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Helicobacter Infection

MedGen UID:
86925
•Concept ID:
C0079487
•
Disease or Syndrome
Synonyms: Helicobacter Infections; Infection, Helicobacter; Infections, Helicobacter

Definition

Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHelicobacter Infection

Professional guidelines

PubMed

A new approach to the management of uninvestigated dyspepsia in primary care.
Salihefendic N, Zildzic M, Cabric E
Med Arch 2015 Apr;69(2):133-4. Epub 2015 Apr 6 doi: 10.5455/medarh.2015.69.133-134. PMID: 26005267Free PMC Article
Rationale in diagnosis and screening of atrophic gastritis with stomach-specific plasma biomarkers.
Agréus L, Kuipers EJ, Kupcinskas L, Malfertheiner P, Di Mario F, Leja M, Mahachai V, Yaron N, van Oijen M, Perez Perez G, Rugge M, Ronkainen J, Salaspuro M, Sipponen P, Sugano K, Sung J
Scand J Gastroenterol 2012 Feb;47(2):136-47. doi: 10.3109/00365521.2011.645501. PMID: 22242613Free PMC Article
Importance of gastrin in the pathogenesis and treatment of gastric tumors.
Burkitt MD, Varro A, Pritchard DM
World J Gastroenterol 2009 Jan 7;15(1):1-16. doi: 10.3748/wjg.15.1. PMID: 19115463Free PMC Article

Recent clinical studies

Etiology

Dietary amelioration of Helicobacter infection.
Fahey JW, Stephenson KK, Wallace AJ
Nutr Res 2015 Jun;35(6):461-73. Epub 2015 Mar 6 doi: 10.1016/j.nutres.2015.03.001. PMID: 25799054Free PMC Article
Stem cells in gastric cancer.
Zhao Y, Feng F, Zhou YN
World J Gastroenterol 2015 Jan 7;21(1):112-23. doi: 10.3748/wjg.v21.i1.112. PMID: 25574084Free PMC Article
Carcinogenesis of Helicobacter pylori.
Correa P, Houghton J
Gastroenterology 2007 Aug;133(2):659-72. doi: 10.1053/j.gastro.2007.06.026. PMID: 17681184
Helicobacter and digestive malignancies.
Starzyñska T, Malfertheiner P
Helicobacter 2006 Oct;11 Suppl 1:32-5. doi: 10.1111/j.1478-405X.2006.00431.x. PMID: 16925609
Helicobacter infection and gastric neoplasia.
Peek RM Jr, Crabtree JE
J Pathol 2006 Jan;208(2):233-48. doi: 10.1002/path.1868. PMID: 16362989

Diagnosis

Helicobacter pylori Infection in Rural and Urban Dyspeptic Patients from Venezuela.
Contreras M, Fernández-Delgado M, Reyes N, García-Amado MA, Rojas H, Michelangeli F
Am J Trop Med Hyg 2015 Oct;93(4):730-2. Epub 2015 Jul 20 doi: 10.4269/ajtmh.15-0021. PMID: 26195456Free PMC Article
Helicobacter pylori infection and eye diseases: a systematic review.
Saccà SC, Vagge A, Pulliero A, Izzotti A
Medicine (Baltimore) 2014 Dec;93(28):e216. doi: 10.1097/MD.0000000000000216. PMID: 25526440Free PMC Article
Rationale in diagnosis and screening of atrophic gastritis with stomach-specific plasma biomarkers.
Agréus L, Kuipers EJ, Kupcinskas L, Malfertheiner P, Di Mario F, Leja M, Mahachai V, Yaron N, van Oijen M, Perez Perez G, Rugge M, Ronkainen J, Salaspuro M, Sipponen P, Sugano K, Sung J
Scand J Gastroenterol 2012 Feb;47(2):136-47. doi: 10.3109/00365521.2011.645501. PMID: 22242613Free PMC Article
Effects of Helicobacter infection on research: the case for eradication of Helicobacter from rodent research colonies.
Chichlowski M, Hale LP
Comp Med 2009 Feb;59(1):10-7. PMID: 19295050Free PMC Article
Helicobacter pylori infection.
Vandenplas Y, Badriul H
Acta Paediatr Taiwan 1999 Jul-Aug;40(4):212-24. PMID: 10910617

