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Obstructive azoospermia

MedGen UID:
868703
Concept ID:
C4023106
Disease or Syndrome
HPO: HP:0011962

Definition

Absence of any measurable level of sperm in his semen, resulting from post-testicular obstruction or retrograde ejaculation. This can be differentiated from obstructive azoospermia on the basis of testicular biopsy. [from HPO]

Conditions with this feature

Azoospermia, obstructive, with nephrolithiasis
MedGen UID:
1779119
Concept ID:
C5542351
Disease or Syndrome
Obstructive azoospermia with nephrolithiasis (OAZON) is characterized by male infertility due to obstruction at the head of the epididymis, as well as hypercalciuria and kidney stones (Askari et al., 2019).

Professional guidelines

PubMed

Hibi H, Sugie M, Sonohara M, Fukunaga N, Asada Y
Nagoya J Med Sci 2023 May;85(2):233-240. doi: 10.18999/nagjms.85.2.233. PMID: 37346843Free PMC Article
Roshandel E, Mehravar M, Nikoonezhad M, Alizadeh AM, Majidi M, Salimi M, Hajifathali A
Reprod Sci 2023 May;30(5):1482-1494. Epub 2022 Nov 15 doi: 10.1007/s43032-022-01115-6. PMID: 36380137Free PMC Article
Hull MG, Glazener CM, Kelly NJ, Conway DI, Foster PA, Hinton RA, Coulson C, Lambert PA, Watt EM, Desai KM
Br Med J (Clin Res Ed) 1985 Dec 14;291(6510):1693-7. doi: 10.1136/bmj.291.6510.1693. PMID: 3935248Free PMC Article

Recent clinical studies

Etiology

Xia P, Ouyang S, Shen R, Guo Z, Zhang G, Liu X, Yang X, Xie K, Wang D
Int J Mol Sci 2023 May 16;24(10) doi: 10.3390/ijms24108819. PMID: 37240164Free PMC Article
Ran L, Gao Z, Chen Q, Cui F, Liu X, Xue B
Aging (Albany NY) 2023 May 24;15(10):4465-4480. doi: 10.18632/aging.204749. PMID: 37227814Free PMC Article
Xie C, Wang W, Tu C, Meng L, Lu G, Lin G, Lu LY, Tan YQ
Hum Reprod Update 2022 Nov 2;28(6):763-797. doi: 10.1093/humupd/dmac024. PMID: 35613017
Kasak L, Laan M
Hum Genet 2021 Jan;140(1):135-154. Epub 2020 Jan 18 doi: 10.1007/s00439-020-02112-y. PMID: 31955275
Van Steirteghem A
Baillieres Clin Obstet Gynaecol 1997 Dec;11(4):725-38. doi: 10.1016/s0950-3552(97)80009-0. PMID: 9692013

Diagnosis

Xie C, Wang W, Tu C, Meng L, Lu G, Lin G, Lu LY, Tan YQ
Hum Reprod Update 2022 Nov 2;28(6):763-797. doi: 10.1093/humupd/dmac024. PMID: 35613017
Kherraf ZE, Cazin C, Bouker A, Fourati Ben Mustapha S, Hennebicq S, Septier A, Coutton C, Raymond L, Nouchy M, Thierry-Mieg N, Zouari R, Arnoult C, Ray PF
Am J Hum Genet 2022 Mar 3;109(3):508-517. Epub 2022 Feb 15 doi: 10.1016/j.ajhg.2022.01.011. PMID: 35172124Free PMC Article
Cioppi F, Rosta V, Krausz C
Int J Mol Sci 2021 Mar 23;22(6) doi: 10.3390/ijms22063264. PMID: 33806855Free PMC Article
Zhao L, Yao C, Xing X, Jing T, Li P, Zhu Z, Yang C, Zhai J, Tian R, Chen H, Luo J, Liu N, Deng Z, Lin X, Li N, Fang J, Sun J, Wang C, Zhou Z, Li Z
Nat Commun 2020 Nov 10;11(1):5683. doi: 10.1038/s41467-020-19414-4. PMID: 33173058Free PMC Article
Krausz C, Riera-Escamilla A
Nat Rev Urol 2018 Jun;15(6):369-384. doi: 10.1038/s41585-018-0003-3. PMID: 29622783

