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Ectopic ossification in ligament tissue

MedGen UID:
868691
Concept ID:
C4023094
Anatomical Abnormality
HPO: HP:0011989

Definition

Formation of abnormal bony tissue within ligament tissue. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEctopic ossification in ligament tissue

Conditions with this feature

Progressive myositis ossificans
MedGen UID:
4698
Concept ID:
C0016037
Disease or Syndrome
Fibrodysplasia ossificans progressiva (FOP) is characterized by congenital bilateral hallux valgus malformations and early-onset heterotopic ossification, which may be spontaneous or precipitated by trauma including intramuscular vaccinations. Painful, recurrent soft-tissue swellings (flare-ups) may precede localized heterotopic ossification. Heterotopic ossification can occur at any location, but typically affects regions in close proximity to the axial skeleton in the early/mild stages, before progressing to the appendicular skeleton. This can lead to restriction of movement as a result of ossification impacting joint mobility. Problems with swallowing and speaking can occur with ossification affecting the jaw, head, and neck, and restriction of the airway and breathing may lead to thoracic insufficiency syndrome.
Superior transverse scapular ligament, calcification of, familial
MedGen UID:
355711
Concept ID:
C1866424
Disease or Syndrome

Professional guidelines

PubMed

Le HV, Wick JB, Van BW, Klineberg EO
J Am Acad Orthop Surg 2022 Sep 1;30(17):820-830. Epub 2022 May 18 doi: 10.5435/JAAOS-D-22-00049. PMID: 35587949
Łęgosz P, Drela K, Pulik Ł, Sarzyńska S, Małdyk P
Clin Exp Pharmacol Physiol 2018 Dec;45(12):1229-1235. Epub 2018 Oct 4 doi: 10.1111/1440-1681.13025. PMID: 30144316
Rammelt S, Obruba P
Eur J Trauma Emerg Surg 2015 Dec;41(6):601-14. Epub 2014 Nov 12 doi: 10.1007/s00068-014-0466-8. PMID: 26037997

Recent clinical studies

Etiology

Kato H, Braddock DT, Ito N
Curr Osteoporos Rep 2023 Oct;21(5):552-566. Epub 2023 Aug 2 doi: 10.1007/s11914-023-00814-6. PMID: 37530996Free PMC Article
Fujita R, Endo T, Takahata M, Koike Y, Yoneoka D, Suzuki R, Tanaka M, Yamada K, Sudo H, Hasegawa T, Terkawi MA, Kadoya K, Iwasaki N
Spine J 2023 Oct;23(10):1461-1470. Epub 2023 Jul 10 doi: 10.1016/j.spinee.2023.06.400. PMID: 37437695
Zhai J, Guo S, Li J, Chen B, Zhao Y
Orthop Surg 2022 Sep;14(9):1958-1963. Epub 2022 Jul 15 doi: 10.1111/os.13291. PMID: 35837729Free PMC Article
Yuan X, Shi L, Chen Y
Eur Spine J 2021 Apr;30(4):801-808. Epub 2021 Jan 2 doi: 10.1007/s00586-020-06687-y. PMID: 33387048
Slobodin G, Rimar D, Boulman N, Kaly L, Rozenbaum M, Rosner I, Odeh M
Clin Rheumatol 2015 Dec;34(12):2001-10. Epub 2015 Sep 10 doi: 10.1007/s10067-015-3068-x. PMID: 26354427

Diagnosis

Kato H, Braddock DT, Ito N
Curr Osteoporos Rep 2023 Oct;21(5):552-566. Epub 2023 Aug 2 doi: 10.1007/s11914-023-00814-6. PMID: 37530996Free PMC Article
Le HV, Wick JB, Van BW, Klineberg EO
J Am Acad Orthop Surg 2022 Sep 1;30(17):820-830. Epub 2022 May 18 doi: 10.5435/JAAOS-D-22-00049. PMID: 35587949
Yuan X, Shi L, Chen Y
Eur Spine J 2021 Apr;30(4):801-808. Epub 2021 Jan 2 doi: 10.1007/s00586-020-06687-y. PMID: 33387048
Sharif B, Welck M, Saifuddin A
Skeletal Radiol 2020 Jan;49(1):1-17. Epub 2019 Jul 9 doi: 10.1007/s00256-019-03260-7. PMID: 31289899
Slobodin G, Rimar D, Boulman N, Kaly L, Rozenbaum M, Rosner I, Odeh M
Clin Rheumatol 2015 Dec;34(12):2001-10. Epub 2015 Sep 10 doi: 10.1007/s10067-015-3068-x. PMID: 26354427

