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Abnormal hand epiphysis morphology

MedGen UID:
870653
•Concept ID:
C4025107
•
Anatomical Abnormality
Synonyms: Abnormality of the end part of the hand bone; Abnormality of the end part of the hand bones; Abnormality of the epiphyses of the fingers; Abnormality of the epiphyses of the hand; Abnormality of the epiphyses of the phalanges of the hand
 
HPO: HP:0005924

Definition

Any abnormality of the epiphyses of the phalanges or metacarpal bones. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal hand epiphysis morphology

Professional guidelines

PubMed

Severe nasomaxillary hypoplasia (Binder phenotype) on prenatal US/MRI: an important marker for the prenatal diagnosis of chondrodysplasia punctata.
Blask AR, Rubio EI, Chapman KA, Lawrence AK, Bulas DI
Pediatr Radiol 2018 Jul;48(7):979-991. Epub 2018 Mar 23 doi: 10.1007/s00247-018-4098-8. PMID: 29572747Free PMC Article
Revisit of multiple epiphyseal dysplasia: ethnic difference in genotypes and comparison of radiographic features linked to the COMP and MATN3 genes.
Kim OH, Park H, Seong MW, Cho TJ, Nishimura G, Superti-Furga A, Unger S, Ikegawa S, Choi IH, Song HR, Kim HW, Yoo WJ, Shim JS, Chung CY, Oh CW, Jeong C, Song KS, Seo SG, Cho SI, Yeo IK, Kim SY, Park S, Park SS
Am J Med Genet A 2011 Nov;155A(11):2669-80. Epub 2011 Sep 30 doi: 10.1002/ajmg.a.34246. PMID: 21965141
Radiographic evaluation and unusual bone formations in different genetic patterns in synpolydactyly.
Yucel A, Kuru I, Bozan ME, Acar M, Solak M
Skeletal Radiol 2005 Aug;34(8):468-76. Epub 2005 Jun 10 doi: 10.1007/s00256-005-0928-5. PMID: 15947976

Recent clinical studies

Etiology

Phalangeal Intra-Articular Osteochondroma Caused a Rare Clinodactyly Deformity in Children: Case Series and Literature Review.
Hao Y, Guo JC, Wang XL, Shao JF, Feng JX, He JP
Front Endocrinol (Lausanne) 2021;12:677245. Epub 2021 Aug 12 doi: 10.3389/fendo.2021.677245. PMID: 34456858Free PMC Article
Chondrosarcomas of the hands and feet: A case series and systematic review of the literature.
Fayad LM, Ahlawat S, Khan MS, McCarthy E
Eur J Radiol 2015 Oct;84(10):2004-12. Epub 2015 Jul 2 doi: 10.1016/j.ejrad.2015.06.026. PMID: 26189572
Wolcott-Rallison syndrome.
Julier C, Nicolino M
Orphanet J Rare Dis 2010 Nov 4;5:29. doi: 10.1186/1750-1172-5-29. PMID: 21050479Free PMC Article
Genetic and molecular aspects of acromelic dysplasia.
Le Goff C, Cormier-Daire V
Pediatr Endocrinol Rev 2009 Mar;6(3):418-23. PMID: 19396027
Ulnar dysmelia.
Ogden JA, Watson HK, Bohne W
J Bone Joint Surg Am 1976 Jun;58(4):467-75. PMID: 818089

Diagnosis

Trichorhinophalangeal syndrome.
Vargas Lebrón C, Ruiz Montesino MD, Moreira Navarrete V, Aróstegui Gorospe JI
Reumatol Clin (Engl Ed) 2020 Nov-Dec;16(6):499-501. Epub 2018 Dec 3 doi: 10.1016/j.reuma.2018.08.015. PMID: 30522940
Radial Polydactyly. What's New?
Perez-Lopez LM, la Iglesia DG, Cabrera-Gonzalez M
Curr Pediatr Rev 2018;14(2):91-96. doi: 10.2174/1573396314666180124102012. PMID: 29366421
Cone-shaped epiphysis.
Durmus O, Cakar E, Ata E, Dincer U, Kiralp MZ
Am J Phys Med Rehabil 2014 Jan;93(1):92-3. doi: 10.1097/PHM.0b013e3182644034. PMID: 22854906
Wolcott-Rallison syndrome.
Julier C, Nicolino M
Orphanet J Rare Dis 2010 Nov 4;5:29. doi: 10.1186/1750-1172-5-29. PMID: 21050479Free PMC Article
Craniofacial conodysplasia.
Beals RK, Piatt JH, Zonana J
J Pediatr Orthop 1995 Sep-Oct;15(5):633-6. doi: 10.1097/01241398-199509000-00016. PMID: 7593576

