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Exercise-induced leg cramps

MedGen UID:
870174
•Concept ID:
C4024607
•
Sign or Symptom
HPO: HP:0008991

Definition

Sudden and involuntary contractions of one or more muscles of the leg brought on by physical exertion. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVExercise-induced leg cramps

Conditions with this feature

Restless legs syndrome, susceptibility to, 1
MedGen UID:
360293
•Concept ID:
C1876177
•
Finding
Restless legs syndrome (RLS) is a neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation (Bonati et al., 2003). Genetic Heterogeneity of Restless Legs Syndrome RLS1 has been mapped to chromosome 12q. Other susceptibility loci for RLS include RLS2 (608831) on chromosome 14q13-q31; RLS3 (610438) on chromosome 9p24-p22; RLS4 (610439) on chromosome 2q33; RLS5 (611242) on chromosome 20p13; RLS6 (611185) on chromosome 6p21; RLS7 (612853) on chromosome 2p14; and RLS8 (615197) on chromosome 5q31.
See: Condition Record
Restless legs syndrome, susceptibility to, 1

Professional guidelines

PubMed

Patient-Reported Prevalence, Characteristics, and Impact of Leg Cramps in an Urban Primary Care Clinic.
Khandalavala B, Geske J, Klein J
Ann Fam Med 2023 Sep-Oct;21(5):440-443. doi: 10.1370/afm.3013. PMID: 37748902Free PMC Article

Recent clinical studies

Etiology

Fasciotomy for Deep Posterior Compartment Syndrome in the Lower Leg: A Prospective Study.
Winkes MB, van Zantvoort AP, de Bruijn JA, Smeets SJ, van der Cruijsen-Raaijmakers M, Hoogeveen AR, Scheltinga MR
Am J Sports Med 2016 May;44(5):1309-16. Epub 2016 Feb 17 doi: 10.1177/0363546515626540. PMID: 26888880

Diagnosis

Myopathic causes of exercise intolerance with rhabdomyolysis.
Quinlivan R, Jungbluth H
Dev Med Child Neurol 2012 Oct;54(10):886-91. Epub 2012 May 23 doi: 10.1111/j.1469-8749.2012.04320.x. PMID: 22616958

Therapy

Fasciotomy for Deep Posterior Compartment Syndrome in the Lower Leg: A Prospective Study.
Winkes MB, van Zantvoort AP, de Bruijn JA, Smeets SJ, van der Cruijsen-Raaijmakers M, Hoogeveen AR, Scheltinga MR
Am J Sports Med 2016 May;44(5):1309-16. Epub 2016 Feb 17 doi: 10.1177/0363546515626540. PMID: 26888880
Three percent hypohydration does not affect threshold frequency of electrically induced cramps.
Miller KC, Mack GW, Knight KL, Hopkins JT, Draper DO, Fields PJ, Hunter I
Med Sci Sports Exerc 2010 Nov;42(11):2056-63. doi: 10.1249/MSS.0b013e3181dd5e3a. PMID: 20351595
Availability of glucose ingested during muscle exercise performed under acipimox-induced lipolysis blockade.
Gautier JF, Pirnay F, Jandrain B, Lacroix M, Mosora F, Scheen AJ, Cathelineau G, Lefèbvre PJ
Eur J Appl Physiol Occup Physiol 1994;68(5):406-12. doi: 10.1007/BF00843737. PMID: 8076620

Clinical prediction guides

Fasciotomy for Deep Posterior Compartment Syndrome in the Lower Leg: A Prospective Study.
Winkes MB, van Zantvoort AP, de Bruijn JA, Smeets SJ, van der Cruijsen-Raaijmakers M, Hoogeveen AR, Scheltinga MR
Am J Sports Med 2016 May;44(5):1309-16. Epub 2016 Feb 17 doi: 10.1177/0363546515626540. PMID: 26888880
Three percent hypohydration does not affect threshold frequency of electrically induced cramps.
Miller KC, Mack GW, Knight KL, Hopkins JT, Draper DO, Fields PJ, Hunter I
Med Sci Sports Exerc 2010 Nov;42(11):2056-63. doi: 10.1249/MSS.0b013e3181dd5e3a. PMID: 20351595
Availability of glucose ingested during muscle exercise performed under acipimox-induced lipolysis blockade.
Gautier JF, Pirnay F, Jandrain B, Lacroix M, Mosora F, Scheen AJ, Cathelineau G, Lefèbvre PJ
Eur J Appl Physiol Occup Physiol 1994;68(5):406-12. doi: 10.1007/BF00843737. PMID: 8076620

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