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Abnormality of neutrophil physiology

MedGen UID:
868690
•Concept ID:
C4023093
•
Pathologic Function
HPO: HP:0011990

Definition

A functional abnormality of neutrophils. [from HPO]

Professional guidelines

PubMed

Essential thrombocythemia: 2024 update on diagnosis, risk stratification, and management.
Tefferi A, Vannucchi AM, Barbui T
Am J Hematol 2024 Apr;99(4):697-718. Epub 2024 Jan 25 doi: 10.1002/ajh.27216. PMID: 38269572
Polycythemia vera: 2024 update on diagnosis, risk-stratification, and management.
Tefferi A, Barbui T
Am J Hematol 2023 Sep;98(9):1465-1487. Epub 2023 Jun 26 doi: 10.1002/ajh.27002. PMID: 37357958
Autoimmune Neutropenia Updates: Etiology, Pathology, and Treatment.
Afzal W, Owlia MB, Hasni S, Newman KA
South Med J 2017 Apr;110(4):300-307. doi: 10.14423/SMJ.0000000000000637. PMID: 28376530

Recent clinical studies

Etiology

Loss of TET2 in human hematopoietic stem cells alters the development and function of neutrophils.
Huerga Encabo H, Aramburu IV, Garcia-Albornoz M, Piganeau M, Wood H, Song A, Ferrelli A, Sharma A, Minutti CM, Domart MC, Papazoglou D, Gurashi K, Llorian Sopena M, Goldstone R, Fallesen T, Wang Q, Ariza-McNaughton L, Wiseman DH, Batta K, Gupta R, Papayannopoulos V, Bonnet D
Cell Stem Cell 2023 Jun 1;30(6):781-799.e9. doi: 10.1016/j.stem.2023.05.004. PMID: 37267914
Interactions of HIV and Antiretroviral Therapy With Neutrophils and Platelets.
Madzime M, Rossouw TM, Theron AJ, Anderson R, Steel HC
Front Immunol 2021;12:634386. Epub 2021 Mar 12 doi: 10.3389/fimmu.2021.634386. PMID: 33777022Free PMC Article
Role of Neutrophils in Psoriasis.
Wang WM, Jin HZ
J Immunol Res 2020;2020:3709749. Epub 2020 Jun 5 doi: 10.1155/2020/3709749. PMID: 32587871Free PMC Article
Disordered haematopoiesis and athero-thrombosis.
Murphy AJ, Tall AR
Eur Heart J 2016 Apr 7;37(14):1113-21. Epub 2016 Feb 10 doi: 10.1093/eurheartj/ehv718. PMID: 26869607Free PMC Article
Lysosome-related organelles.
Dell'Angelica EC, Mullins C, Caplan S, Bonifacino JS
FASEB J 2000 Jul;14(10):1265-78. doi: 10.1096/fj.14.10.1265. PMID: 10877819

Diagnosis

The lipid-metabolism enzyme ECI2 reduces neutrophil extracellular traps formation for colorectal cancer suppression.
Chen L, Dai P, Liu L, Chen Y, Lu Y, Zheng L, Wang H, Yuan Q, Li X
Nat Commun 2024 Aug 21;15(1):7184. doi: 10.1038/s41467-024-51489-1. PMID: 39169021Free PMC Article
Computational analysis of peripheral blood smears detects disease-associated cytomorphologies.
de Almeida JG, Gudgin E, Besser M, Dunn WG, Cooper J, Haferlach T, Vassiliou GS, Gerstung M
Nat Commun 2023 Jul 20;14(1):4378. doi: 10.1038/s41467-023-39676-y. PMID: 37474506Free PMC Article
Neutrophils in critical illness.
McDonald B
Cell Tissue Res 2018 Mar;371(3):607-615. Epub 2017 Dec 15 doi: 10.1007/s00441-017-2752-3. PMID: 29247324
Pathophysiology of ANCA-associated Vasculitis.
Al-Hussain T, Hussein MH, Conca W, Al Mana H, Akhtar M
Adv Anat Pathol 2017 Jul;24(4):226-234. doi: 10.1097/PAP.0000000000000154. PMID: 28537941
Neutrophilic panniculitis.
Sutra-Loubet C, Carlotti A, Guillemette J, Wallach D
J Am Acad Dermatol 2004 Feb;50(2):280-5. doi: 10.1016/j.jaad.2003.10.006. PMID: 14726888

