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Circumungual hyperkeratosis

MedGen UID:
870243
•Concept ID:
C4024681
•
Disease or Syndrome
Synonym: Thick skin around nails
 
HPO: HP:0008399

Definition

A thickening of the stratum corneum, the outer layer of the skin, in the region surrounding the nails. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCircumungual hyperkeratosis

Conditions with this feature

Focal palmoplantar and gingival keratoderma
MedGen UID:
372097
•Concept ID:
C1835650
•
Disease or Syndrome
A very rare form of focal palmoplantar keratoderma with characteristics of painful circumscribed hyperkeratotic lesions on weight-bearing areas of soles, moderate focal hyperkeratosis of palmar pressure-related areas and an asymptomatic leukokeratosis confined to labial and lingual attached gingiva. Additional occasional features may include hyperhidrosis, follicular keratosis and extended oral mucosa involvement.
See: Condition Record
Focal palmoplantar and gingival keratoderma

Professional guidelines

PubMed

Keratosis pilaris: an update and approach to management.
Kodali N, Patel VM, Schwartz RA
Ital J Dermatol Venerol 2023 Jun;158(3):217-223. Epub 2023 May 11 doi: 10.23736/S2784-8671.23.07594-1. PMID: 37166753
Treatment of actinic keratosis: a systematic review.
Worley B, Harikumar V, Reynolds K, Dirr MA, Christensen RE, Anvery N, Yi MD, Poon E, Alam M
Arch Dermatol Res 2023 Jul;315(5):1099-1108. Epub 2022 Dec 1 doi: 10.1007/s00403-022-02490-5. PMID: 36454335
Albinism: epidemiology, genetics, cutaneous characterization, psychosocial factors.
Marçon CR, Maia M
An Bras Dermatol 2019 Sep-Oct;94(5):503-520. Epub 2019 Sep 30 doi: 10.1016/j.abd.2019.09.023. PMID: 31777350Free PMC Article

Recent clinical studies

Etiology

Actinic keratosis metrics.
Burstein SE, Maibach H
Arch Dermatol Res 2024 Aug 20;316(8):543. doi: 10.1007/s00403-024-03305-5. PMID: 39162820Free PMC Article
Ichthyosis: presentation and management.
Butala S, Mazereeuw-Hautier J, Paller AS
Curr Opin Pediatr 2023 Aug 1;35(4):467-474. Epub 2023 Jun 22 doi: 10.1097/MOP.0000000000001264. PMID: 37345742
Actinic keratoses: review of clinical, dermoscopic, and therapeutic aspects.
Reinehr CPH, Bakos RM
An Bras Dermatol 2019 Nov-Dec;94(6):637-657. Epub 2019 Nov 6 doi: 10.1016/j.abd.2019.10.004. PMID: 31789244Free PMC Article
Inherited ichthyosis: Non-syndromic forms.
Takeichi T, Akiyama M
J Dermatol 2016 Mar;43(3):242-51. doi: 10.1111/1346-8138.13243. PMID: 26945532
Psoriasiform keratosis.
Walsh SN, Hurt MA, Santa Cruz DJ
Am J Dermatopathol 2007 Apr;29(2):137-40. doi: 10.1097/01.dad.0000246177.63145.b3. PMID: 17414434

Diagnosis

Seborrheic keratosis.
Barthelmann S, Butsch F, Lang BM, Stege H, Großmann B, Schepler H, Grabbe S
J Dtsch Dermatol Ges 2023 Mar;21(3):265-277. Epub 2023 Mar 9 doi: 10.1111/ddg.14984. PMID: 36892019
Frictional Keratosis, Contact Keratosis and Smokeless Tobacco Keratosis: Features of Reactive White Lesions of the Oral Mucosa.
Müller S
Head Neck Pathol 2019 Mar;13(1):16-24. Epub 2019 Jan 22 doi: 10.1007/s12105-018-0986-3. PMID: 30671762Free PMC Article
Athlete's nodule.
Uchiyama M, Tsuboi R, Mitsuhashi Y
J Dermatol 2009 Nov;36(11):608-11. doi: 10.1111/j.1346-8138.2009.00718.x. PMID: 19878395
Obesity and dermatology.
Scheinfeld NS
Clin Dermatol 2004 Jul-Aug;22(4):303-9. doi: 10.1016/j.clindermatol.2004.01.001. PMID: 15475230
Spiny keratoderma.
Helm TN, Lee J, Helm KF
Cutis 2000 Sep;66(3):191-2. PMID: 11006853

Therapy

Tirbanibulin: First Approval.
Markham A, Duggan S
Drugs 2021 Mar;81(4):509-513. doi: 10.1007/s40265-021-01479-0. PMID: 33713299
Frictional Keratosis, Contact Keratosis and Smokeless Tobacco Keratosis: Features of Reactive White Lesions of the Oral Mucosa.
Müller S
Head Neck Pathol 2019 Mar;13(1):16-24. Epub 2019 Jan 22 doi: 10.1007/s12105-018-0986-3. PMID: 30671762Free PMC Article
Real-world approach to actinic keratosis management: practical treatment algorithm for office-based dermatology.
Dirschka T, Gupta G, Micali G, Stockfleth E, Basset-Séguin N, Del Marmol V, Dummer R, Jemec GBE, Malvehy J, Peris K, Puig S, Stratigos AJ, Zalaudek I, Pellacani G
J Dermatolog Treat 2017 Aug;28(5):431-442. Epub 2016 Nov 13 doi: 10.1080/09546634.2016.1254328. PMID: 27796187
Seborrheic keratosis.
Hafner C, Vogt T
J Dtsch Dermatol Ges 2008 Aug;6(8):664-77. doi: 10.1111/j.1610-0387.2008.06788.x. PMID: 18801147
Acrokeratoelastoidosis.
Hu W, Cook TF, Vicki GJ, Glaser DA
Pediatr Dermatol 2002 Jul-Aug;19(4):320-2. doi: 10.1046/j.1525-1470.2002.00091.x. PMID: 12220276

