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Libman-Sacks lesions

MedGen UID:
868811
•Concept ID:
C4023221
•
Disease or Syndrome
HPO: HP:0011714

Definition

Libman-Sacks valvular lesions are sterile fibrofibrinous vegetations that favor the left-sided heart valves and usually form on the ventricular surface of the mitral valve. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLibman-Sacks lesions

Recent clinical studies

Etiology

Severe Libman-Sacks endocarditis complicating antiphospholipid syndrome: a retrospective analysis of 23 operated cases.
Chalvon NB, Costedoat-Chalumeau N, Pennaforte JL, Servettaz A, Boulagnon Rombi C, Gavand PE, Lekieffre M, Le Guern V, Morel N, Cohen Aubart F, Haroche J, Mathian A, Collet JP, Piette JC, Amoura Z, Orquevaux P
Rheumatology (Oxford) 2023 Feb 1;62(2):707-715. doi: 10.1093/rheumatology/keac315. PMID: 35686908
Libman-Sacks endocarditis and associated cerebrovascular disease: The role of medical therapy.
Roldan CA, Sibbitt WL Jr, Greene ER, Qualls CR, Jung RE
PLoS One 2021;16(2):e0247052. Epub 2021 Feb 16 doi: 10.1371/journal.pone.0247052. PMID: 33592060Free PMC Article
Libman-Sacks endocarditis and embolic cerebrovascular disease.
Roldan CA, Sibbitt WL Jr, Qualls CR, Jung RE, Greene ER, Gasparovic CM, Hayek RA, Charlton GA, Crookston K
JACC Cardiovasc Imaging 2013 Sep;6(9):973-83. doi: 10.1016/j.jcmg.2013.04.012. PMID: 24029368Free PMC Article
Libman-Sacks endocarditis in systemic lupus erythematosus: prevalence, associations, and evolution.
Moyssakis I, Tektonidou MG, Vasilliou VA, Samarkos M, Votteas V, Moutsopoulos HM
Am J Med 2007 Jul;120(7):636-42. doi: 10.1016/j.amjmed.2007.01.024. PMID: 17602939
Heart valve involvement (Libman-Sacks endocarditis) in the antiphospholipid syndrome.
Hojnik M, George J, Ziporen L, Shoenfeld Y
Circulation 1996 Apr 15;93(8):1579-87. doi: 10.1161/01.cir.93.8.1579. PMID: 8608627

Diagnosis

Diagnosis and surgical treatment for isolated tricuspid Libman-Sacks endocarditis: a rare case report and literatures review.
Bai Z, Hou J, Ren W, Guo Y
J Cardiothorac Surg 2015 Jul 8;10:93. doi: 10.1186/s13019-015-0302-1. PMID: 26152222Free PMC Article
Libman-Sacks endocarditis and embolic cerebrovascular disease.
Roldan CA, Sibbitt WL Jr, Qualls CR, Jung RE, Greene ER, Gasparovic CM, Hayek RA, Charlton GA, Crookston K
JACC Cardiovasc Imaging 2013 Sep;6(9):973-83. doi: 10.1016/j.jcmg.2013.04.012. PMID: 24029368Free PMC Article
Revisiting Libman-Sacks endocarditis: a historical review and update.
Lee JL, Naguwa SM, Cheema GS, Gershwin ME
Clin Rev Allergy Immunol 2009 Jun;36(2-3):126-30. doi: 10.1007/s12016-008-8113-y. PMID: 19089657
Cardiovascular involvement in systemic lupus erythematosus.
Mandell BF
Semin Arthritis Rheum 1987 Nov;17(2):126-41. doi: 10.1016/0049-0172(87)90035-7. PMID: 3334284
Cardiovascular manifestations of systemic lupus erythematosus.
Doherty NE, Siegel RJ
Am Heart J 1985 Dec;110(6):1257-65. doi: 10.1016/0002-8703(85)90023-7. PMID: 3907317

Therapy

Libman-Sacks endocarditis: regression after immunosuppressive and antiplatelet therapy in a patient with newly diagnosed systemic lupus erythematosus and positive antiphospholipid antibodies.
Tran HY, Duong CL, Nguyen TH, Nguyen TV
BMJ Case Rep 2023 Sep 11;16(9) doi: 10.1136/bcr-2023-255726. PMID: 37696608Free PMC Article
Mitral Valve Replacement for Enlarged Libman-Sacks Endocarditis in a Patient with Persistent Primary Antiphospholipid Syndrome and Recurrent Stroke: A Case Report.
Takeuchi K, Izumi T, Nanaura H, Yamada N, Hayata Y, Obayashi C, Sugie K
Am J Case Rep 2023 Feb 6;24:e938930. doi: 10.12659/AJCR.938930. PMID: 36740820Free PMC Article
Double-valve Libman-Sacks endocarditis causing ventricular fibrillation cardiac arrest.
Tanawuttiwat T, Dia M, Hanif T, Mihailescu M
Tex Heart Inst J 2011;38(3):295-7. PMID: 21720477Free PMC Article
Five-year follow-up by transesophageal echocardiographic studies in primary antiphospholipid syndrome.
Turiel M, Sarzi-Puttini P, Peretti R, Bonizzato S, Muzzupappa S, Atzeni F, Rossi E, Doria A
Am J Cardiol 2005 Aug 15;96(4):574-9. doi: 10.1016/j.amjcard.2005.04.022. PMID: 16098314
Prevalence, morphologic types, and evolution of cardiac valvular disease in systemic lupus erythematosus.
Galve E, Candell-Riera J, Pigrau C, Permanyer-Miralda G, Garcia-Del-Castillo H, Soler-Soler J
N Engl J Med 1988 Sep 29;319(13):817-23. doi: 10.1056/NEJM198809293191302. PMID: 3412413