Therapy

Role of nitazoxanide as a repurposed drug in the treatment and management of various diseases.
Bharti C, Sharma S, Goswami N, Sharma H, Rabbani SA, Kumar S
Drugs Today (Barc) 2021 Jul;57(7):455-473. doi: 10.1358/dot.2021.57.7.3235211. PMID: 34268533
Other Helicobacters, gastric and gut microbiota.
Péré-Védrenne C, Flahou B, Loke MF, Ménard A, Vadivelu J
Helicobacter 2017 Sep;22 Suppl 1 doi: 10.1111/hel.12407. PMID: 28891140
Effects of Helicobacter infection on research: the case for eradication of Helicobacter from rodent research colonies.
Chichlowski M, Hale LP
Comp Med 2009 Feb;59(1):10-7. PMID: 19295050Free PMC Article
Carcinogenesis of Helicobacter pylori.
Correa P, Houghton J
Gastroenterology 2007 Aug;133(2):659-72. doi: 10.1053/j.gastro.2007.06.026. PMID: 17681184
Inflammation, immunity, and vaccines for Helicobacter infection.
Permin H, Andersen LP
Helicobacter 2005;10 Suppl 1:21-5. doi: 10.1111/j.1523-5378.2005.00337.x. PMID: 16178967

Prognosis

Incidences of Helicobacter infection in pigs and tracing occupational hazard in pig farmers.
Pegu SR, Sonowal J, Rajkhowa S, Jyoti Das P, Sengar GS, Deb R, Choudhury M, Deka NJ, Paul S, Doley J, Sarma DK, Das S, Mohan NH, Thomas R, Gupta VK
Comp Immunol Microbiol Infect Dis 2024 Mar;106:102128. Epub 2024 Jan 15 doi: 10.1016/j.cimid.2024.102128. PMID: 38309206
Involvement of non-Helicobacter pylori helicobacter infections in Helicobacter pylori-negative gastric MALT lymphoma pathogenesis and efficacy of eradication therapy.
Takigawa H, Yuge R, Masaki S, Otani R, Kadota H, Naito T, Hayashi R, Urabe Y, Oka S, Tanaka S, Chayama K, Kitadai Y
Gastric Cancer 2021 Jul;24(4):937-945. Epub 2021 Feb 27 doi: 10.1007/s10120-021-01172-x. PMID: 33638751
Atypical Lymphoid Proliferations and Clonality in Helicobacter-associated Inflammatory Infiltrates in Children.
Ju JY, Stelow EB, Mahadevan MS, Fan J, Aguilera NS
Am J Surg Pathol 2019 Oct;43(10):1361-1367. doi: 10.1097/PAS.0000000000001317. PMID: 31261290
Gastric Adenocarcinoma of the Fundic Gland Type: Update and Literature Review.
Benedict MA, Lauwers GY, Jain D
Am J Clin Pathol 2018 Apr 25;149(6):461-473. doi: 10.1093/ajcp/aqy019. PMID: 29648578
Oxyntic atrophy, metaplasia, and gastric cancer.
Goldenring JR, Nam KT
Prog Mol Biol Transl Sci 2010;96:117-31. doi: 10.1016/B978-0-12-381280-3.00005-1. PMID: 21075342Free PMC Article

Clinical prediction guides

Analysis of Innate Immune Responses to Helicobacter pylori.
Chonwerawong M, Ferrero RL
Methods Mol Biol 2021;2283:191-214. doi: 10.1007/978-1-0716-1302-3_17. PMID: 33765319
Involvement of non-Helicobacter pylori helicobacter infections in Helicobacter pylori-negative gastric MALT lymphoma pathogenesis and efficacy of eradication therapy.
Takigawa H, Yuge R, Masaki S, Otani R, Kadota H, Naito T, Hayashi R, Urabe Y, Oka S, Tanaka S, Chayama K, Kitadai Y
Gastric Cancer 2021 Jul;24(4):937-945. Epub 2021 Feb 27 doi: 10.1007/s10120-021-01172-x. PMID: 33638751
Effects of Helicobacter pylori on Levodopa Pharmacokinetics.
Nyholm D, Hellström PM
J Parkinsons Dis 2021;11(1):61-69. doi: 10.3233/JPD-202298. PMID: 33164946Free PMC Article
Rodent models of Helicobacter infection, inflammation, and disease.
Zhang S, Moss SF
Methods Mol Biol 2012;921:89-98. doi: 10.1007/978-1-62703-005-2_12. PMID: 23015495Free PMC Article
Are Helicobacter pylori and other Helicobacter species infection associated with human biliary lithiasis? A meta-analysis.
Zhou D, Zhang Y, Gong W, Mohamed SO, Ogbomo H, Wang X, Liu Y, Quan Z
PLoS One 2011;6(11):e27390. Epub 2011 Nov 8 doi: 10.1371/journal.pone.0027390. PMID: 22087306Free PMC Article

Recent systematic reviews

Treatment of Helicobacter pylori with nitazoxanide-containing regimens: a systematic review.
Lee S, Sneed GT, Brown JN
Infect Dis (Lond) 2020 Jun;52(6):381-390. Epub 2020 Jan 3 doi: 10.1080/23744235.2019.1708454. PMID: 31900002
Helicobacter pylori infection and eye diseases: a systematic review.
Saccà SC, Vagge A, Pulliero A, Izzotti A
Medicine (Baltimore) 2014 Dec;93(28):e216. doi: 10.1097/MD.0000000000000216. PMID: 25526440Free PMC Article

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