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Obstructive azoospermia

MedGen UID:
868703
Concept ID:
C4023106
Disease or Syndrome
HPO: HP:0011962

Definition

Absence of any measurable level of sperm in his semen, resulting from post-testicular obstruction or retrograde ejaculation. This can be differentiated from obstructive azoospermia on the basis of testicular biopsy. [from HPO]

Conditions with this feature

Azoospermia, obstructive, with nephrolithiasis
MedGen UID:
1779119
Concept ID:
C5542351
Disease or Syndrome
Obstructive azoospermia with nephrolithiasis (OAZON) is characterized by male infertility due to obstruction at the head of the epididymis, as well as hypercalciuria and kidney stones (Askari et al., 2019).

Professional guidelines

PubMed

Roshandel E, Mehravar M, Nikoonezhad M, Alizadeh AM, Majidi M, Salimi M, Hajifathali A
Reprod Sci 2023 May;30(5):1482-1494. Epub 2022 Nov 15 doi: 10.1007/s43032-022-01115-6. PMID: 36380137Free PMC Article
Practice Committee of the American Society for Reproductive Medicine in collaboration with the Society for Male Reproduction and Urology. Electronic address: asrm@asrm.org
Fertil Steril 2019 May;111(5):873-880. doi: 10.1016/j.fertnstert.2019.02.013. PMID: 31029241
Modgil V, Rai S, Ralph DJ, Muneer A
Nat Rev Urol 2016 Jan;13(1):13-20. Epub 2015 Dec 1 doi: 10.1038/nrurol.2015.276. PMID: 26620608

Recent clinical studies

Etiology

Xie C, Wang W, Tu C, Meng L, Lu G, Lin G, Lu LY, Tan YQ
Hum Reprod Update 2022 Nov 2;28(6):763-797. doi: 10.1093/humupd/dmac024. PMID: 35613017
Tharakan T, Corona G, Foran D, Salonia A, Sofikitis N, Giwercman A, Krausz C, Yap T, Jayasena CN, Minhas S
Hum Reprod Update 2022 Aug 25;28(5):609-628. doi: 10.1093/humupd/dmac016. PMID: 35526153Free PMC Article
Majzoub A, Arafa M, Clemens H, Imperial J, Leisegang K, Khalafalla K, Agarwal A, Henkel R, Elbardisi H
Andrologia 2022 Apr;54(3):e14303. Epub 2021 Nov 2 doi: 10.1111/and.14303. PMID: 34729809
Thakker S, Persily J, Najari BB
Best Pract Res Clin Endocrinol Metab 2020 Dec;34(6):101475. Epub 2020 Dec 1 doi: 10.1016/j.beem.2020.101475. PMID: 33419659
Corona G, Minhas S, Giwercman A, Bettocchi C, Dinkelman-Smit M, Dohle G, Fusco F, Kadioglou A, Kliesch S, Kopa Z, Krausz C, Pelliccione F, Pizzocaro A, Rassweiler J, Verze P, Vignozzi L, Weidner W, Maggi M, Sofikitis N
Hum Reprod Update 2019 Nov 5;25(6):733-757. doi: 10.1093/humupd/dmz028. PMID: 31665451

Diagnosis

Cioppi F, Rosta V, Krausz C
Int J Mol Sci 2021 Mar 23;22(6) doi: 10.3390/ijms22063264. PMID: 33806855Free PMC Article
Peña VN, Kohn TP, Herati AS
Best Pract Res Clin Endocrinol Metab 2020 Dec;34(6):101479. Epub 2020 Dec 15 doi: 10.1016/j.beem.2020.101479. PMID: 33390350
Zhao L, Yao C, Xing X, Jing T, Li P, Zhu Z, Yang C, Zhai J, Tian R, Chen H, Luo J, Liu N, Deng Z, Lin X, Li N, Fang J, Sun J, Wang C, Zhou Z, Li Z
Nat Commun 2020 Nov 10;11(1):5683. doi: 10.1038/s41467-020-19414-4. PMID: 33173058Free PMC Article
Krausz C, Riera-Escamilla A
Nat Rev Urol 2018 Jun;15(6):369-384. doi: 10.1038/s41585-018-0003-3. PMID: 29622783
Wosnitzer MS, Goldstein M
Urol Clin North Am 2014 Feb;41(1):83-95. Epub 2013 Oct 15 doi: 10.1016/j.ucl.2013.08.013. PMID: 24286769