Prognosis

Diagnosis and surgical treatment for isolated tricuspid Libman-Sacks endocarditis: a rare case report and literatures review.
Bai Z, Hou J, Ren W, Guo Y
J Cardiothorac Surg 2015 Jul 8;10:93. doi: 10.1186/s13019-015-0302-1. PMID: 26152222Free PMC Article
Libman-Sacks endocarditis and embolic cerebrovascular disease.
Roldan CA, Sibbitt WL Jr, Qualls CR, Jung RE, Greene ER, Gasparovic CM, Hayek RA, Charlton GA, Crookston K
JACC Cardiovasc Imaging 2013 Sep;6(9):973-83. doi: 10.1016/j.jcmg.2013.04.012. PMID: 24029368Free PMC Article
Libman-Sacks endocarditis as the first manifestation of systemic lupus erythematosus in an adolescent, with a review of the literature.
Sharma J, Lasic Z, Bornstein A, Cooper R, Chen J
Cardiol Young 2013 Feb;23(1):1-6. Epub 2012 Jul 18 doi: 10.1017/S1047951112001023. PMID: 22805592
Libman-Sacks endocarditis in systemic lupus erythematosus: prevalence, associations, and evolution.
Moyssakis I, Tektonidou MG, Vasilliou VA, Samarkos M, Votteas V, Moutsopoulos HM
Am J Med 2007 Jul;120(7):636-42. doi: 10.1016/j.amjmed.2007.01.024. PMID: 17602939
Cardiovascular involvement in systemic lupus erythematosus.
Mandell BF
Semin Arthritis Rheum 1987 Nov;17(2):126-41. doi: 10.1016/0049-0172(87)90035-7. PMID: 3334284

Clinical prediction guides

Severe Libman-Sacks endocarditis complicating antiphospholipid syndrome: a retrospective analysis of 23 operated cases.
Chalvon NB, Costedoat-Chalumeau N, Pennaforte JL, Servettaz A, Boulagnon Rombi C, Gavand PE, Lekieffre M, Le Guern V, Morel N, Cohen Aubart F, Haroche J, Mathian A, Collet JP, Piette JC, Amoura Z, Orquevaux P
Rheumatology (Oxford) 2023 Feb 1;62(2):707-715. doi: 10.1093/rheumatology/keac315. PMID: 35686908
Cardiovascular magnetic resonance evaluation of paediatric patients with systemic lupus erythematosus and cardiac symptoms.
Mavrogeni S, Smerla R, Grigoriadou G, Servos G, Koutsogeorgopoulou L, Karabela G, Stavropoulos E, Spiliotis G, Kolovou G, Papadopoulos G
Lupus 2016 Mar;25(3):289-95. Epub 2015 Oct 8 doi: 10.1177/0961203315611496. PMID: 26453663
Libman-Sacks endocarditis as the first manifestation of systemic lupus erythematosus in an adolescent, with a review of the literature.
Sharma J, Lasic Z, Bornstein A, Cooper R, Chen J
Cardiol Young 2013 Feb;23(1):1-6. Epub 2012 Jul 18 doi: 10.1017/S1047951112001023. PMID: 22805592
Cardiovascular lesions in collagen-vascular diseases.
Ferrans VJ, Rodríguez ER
Heart Vessels Suppl 1985;1:256-61. doi: 10.1007/BF02072405. PMID: 3916476
Immunopathology of cardiac lesions in fatal systemic lupus erythematosus.
Bidani AK, Roberts JL, Schwartz MM, Lewis EJ
Am J Med 1980 Dec;69(6):849-58. doi: 10.1016/s0002-9343(80)80010-6. PMID: 7004181

Recent systematic reviews

Association of antiphospholipid antibodies with valvulopathy in systemic lupus erythematosus: a systematic review.
Mattos P, Santiago MB
Clin Rheumatol 2011 Feb;30(2):165-71. Epub 2011 Jan 5 doi: 10.1007/s10067-010-1662-5. PMID: 21207090
Mitral valve surgery for mitral regurgitation caused by Libman-Sacks endocarditis: a report of four cases and a systematic review of the literature.
Bouma W, Klinkenberg TJ, van der Horst IC, Wijdh-den Hamer IJ, Erasmus ME, Bijl M, Suurmeijer AJ, Zijlstra F, Mariani MA
J Cardiothorac Surg 2010 Mar 23;5:13. doi: 10.1186/1749-8090-5-13. PMID: 20331896Free PMC Article

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