U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormal lacrimal gland morphology

MedGen UID:
868924
•Concept ID:
C4023336
•
Anatomical Abnormality
Synonym: Abnormality of the lacrimal gland
 
HPO: HP:0011482

Definition

Abnormality of the lacrimal gland, i.e., of the almond-shaped gland that secretes the aqueous layer of the tear film for each eye. [from HPO]

Professional guidelines

PubMed

Congenital nasolacrimal duct obstruction: clinical guideline.
Sasaki T, Matsumura N, Miyazaki C, Kamao T, Yokoi N, Fujimoto M, Hayami M, Iwasaki A, Mimura M, Murata A, Nakayama T, Shinomiya K, Tanaka H, Ueta Y; Congenital Nasolacrimal Duct Obstruction: Clinical Guideline Preparation Team; Committee for Congenital Nasolacrimal Duct Obstruction Clinical Guideline
Jpn J Ophthalmol 2024 Jul;68(4):367-388. Epub 2024 Aug 16 doi: 10.1007/s10384-024-01064-4. PMID: 39150609
The Immunological Basis of Dry Eye Disease and Current Topical Treatment Options.
Periman LM, Perez VL, Saban DR, Lin MC, Neri P
J Ocul Pharmacol Ther 2020 Apr;36(3):137-146. Epub 2020 Mar 12 doi: 10.1089/jop.2019.0060. PMID: 32175799Free PMC Article
Current concepts on Sjögren's syndrome - classification criteria and biomarkers.
Jonsson R, Brokstad KA, Jonsson MV, Delaleu N, Skarstein K
Eur J Oral Sci 2018 Oct;126 Suppl 1(Suppl Suppl 1):37-48. doi: 10.1111/eos.12536. PMID: 30178554Free PMC Article

Recent clinical studies

Etiology

Etiopathogenesis of primary acquired nasolacrimal duct obstruction (PANDO).
Ali MJ
Prog Retin Eye Res 2023 Sep;96:101193. Epub 2023 Jul 1 doi: 10.1016/j.preteyeres.2023.101193. PMID: 37394093
Congenital inner eyelid folds.
Millett M, Hyasat JG, Lueder GT
Ophthalmic Genet 2023 Aug;44(4):401-402. Epub 2023 Jan 13 doi: 10.1080/13816810.2022.2127151. PMID: 36636984
Current concepts on Sjögren's syndrome - classification criteria and biomarkers.
Jonsson R, Brokstad KA, Jonsson MV, Delaleu N, Skarstein K
Eur J Oral Sci 2018 Oct;126 Suppl 1(Suppl Suppl 1):37-48. doi: 10.1111/eos.12536. PMID: 30178554Free PMC Article
Sjögren syndrome.
Brito-Zerón P, Baldini C, Bootsma H, Bowman SJ, Jonsson R, Mariette X, Sivils K, Theander E, Tzioufas A, Ramos-Casals M
Nat Rev Dis Primers 2016 Jul 7;2:16047. doi: 10.1038/nrdp.2016.47. PMID: 27383445
Hereditary disorders affecting the lacrimal system.
Allen RC
Curr Opin Ophthalmol 2014 Sep;25(5):424-31. doi: 10.1097/ICU.0000000000000092. PMID: 25029093

Diagnosis

Congenital inner eyelid folds.
Millett M, Hyasat JG, Lueder GT
Ophthalmic Genet 2023 Aug;44(4):401-402. Epub 2023 Jan 13 doi: 10.1080/13816810.2022.2127151. PMID: 36636984
Congenital alacrima.
Zhao Z, Allen RC
Orbit 2022 Apr;41(2):162-169. Epub 2021 Sep 5 doi: 10.1080/01676830.2021.1974057. PMID: 34486478
Current concepts on Sjögren's syndrome - classification criteria and biomarkers.
Jonsson R, Brokstad KA, Jonsson MV, Delaleu N, Skarstein K
Eur J Oral Sci 2018 Oct;126 Suppl 1(Suppl Suppl 1):37-48. doi: 10.1111/eos.12536. PMID: 30178554Free PMC Article
Sjögren syndrome.
Brito-Zerón P, Baldini C, Bootsma H, Bowman SJ, Jonsson R, Mariette X, Sivils K, Theander E, Tzioufas A, Ramos-Casals M
Nat Rev Dis Primers 2016 Jul 7;2:16047. doi: 10.1038/nrdp.2016.47. PMID: 27383445
The lacrimal system.
Örge FH, Boente CS
Pediatr Clin North Am 2014 Jun;61(3):529-39. doi: 10.1016/j.pcl.2014.03.002. PMID: 24852150