Therapy

Brant A, Schlegel PN
Curr Opin Urol 2023 Jan 1;33(1):39-44. Epub 2022 Oct 27 doi: 10.1097/MOU.0000000000001055. PMID: 36301052
Tharakan T, Corona G, Foran D, Salonia A, Sofikitis N, Giwercman A, Krausz C, Yap T, Jayasena CN, Minhas S
Hum Reprod Update 2022 Aug 25;28(5):609-628. doi: 10.1093/humupd/dmac016. PMID: 35526153Free PMC Article
Ghieh F, Barbotin AL, Swierkowski-Blanchard N, Leroy C, Fortemps J, Gerault C, Hue C, Mambu Mambueni H, Jaillard S, Albert M, Bailly M, Izard V, Molina-Gomes D, Marcelli F, Prasivoravong J, Serazin V, Dieudonne MN, Delcroix M, Garchon HJ, Louboutin A, Mandon-Pepin B, Ferlicot S, Vialard F
Hum Reprod 2022 May 30;37(6):1334-1350. doi: 10.1093/humrep/deac057. PMID: 35413094Free PMC Article
Zhankina R, Baghban N, Askarov M, Saipiyeva D, Ibragimov A, Kadirova B, Khoradmehr A, Nabipour I, Shirazi R, Zhanbyrbekuly U, Tamadon A
Stem Cell Res Ther 2021 Apr 6;12(1):229. doi: 10.1186/s13287-021-02295-9. PMID: 33823925Free PMC Article
Corona G, Minhas S, Giwercman A, Bettocchi C, Dinkelman-Smit M, Dohle G, Fusco F, Kadioglou A, Kliesch S, Kopa Z, Krausz C, Pelliccione F, Pizzocaro A, Rassweiler J, Verze P, Vignozzi L, Weidner W, Maggi M, Sofikitis N
Hum Reprod Update 2019 Nov 5;25(6):733-757. doi: 10.1093/humupd/dmz028. PMID: 31665451

Prognosis

Chen T, Wang Y, Tian L, Guo X, Xia J, Wang Z, Song N
Front Immunol 2022;13:821010. Epub 2022 Jun 27 doi: 10.3389/fimmu.2022.821010. PMID: 35833143Free PMC Article
Ghieh F, Barbotin AL, Swierkowski-Blanchard N, Leroy C, Fortemps J, Gerault C, Hue C, Mambu Mambueni H, Jaillard S, Albert M, Bailly M, Izard V, Molina-Gomes D, Marcelli F, Prasivoravong J, Serazin V, Dieudonne MN, Delcroix M, Garchon HJ, Louboutin A, Mandon-Pepin B, Ferlicot S, Vialard F
Hum Reprod 2022 May 30;37(6):1334-1350. doi: 10.1093/humrep/deac057. PMID: 35413094Free PMC Article
Majzoub A, Arafa M, Clemens H, Imperial J, Leisegang K, Khalafalla K, Agarwal A, Henkel R, Elbardisi H
Andrologia 2022 Apr;54(3):e14303. Epub 2021 Nov 2 doi: 10.1111/and.14303. PMID: 34729809
Jiao SY, Yang YH, Chen SR
Hum Reprod Update 2021 Jan 4;27(1):154-189. doi: 10.1093/humupd/dmaa034. PMID: 33118031
Corona G, Minhas S, Giwercman A, Bettocchi C, Dinkelman-Smit M, Dohle G, Fusco F, Kadioglou A, Kliesch S, Kopa Z, Krausz C, Pelliccione F, Pizzocaro A, Rassweiler J, Verze P, Vignozzi L, Weidner W, Maggi M, Sofikitis N
Hum Reprod Update 2019 Nov 5;25(6):733-757. doi: 10.1093/humupd/dmz028. PMID: 31665451

