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Impaired myocardial contractility

MedGen UID:
870561
•Concept ID:
C4025009
•
Disease or Syndrome
HPO: HP:0006670

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVImpaired myocardial contractility

Conditions with this feature

Dilated cardiomyopathy 1O
MedGen UID:
325268
•Concept ID:
C1837839
•
Disease or Syndrome
Any familial isolated dilated cardiomyopathy in which the cause of the disease is a mutation in the ABCC9 gene.
See: Condition Record
Dilated cardiomyopathy 1M
MedGen UID:
334498
•Concept ID:
C1843808
•
Disease or Syndrome
Any familial isolated dilated cardiomyopathy in which the cause of the disease is a mutation in the CSRP3 gene.
See: Condition Record
Cardiomyopathy, familial hypertrophic 27
MedGen UID:
1648325
•Concept ID:
C4748014
•
Disease or Syndrome
CMH27 is a severe, early-onset cardiomyopathy with morphologic features of both dilated and hypertrophic disease, characterized by biventricular involvement and atypical distribution of hypertrophy. Heterozygotes are at increased risk of developing cardiomyopathy (Almomani et al., 2016). For a general phenotypic description and a discussion of genetic heterogeneity of hypertrophic cardiomyopathy, see CMH1 (192600). An oligogenic form of hypertrophic cardiomyopathy, involving heterozygous mutations in the ALPK3, TTN (188840), and MYL3 (160790) genes has also been reported in 1 family.
See: Condition Record
Dilated cardiomyopathy 1B
MedGen UID:
1814491
•Concept ID:
C5700078
•
Disease or Syndrome
A dilated cardiomyopathy that has material basis in variation in the chromosome region 9q13.
See: Condition Record
Cardiomyopathy, familial hypertrophic 27
Dilated cardiomyopathy 1B
Dilated cardiomyopathy 1M
Dilated cardiomyopathy 1O

Professional guidelines

PubMed

The many "faces" of copper in medicine and treatment.
Hordyjewska A, Popiołek Ł, Kocot J
Biometals 2014 Aug;27(4):611-21. Epub 2014 Apr 20 doi: 10.1007/s10534-014-9736-5. PMID: 24748564Free PMC Article

Recent clinical studies

Etiology

Maternal Cardiac Changes in Women With Obesity and Gestational Diabetes Mellitus.
Thirunavukarasu S, Ansari F, Cubbon R, Forbes K, Bucciarelli-Ducci C, Newby DE, Dweck MR, Rider OJ, Valkovič L, Rodgers CT, Tyler DJ, Chowdhary A, Jex N, Kotha S, Morley L, Xue H, Swoboda P, Kellman P, Greenwood JP, Plein S, Everett T, Scott E, Levelt E
Diabetes Care 2022 Dec 1;45(12):3007-3015. doi: 10.2337/dc22-0401. PMID: 36099225Free PMC Article
Disorganization of intercalated discs in dilated cardiomyopathy.
Ito Y, Yoshida M, Masuda H, Maeda D, Kudo-Asabe Y, Umakoshi M, Nanjo H, Goto A
Sci Rep 2021 Jun 4;11(1):11852. doi: 10.1038/s41598-021-90502-1. PMID: 34088908Free PMC Article
Resting global and regional left ventricular contractility in patients with heart failure and normal ejection fraction: insights from speckle-tracking echocardiography.
Yip GW, Zhang Q, Xie JM, Liang YJ, Liu YM, Yan B, Lam YY, Yu CM
Heart 2011 Feb;97(4):287-94. Epub 2010 Dec 30 doi: 10.1136/hrt.2010.205815. PMID: 21193686
Adverse effects of statins - mechanisms and consequences.
Bełtowski J, Wójcicka G, Jamroz-Wiśniewska A
Curr Drug Saf 2009 Sep;4(3):209-28. Epub 2009 Sep 1 doi: 10.2174/157488609789006949. PMID: 19534648
Plasma atrial natriuretic factor levels, impaired myocardial contractility and pain intensity in uncomplicated acute myocardial infarction.
Fontana F, Pasquale B, Mirri D, Iuculano G, Menchetti A, Boschi S, Iasio R, Capelli M
Pain 1995 Aug;62(2):213-218. doi: 10.1016/0304-3959(94)00269-K. PMID: 8545147