Therapy

Etiopathogenesis of primary acquired nasolacrimal duct obstruction (PANDO).
Ali MJ
Prog Retin Eye Res 2023 Sep;96:101193. Epub 2023 Jul 1 doi: 10.1016/j.preteyeres.2023.101193. PMID: 37394093
The Immunological Basis of Dry Eye Disease and Current Topical Treatment Options.
Periman LM, Perez VL, Saban DR, Lin MC, Neri P
J Ocul Pharmacol Ther 2020 Apr;36(3):137-146. Epub 2020 Mar 12 doi: 10.1089/jop.2019.0060. PMID: 32175799Free PMC Article
Congenital aberrant tearing: a re-look.
Miller MT, Strömland K, Ventura L
Trans Am Ophthalmol Soc 2008;106:100-15; discussion 115-6. PMID: 19277226Free PMC Article
Dry eye after refractive surgery.
Ang RT, Dartt DA, Tsubota K
Curr Opin Ophthalmol 2001 Aug;12(4):318-22. doi: 10.1097/00055735-200108000-00013. PMID: 11507347
The pathology of dry eye: the interaction between the ocular surface and lacrimal glands.
Stern ME, Beuerman RW, Fox RI, Gao J, Mircheff AK, Pflugfelder SC
Cornea 1998 Nov;17(6):584-9. doi: 10.1097/00003226-199811000-00002. PMID: 9820935

Prognosis

Nasal and Lacrimal Sac Histopathology in Patients With Systemic Sarcoidosis Undergoing External Lacrimal Drainage Surgery.
Stewart CM, Luthert PJ, Rose GE
Ophthalmic Plast Reconstr Surg 2019 May/Jun;35(3):247-250. doi: 10.1097/IOP.0000000000001217. PMID: 30234834
Proboscis lateralis.
Lelli GJ Jr, Maher EA, Milite JP, Dyleski R
Ophthalmic Plast Reconstr Surg 2008 Nov-Dec;24(6):499-501. doi: 10.1097/IOP.0b013e31818b6e57. PMID: 19033859
Lymphoproliferative disorders of the ocular adnexa.
Cockerham GC, Jakobiec FA
Int Ophthalmol Clin 1997 Fall;37(4):39-59. doi: 10.1097/00004397-199703740-00005. PMID: 9429931
Lacrimal gland lymphoma: a cytomorphologic and immunophenotypic study.
Jeffrey PB, Cartwright D, Atwater SK, Char DH, Miller TR
Diagn Cytopathol 1995 May;12(3):215-22. doi: 10.1002/dc.2840120305. PMID: 7621716
Paediatric dacryocystorhinostomy.
Hakin KN, Sullivan TJ, Sharma A, Welham RA
Aust N Z J Ophthalmol 1994 Nov;22(4):231-5. doi: 10.1111/j.1442-9071.1994.tb00789.x. PMID: 7727099

Clinical prediction guides

Sjögren syndrome.
Brito-Zerón P, Baldini C, Bootsma H, Bowman SJ, Jonsson R, Mariette X, Sivils K, Theander E, Tzioufas A, Ramos-Casals M
Nat Rev Dis Primers 2016 Jul 7;2:16047. doi: 10.1038/nrdp.2016.47. PMID: 27383445
The Differential Diagnosis of Dry Eyes, Dry Mouth, and Parotidomegaly: A Comprehensive Review.
Cornec D, Saraux A, Jousse-Joulin S, Pers JO, Boisramé-Gastrin S, Renaudineau Y, Gauvin Y, Roguedas-Contios AM, Genestet S, Chastaing M, Cochener B, Devauchelle-Pensec V
Clin Rev Allergy Immunol 2015 Dec;49(3):278-87. doi: 10.1007/s12016-014-8431-1. PMID: 24952023
A lacrimal gland is a lacrimal gland, but rodent's and rabbit's are not human.
Schechter JE, Warren DW, Mircheff AK
Ocul Surf 2010 Jul;8(3):111-34. doi: 10.1016/s1542-0124(12)70222-7. PMID: 20712969
Orbital syndromes.
Bhatti MT
Semin Neurol 2007 Jul;27(3):269-87. doi: 10.1055/s-2007-979685. PMID: 17577868
Lacrimal outflow dysgenesis.
Yuen SJ, Oley C, Sullivan TJ
Ophthalmology 2004 Sep;111(9):1782-90. doi: 10.1016/j.ophtha.2004.02.011. PMID: 15350337

Recent systematic reviews

Assessing the success rate of treatment in simple and complex congenital nasolacrimal duct obstruction: a systematic review and meta-analysis.
Eshraghi B, Babaei L, Moradi M, Chaibakhsh S, Aghajani A
Graefes Arch Clin Exp Ophthalmol 2024 Jul;262(7):1993-2004. Epub 2023 Dec 7 doi: 10.1007/s00417-023-06318-4. PMID: 38059998
Phenotypic spectrum of FGF10-related disorders: a systematic review.
Bzdega K, Karolak JA
PeerJ 2022;10:e14003. Epub 2022 Sep 14 doi: 10.7717/peerj.14003. PMID: 36124135Free PMC Article
Nasolacrimal Duct Probing for Young Children With Congenital Nasolacrimal Duct Obstructions in China: A 10-Year Systematic Review.
Xiang Q, Gao X, Chen X, Qi J, Fang J
J Pediatr Ophthalmol Strabismus 2019 Nov 1;56(6):365-372. doi: 10.3928/01913913-20190923-04. PMID: 31743404

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...