U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

EEG with generalized polyspikes

MedGen UID:
868685
Concept ID:
C4023088
Finding
Synonym: EEG with generalised polyspikes
 
HPO: HP:0012001

Definition

EEG with repetitive generalized sharp transient waves of a duration less than 80 msec. [from HPO]

Term Hierarchy

Conditions with this feature

Myoclonic epilepsy, juvenile, susceptibility to, 1
MedGen UID:
342587
Concept ID:
C1850778
Finding
Juvenile myoclonic epilepsy (EJM, JME) is a subtype of idiopathic generalized epilepsy (EIG; see 600669), affecting up to 26% of all individuals with EIG. Individuals with EJM have afebrile seizures only, with onset in adolescence of myoclonic jerks. Myoclonic jerks usually occur in the morning (Janz and Durner, 1997). Genetic Heterogeneity of Juvenile Myoclonic Seizures Susceptibility to EJM can be conferred by variation in several other genes: EJM5 (611136), by variation in the GABRA1 gene (137160) on 5q34; EJM6 (see 607682), by variation in the CACNB4 gene (601949) on 2q23; EJM7 (see 613060), by variation in the GABRD gene (137163) on 1p36; EJM8 (see 607628), by variation in the CLCN2 gene (600570) on 3q27; and EJM10 (617924), by variation in the ICK gene (612325) on chromosome 6p12. In addition, EJM loci have been identified by linkage analysis: EJM2 (see 604827) on 15q14, EJM3 (608816) on 6p21, EJM4 (611364) on 5q12-q14, and EJM9 (614280) on 2q33-q36.
Neuronal ceroid lipofuscinosis 11
MedGen UID:
761331
Concept ID:
C3539123
Disease or Syndrome
Neuronal ceroid lipofuscinosis-11 is an autosomal recessive neurologic disorder characterized by rapidly progressive visual loss due to retinal dystrophy, seizures, cerebellar ataxia, and cerebellar atrophy. Cognitive decline may also occur (summary by Smith et al., 2012). For a general phenotypic description and a discussion of genetic heterogeneity of CLN, see CLN1 (256730).
Developmental and epileptic encephalopathy 94
MedGen UID:
815608
Concept ID:
C3809278
Disease or Syndrome
CHD2-related neurodevelopmental disorders are characterized by early-onset epileptic encephalopathy (i.e., refractory seizures and cognitive slowing or regression associated with frequent ongoing epileptiform activity). Seizure onset is typically between ages six months and four years. Seizure types typically include drop attacks, myoclonus, and rapid onset of multiple seizure types associated with generalized spike-wave on EEG, atonic-myoclonic-absence seizures, and clinical photosensitivity. Intellectual disability and/or autism spectrum disorders are common.

Professional guidelines

PubMed

Harvey S, Shahwan A
Seizure 2023 Aug;110:1-10. Epub 2023 May 31 doi: 10.1016/j.seizure.2023.05.021. PMID: 37295276
Corniello C, Dono F, Evangelista G, Consoli S, De Angelis S, Cipollone S, Liviello D, Polito G, Melchiorre S, Russo M, Granzotto A, Anzellotti F, Onofrj M, Thomas A, Sensi SL
Seizure 2023 Jul;109:62-67. Epub 2023 May 21 doi: 10.1016/j.seizure.2023.05.017. PMID: 37267668
Panayiotopoulos CP
Paediatr Drugs 2001;3(5):379-403. doi: 10.2165/00128072-200103050-00006. PMID: 11393330

Recent clinical studies

Etiology

Jiang T, Zhang X, Zhang M, Liu M, Zhu H, Sun Y
Epilepsy Behav 2023 Sep;146:109364. Epub 2023 Jul 29 doi: 10.1016/j.yebeh.2023.109364. PMID: 37523796
Stasiowski MJ, Duława A, Król S, Marciniak R, Kaspera W, Niewiadomska E, Krawczyk L, Ładziński P, Grabarek BO, Jałowiecki P
Clin EEG Neurosci 2023 May;54(3):289-304. Epub 2020 Nov 26 doi: 10.1177/1550059420974571. PMID: 33241952
Das Pektezel L, Tezer FI, Saygi S
Neurol Sci 2022 Jun;43(6):3857-3866. Epub 2022 Jan 16 doi: 10.1007/s10072-021-05808-9. PMID: 35034232
Epitashvili N, San Antonio-Arce V, Brandt A, Schulze-Bonhage A
Clin Neurophysiol 2021 Sep;132(9):2146-2151. Epub 2021 Jun 15 doi: 10.1016/j.clinph.2021.05.019. PMID: 34284250
Jensen CD, Gesche J, Krøigård T, Beier CP
J Clin Neurophysiol 2021 May 1;38(3):208-212. doi: 10.1097/WNP.0000000000000679. PMID: 31880591

Diagnosis

Das Pektezel L, Tezer FI, Saygi S
Neurol Sci 2022 Jun;43(6):3857-3866. Epub 2022 Jan 16 doi: 10.1007/s10072-021-05808-9. PMID: 35034232
Kamitaki BK, Janmohamed M, Kandula P, Elder C, Mani R, Wong S, Perucca P, O'Brien TJ, Lin H, Heiman GA, Choi H
Epilepsia 2022 Jan;63(1):150-161. Epub 2021 Oct 27 doi: 10.1111/epi.17104. PMID: 34705264
Jensen CD, Gesche J, Krøigård T, Beier CP
J Clin Neurophysiol 2021 May 1;38(3):208-212. doi: 10.1097/WNP.0000000000000679. PMID: 31880591
Alfradique I, Vasconcelos MM
Arq Neuropsiquiatr 2007 Dec;65(4B):1266-71. doi: 10.1590/s0004-282x2007000700036. PMID: 18345445
Koskiniemi ML
Adv Neurol 1986;43:57-64. PMID: 2418650

