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Low intestinal alkaline phosphatase

MedGen UID:
869312
•Concept ID:
C4023738
•
Finding
Synonym: Low intestinal ALP
 
HPO: HP:0010687

Definition

An abnormally reduced level of alkaline phosphatase, intestinal type in the blood. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLow intestinal alkaline phosphatase

Professional guidelines

PubMed

Teriparatide (rhPTH 1-34) treatment in the pediatric age: long-term efficacy and safety data in a cohort with genetic hypoparathyroidism.
Tuli G, Buganza R, Tessaris D, Einaudi S, Matarazzo P, de Sanctis L
Endocrine 2020 Feb;67(2):457-465. Epub 2019 Nov 8 doi: 10.1007/s12020-019-02128-z. PMID: 31705387
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Wang M, Ma LJ, Yang Y, Xiao Z, Wan JB
Crit Rev Food Sci Nutr 2019;59(sup1):S116-S129. Epub 2018 Dec 22 doi: 10.1080/10408398.2018.1544542. PMID: 30580553
Clinical guidelines for the treatment of osteoporosis in Japan.
Fujita T
Calcif Tissue Int 1996;59 Suppl 1:S34-7. doi: 10.1007/s002239900174. PMID: 8974729

Recent clinical studies

Etiology

Significance of intestinal alkaline phosphatase in predicting histological activity of pediatric inflammatory bowel disease.
Ateş BB, Talim B, Gülşen HH, Demir H, Karaismailoğlu E, Özen H, Saltık-Temizel İN
Turk J Pediatr 2022;64(6):1068-1076. doi: 10.24953/turkjped.2021.5413. PMID: 36583889
Screening for Metabolic Bone Disease of prematurity.
Rayannavar A, Calabria AC
Semin Fetal Neonatal Med 2020 Feb;25(1):101086. Epub 2020 Jan 16 doi: 10.1016/j.siny.2020.101086. PMID: 32081592
Sarcoporosis Is a Part of Aging.
Broulík P
Prague Med Rep 2019;120(2-3):84-94. doi: 10.14712/23362936.2019.13. PMID: 31586507
Ontogeny of alkaline phosphatase activity in infant intestines and breast milk.
Yang Y, Rader E, Peters-Carr M, Bent RC, Smilowitz JT, Guillemin K, Rader B
BMC Pediatr 2019 Jan 3;19(1):2. doi: 10.1186/s12887-018-1379-1. PMID: 30606146Free PMC Article
Alkaline Phosphatase Activity and Endotoxemia After Infant Cardiothoracic Surgery.
Davidson JA, Urban TT, Tong S, Maddux A, Hill G, Frank BS, Watson JD, Jaggers J, Simões EAF, Wischmeyer P
Shock 2019 Mar;51(3):328-336. doi: 10.1097/SHK.0000000000001162. PMID: 29664834Free PMC Article

Diagnosis

Alkaline phosphatase in clinical practice in childhood: Focus on rickets.
Cannalire G, Pilloni S, Esposito S, Biasucci G, Di Franco A, Street ME
Front Endocrinol (Lausanne) 2023;14:1111445. Epub 2023 Feb 2 doi: 10.3389/fendo.2023.1111445. PMID: 36817604Free PMC Article
Osteomalacia Is Not a Single Disease.
Cianferotti L
Int J Mol Sci 2022 Nov 28;23(23) doi: 10.3390/ijms232314896. PMID: 36499221Free PMC Article
Screening for Metabolic Bone Disease of prematurity.
Rayannavar A, Calabria AC
Semin Fetal Neonatal Med 2020 Feb;25(1):101086. Epub 2020 Jan 16 doi: 10.1016/j.siny.2020.101086. PMID: 32081592
Association of Intestinal Alkaline Phosphatase With Necrotizing Enterocolitis Among Premature Infants.
Heath M, Buckley R, Gerber Z, Davis P, Linneman L, Gong Q, Barkemeyer B, Fang Z, Good M, Penn D, Kim S
JAMA Netw Open 2019 Nov 1;2(11):e1914996. doi: 10.1001/jamanetworkopen.2019.14996. PMID: 31702803Free PMC Article
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Wang M, Ma LJ, Yang Y, Xiao Z, Wan JB
Crit Rev Food Sci Nutr 2019;59(sup1):S116-S129. Epub 2018 Dec 22 doi: 10.1080/10408398.2018.1544542. PMID: 30580553