Therapy

Clinical Characteristics and Surgical Outcomes of Congenital Ulnar-deviated Thumbs: Delta Triphalangeal Thumbs and Irregular Epiphyses.
Han B, Shen K, Wang Z, Xu Y
J Pediatr Orthop 2021 Jan;41(1):28-32. doi: 10.1097/BPO.0000000000001679. PMID: 33086366Free PMC Article
Cone-shaped epiphysis.
Durmus O, Cakar E, Ata E, Dincer U, Kiralp MZ
Am J Phys Med Rehabil 2014 Jan;93(1):92-3. doi: 10.1097/PHM.0b013e3182644034. PMID: 22854906
Percutaneous distraction lengthening in brachymetacarpia.
Volpi AD, Fragomen AT
Orthopedics 2011 Aug 8;34(8):e424-7. doi: 10.3928/01477447-20110627-29. PMID: 21815589
Very distal radial osteotomy for Madelung's deformity.
McCarroll HR Jr, James MA
Tech Hand Up Extrem Surg 2010 Jun;14(2):85-93. doi: 10.1097/BTH.0b013e3181dba5fe. PMID: 20526161
Metacarpal lengthening by distraction osteogenesis in childhood brachydactyly.
Arslan H
Acta Orthop Belg 2001 Jun;67(3):242-7. PMID: 11486686

Prognosis

Correction of Clinodactyly by Early Physiolysis: 6-Year Results.
Medina JA, Lorea P, Elliot D, Foucher G
J Hand Surg Am 2016 Jun;41(6):e123-7. Epub 2016 Mar 10 doi: 10.1016/j.jhsa.2016.02.006. PMID: 26972556
Radial Polydactyly and the Incidence of Reoperation Using A New Classification System.
Evanson BJ, Hosseinzadeh P, Riley SA, Burgess RC
J Pediatr Orthop 2016 Mar;36(2):158-60. doi: 10.1097/BPO.0000000000000395. PMID: 25633612
Percutaneous distraction lengthening in brachymetacarpia.
Volpi AD, Fragomen AT
Orthopedics 2011 Aug 8;34(8):e424-7. doi: 10.3928/01477447-20110627-29. PMID: 21815589
Wolcott-Rallison syndrome.
Julier C, Nicolino M
Orphanet J Rare Dis 2010 Nov 4;5:29. doi: 10.1186/1750-1172-5-29. PMID: 21050479Free PMC Article
Ulnar dysmelia.
Ogden JA, Watson HK, Bohne W
J Bone Joint Surg Am 1976 Jun;58(4):467-75. PMID: 818089

Clinical prediction guides

Modified Bilhaut-Cloquet procedure for Wassel type III-IV polydactyly.
Guo X, Wei Y, Wang F, Zhou X, Zhao S
J Orthop Surg Res 2024 Jan 16;19(1):71. doi: 10.1186/s13018-024-04553-x. PMID: 38229071Free PMC Article
Clinical Characteristics and Surgical Outcomes of Congenital Ulnar-deviated Thumbs: Delta Triphalangeal Thumbs and Irregular Epiphyses.
Han B, Shen K, Wang Z, Xu Y
J Pediatr Orthop 2021 Jan;41(1):28-32. doi: 10.1097/BPO.0000000000001679. PMID: 33086366Free PMC Article
Radial Polydactyly. What's New?
Perez-Lopez LM, la Iglesia DG, Cabrera-Gonzalez M
Curr Pediatr Rev 2018;14(2):91-96. doi: 10.2174/1573396314666180124102012. PMID: 29366421
The fate of hips that are conservatively treated in multiple epiphyseal dysplasia.
Kim SJ, Ramanathan AK, Jeon YS, Song HR
J Pediatr Orthop B 2017 Nov;26(6):526-531. doi: 10.1097/BPB.0000000000000368. PMID: 27398645
Ulnar dysmelia.
Ogden JA, Watson HK, Bohne W
J Bone Joint Surg Am 1976 Jun;58(4):467-75. PMID: 818089

Recent systematic reviews

Chondrosarcomas of the hands and feet: A case series and systematic review of the literature.
Fayad LM, Ahlawat S, Khan MS, McCarthy E
Eur J Radiol 2015 Oct;84(10):2004-12. Epub 2015 Jul 2 doi: 10.1016/j.ejrad.2015.06.026. PMID: 26189572
The prevalence of Os acromiale: a systematic review and meta-analysis.
Yammine K
Clin Anat 2014 May;27(4):610-21. Epub 2013 Dec 2 doi: 10.1002/ca.22343. PMID: 24302513

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