Prognosis

Single-cell sequencing highlights heterogeneity and malignant progression in actinic keratosis and cutaneous squamous cell carcinoma.
Zou DD, Sun YZ, Li XJ, Wu WJ, Xu D, He YT, Qi J, Tu Y, Tang Y, Tu YH, Wang XL, Li X, Lu FY, Huang L, Long H, He L, Li X
Elife 2023 Dec 15;12 doi: 10.7554/eLife.85270. PMID: 38099574Free PMC Article
Aquagenic keratoderma.
Marín-Hernández E, García-Alonso MJ, Cruz-Flores ED, Flores-Salgado M
Bol Med Hosp Infant Mex 2022;79(3):193-198. doi: 10.24875/BMHIM.21000084. PMID: 35882021
Field cancerization: Definition, epidemiology, risk factors, and outcomes.
Willenbrink TJ, Ruiz ES, Cornejo CM, Schmults CD, Arron ST, Jambusaria-Pahlajani A
J Am Acad Dermatol 2020 Sep;83(3):709-717. Epub 2020 May 7 doi: 10.1016/j.jaad.2020.03.126. PMID: 32387665
Psoriasiform keratosis.
Walsh SN, Hurt MA, Santa Cruz DJ
Am J Dermatopathol 2007 Apr;29(2):137-40. doi: 10.1097/01.dad.0000246177.63145.b3. PMID: 17414434
Acrokeratoelastoidosis.
Hu W, Cook TF, Vicki GJ, Glaser DA
Pediatr Dermatol 2002 Jul-Aug;19(4):320-2. doi: 10.1046/j.1525-1470.2002.00091.x. PMID: 12220276

Clinical prediction guides

Actinic keratosis metrics.
Burstein SE, Maibach H
Arch Dermatol Res 2024 Aug 20;316(8):543. doi: 10.1007/s00403-024-03305-5. PMID: 39162820Free PMC Article
Diagnosis and therapy of actinic keratosis.
Thamm JR, Welzel J, Schuh S
J Dtsch Dermatol Ges 2024 May;22(5):675-690. Epub 2024 Mar 8 doi: 10.1111/ddg.15288. PMID: 38456369
Aquagenic keratoderma.
Marín-Hernández E, García-Alonso MJ, Cruz-Flores ED, Flores-Salgado M
Bol Med Hosp Infant Mex 2022;79(3):193-198. doi: 10.24875/BMHIM.21000084. PMID: 35882021
Pitted keratolysis.
de Almeida HL Jr, Siqueira RN, Meireles Rda S, Rampon G, de Castro LA, Silva RM
An Bras Dermatol 2016 Jan-Feb;91(1):106-8. doi: 10.1590/abd1806-4841.20164096. PMID: 26982791Free PMC Article
Diagnosis of arsenicosis.
Saha KC
J Environ Sci Health A Tox Hazard Subst Environ Eng 2003 Jan;38(1):255-72. doi: 10.1081/ese-120016893. PMID: 12635831

Recent systematic reviews

Treatment of actinic keratosis: a systematic review.
Worley B, Harikumar V, Reynolds K, Dirr MA, Christensen RE, Anvery N, Yi MD, Poon E, Alam M
Arch Dermatol Res 2023 Jul;315(5):1099-1108. Epub 2022 Dec 1 doi: 10.1007/s00403-022-02490-5. PMID: 36454335
Efficacy and safety of topical treatments for seborrheic keratoses: a systematic review.
Natarelli N, Krenitsky A, Hennessy K, Moore S, Grichnik J
J Dermatolog Treat 2023 Dec;34(1):2133532. Epub 2022 Nov 13 doi: 10.1080/09546634.2022.2133532. PMID: 36215682
Treatment of keratosis pilaris and its variants: a systematic review.
Maghfour J, Ly S, Haidari W, Taylor SL, Feldman SR
J Dermatolog Treat 2022 May;33(3):1231-1242. Epub 2020 Sep 14 doi: 10.1080/09546634.2020.1818678. PMID: 32886029
Guidelines of care for the management of actinic keratosis.
Eisen DB, Asgari MM, Bennett DD, Connolly SM, Dellavalle RP, Freeman EE, Goldenberg G, Leffell DJ, Peschin S, Sligh JE, Wu PA, Frazer-Green L, Malik S, Schlesinger TE
J Am Acad Dermatol 2021 Oct;85(4):e209-e233. Epub 2021 Apr 2 doi: 10.1016/j.jaad.2021.02.082. PMID: 33820677
Worldwide prevalence of oral lichen planus: A systematic review and meta-analysis.
González-Moles MÁ, Warnakulasuriya S, González-Ruiz I, González-Ruiz L, Ayén Á, Lenouvel D, Ruiz-Ávila I, Ramos-García P
Oral Dis 2021 May;27(4):813-828. Epub 2020 Apr 2 doi: 10.1111/odi.13323. PMID: 32144836

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