Therapy

Brant A, Schlegel PN
Curr Opin Urol 2023 Jan 1;33(1):39-44. Epub 2022 Oct 27 doi: 10.1097/MOU.0000000000001055. PMID: 36301052
Xie X, Murtaza G, Li Y, Zhou J, Ye J, Khan R, Jiang L, Khan I, Zubair M, Yin H, Jiang H, Liu W, Shi B, Hou X, Gong C, Fan S, Wang Y, Jiang X, Zhang Y, Zhang H, Ma H, Shi Q
Hum Reprod 2022 Jun 30;37(7):1664-1677. doi: 10.1093/humrep/deac092. PMID: 35526155
Shiraishi K, Oka S, Matsuyama H
J Clin Endocrinol Metab 2021 Mar 25;106(4):e1803-e1815. doi: 10.1210/clinem/dgaa860. PMID: 33236081
Shiraishi K, Matsuyama H
Endocr J 2017 Feb 27;64(2):123-131. Epub 2017 Jan 19 doi: 10.1507/endocrj.EJ17-0001. PMID: 28100869
Schlegel PN
Fertil Steril 2012 Dec;98(6):1359-62. Epub 2012 Oct 25 doi: 10.1016/j.fertnstert.2012.10.023. PMID: 23103016

Prognosis

Goss DM, Vasilescu SA, Sacks G, Gardner DK, Warkiani ME
Nat Rev Urol 2023 Feb;20(2):66-95. Epub 2022 Nov 8 doi: 10.1038/s41585-022-00660-8. PMID: 36348030
Jiao SY, Yang YH, Chen SR
Hum Reprod Update 2021 Jan 4;27(1):154-189. doi: 10.1093/humupd/dmaa034. PMID: 33118031
Kasak L, Laan M
Hum Genet 2021 Jan;140(1):135-154. Epub 2020 Jan 18 doi: 10.1007/s00439-020-02112-y. PMID: 31955275
Esteves SC, Agarwal A
Int Braz J Urol 2011 Jan-Feb;37(1):5-15. doi: 10.1590/s1677-55382011000100002. PMID: 21385475
Van Steirteghem A
Baillieres Clin Obstet Gynaecol 1997 Dec;11(4):725-38. doi: 10.1016/s0950-3552(97)80009-0. PMID: 9692013

Clinical prediction guides

Xia P, Ouyang S, Shen R, Guo Z, Zhang G, Liu X, Yang X, Xie K, Wang D
Int J Mol Sci 2023 May 16;24(10) doi: 10.3390/ijms24108819. PMID: 37240164Free PMC Article
Song J, Sha Y, Liu X, Zeng X, Zhao X
Front Endocrinol (Lausanne) 2023;14:1159723. Epub 2023 Apr 14 doi: 10.3389/fendo.2023.1159723. PMID: 37124723Free PMC Article
Jiao SY, Yang YH, Chen SR
Hum Reprod Update 2021 Jan 4;27(1):154-189. doi: 10.1093/humupd/dmaa034. PMID: 33118031
Kasak L, Laan M
Hum Genet 2021 Jan;140(1):135-154. Epub 2020 Jan 18 doi: 10.1007/s00439-020-02112-y. PMID: 31955275
Wu B, Wong D, Lu S, Dickstein S, Silva M, Gelety TJ
J Assist Reprod Genet 2005 Dec;22(11-12):389-94. doi: 10.1007/s10815-005-7481-y. PMID: 16331535Free PMC Article

Recent systematic reviews

Wan B, Wu Y, Wu Z, Zhou Z, Lu W
Andrology 2023 Jan;11(1):103-111. Epub 2022 Sep 26 doi: 10.1111/andr.13300. PMID: 36116029
Corona G, Minhas S, Giwercman A, Bettocchi C, Dinkelman-Smit M, Dohle G, Fusco F, Kadioglou A, Kliesch S, Kopa Z, Krausz C, Pelliccione F, Pizzocaro A, Rassweiler J, Verze P, Vignozzi L, Weidner W, Maggi M, Sofikitis N
Hum Reprod Update 2019 Nov 5;25(6):733-757. doi: 10.1093/humupd/dmz028. PMID: 31665451
Corona G, Pizzocaro A, Lanfranco F, Garolla A, Pelliccione F, Vignozzi L, Ferlin A, Foresta C, Jannini EA, Maggi M, Lenzi A, Pasquali D, Francavilla S; Klinefelter ItaliaN Group (KING)
Hum Reprod Update 2017 May 1;23(3):265-275. doi: 10.1093/humupd/dmx008. PMID: 28379559
Kordzadeh A, Liu MO, Jayanthi NV
Hernia 2017 Feb;21(1):1-7. Epub 2016 Dec 3 doi: 10.1007/s10029-016-1560-0. PMID: 27915384
Lotti F, Maggi M
Hum Reprod Update 2015 Jan-Feb;21(1):56-83. Epub 2014 Jul 19 doi: 10.1093/humupd/dmu042. PMID: 25038770

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