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Intestinal lymphoid nodular hyperplasia

MedGen UID:
868706
•Concept ID:
C4023109
•
Finding
HPO: HP:0011956

Definition

A lymphoproliferative abnormality of the intestine characterized by numerous visible mucosal nodules measuring up to, and rarely exceeding, 0.5 cm in diameter Histologically, hyperplastic lymphoid follicles with large germinal centers are seen in the lamina propria and superficial submucosa. There is enlargement of the mucosal B cell follicles caused by hyperplasia of the follicle centers; surrounded by a normal appearing mantle zone. Disease may involve the stomach, the entire small intestine, and the large intestine. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIntestinal lymphoid nodular hyperplasia

Professional guidelines

PubMed

Management of small bowel polyps: A literature review.
de Latour RA, Kilaru SM, Gross SA
Best Pract Res Clin Gastroenterol 2017 Aug;31(4):401-408. Epub 2017 Jun 27 doi: 10.1016/j.bpg.2017.06.003. PMID: 28842049
Pathophysiology, clinical presentation and management of diversion colitis: a review of current literature.
Kabir SI, Kabir SA, Richards R, Ahmed J, MacFie J
Int J Surg 2014 Oct;12(10):1088-92. Epub 2014 Aug 20 doi: 10.1016/j.ijsu.2014.08.350. PMID: 25150021
Diagnosis and treatment of gastrointestinal disorders in patients with primary immunodeficiency.
Agarwal S, Mayer L
Clin Gastroenterol Hepatol 2013 Sep;11(9):1050-63. Epub 2013 Mar 13 doi: 10.1016/j.cgh.2013.02.024. PMID: 23501398Free PMC Article

Recent clinical studies

Etiology

Intestinal lymphoid nodular hyperplasia in children: the relationship to food allergy.
Lucarelli S, Lastrucci G, Di Nardo G, D'Alfonso Y, Aloi M, Oliva S, Frediani S, Rossetti D, Frediani T
Pediatr Allergy Immunol 2015 Feb;26(1):18-24. doi: 10.1111/pai.12328. PMID: 25684674
Enterokinase and trypsin activities in pancreatic insufficiency and diseases of the small intestine.
Lebenthal E, Antonowicz I, Shwachman H
Gastroenterology 1976 Apr;70(4):508-12. PMID: 943355

Diagnosis

Intestinal lymphoid nodular hyperplasia in children: the relationship to food allergy.
Lucarelli S, Lastrucci G, Di Nardo G, D'Alfonso Y, Aloi M, Oliva S, Frediani S, Rossetti D, Frediani T
Pediatr Allergy Immunol 2015 Feb;26(1):18-24. doi: 10.1111/pai.12328. PMID: 25684674
Review article: intestinal lymphoid nodular hyperplasia in children--the relationship to food hypersensitivity.
Mansueto P, Iacono G, Seidita A, D'Alcamo A, Sprini D, Carroccio A
Aliment Pharmacol Ther 2012 May;35(9):1000-9. Epub 2012 Mar 20 doi: 10.1111/j.1365-2036.2012.05062.x. PMID: 22428565
Enterokinase and trypsin activities in pancreatic insufficiency and diseases of the small intestine.
Lebenthal E, Antonowicz I, Shwachman H
Gastroenterology 1976 Apr;70(4):508-12. PMID: 943355

Therapy

Intestinal lymphoid nodular hyperplasia in children: the relationship to food allergy.
Lucarelli S, Lastrucci G, Di Nardo G, D'Alfonso Y, Aloi M, Oliva S, Frediani S, Rossetti D, Frediani T
Pediatr Allergy Immunol 2015 Feb;26(1):18-24. doi: 10.1111/pai.12328. PMID: 25684674
Review article: intestinal lymphoid nodular hyperplasia in children--the relationship to food hypersensitivity.
Mansueto P, Iacono G, Seidita A, D'Alcamo A, Sprini D, Carroccio A
Aliment Pharmacol Ther 2012 May;35(9):1000-9. Epub 2012 Mar 20 doi: 10.1111/j.1365-2036.2012.05062.x. PMID: 22428565
Common variable hypogammaglobulinemia with T-cell nodular lymphoid interstitial pneumonitis and B-cell nodular lymphoid hyperplasia: different lymphocyte populations with a similar response to prednisone therapy.
Kohler PF, Cook RD, Brown WR, Manguso RL
J Allergy Clin Immunol 1982 Oct;70(4):299-305. doi: 10.1016/0091-6749(82)90066-5. PMID: 6981662
Enterokinase and trypsin activities in pancreatic insufficiency and diseases of the small intestine.
Lebenthal E, Antonowicz I, Shwachman H
Gastroenterology 1976 Apr;70(4):508-12. PMID: 943355

Prognosis

Intestinal lymphoid nodular hyperplasia in children: the relationship to food allergy.
Lucarelli S, Lastrucci G, Di Nardo G, D'Alfonso Y, Aloi M, Oliva S, Frediani S, Rossetti D, Frediani T
Pediatr Allergy Immunol 2015 Feb;26(1):18-24. doi: 10.1111/pai.12328. PMID: 25684674

Clinical prediction guides

Intestinal lymphoid nodular hyperplasia in children: the relationship to food allergy.
Lucarelli S, Lastrucci G, Di Nardo G, D'Alfonso Y, Aloi M, Oliva S, Frediani S, Rossetti D, Frediani T
Pediatr Allergy Immunol 2015 Feb;26(1):18-24. doi: 10.1111/pai.12328. PMID: 25684674
Review article: intestinal lymphoid nodular hyperplasia in children--the relationship to food hypersensitivity.
Mansueto P, Iacono G, Seidita A, D'Alcamo A, Sprini D, Carroccio A
Aliment Pharmacol Ther 2012 May;35(9):1000-9. Epub 2012 Mar 20 doi: 10.1111/j.1365-2036.2012.05062.x. PMID: 22428565

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