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Bleeding with minor or no trauma

MedGen UID:
868738
•Concept ID:
C4023143
•
Finding; Pathologic Function
Synonym: Easy bleeding
 
HPO: HP:0011889

Definition

Significant bleeding or hemorrhage without significant precipitating factor. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBleeding with minor or no trauma

Conditions with this feature

Congenital disorder of glycosylation, type IIw
MedGen UID:
1794196
•Concept ID:
C5561986
•
Disease or Syndrome
Congenital disorder of glycosylation type IIw (CDG2W) is an autosomal dominant metabolic disorder characterized by liver dysfunction, coagulation deficiencies, and profound abnormalities in N-glycosylation of serum specific proteins. All reported patients carry the same mutation (602671.0017) (summary by Ng et al., 2021). For an overview of congenital disorders of glycosylation, see CDG1A (212065) and CDG2A (212066).
See: Condition Record
Congenital disorder of glycosylation, type IIw

Professional guidelines

PubMed

Perioperative Management of Antithrombotic Therapy: An American College of Chest Physicians Clinical Practice Guideline.
Douketis JD, Spyropoulos AC, Murad MH, Arcelus JI, Dager WE, Dunn AS, Fargo RA, Levy JH, Samama CM, Shah SH, Sherwood MW, Tafur AJ, Tang LV, Moores LK
Chest 2022 Nov;162(5):e207-e243. Epub 2022 Aug 11 doi: 10.1016/j.chest.2022.07.025. PMID: 35964704
Diagnosis, treatment and prevention of ankle sprains: update of an evidence-based clinical guideline.
Vuurberg G, Hoorntje A, Wink LM, van der Doelen BFW, van den Bekerom MP, Dekker R, van Dijk CN, Krips R, Loogman MCM, Ridderikhof ML, Smithuis FF, Stufkens SAS, Verhagen EALM, de Bie RA, Kerkhoffs GMMJ
Br J Sports Med 2018 Aug;52(15):956. Epub 2018 Mar 7 doi: 10.1136/bjsports-2017-098106. PMID: 29514819
Recovery and Performance in Sport: Consensus Statement.
Kellmann M, Bertollo M, Bosquet L, Brink M, Coutts AJ, Duffield R, Erlacher D, Halson SL, Hecksteden A, Heidari J, Kallus KW, Meeusen R, Mujika I, Robazza C, Skorski S, Venter R, Beckmann J
Int J Sports Physiol Perform 2018 Feb 1;13(2):240-245. Epub 2018 Feb 19 doi: 10.1123/ijspp.2017-0759. PMID: 29345524

Recent clinical studies

Etiology

Immunopathophysiology of trauma-related acute kidney injury.
Messerer DAC, Halbgebauer R, Nilsson B, Pavenstädt H, Radermacher P, Huber-Lang M
Nat Rev Nephrol 2021 Feb;17(2):91-111. Epub 2020 Sep 21 doi: 10.1038/s41581-020-00344-9. PMID: 32958893
Blunt trauma related chest wall and pulmonary injuries: An overview.
Dogrul BN, Kiliccalan I, Asci ES, Peker SC
Chin J Traumatol 2020 Jun;23(3):125-138. Epub 2020 Apr 20 doi: 10.1016/j.cjtee.2020.04.003. PMID: 32417043Free PMC Article
Obesity in Pediatric Trauma.
Ashley P, Gilbert SR
Orthop Clin North Am 2018 Jul;49(3):335-343. doi: 10.1016/j.ocl.2018.02.007. PMID: 29929715
Trauma in pregnancy: assessment, management, and prevention.
Murphy NJ, Quinlan JD
Am Fam Physician 2014 Nov 15;90(10):717-22. PMID: 25403036
Haemobilia.
Green MH, Duell RM, Johnson CD, Jamieson NV
Br J Surg 2001 Jun;88(6):773-86. doi: 10.1046/j.1365-2168.2001.01756.x. PMID: 11412246

