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Low placental alkaline phosphatase

MedGen UID:
869311
•Concept ID:
C4023737
•
Finding
Synonym: Low placental ALP
 
HPO: HP:0010688

Definition

An abnormally reduced level of alkaline phosphatase, placental type in the blood. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLow placental alkaline phosphatase

Professional guidelines

PubMed

In Vitro Human Placental Studies to Support Adenovirus-Mediated VEGF-D(ΔNΔC) Maternal Gene Therapy for the Treatment of Severe Early-Onset Fetal Growth Restriction.
Desforges M, Rogue A, Pearson N, Rossi C, Olearo E, Forster R, Lees M, Sebire NJ, Greenwood SL, Sibley CP, David AL, Brownbill P
Hum Gene Ther Clin Dev 2018 Mar;29(1):10-23. Epub 2018 Mar 12 doi: 10.1089/humc.2017.090. PMID: 29228803
Pretreatment serum levels of CA-125, carcinoembryonic antigen, tissue polypeptide antigen, and placental alkaline phosphatase, in patients with ovarian carcinoma, borderline tumors, or benign adnexal masses: relevance for differential diagnosis.
Tholander B, Taube A, Lindgren A, Sjöberg O, Stendahl U, Kiviranta A, Hallman K, Holm L, Weiner E, Tamsen L
Gynecol Oncol 1990 Oct;39(1):16-25. doi: 10.1016/0090-8258(90)90393-y. PMID: 2227569
Serum isoenzymes in cancer diagnosis and management.
Mercer DW
Immunol Ser 1990;53:613-29. PMID: 2100575

Recent clinical studies

Etiology

Total alkaline phosphatase levels by gestational age in a large sample of pregnant women.
Titaux C, Ternynck C, Pauchet M, Stichelbout M, Bizet G, Maboudou P, Onraed B, Clément G, Lenne X, Potier G, Subtil D, Chudzinski A
Placenta 2023 Feb;132:32-37. Epub 2022 Dec 20 doi: 10.1016/j.placenta.2022.12.005. PMID: 36623417
Magnetic enrichment of immuno-specific extracellular vesicles for mass spectrometry using biofilm-derived iron oxide nanowires.
Pham QN, Winter M, Milanova V, Young C, Condina MR, Hoffmann P, Pham NTH, Tung TT, Losic D, Thierry B
Nanoscale 2023 Jan 19;15(3):1236-1247. doi: 10.1039/d2nr05619d. PMID: 36541661
In silico exploration of binding of selected bisphosphonate derivatives to placental alkaline phosphatase via docking and molecular dynamics.
Madaj R, Pawlowska R, Chworos A
J Mol Graph Model 2021 Mar;103:107801. Epub 2020 Nov 16 doi: 10.1016/j.jmgm.2020.107801. PMID: 33296741
Placental type alkaline phosphatase tissue expression in ovarian serous carcinoma.
Orsaria M, Londero AP, Marzinotto S, Di Loreto C, Marchesoni D, Mariuzzi L
Cancer Biomark 2016;17(4):479-486. doi: 10.3233/CBM-160665. PMID: 27802199
Placental alkaline phosphatase compared with human placental lactogen and oestriol in high-risk pregnancies.
Ronin-Walknowska E, Holmgren PA, von Schoultz B, Stigbrand T
Gynecol Obstet Invest 1984;18(4):206-11. doi: 10.1159/000299082. PMID: 6510780

Diagnosis

Alkaline phosphatase in clinical practice in childhood: Focus on rickets.
Cannalire G, Pilloni S, Esposito S, Biasucci G, Di Franco A, Street ME
Front Endocrinol (Lausanne) 2023;14:1111445. Epub 2023 Feb 2 doi: 10.3389/fendo.2023.1111445. PMID: 36817604Free PMC Article
Quantification of placental extracellular vesicles in different pregnancy status via single particle analysis method.
Li Z, Tao M, Huang M, Pan W, Huang Q, Wang P, Zhang Y, Situ B, Zheng L
Clin Chim Acta 2023 Jan 15;539:266-273. Epub 2022 Dec 30 doi: 10.1016/j.cca.2022.12.021. PMID: 36587781
Pattern of placental alkaline phosphatase (PLAP) expression in human tumors: a tissue microarray study on 12,381 tumors.
Reiswich V, Gorbokon N, Luebke AM, Burandt E, Menz A, Kluth M, Hube-Magg C, Wittmer C, Weidemann S, Fraune C, Möller K, Lebok P, Sauter G, Simon R, Uhlig R, Wilczak W, Jacobsen F, Minner S, Krech R, Bernreuther C, Marx A, Steurer S, Clauditz T, Krech T
J Pathol Clin Res 2021 Nov;7(6):577-589. Epub 2021 Aug 7 doi: 10.1002/cjp2.237. PMID: 34363325Free PMC Article
Extreme elevation of placental alkaline phosphatase as a marker of preterm delivery, placental insufficiency and low birth weight.
Ferianec V, Linhartová L
Neuro Endocrinol Lett 2011;32(2):154-7. PMID: 21552196
Carcinoma of the thymus with clear-cell features. Report of eight cases and review of the literature.
Hasserjian RP, Klimstra DS, Rosai J
Am J Surg Pathol 1995 Jul;19(7):835-41. doi: 10.1097/00000478-199507000-00012. PMID: 7793482