Clinical prediction guides

Tharakan T, Corona G, Foran D, Salonia A, Sofikitis N, Giwercman A, Krausz C, Yap T, Jayasena CN, Minhas S
Hum Reprod Update 2022 Aug 25;28(5):609-628. doi: 10.1093/humupd/dmac016. PMID: 35526153Free PMC Article
Majzoub A, Arafa M, Clemens H, Imperial J, Leisegang K, Khalafalla K, Agarwal A, Henkel R, Elbardisi H
Andrologia 2022 Apr;54(3):e14303. Epub 2021 Nov 2 doi: 10.1111/and.14303. PMID: 34729809
Jiao SY, Yang YH, Chen SR
Hum Reprod Update 2021 Jan 4;27(1):154-189. doi: 10.1093/humupd/dmaa034. PMID: 33118031
Corona G, Minhas S, Giwercman A, Bettocchi C, Dinkelman-Smit M, Dohle G, Fusco F, Kadioglou A, Kliesch S, Kopa Z, Krausz C, Pelliccione F, Pizzocaro A, Rassweiler J, Verze P, Vignozzi L, Weidner W, Maggi M, Sofikitis N
Hum Reprod Update 2019 Nov 5;25(6):733-757. doi: 10.1093/humupd/dmz028. PMID: 31665451
Corona G, Pizzocaro A, Lanfranco F, Garolla A, Pelliccione F, Vignozzi L, Ferlin A, Foresta C, Jannini EA, Maggi M, Lenzi A, Pasquali D, Francavilla S; Klinefelter ItaliaN Group (KING)
Hum Reprod Update 2017 May 1;23(3):265-275. doi: 10.1093/humupd/dmx008. PMID: 28379559

Recent systematic reviews

Tharakan T, Corona G, Foran D, Salonia A, Sofikitis N, Giwercman A, Krausz C, Yap T, Jayasena CN, Minhas S
Hum Reprod Update 2022 Aug 25;28(5):609-628. doi: 10.1093/humupd/dmac016. PMID: 35526153Free PMC Article
Majzoub A, Arafa M, Clemens H, Imperial J, Leisegang K, Khalafalla K, Agarwal A, Henkel R, Elbardisi H
Andrologia 2022 Apr;54(3):e14303. Epub 2021 Nov 2 doi: 10.1111/and.14303. PMID: 34729809
Zhankina R, Baghban N, Askarov M, Saipiyeva D, Ibragimov A, Kadirova B, Khoradmehr A, Nabipour I, Shirazi R, Zhanbyrbekuly U, Tamadon A
Stem Cell Res Ther 2021 Apr 6;12(1):229. doi: 10.1186/s13287-021-02295-9. PMID: 33823925Free PMC Article
Corona G, Minhas S, Giwercman A, Bettocchi C, Dinkelman-Smit M, Dohle G, Fusco F, Kadioglou A, Kliesch S, Kopa Z, Krausz C, Pelliccione F, Pizzocaro A, Rassweiler J, Verze P, Vignozzi L, Weidner W, Maggi M, Sofikitis N
Hum Reprod Update 2019 Nov 5;25(6):733-757. doi: 10.1093/humupd/dmz028. PMID: 31665451
Corona G, Pizzocaro A, Lanfranco F, Garolla A, Pelliccione F, Vignozzi L, Ferlin A, Foresta C, Jannini EA, Maggi M, Lenzi A, Pasquali D, Francavilla S; Klinefelter ItaliaN Group (KING)
Hum Reprod Update 2017 May 1;23(3):265-275. doi: 10.1093/humupd/dmx008. PMID: 28379559

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