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Low alkaline phosphatase of hepatic origin

MedGen UID:
869313
•Concept ID:
C4023739
•
Finding
Synonym: Low ALP of hepatic origin
 
HPO: HP:0010686

Definition

An abnormally reduced level of liver isoforms of alkaline phosphatase in the blood. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLow alkaline phosphatase of hepatic origin

Recent clinical studies

Etiology

USING OF CELL LINE HepG2 FOR ASSESSMENT OF TOXIC AND METABOLIC EFECTS OF ANTIPSYCHOTIC DRUGS.
Snopov SA, Teryukova NP, Sakhenberg EI, Tepliashina VV, Nasyrova RF
Tsitologiia 2017;59(3):210-9. PMID: 30183185
Prevalence and clinical significance of immunoglobulin A antibodies against tissue transglutaminase in patients with diverse chronic liver diseases.
Germenis AE, Yiannaki EE, Zachou K, Roka V, Barbanis S, Liaskos C, Adam K, Kapsoritakis AN, Potamianos S, Dalekos GN
Clin Diagn Lab Immunol 2005 Aug;12(8):941-8. doi: 10.1128/CDLI.12.8.941-948.2005. PMID: 16085912Free PMC Article
Wilson's disease with hepatic presentation in childhood.
Yüce A, Kocak N, Gürakan F, Ozen H
Indian Pediatr 2000 Jan;37(1):31-6. PMID: 10745386
Single and multiple pyogenic liver abscesses: clinical course, etiology, and results of treatment.
Chou FF, Sheen-Chen SM, Chen YS, Chen MC
World J Surg 1997 May;21(4):384-8; discussion 388-9. doi: 10.1007/pl00012258. PMID: 9143569

Diagnosis

Prevalence and clinical significance of immunoglobulin A antibodies against tissue transglutaminase in patients with diverse chronic liver diseases.
Germenis AE, Yiannaki EE, Zachou K, Roka V, Barbanis S, Liaskos C, Adam K, Kapsoritakis AN, Potamianos S, Dalekos GN
Clin Diagn Lab Immunol 2005 Aug;12(8):941-8. doi: 10.1128/CDLI.12.8.941-948.2005. PMID: 16085912Free PMC Article
Wilson's disease with hepatic presentation in childhood.
Yüce A, Kocak N, Gürakan F, Ozen H
Indian Pediatr 2000 Jan;37(1):31-6. PMID: 10745386
Metachronous bile duct cancer in a patient surviving for a decade and undergoing curative surgery twice.
Saiura A, Takayama T, Sano K, Toyoda H, Abe H, Kubota K, Mori M, Makuuchi M
Jpn J Clin Oncol 1999 Jul;29(7):353-5. doi: 10.1093/jjco/29.7.353. PMID: 10470661
Malignant lymphoma imitating hepatitis.
Harris AC, Kornstein MJ
Cancer 1993 Apr 15;71(8):2639-46. doi: 10.1002/1097-0142(19930415)71:8<2639::aid-cncr2820710832>3.0.co;2-q. PMID: 8453587
Serum gamma-glutamyl transpeptidase: its specificity and clinical value.
Levinson M, Holbert J, Blackwell C, Wruble LD
South Med J 1979 Jul;72(7):837-41. doi: 10.1097/00007611-197907000-00021. PMID: 36671

Therapy

USING OF CELL LINE HepG2 FOR ASSESSMENT OF TOXIC AND METABOLIC EFECTS OF ANTIPSYCHOTIC DRUGS.
Snopov SA, Teryukova NP, Sakhenberg EI, Tepliashina VV, Nasyrova RF
Tsitologiia 2017;59(3):210-9. PMID: 30183185

Prognosis

Single and multiple pyogenic liver abscesses: clinical course, etiology, and results of treatment.
Chou FF, Sheen-Chen SM, Chen YS, Chen MC
World J Surg 1997 May;21(4):384-8; discussion 388-9. doi: 10.1007/pl00012258. PMID: 9143569
Malignant lymphoma imitating hepatitis.
Harris AC, Kornstein MJ
Cancer 1993 Apr 15;71(8):2639-46. doi: 10.1002/1097-0142(19930415)71:8<2639::aid-cncr2820710832>3.0.co;2-q. PMID: 8453587
Serum gamma-glutamyl transpeptidase: its specificity and clinical value.
Levinson M, Holbert J, Blackwell C, Wruble LD
South Med J 1979 Jul;72(7):837-41. doi: 10.1097/00007611-197907000-00021. PMID: 36671

Clinical prediction guides

USING OF CELL LINE HepG2 FOR ASSESSMENT OF TOXIC AND METABOLIC EFECTS OF ANTIPSYCHOTIC DRUGS.
Snopov SA, Teryukova NP, Sakhenberg EI, Tepliashina VV, Nasyrova RF
Tsitologiia 2017;59(3):210-9. PMID: 30183185

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