Therapy

Germinoma located in the basal ganglia in an 8-year-old girl.
Klein O, Voirin J, Civit T, Auque J, Marchal JC
Childs Nerv Syst 2007 Jan;23(1):105-8. Epub 2006 Oct 21 doi: 10.1007/s00381-006-0160-1. PMID: 17058090
Ligand-dependent regulation of plasmid-based transgene expression in vivo.
Abruzzese RV, Godin D, Burcin M, Mehta V, French M, Li Y, O'Malley BW, Nordstrom JL
Hum Gene Ther 1999 Jun 10;10(9):1499-507. doi: 10.1089/10430349950017833. PMID: 10395375
Simulated lung transfection by nebulization of liposome cDNA complexes using a cascade impactor seeded with 2-CFSME0-cells.
Schreier H, Gagné L, Conary JT, Laurian G
J Aerosol Med 1998 Spring;11(1):1-13. doi: 10.1089/jam.1998.11.1. PMID: 10177217
Low sodium diet in pregnancy: effects on maternal nutritional status.
van der Maten GD
Eur J Obstet Gynecol Reprod Biol 1995 Jul;61(1):63-4. doi: 10.1016/0028-2243(95)02154-k. PMID: 8549849
Effects of ricin A chain conjugates of monoclonal antibodies to human alpha-fetoprotein and placental alkaline phosphatase on antigen-producing tumor cells in culture.
Tsukazaki K, Hayman EG, Ruoslahti E
Cancer Res 1985 Apr;45(4):1834-8. PMID: 2579736

Prognosis

Pattern of placental alkaline phosphatase (PLAP) expression in human tumors: a tissue microarray study on 12,381 tumors.
Reiswich V, Gorbokon N, Luebke AM, Burandt E, Menz A, Kluth M, Hube-Magg C, Wittmer C, Weidemann S, Fraune C, Möller K, Lebok P, Sauter G, Simon R, Uhlig R, Wilczak W, Jacobsen F, Minner S, Krech R, Bernreuther C, Marx A, Steurer S, Clauditz T, Krech T
J Pathol Clin Res 2021 Nov;7(6):577-589. Epub 2021 Aug 7 doi: 10.1002/cjp2.237. PMID: 34363325Free PMC Article
Protein Profile Changes in Circulating Placental Extracellular Vesicles in Term and Preterm Births: A Longitudinal Study.
Menon R, Debnath C, Lai A, Guanzon D, Bhatnagar S, Kshetrapal P, Sheller-Miller S, Salomon C
Endocrinology 2020 Apr 1;161(4) doi: 10.1210/endocr/bqaa009. PMID: 31995166Free PMC Article
Placental type alkaline phosphatase tissue expression in ovarian serous carcinoma.
Orsaria M, Londero AP, Marzinotto S, Di Loreto C, Marchesoni D, Mariuzzi L
Cancer Biomark 2016;17(4):479-486. doi: 10.3233/CBM-160665. PMID: 27802199
Extreme elevation of placental alkaline phosphatase as a marker of preterm delivery, placental insufficiency and low birth weight.
Ferianec V, Linhartová L
Neuro Endocrinol Lett 2011;32(2):154-7. PMID: 21552196
Is placental alkaline phosphatase (PLAP) a useful marker for seminoma?
Nielsen OS, Munro AJ, Duncan W, Sturgeon J, Gospodarowicz MK, Jewett MA, Malkin A, Thomas GM
Eur J Cancer 1990;26(10):1049-54. doi: 10.1016/0277-5379(90)90049-y. PMID: 2148879

Clinical prediction guides

Total alkaline phosphatase levels by gestational age in a large sample of pregnant women.
Titaux C, Ternynck C, Pauchet M, Stichelbout M, Bizet G, Maboudou P, Onraed B, Clément G, Lenne X, Potier G, Subtil D, Chudzinski A
Placenta 2023 Feb;132:32-37. Epub 2022 Dec 20 doi: 10.1016/j.placenta.2022.12.005. PMID: 36623417
Generation and Functional Characterization of PLAP CAR-T Cells against Cervical Cancer Cells.
Yekehfallah V, Pahlavanneshan S, Sayadmanesh A, Momtahan Z, Ma B, Basiri M
Biomolecules 2022 Sep 14;12(9) doi: 10.3390/biom12091296. PMID: 36139135Free PMC Article
Pattern of placental alkaline phosphatase (PLAP) expression in human tumors: a tissue microarray study on 12,381 tumors.
Reiswich V, Gorbokon N, Luebke AM, Burandt E, Menz A, Kluth M, Hube-Magg C, Wittmer C, Weidemann S, Fraune C, Möller K, Lebok P, Sauter G, Simon R, Uhlig R, Wilczak W, Jacobsen F, Minner S, Krech R, Bernreuther C, Marx A, Steurer S, Clauditz T, Krech T
J Pathol Clin Res 2021 Nov;7(6):577-589. Epub 2021 Aug 7 doi: 10.1002/cjp2.237. PMID: 34363325Free PMC Article
Placental type alkaline phosphatase tissue expression in ovarian serous carcinoma.
Orsaria M, Londero AP, Marzinotto S, Di Loreto C, Marchesoni D, Mariuzzi L
Cancer Biomark 2016;17(4):479-486. doi: 10.3233/CBM-160665. PMID: 27802199
Carcinoma in situ of the testis: review of biological and clinical features.
Dieckmann KP, Skakkebaek NE
Int J Cancer 1999 Dec 10;83(6):815-22. doi: 10.1002/(sici)1097-0215(19991210)83:6<815::aid-ijc21>3.0.co;2-z. PMID: 10597201

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