Therapy

Endo T, Takahata M, Koike Y, Fujita R, Suzuki R, Hisada Y, Hasegawa Y, Suzuki H, Yamada K, Iwata A, Sudo H, Yoneoka D, Iwasaki N
J Bone Miner Metab 2022 Mar;40(2):337-347. Epub 2022 Jan 16 doi: 10.1007/s00774-021-01292-5. PMID: 35034211
James EW, Taber CE, Marx RG
J Knee Surg 2021 May;34(6):587-591. Epub 2021 Feb 5 doi: 10.1055/s-0041-1723016. PMID: 33545732
Marom N, Ruzbarsky JJ, Roselaar N, Marx RG
Clin Sports Med 2018 Apr;37(2):281-291. doi: 10.1016/j.csm.2017.12.011. PMID: 29525028
O'Connor JP, Lysz T
Drugs Today (Barc) 2008 Sep;44(9):693-709. doi: 10.1358/dot.2008.44.9.1251573. PMID: 19137124
Epstein N
Spine J 2002 Nov-Dec;2(6):436-49. doi: 10.1016/s1529-9430(02)00394-7. PMID: 14589269

Prognosis

Kato H, Braddock DT, Ito N
Curr Osteoporos Rep 2023 Oct;21(5):552-566. Epub 2023 Aug 2 doi: 10.1007/s11914-023-00814-6. PMID: 37530996Free PMC Article
Zhao Y, Xiang Q, Jiang S, Wang L, Lin J, Sun C, Li W
Eur Spine J 2023 Apr;32(4):1245-1253. Epub 2023 Mar 6 doi: 10.1007/s00586-023-07625-4. PMID: 36877368
Guan J, Yuan C, Du Y, Jia S, Zhang C, Liu Z, Wang K, Duan W, Wang Z, Wang X, Wu H, Chen Z, Jian F
Eur Spine J 2022 Dec;31(12):3462-3469. Epub 2022 Oct 11 doi: 10.1007/s00586-022-07402-9. PMID: 36220957
Yoo M, Park YG, Cho YE, Lim CH, Chung SY, Kim D, Park J
J Clin Monit Comput 2022 Feb;36(1):247-258. Epub 2021 Feb 6 doi: 10.1007/s10877-020-00646-0. PMID: 33548015
Mahboubi S, Glaser DL, Shore EM, Kaplan FS
Pediatr Radiol 2001 May;31(5):307-14. doi: 10.1007/s002470100447. PMID: 11379597

Clinical prediction guides

Chen S, Li Z, Chen D, Cui H, Wang J, Li Z, Li X, Zheng Z, Zhan Z, Liu H
Ann Rheum Dis 2023 Apr;82(4):533-545. Epub 2022 Dec 21 doi: 10.1136/ard-2022-223428. PMID: 36543525
Singh R
J Craniofac Surg 2022 Jul-Aug 01;33(5):1603-1606. Epub 2022 May 25 doi: 10.1097/SCS.0000000000008330. PMID: 35610745
Le HV, Wick JB, Van BW, Klineberg EO
J Am Acad Orthop Surg 2022 Sep 1;30(17):820-830. Epub 2022 May 18 doi: 10.5435/JAAOS-D-22-00049. PMID: 35587949
Li Z, Chen S, Cui H, Li X, Chen D, Hao W, Wang J, Li Z, Zheng Z, Zhang Z, Liu H
Ann Rheum Dis 2021 Jul;80(7):891-902. Epub 2021 Apr 15 doi: 10.1136/annrheumdis-2021-220002. PMID: 33858850Free PMC Article
Gossman JR Jr, Tarsitano JJ
J Oral Surg 1977 Jul;35(7):555-60. PMID: 406372

Recent systematic reviews

Frugone-Zambra R, Berzaghi A, Gómez-Álvarez J, Bianchi A, Bortolini S
Minerva Dent Oral Sci 2024 Apr;73(2):119-130. Epub 2022 Oct 5 doi: 10.23736/S2724-6329.22.04724-6. PMID: 36197280
Zhao Y, Xiang Q, Jiang S, Wang L, Lin J, Sun C, Li W
Eur Spine J 2023 Apr;32(4):1245-1253. Epub 2023 Mar 6 doi: 10.1007/s00586-023-07625-4. PMID: 36877368
Byvaltsev VA, Kalinin AA, Hernandez PA, Shepelev VV, Pestryakov YY, Aliyev MA, Giers MB
Int J Mol Sci 2022 Nov 3;23(21) doi: 10.3390/ijms232113479. PMID: 36362274Free PMC Article
Ververidis AN, Keskinis A, Paraskevopoulos K, Ververidis NA, Tottas S, Drosos G, Tilkeridis K
Knee Surg Sports Traumatol Arthrosc 2021 Sep;29(9):3037-3048. Epub 2020 Oct 31 doi: 10.1007/s00167-020-06338-1. PMID: 33128588
Chen G, Fan T, Yang X, Sun C, Fan D, Chen Z
Eur Spine J 2020 Sep;29(9):2164-2172. Epub 2020 Jul 15 doi: 10.1007/s00586-020-06520-6. PMID: 32671614

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