Therapy

Association of Intestinal Alkaline Phosphatase With Necrotizing Enterocolitis Among Premature Infants.
Heath M, Buckley R, Gerber Z, Davis P, Linneman L, Gong Q, Barkemeyer B, Fang Z, Good M, Penn D, Kim S
JAMA Netw Open 2019 Nov 1;2(11):e1914996. doi: 10.1001/jamanetworkopen.2019.14996. PMID: 31702803Free PMC Article
Recent advances in intestinal alkaline phosphatase, inflammation, and nutrition.
Lallès JP
Nutr Rev 2019 Oct 1;77(10):710-724. doi: 10.1093/nutrit/nuz015. PMID: 31086953
n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.
Wang M, Ma LJ, Yang Y, Xiao Z, Wan JB
Crit Rev Food Sci Nutr 2019;59(sup1):S116-S129. Epub 2018 Dec 22 doi: 10.1080/10408398.2018.1544542. PMID: 30580553
Alkaline Phosphatase Activity and Endotoxemia After Infant Cardiothoracic Surgery.
Davidson JA, Urban TT, Tong S, Maddux A, Hill G, Frank BS, Watson JD, Jaggers J, Simões EAF, Wischmeyer P
Shock 2019 Mar;51(3):328-336. doi: 10.1097/SHK.0000000000001162. PMID: 29664834Free PMC Article
Intestinal alkaline phosphatase: novel functions and protective effects.
Lallès JP
Nutr Rev 2014 Feb;72(2):82-94. Epub 2013 Dec 9 doi: 10.1111/nure.12082. PMID: 24506153

Prognosis

Significance of intestinal alkaline phosphatase in predicting histological activity of pediatric inflammatory bowel disease.
Ateş BB, Talim B, Gülşen HH, Demir H, Karaismailoğlu E, Özen H, Saltık-Temizel İN
Turk J Pediatr 2022;64(6):1068-1076. doi: 10.24953/turkjped.2021.5413. PMID: 36583889
Association of Intestinal Alkaline Phosphatase With Necrotizing Enterocolitis Among Premature Infants.
Heath M, Buckley R, Gerber Z, Davis P, Linneman L, Gong Q, Barkemeyer B, Fang Z, Good M, Penn D, Kim S
JAMA Netw Open 2019 Nov 1;2(11):e1914996. doi: 10.1001/jamanetworkopen.2019.14996. PMID: 31702803Free PMC Article
A New Proposal for the Pathogenic Mechanism of Non-Coeliac/Non-Allergic Gluten/Wheat Sensitivity: Piecing Together the Puzzle of Recent Scientific Evidence.
Leccioli V, Oliveri M, Romeo M, Berretta M, Rossi P
Nutrients 2017 Nov 2;9(11) doi: 10.3390/nu9111203. PMID: 29099090Free PMC Article
Duodenal histopathology and laboratory deficiencies related to bone metabolism in coeliac disease.
Posthumus L, Al-Toma A
Eur J Gastroenterol Hepatol 2017 Aug;29(8):897-903. doi: 10.1097/MEG.0000000000000880. PMID: 28452813
Human intestinal alkaline phosphatase--release to the blood is linked to lipid absorption, but removal from the blood is not linked to lipoprotein clearance.
Domar U, Karpe F, Hamsten A, Stigbrand T, Olivecrona T
Eur J Clin Invest 1993 Nov;23(11):753-60. doi: 10.1111/j.1365-2362.1993.tb01296.x. PMID: 8307095

Clinical prediction guides

Significance of intestinal alkaline phosphatase in predicting histological activity of pediatric inflammatory bowel disease.
Ateş BB, Talim B, Gülşen HH, Demir H, Karaismailoğlu E, Özen H, Saltık-Temizel İN
Turk J Pediatr 2022;64(6):1068-1076. doi: 10.24953/turkjped.2021.5413. PMID: 36583889
Rifampicin induces the bone form of alkaline phosphatase in humans.
Nabil H, Kummu O, Lehenkari P, Rysä J, Risteli J, Hakkola J, Hukkanen J
Basic Clin Pharmacol Toxicol 2022 Jan;130 Suppl 1:81-94. Epub 2021 May 7 doi: 10.1111/bcpt.13586. PMID: 33851518
Association of Intestinal Alkaline Phosphatase With Necrotizing Enterocolitis Among Premature Infants.
Heath M, Buckley R, Gerber Z, Davis P, Linneman L, Gong Q, Barkemeyer B, Fang Z, Good M, Penn D, Kim S
JAMA Netw Open 2019 Nov 1;2(11):e1914996. doi: 10.1001/jamanetworkopen.2019.14996. PMID: 31702803Free PMC Article
Ontogeny of alkaline phosphatase activity in infant intestines and breast milk.
Yang Y, Rader E, Peters-Carr M, Bent RC, Smilowitz JT, Guillemin K, Rader B
BMC Pediatr 2019 Jan 3;19(1):2. doi: 10.1186/s12887-018-1379-1. PMID: 30606146Free PMC Article
Alkaline Phosphatase in Infant Cardiopulmonary Bypass: Kinetics and Relationship to Organ Injury and Major Cardiovascular Events.
Davidson JA, Urban TT, Baird C, Tong S, Woodruff A, Twite M, Jaggers J, Simões EAF, Wischmeyer P
J Pediatr 2017 Nov;190:49-55.e2. doi: 10.1016/j.jpeds.2017.07.035. PMID: 29144270Free PMC Article

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