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Dermatoglyphic variants

MedGen UID:: 870662
•Concept ID:: C4025116
•: Anatomical Abnormality

HPO:	HP:0005882

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVDermatoglyphic variants

Abnormality of limbs
- Abnormality of the upper limb
  - Abnormality of the hand
    - Abnormal palm morphology
      - Abnormal skin morphology of the palm
        Abnormal palmar dermatoglyphics
        Dermatoglyphic variants
        Index finger dermatoglyphic radial loop
        Unusual dermatoglyphics

Conditions with this feature

Chromosome 9p deletion syndrome

MedGen UID:: 167073
•Concept ID:: C0795830
•: Disease or Syndrome

A rare chromosomal anomaly with characteristics of psychomotor developmental delay, facial dysmorphism (trigonocephaly, midface hypoplasia, upslanting palpebral fissures, dysplastic small ears, flat nasal bridge with anteverted nostrils and long philtrum, micrognathia, choanal atresia, short neck), single umbilical artery, omphalocele, inguinal or umbilical hernia, genital abnormalities (hypospadia, cryptorchidism), muscular hypotonia and scoliosis.

See: Condition Record

Chromosome 9p deletion syndrome

Professional guidelines

PubMed

Studies of malformation syndromes in man XXXX: multiple congenital anomalies/mental retardation syndrome or variant familial developmental pattern; differential diagnosis and description of the McDonough syndrome (with XXY son from XY/XXY father).

Neuhäuser G, Opitz JM
Z Kinderheilkd 1975 Nov 13;120(4):231-42. doi: 10.1007/BF00440262. PMID: 1189520

See all (1)

Recent clinical studies

Etiology

Limb development genes underlie variation in human fingerprint patterns.

Li J, Glover JD, Zhang H, Peng M, Tan J, Mallick CB, Hou D, Yang Y, Wu S, Liu Y, Peng Q, Zheng SC, Crosse EI, Medvinsky A, Anderson RA, Brown H, Yuan Z, Zhou S, Xu Y, Kemp JP, Ho YYW, Loesch DZ, Wang L, Li Y, Tang S, Wu X, Walters RG, Lin K, Meng R, Lv J, Chernus JM, Neiswanger K, Feingold E, Evans DM, Medland SE, Martin NG, Weinberg SM, Marazita ML, Chen G, Chen Z, Zhou Y, Cheeseman M, Wang L, Jin L, Headon DJ, Wang S
Cell 2022 Jan 6;185(1):95-112.e18. doi: 10.1016/j.cell.2021.12.008. PMID: 34995520 Free PMC Article

Impact of NRG1 HapICE gene variants on digit ratio and dermatoglyphic measures in schizophrenia.

Rajasekaran A, Shivakumar V, Kalmady SV, Parlikar R, Chhabra H, Prabhu A, Subbanna M, Venugopal D, Amaresha AC, Agarwal SM, Bose A, Narayanaswamy JC, Debnath M, Venkatasubramanian G
Asian J Psychiatr 2020 Dec;54:102363. Epub 2020 Aug 25 doi: 10.1016/j.ajp.2020.102363. PMID: 33271685

Characterization of dermatoglyphics in PHOX2B-confirmed congenital central hypoventilation syndrome.

Todd ES, Scott NM, Weese-Mayer DE, Weinberg SM, Berry-Kravis EM, Silvestri JM, Kenny AS, Hauptman SA, Zhou L, Marazita ML
Pediatrics 2006 Aug;118(2):e408-14. doi: 10.1542/peds.2005-3134. PMID: 16882781

Genetic diseases in Lebanon.

Der Kaloustian VM, Naffah J, Loiselet J
Am J Med Genet 1980;7(2):187-203. doi: 10.1002/ajmg.1320070212. PMID: 7468647

Palmar crease variants and their clinical significance: a study of newborns at risk.

Dar H, Schmidt R, Nitowsky HM
Pediatr Res 1977 Feb;11(2):103-8. doi: 10.1203/00006450-197702000-00004. PMID: 138837

See all (15)

Diagnosis

Near complete deletion of KMT2D in a college student.

Gooch C, Souder JP, Tedder ML, Kerkhof J, Lee JA, Louie RJ, Sadikovic B, Fletcher RS, Robin NH
Am J Med Genet A 2022 May;188(5):1550-1555. Epub 2022 Jan 18 doi: 10.1002/ajmg.a.62652. PMID: 35040536 Free PMC Article

Palmar Creases: Classification, Reliability and Relationships to Fetal Alcohol Spectrum Disorders (FASD).

Mattison SM, Brunson EK, Holman DJ
Coll Antropol 2015 Sep;39(3):769-74. PMID: 26898079

Mutation spectrum of MLL2 in a cohort of Kabuki syndrome patients.