Diagnosis

Blunt trauma related chest wall and pulmonary injuries: An overview.
Dogrul BN, Kiliccalan I, Asci ES, Peker SC
Chin J Traumatol 2020 Jun;23(3):125-138. Epub 2020 Apr 20 doi: 10.1016/j.cjtee.2020.04.003. PMID: 32417043Free PMC Article
Pediatric Orthopedic Trauma.
Grossman J, Giliberti B, Dolitsky R, Parker G, Kim B, Kutzarov K, Curatolo E
Pediatr Clin North Am 2020 Feb;67(1):101-118. doi: 10.1016/j.pcl.2019.09.010. PMID: 31779827
Pediatric Abdominal Trauma.
Lynch T, Kilgar J, Al Shibli A
Curr Pediatr Rev 2018;14(1):59-63. doi: 10.2174/1573396313666170815100547. PMID: 28814248
Trauma in pregnancy: assessment, management, and prevention.
Murphy NJ, Quinlan JD
Am Fam Physician 2014 Nov 15;90(10):717-22. PMID: 25403036
Muscle injuries: optimising recovery.
Järvinen TA, Järvinen TL, Kääriäinen M, Aärimaa V, Vaittinen S, Kalimo H, Järvinen M
Best Pract Res Clin Rheumatol 2007 Apr;21(2):317-31. doi: 10.1016/j.berh.2006.12.004. PMID: 17512485

Therapy

Surgical outcomes in people with hemophilia A taking emicizumab prophylaxis: experience from the HAVEN 1-4 studies.
Kruse-Jarres R, Peyvandi F, Oldenburg J, Chang T, Chebon S, Doral MY, Croteau SE, Lambert T, Kempton CL, Pipe SW, Ko RH, Trzaskoma B, Dhalluin C, Bienz NS, Niggli M, Lehle M, Paz-Priel I, Young G, Jiménez-Yuste V
Blood Adv 2022 Dec 27;6(24):6140-6150. doi: 10.1182/bloodadvances.2022007458. PMID: 35939785Free PMC Article
Review of massive transfusion protocols in the injured, bleeding patient.
Abuzeid AM, O'Keeffe T
Curr Opin Crit Care 2019 Dec;25(6):661-667. doi: 10.1097/MCC.0000000000000668. PMID: 31574016
Emergency ultrasound-based algorithms for diagnosing blunt abdominal trauma.
Stengel D, Rademacher G, Ekkernkamp A, Güthoff C, Mutze S
Cochrane Database Syst Rev 2015 Sep 14;2015(9):CD004446. doi: 10.1002/14651858.CD004446.pub4. PMID: 26368505Free PMC Article
Thromboprophylaxis for trauma patients.
Barrera LM, Perel P, Ker K, Cirocchi R, Farinella E, Morales Uribe CH
Cochrane Database Syst Rev 2013 Mar 28;(3):CD008303. doi: 10.1002/14651858.CD008303.pub2. PMID: 23543562
Muscle injuries: optimising recovery.
Järvinen TA, Järvinen TL, Kääriäinen M, Aärimaa V, Vaittinen S, Kalimo H, Järvinen M
Best Pract Res Clin Rheumatol 2007 Apr;21(2):317-31. doi: 10.1016/j.berh.2006.12.004. PMID: 17512485

