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Unilateral multifocal epileptiform discharges

MedGen UID:
869065
•Concept ID:
C4023483
•
Finding
HPO: HP:0011191

Definition

Epileptiform discharges being identified at multiple locations in one hemisphere. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnilateral multifocal epileptiform discharges

Recent clinical studies

Etiology

Epileptic spasms in paediatric post-traumatic epilepsy at a tertiary referral centre.
Park JT, Chugani HT
Epileptic Disord 2017 Mar 1;19(1):24-34. doi: 10.1684/epd.2017.0900. PMID: 28316319
Corpus callosotomy in multistage epilepsy surgery in the pediatric population.
Lin JS, Lew SM, Marcuccilli CJ, Mueller WM, Matthews AE, Koop JI, Zupanc ML
J Neurosurg Pediatr 2011 Feb;7(2):189-200. doi: 10.3171/2010.11.PEDS10334. PMID: 21284466
Uncovered primary seizure foci in Lennox-Gastaut syndrome after corpus callosotomy.
Hur YJ, Kang HC, Kim DS, Choi SR, Kim HD, Lee JS
Brain Dev 2011 Sep;33(8):672-7. Epub 2010 Dec 13 doi: 10.1016/j.braindev.2010.11.005. PMID: 21146944
Vagus nerve stimulation: outcome and predictors of seizure freedom in long-term follow-up.
Ghaemi K, Elsharkawy AE, Schulz R, Hoppe M, Polster T, Pannek H, Ebner A
Seizure 2010 Jun;19(5):264-8. Epub 2010 Apr 1 doi: 10.1016/j.seizure.2010.03.002. PMID: 20362466
Temporal lobe dysembryoplastic neuroepithelial tumour: significance of discordant interictal spikes.
Labate A, Briellmann RS, Harvey AS, Berkovic SF, Federico P, Kalnins RM, Fabinyi GC, Jackson GD
Epileptic Disord 2004 Jun;6(2):107-14. PMID: 15246955

Diagnosis

Epileptic spasms in paediatric post-traumatic epilepsy at a tertiary referral centre.
Park JT, Chugani HT
Epileptic Disord 2017 Mar 1;19(1):24-34. doi: 10.1684/epd.2017.0900. PMID: 28316319
Atypical multifocal Dravet syndrome lacks generalized seizures and may show later cognitive decline.
Kim YO, Bellows S, McMahon JM, Iona X, Damiano J, Dibbens L, Kelley K, Gill D, Cross JH, Berkovic SF, Scheffer IE
Dev Med Child Neurol 2014 Jan;56(1):85-90. Epub 2013 Oct 25 doi: 10.1111/dmcn.12322. PMID: 24328833
Discontinuation of antiepileptic drugs after successful epilepsy surgery. a Canadian survey.
Téllez-Zenteno JF, Ronquillo LH, Jette N, Burneo JG, Nguyen DK, Donner EJ, Sadler M, Javidan M M, Gross DW, Wiebe S; Canadian Epilepsy Surgery Study Group
Epilepsy Res 2012 Nov;102(1-2):23-33. Epub 2012 May 15 doi: 10.1016/j.eplepsyres.2012.04.018. PMID: 22595484
Temporal lobe dysembryoplastic neuroepithelial tumour: significance of discordant interictal spikes.
Labate A, Briellmann RS, Harvey AS, Berkovic SF, Federico P, Kalnins RM, Fabinyi GC, Jackson GD
Epileptic Disord 2004 Jun;6(2):107-14. PMID: 15246955
Seizures in patients with multiple sclerosis seen at Mayo Clinic, Rochester, Minn, 1990-1998.
Nyquist PA, Cascino GD, Rodriguez M
Mayo Clin Proc 2001 Oct;76(10):983-6. doi: 10.4065/76.10.983. PMID: 11605699

Therapy

Discontinuation of antiepileptic drugs after successful epilepsy surgery. a Canadian survey.
Téllez-Zenteno JF, Ronquillo LH, Jette N, Burneo JG, Nguyen DK, Donner EJ, Sadler M, Javidan M M, Gross DW, Wiebe S; Canadian Epilepsy Surgery Study Group
Epilepsy Res 2012 Nov;102(1-2):23-33. Epub 2012 May 15 doi: 10.1016/j.eplepsyres.2012.04.018. PMID: 22595484
Vagus nerve stimulation: outcome and predictors of seizure freedom in long-term follow-up.
Ghaemi K, Elsharkawy AE, Schulz R, Hoppe M, Polster T, Pannek H, Ebner A
Seizure 2010 Jun;19(5):264-8. Epub 2010 Apr 1 doi: 10.1016/j.seizure.2010.03.002. PMID: 20362466
Epileptic spasms in older pediatric patients: MEG and ictal high-frequency oscillations suggest focal-onset seizures in a subset of epileptic spasms.
Ramachandrannair R, Ochi A, Imai K, Benifla M, Akiyama T, Holowka S, Rutka JT, Snead OC 3rd, Otsubo H
Epilepsy Res 2008 Feb;78(2-3):216-24. Epub 2008 Jan 22 doi: 10.1016/j.eplepsyres.2007.12.007. PMID: 18215506
Seizures in patients with multiple sclerosis seen at Mayo Clinic, Rochester, Minn, 1990-1998.
Nyquist PA, Cascino GD, Rodriguez M
Mayo Clin Proc 2001 Oct;76(10):983-6. doi: 10.4065/76.10.983. PMID: 11605699

Prognosis

Vagus nerve stimulation: outcome and predictors of seizure freedom in long-term follow-up.
Ghaemi K, Elsharkawy AE, Schulz R, Hoppe M, Polster T, Pannek H, Ebner A
Seizure 2010 Jun;19(5):264-8. Epub 2010 Apr 1 doi: 10.1016/j.seizure.2010.03.002. PMID: 20362466
Temporal lobe dysembryoplastic neuroepithelial tumour: significance of discordant interictal spikes.
Labate A, Briellmann RS, Harvey AS, Berkovic SF, Federico P, Kalnins RM, Fabinyi GC, Jackson GD
Epileptic Disord 2004 Jun;6(2):107-14. PMID: 15246955
Interictal, unifocal spikes in refractory extratemporal epilepsy predict ictal origin and postsurgical outcome.
Holmes MD, Kutsy RL, Ojemann GA, Wilensky AJ, Ojemann LM
Clin Neurophysiol 2000 Oct;111(10):1802-8. doi: 10.1016/s1388-2457(00)00389-8. PMID: 11018495

Clinical prediction guides

Vagus nerve stimulation: outcome and predictors of seizure freedom in long-term follow-up.
Ghaemi K, Elsharkawy AE, Schulz R, Hoppe M, Polster T, Pannek H, Ebner A
Seizure 2010 Jun;19(5):264-8. Epub 2010 Apr 1 doi: 10.1016/j.seizure.2010.03.002. PMID: 20362466
Temporal lobe dysembryoplastic neuroepithelial tumour: significance of discordant interictal spikes.
Labate A, Briellmann RS, Harvey AS, Berkovic SF, Federico P, Kalnins RM, Fabinyi GC, Jackson GD
Epileptic Disord 2004 Jun;6(2):107-14. PMID: 15246955
Interictal, unifocal spikes in refractory extratemporal epilepsy predict ictal origin and postsurgical outcome.
Holmes MD, Kutsy RL, Ojemann GA, Wilensky AJ, Ojemann LM
Clin Neurophysiol 2000 Oct;111(10):1802-8. doi: 10.1016/s1388-2457(00)00389-8. PMID: 11018495

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