Micale L, Augello B, Fusco C, Selicorni A, Loviglio MN, Silengo MC, Reymond A, Gumiero B, Zucchetti F, D'Addetta EV, Belligni E, Calcagnì A, Digilio MC, Dallapiccola B, Faravelli F, Forzano F, Accadia M, Bonfante A, Clementi M, Daolio C, Douzgou S, Ferrari P, Fischetto R, Garavelli L, Lapi E, Mattina T, Melis D, Patricelli MG, Priolo M, Prontera P, Renieri A, Mencarelli MA, Scarano G, della Monica M, Toschi B, Turolla L, Vancini A, Zatterale A, Gabrielli O, Zelante L, Merla G
Orphanet J Rare Dis 2011 Jun 9;6:38. doi: 10.1186/1750-1172-6-38. PMID: 21658225 Free PMC Article

Clinical and cytogenetic survey of 39 individuals with Prader-Labhart-Willi syndrome.

Butler MG, Meaney FJ, Palmer CG
Am J Med Genet 1986 Mar;23(3):793-809. doi: 10.1002/ajmg.1320230307. PMID: 3953677 Free PMC Article

Palmar crease variants and their clinical significance: a study of newborns at risk.

Dar H, Schmidt R, Nitowsky HM
Pediatr Res 1977 Feb;11(2):103-8. doi: 10.1203/00006450-197702000-00004. PMID: 138837

See all (22)

Therapy

Clinical report: one year of treatment of Proteus syndrome with miransertib (ARQ 092).

Biesecker LG, Edwards M, O'Donnell S, Doherty P, MacDougall T, Tith K, Kazakin J, Schwartz B
Cold Spring Harb Mol Case Stud 2020 Feb;6(1) Epub 2020 Feb 3 doi: 10.1101/mcs.a004549. PMID: 32014856 Free PMC Article

Proteomic genotyping of fingermark donors with genetically variant peptides.

Borja T, Karim N, Goecker Z, Salemi M, Phinney B, Naeem M, Rice R, Parker G
Forensic Sci Int Genet 2019 Sep;42:21-30. Epub 2019 May 28 doi: 10.1016/j.fsigen.2019.05.005. PMID: 31212206

Palmar Creases: Classification, Reliability and Relationships to Fetal Alcohol Spectrum Disorders (FASD).

Mattison SM, Brunson EK, Holman DJ
Coll Antropol 2015 Sep;39(3):769-74. PMID: 26898079

Digit length ratios predict reactive aggression in women, but not in men.

Benderlioglu Z, Nelson RJ
Horm Behav 2004 Dec;46(5):558-64. doi: 10.1016/j.yhbeh.2004.06.004. PMID: 15555497

Palmar crease variants and their clinical significance: a study of newborns at risk.

Dar H, Schmidt R, Nitowsky HM
Pediatr Res 1977 Feb;11(2):103-8. doi: 10.1203/00006450-197702000-00004. PMID: 138837

See all (6)

Prognosis

Mutation spectrum of MLL2 in a cohort of Kabuki syndrome patients.

Digit length ratios predict reactive aggression in women, but not in men.

Benderlioglu Z, Nelson RJ
Horm Behav 2004 Dec;46(5):558-64. doi: 10.1016/j.yhbeh.2004.06.004. PMID: 15555497

Follow-up study in a patient with Setleis syndrome.

Tsukahara M, Okabe T, Ohtsuka M, Furukawa S
Am J Med Genet 1995 Jul 3;57(3):444-6. doi: 10.1002/ajmg.1320570316. PMID: 7677148

See all (3)

Clinical prediction guides

BRCA1 gene polymorphism and finger dermatoglyphic patterns in Ghanaian breast cancer patients: a quantitative cross-sectional approach.

Nkansah EO, Ahenkorah J, Adutwum-Ofosu K, Adjei RL, Adu-Aryee NA, Tagoe EA, Koney NK, Aryee NA, Hottor BA, Blay RM, Clegg-Lamptey JN, Arko-Boham B
Pan Afr Med J 2022;43:209. Epub 2022 Dec 28 doi: 10.11604/pamj.2022.43.209.33136. PMID: 36942145 Free PMC Article

Palmar Creases: Classification, Reliability and Relationships to Fetal Alcohol Spectrum Disorders (FASD).

Mattison SM, Brunson EK, Holman DJ
Coll Antropol 2015 Sep;39(3):769-74. PMID: 26898079

Mutation spectrum of MLL2 in a cohort of Kabuki syndrome patients.

Clinical and cytogenetic survey of 39 individuals with Prader-Labhart-Willi syndrome.

Butler MG, Meaney FJ, Palmer CG
Am J Med Genet 1986 Mar;23(3):793-809. doi: 10.1002/ajmg.1320230307. PMID: 3953677 Free PMC Article

Palmar crease variants and their clinical significance: a study of newborns at risk.

Dar H, Schmidt R, Nitowsky HM
Pediatr Res 1977 Feb;11(2):103-8. doi: 10.1203/00006450-197702000-00004. PMID: 138837

See all (12)