Prognosis

Diagnosis, management and treatment of neck trauma.
Petrone P, Velaz-Pardo L, Gendy A, Velcu L, Brathwaite CEM, Joseph DK
Cir Esp (Engl Ed) 2019 Nov;97(9):489-500. Epub 2019 Jul 27 doi: 10.1016/j.ciresp.2019.06.001. PMID: 31358299
Why are bleeding trauma patients still dying?
Brohi K, Gruen RL, Holcomb JB
Intensive Care Med 2019 May;45(5):709-711. Epub 2019 Feb 11 doi: 10.1007/s00134-019-05560-x. PMID: 30741331
Trauma induced acute kidney injury.
Perkins ZB, Captur G, Bird R, Gleeson L, Singer B, O'Brien B
PLoS One 2019;14(1):e0211001. Epub 2019 Jan 25 doi: 10.1371/journal.pone.0211001. PMID: 30682106Free PMC Article
Maternal mortality.
Mhyre JM
Curr Opin Anaesthesiol 2012 Jun;25(3):277-85. doi: 10.1097/ACO.0b013e3283530580. PMID: 22459982
Preventable trauma deaths.
Settervall CH, Domingues Cde A, Sousa RM, Nogueira Lde S
Rev Saude Publica 2012 Apr;46(2):367-75. Epub 2012 Feb 3 doi: 10.1590/s0034-89102012005000010. PMID: 22310649

Clinical prediction guides

An update on urotrauma.
Stein DM, Santucci RA
Curr Opin Urol 2015 Jul;25(4):323-30. doi: 10.1097/MOU.0000000000000184. PMID: 26049876
Trauma scoring systems and databases.
Lecky F, Woodford M, Edwards A, Bouamra O, Coats T
Br J Anaesth 2014 Aug;113(2):286-94. doi: 10.1093/bja/aeu242. PMID: 25038159
Pancreatic trauma: a concise review.
Debi U, Kaur R, Prasad KK, Sinha SK, Sinha A, Singh K
World J Gastroenterol 2013 Dec 21;19(47):9003-11. doi: 10.3748/wjg.v19.i47.9003. PMID: 24379625Free PMC Article
Trauma scoring systems.
Lefering R
Curr Opin Crit Care 2012 Dec;18(6):637-40. doi: 10.1097/MCC.0b013e3283585356. PMID: 22918259
Anticoagulant-related bleeding: clinical epidemiology, prediction, and prevention.
Landefeld CS, Beyth RJ
Am J Med 1993 Sep;95(3):315-28. doi: 10.1016/0002-9343(93)90285-w. PMID: 8368229

Recent systematic reviews

Vaccination after spleen embolization: A practice management guideline from the Eastern Association for the Surgery of Trauma.
Freeman JJ, Yorkgitis BK, Haines K, Koganti D, Patel N, Maine R, Chiu W, Tran TL, Como JJ, Kasotakis G
Injury 2022 Nov;53(11):3569-3574. Epub 2022 Aug 4 doi: 10.1016/j.injury.2022.08.006. PMID: 36038390
The Effect of Amino Acids on Wound Healing: A Systematic Review and Meta-Analysis on Arginine and Glutamine.
Arribas-López E, Zand N, Ojo O, Snowden MJ, Kochhar T
Nutrients 2021 Jul 22;13(8) doi: 10.3390/nu13082498. PMID: 34444657Free PMC Article
Diagnosis, management and treatment of neck trauma.
Petrone P, Velaz-Pardo L, Gendy A, Velcu L, Brathwaite CEM, Joseph DK
Cir Esp (Engl Ed) 2019 Nov;97(9):489-500. Epub 2019 Jul 27 doi: 10.1016/j.ciresp.2019.06.001. PMID: 31358299
The humanistic and economic burden of chronic wounds: A systematic review.
Olsson M, Järbrink K, Divakar U, Bajpai R, Upton Z, Schmidtchen A, Car J
Wound Repair Regen 2019 Jan;27(1):114-125. Epub 2018 Dec 2 doi: 10.1111/wrr.12683. PMID: 30362646
Thromboprophylaxis for trauma patients.
Barrera LM, Perel P, Ker K, Cirocchi R, Farinella E, Morales Uribe CH
Cochrane Database Syst Rev 2013 Mar 28;(3):CD008303. doi: 10.1002/14651858.CD008303.pub2. PMID: 23543562

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