Therapy

Clinical and functional spectrum of RAC2-related immunodeficiency.
Donkó Á, Sharapova SO, Kabat J, Ganesan S, Hauck FH, Bergerson JRE, Marois L, Abbott J, Moshous D, Williams KW, Campbell N, Martin PL, Lagresle-Peyrou C, Trojan T, Kuzmenko NB, Deordieva EA, Raykina EV, Abers MS, Abolhassani H, Barlogis V, Milla C, Hall G, Mousallem T, Church J, Kapoor N, Cros G, Chapdelaine H, Franco-Jarava C, Lopez-Lerma I, Miano M, Leiding JW, Klein C, Stasia MJ, Fischer A, Hsiao KC, Martelius T, Seppänen MRJ, Barmettler S, Walter J, Masmas TN, Mukhina AA, Falcone EL, Kracker S, Shcherbina A, Holland SM, Leto TL, Hsu AP
Blood 2024 Apr 11;143(15):1476-1487. doi: 10.1182/blood.2023022098. PMID: 38194689Free PMC Article
Long-term Effects of IL-6 Receptor Blockade Therapy on Regulatory Lymphocytes and Neutrophils in Neuromyelitis Optica Spectrum Disorder.
Matsuoka T, Araki M, Lin Y, Okamoto T, Gold R, Chihara N, Sato W, Kimura A, Tachimori H, Miyamoto K, Kusunoki S, Yamamura T
Neurol Neuroimmunol Neuroinflamm 2024 Jan;11(1) Epub 2023 Oct 20 doi: 10.1212/NXI.0000000000200173. PMID: 37863660Free PMC Article
Interactions of HIV and Antiretroviral Therapy With Neutrophils and Platelets.
Madzime M, Rossouw TM, Theron AJ, Anderson R, Steel HC
Front Immunol 2021;12:634386. Epub 2021 Mar 12 doi: 10.3389/fimmu.2021.634386. PMID: 33777022Free PMC Article
Role of Stem Cells in Pathophysiology and Therapy of Spondyloarthropathies-New Therapeutic Possibilities?
Krajewska-Włodarczyk M, Owczarczyk-Saczonek A, Placek W, Osowski A, Engelgardt P, Wojtkiewicz J
Int J Mol Sci 2017 Dec 28;19(1) doi: 10.3390/ijms19010080. PMID: 29283375Free PMC Article
Autoimmune neutropenia in adults.
Akhtari M, Curtis B, Waller EK
Autoimmun Rev 2009 Sep;9(1):62-6. Epub 2009 Mar 14 doi: 10.1016/j.autrev.2009.03.006. PMID: 19293004

Prognosis

The lipid-metabolism enzyme ECI2 reduces neutrophil extracellular traps formation for colorectal cancer suppression.
Chen L, Dai P, Liu L, Chen Y, Lu Y, Zheng L, Wang H, Yuan Q, Li X
Nat Commun 2024 Aug 21;15(1):7184. doi: 10.1038/s41467-024-51489-1. PMID: 39169021Free PMC Article
Computational analysis of peripheral blood smears detects disease-associated cytomorphologies.
de Almeida JG, Gudgin E, Besser M, Dunn WG, Cooper J, Haferlach T, Vassiliou GS, Gerstung M
Nat Commun 2023 Jul 20;14(1):4378. doi: 10.1038/s41467-023-39676-y. PMID: 37474506Free PMC Article
NETosis and Neutrophil Extracellular Traps in COVID-19: Immunothrombosis and Beyond.
Zhu Y, Chen X, Liu X
Front Immunol 2022;13:838011. Epub 2022 Mar 2 doi: 10.3389/fimmu.2022.838011. PMID: 35309344Free PMC Article
Neutropenia and leukemia development: genetic risk factors and prognosis.
Shahrabi S, Maleknia M, Tavakolifar Y, D Zayeri Z, Saki N
Leuk Lymphoma 2019 Dec;60(14):3363-3374. Epub 2019 Jun 19 doi: 10.1080/10428194.2019.1630622. PMID: 31213100
Neutrophils in critical illness.
McDonald B
Cell Tissue Res 2018 Mar;371(3):607-615. Epub 2017 Dec 15 doi: 10.1007/s00441-017-2752-3. PMID: 29247324