Diagnosis

Maternal Cardiac Changes in Women With Obesity and Gestational Diabetes Mellitus.
Thirunavukarasu S, Ansari F, Cubbon R, Forbes K, Bucciarelli-Ducci C, Newby DE, Dweck MR, Rider OJ, Valkovič L, Rodgers CT, Tyler DJ, Chowdhary A, Jex N, Kotha S, Morley L, Xue H, Swoboda P, Kellman P, Greenwood JP, Plein S, Everett T, Scott E, Levelt E
Diabetes Care 2022 Dec 1;45(12):3007-3015. doi: 10.2337/dc22-0401. PMID: 36099225Free PMC Article
Decreased Native T1 Values and Impaired Myocardial Contractility in Anabolic Steroid Users.
de Souza FR, Dos Santos MR, Rochitte CE, Dos Santos RP, Jordão CP, Leite IS, da Fonseca GWP, Fonseca RA, de Oliveira TF, Yonamine M, Pereira RMR, Negrão CE, Alves NNMJ
Int J Sports Med 2022 Feb;43(2):183-191. Epub 2021 Aug 2 doi: 10.1055/a-1518-7953. PMID: 34341973
Disorganization of intercalated discs in dilated cardiomyopathy.
Ito Y, Yoshida M, Masuda H, Maeda D, Kudo-Asabe Y, Umakoshi M, Nanjo H, Goto A
Sci Rep 2021 Jun 4;11(1):11852. doi: 10.1038/s41598-021-90502-1. PMID: 34088908Free PMC Article
Asymptomatic diabetic cardiomyopathy: a noninvasive study.
Attali JR, Sachs RN, Valensi P, Palsky D, Tellier P, Vulpillat M, Lanfranchi J, Sebaoun J
Diabetes Res Clin Pract 1988 Feb 19;4(3):183-90. doi: 10.1016/s0168-8227(88)80016-0. PMID: 3359918
Noninvasive assessment of myocardial contractility in asymptomatic patients with sever aortic regurgitation and normal left ventricular ejection fraction at rest.
Schuler G, von Olshausen K, Schwarz F, Mehmel H, Hofmann M, Hermann HJ, Lange D, Kübler W
Am J Cardiol 1982 Jul;50(1):45-52. doi: 10.1016/0002-9149(82)90007-8. PMID: 7091005

Therapy

Decreased Native T1 Values and Impaired Myocardial Contractility in Anabolic Steroid Users.
de Souza FR, Dos Santos MR, Rochitte CE, Dos Santos RP, Jordão CP, Leite IS, da Fonseca GWP, Fonseca RA, de Oliveira TF, Yonamine M, Pereira RMR, Negrão CE, Alves NNMJ
Int J Sports Med 2022 Feb;43(2):183-191. Epub 2021 Aug 2 doi: 10.1055/a-1518-7953. PMID: 34341973
Myocardial Infarction and Cardiac Arrest in a Patient With Severe Undiagnosed Hypothyroidism During Bronchoscopy.
Awari DW, Dhanasekaran M, Mudrakola HV, Morales DJV, Weingarten TN, Sprung J
J Cardiothorac Vasc Anesth 2022 May;36(5):1410-1414. Epub 2021 Feb 12 doi: 10.1053/j.jvca.2021.02.025. PMID: 33712327
Are statins really wonder drugs?
Grover HS, Luthra S, Maroo S
J Formos Med Assoc 2014 Dec;113(12):892-8. Epub 2013 Nov 11 doi: 10.1016/j.jfma.2013.05.016. PMID: 24231094
Adverse effects of statins - mechanisms and consequences.
Bełtowski J, Wójcicka G, Jamroz-Wiśniewska A
Curr Drug Saf 2009 Sep;4(3):209-28. Epub 2009 Sep 1 doi: 10.2174/157488609789006949. PMID: 19534648
Therapeutic achievements of phosphodiesterase inhibitors and the future.
Jewitt DE
Eur Heart J 1989 Aug;10 Suppl C:53-9. doi: 10.1093/eurheartj/10.suppl_c.53. PMID: 2680498