Therapy

Jiang T, Zhang X, Zhang M, Liu M, Zhu H, Sun Y
Epilepsy Behav 2023 Sep;146:109364. Epub 2023 Jul 29 doi: 10.1016/j.yebeh.2023.109364. PMID: 37523796
Jiang Y, Zhou X
Medicine (Baltimore) 2022 Sep 23;101(38):e30512. doi: 10.1097/MD.0000000000030512. PMID: 36197249Free PMC Article
Kamitaki BK, Janmohamed M, Kandula P, Elder C, Mani R, Wong S, Perucca P, O'Brien TJ, Lin H, Heiman GA, Choi H
Epilepsia 2022 Jan;63(1):150-161. Epub 2021 Oct 27 doi: 10.1111/epi.17104. PMID: 34705264
Alfradique I, Vasconcelos MM
Arq Neuropsiquiatr 2007 Dec;65(4B):1266-71. doi: 10.1590/s0004-282x2007000700036. PMID: 18345445
Clement MJ, Wallace SJ
Arch Dis Child 1988 Sep;63(9):1049-53. doi: 10.1136/adc.63.9.1049. PMID: 3140737Free PMC Article

Prognosis

Jiang T, Zhang X, Zhang M, Liu M, Zhu H, Sun Y
Epilepsy Behav 2023 Sep;146:109364. Epub 2023 Jul 29 doi: 10.1016/j.yebeh.2023.109364. PMID: 37523796
Kamitaki BK, Janmohamed M, Kandula P, Elder C, Mani R, Wong S, Perucca P, O'Brien TJ, Lin H, Heiman GA, Choi H
Epilepsia 2022 Jan;63(1):150-161. Epub 2021 Oct 27 doi: 10.1111/epi.17104. PMID: 34705264
Jensen CD, Gesche J, Krøigård T, Beier CP
J Clin Neurophysiol 2021 May 1;38(3):208-212. doi: 10.1097/WNP.0000000000000679. PMID: 31880591
Camfield CS, Striano P, Camfield PR
Epilepsy Behav 2013 Jul;28 Suppl 1:S15-7. doi: 10.1016/j.yebeh.2012.06.024. PMID: 23756473
Koskiniemi ML
Adv Neurol 1986;43:57-64. PMID: 2418650

Clinical prediction guides

Jiang T, Zhang X, Zhang M, Liu M, Zhu H, Sun Y
Epilepsy Behav 2023 Sep;146:109364. Epub 2023 Jul 29 doi: 10.1016/j.yebeh.2023.109364. PMID: 37523796
Stasiowski MJ, Duława A, Król S, Marciniak R, Kaspera W, Niewiadomska E, Krawczyk L, Ładziński P, Grabarek BO, Jałowiecki P
Clin EEG Neurosci 2023 May;54(3):289-304. Epub 2020 Nov 26 doi: 10.1177/1550059420974571. PMID: 33241952
Kamitaki BK, Janmohamed M, Kandula P, Elder C, Mani R, Wong S, Perucca P, O'Brien TJ, Lin H, Heiman GA, Choi H
Epilepsia 2022 Jan;63(1):150-161. Epub 2021 Oct 27 doi: 10.1111/epi.17104. PMID: 34705264
Shokooh LA, Toffa DH, Pouliot P, Lesage F, Nguyen DK
Epilepsy Res 2021 Oct;176:106739. Epub 2021 Aug 14 doi: 10.1016/j.eplepsyres.2021.106739. PMID: 34455176
Muszkat M, Guimarães RM, da Silva AB, de Campos CJ
Arq Neuropsiquiatr 1990 Sep;48(3):301-5. doi: 10.1590/s0004-282x1990000300006. PMID: 2264785

Recent systematic reviews

Corniello C, Dono F, Evangelista G, Thomas A, Onofrj M, Sensi SL
Seizure 2024 Jan;114:90-95. Epub 2023 Nov 20 doi: 10.1016/j.seizure.2023.11.009. PMID: 38101201
Jiang T, Zhang X, Zhang M, Liu M, Zhu H, Sun Y
Epilepsy Behav 2023 Sep;146:109364. Epub 2023 Jul 29 doi: 10.1016/j.yebeh.2023.109364. PMID: 37523796
Corniello C, Dono F, Evangelista G, Consoli S, De Angelis S, Cipollone S, Liviello D, Polito G, Melchiorre S, Russo M, Granzotto A, Anzellotti F, Onofrj M, Thomas A, Sensi SL
Seizure 2023 Jul;109:62-67. Epub 2023 May 21 doi: 10.1016/j.seizure.2023.05.017. PMID: 37267668
Tashkandi M, Baarma D, Tricco AC, Boelman C, Alkhater R, Minassian BA
Epileptic Disord 2019 Feb 1;21(1):30-41. doi: 10.1684/epd.2019.1024. PMID: 30767897

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...