Clinical prediction guides

Long-term Effects of IL-6 Receptor Blockade Therapy on Regulatory Lymphocytes and Neutrophils in Neuromyelitis Optica Spectrum Disorder.
Matsuoka T, Araki M, Lin Y, Okamoto T, Gold R, Chihara N, Sato W, Kimura A, Tachimori H, Miyamoto K, Kusunoki S, Yamamura T
Neurol Neuroimmunol Neuroinflamm 2024 Jan;11(1) Epub 2023 Oct 20 doi: 10.1212/NXI.0000000000200173. PMID: 37863660Free PMC Article
NETosis and Neutrophil Extracellular Traps in COVID-19: Immunothrombosis and Beyond.
Zhu Y, Chen X, Liu X
Front Immunol 2022;13:838011. Epub 2022 Mar 2 doi: 10.3389/fimmu.2022.838011. PMID: 35309344Free PMC Article
What's wrong with neutrophils in lupus?
Tsai CY, Li KJ, Hsieh SC, Liao HT, Yu CL
Clin Exp Rheumatol 2019 Jul-Aug;37(4):684-693. Epub 2018 Nov 19 PMID: 30557133
Neutrophils in critical illness.
McDonald B
Cell Tissue Res 2018 Mar;371(3):607-615. Epub 2017 Dec 15 doi: 10.1007/s00441-017-2752-3. PMID: 29247324
Therapeutic implications of 'neutrophilic asthma'.
Nair P, Aziz-Ur-Rehman A, Radford K
Curr Opin Pulm Med 2015 Jan;21(1):33-8. doi: 10.1097/MCP.0000000000000120. PMID: 25415406

Recent systematic reviews

Expression of MicroRNAs in Sepsis-Related Organ Dysfunction: A Systematic Review.
Maiese A, Scatena A, Costantino A, Chiti E, Occhipinti C, La Russa R, Di Paolo M, Turillazzi E, Frati P, Fineschi V
Int J Mol Sci 2022 Aug 19;23(16) doi: 10.3390/ijms23169354. PMID: 36012630Free PMC Article
The 2021 European Alliance of Associations for Rheumatology/American College of Rheumatology Points to Consider for Diagnosis and Management of Autoinflammatory Type I Interferonopathies: CANDLE/PRAAS, SAVI, and AGS.
Cetin Gedik K, Lamot L, Romano M, Demirkaya E, Piskin D, Torreggiani S, Adang LA, Armangue T, Barchus K, Cordova DR, Crow YJ, Dale RC, Durrant KL, Eleftheriou D, Fazzi EM, Gattorno M, Gavazzi F, Hanson EP, Lee-Kirsch MA, Montealegre Sanchez GA, Neven B, Orcesi S, Ozen S, Poli MC, Schumacher E, Tonduti D, Uss K, Aletaha D, Feldman BM, Vanderver A, Brogan PA, Goldbach-Mansky R
Arthritis Rheumatol 2022 May;74(5):735-751. Epub 2022 Mar 21 doi: 10.1002/art.42087. PMID: 35315249
Biomarkers of acute kidney injury in pediatric cardiac surgery.
Cavalcante CTMB, Cavalcante MB, Castello Branco KMP, Chan T, Maia ICL, Pompeu RG, de Oliveira Telles AC, Brito AKM, Libório AB
Pediatr Nephrol 2022 Jan;37(1):61-78. Epub 2021 May 25 doi: 10.1007/s00467-021-05094-9. PMID: 34036445
Hematological findings and complications of COVID-19.
Terpos E, Ntanasis-Stathopoulos I, Elalamy I, Kastritis E, Sergentanis TN, Politou M, Psaltopoulou T, Gerotziafas G, Dimopoulos MA
Am J Hematol 2020 Jul;95(7):834-847. Epub 2020 May 23 doi: 10.1002/ajh.25829. PMID: 32282949Free PMC Article
Abnormal peritoneal regulation of chemokine activation-The role of IL-8 in pathogenesis of endometriosis.
Sikora J, Smycz-Kubańska M, Mielczarek-Palacz A, Kondera-Anasz Z
Am J Reprod Immunol 2017 Apr;77(4) Epub 2017 Jan 25 doi: 10.1111/aji.12622. PMID: 28120482

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