Prognosis

Decreased Native T1 Values and Impaired Myocardial Contractility in Anabolic Steroid Users.
de Souza FR, Dos Santos MR, Rochitte CE, Dos Santos RP, Jordão CP, Leite IS, da Fonseca GWP, Fonseca RA, de Oliveira TF, Yonamine M, Pereira RMR, Negrão CE, Alves NNMJ
Int J Sports Med 2022 Feb;43(2):183-191. Epub 2021 Aug 2 doi: 10.1055/a-1518-7953. PMID: 34341973
Disorganization of intercalated discs in dilated cardiomyopathy.
Ito Y, Yoshida M, Masuda H, Maeda D, Kudo-Asabe Y, Umakoshi M, Nanjo H, Goto A
Sci Rep 2021 Jun 4;11(1):11852. doi: 10.1038/s41598-021-90502-1. PMID: 34088908Free PMC Article
Relations of left ventricular mass and systolic function to endothelial function and coronary flow reserve in healthy, new discovered hypertensive subjects.
Palmieri V, Storto G, Arezzi E, Pellegrino T, Mancini M, Di Minno G, Ferrara AL, Cuocolo A, Celentano A
J Hum Hypertens 2005 Dec;19(12):941-50. doi: 10.1038/sj.jhh.1001921. PMID: 16079883
Limiting factors for exercise at extreme altitudes.
West JB
Clin Physiol 1990 May;10(3):265-72. doi: 10.1111/j.1475-097x.1990.tb00095.x. PMID: 2140966
Therapeutic achievements of phosphodiesterase inhibitors and the future.
Jewitt DE
Eur Heart J 1989 Aug;10 Suppl C:53-9. doi: 10.1093/eurheartj/10.suppl_c.53. PMID: 2680498

Clinical prediction guides

Decreased Native T1 Values and Impaired Myocardial Contractility in Anabolic Steroid Users.
de Souza FR, Dos Santos MR, Rochitte CE, Dos Santos RP, Jordão CP, Leite IS, da Fonseca GWP, Fonseca RA, de Oliveira TF, Yonamine M, Pereira RMR, Negrão CE, Alves NNMJ
Int J Sports Med 2022 Feb;43(2):183-191. Epub 2021 Aug 2 doi: 10.1055/a-1518-7953. PMID: 34341973
Disorganization of intercalated discs in dilated cardiomyopathy.
Ito Y, Yoshida M, Masuda H, Maeda D, Kudo-Asabe Y, Umakoshi M, Nanjo H, Goto A
Sci Rep 2021 Jun 4;11(1):11852. doi: 10.1038/s41598-021-90502-1. PMID: 34088908Free PMC Article
Endothelin 1 gene as a modifier in dilated cardiomyopathy.
Matsa LS, Sagurthi SR, Ananthapur V, Nalla S, Nallari P
Gene 2014 Sep 15;548(2):256-62. Epub 2014 Jul 15 doi: 10.1016/j.gene.2014.07.043. PMID: 25042451
NCAM(CD56) and RUNX1(AML1) are up-regulated in human ischemic cardiomyopathy and a rat model of chronic cardiac ischemia.
Gattenlöhner S, Waller C, Ertl G, Bültmann BD, Müller-Hermelink HK, Marx A
Am J Pathol 2003 Sep;163(3):1081-90. doi: 10.1016/S0002-9440(10)63467-0. PMID: 12937148Free PMC Article
Plasma atrial natriuretic factor levels, impaired myocardial contractility and pain intensity in uncomplicated acute myocardial infarction.
Fontana F, Pasquale B, Mirri D, Iuculano G, Menchetti A, Boschi S, Iasio R, Capelli M
Pain 1995 Aug;62(2):213-218. doi: 10.1016/0304-3959(94)00269-K. PMID: 8545147

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