yılmaz A
Neurol Res 2024 Jul;46(7):626-633. Epub 2024 Apr 21 doi: 10.1080/01616412.2024.2339114. PMID: 38643974
Evaluation of patients with epileptiform activities in the posterior temporal-parietal-occipital regions.
Surmeli R, Yeni SN, Demirbilek AV
Neurol Sci 2021 Nov;42(11):4607-4613. Epub 2021 Mar 4 doi: 10.1007/s10072-021-05154-w. PMID: 33661483
Early prediction of encephalopathic transformation in children with benign epilepsy with centro-temporal spikes.
Porat Rein A, Kramer U, Hausman Kedem M, Fattal-Valevski A, Mitelpunkt A
Brain Dev 2021 Feb;43(2):268-279. Epub 2020 Sep 8 doi: 10.1016/j.braindev.2020.08.013. PMID: 32912653
Idiopathic focal epilepsies: the "lost tribe".
Pal DK, Ferrie C, Addis L, Akiyama T, Capovilla G, Caraballo R, de Saint-Martin A, Fejerman N, Guerrini R, Hamandi K, Helbig I, Ioannides AA, Kobayashi K, Lal D, Lesca G, Muhle H, Neubauer BA, Pisano T, Rudolf G, Seegmuller C, Shibata T, Smith A, Striano P, Strug LJ, Szepetowski P, Valeta T, Yoshinaga H, Koutroumanidis M
Epileptic Disord 2016 Sep 1;18(3):252-88. doi: 10.1684/epd.2016.0839. PMID: 27435520
Current trends in electroencephalography.
Blume WT
Curr Opin Neurol 2001 Apr;14(2):193-7. doi: 10.1097/00019052-200104000-00010. PMID: 11262735

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