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Abnormality of glycolysis

MedGen UID:
870873
•Concept ID:
C4025334
•
Finding
HPO: HP:0004366

Definition

An abnormality of glycolysis. [from HPO]

Professional guidelines

PubMed

Pyruvate kinase deficiency: the genotype-phenotype association.
Zanella A, Fermo E, Bianchi P, Chiarelli LR, Valentini G
Blood Rev 2007 Jul;21(4):217-31. Epub 2007 Mar 13 doi: 10.1016/j.blre.2007.01.001. PMID: 17360088

Recent clinical studies

Etiology

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Decorin promotes decidual M1-like macrophage polarization via mitochondrial dysfunction resulting in recurrent pregnancy loss.
Wang L, Wang H, Luo J, Xie T, Mor G, Liao A
Theranostics 2022;12(17):7216-7236. Epub 2022 Oct 17 doi: 10.7150/thno.78467. PMID: 36438479Free PMC Article
Dysfunctional Glucose Metabolism in Alzheimer's Disease Onset and Potential Pharmacological Interventions.
Kumar V, Kim SH, Bishayee K
Int J Mol Sci 2022 Aug 23;23(17) doi: 10.3390/ijms23179540. PMID: 36076944Free PMC Article
Role of long noncoding RNA taurine-upregulated gene 1 in cancers.
Da M, Zhuang J, Zhou Y, Qi Q, Han S
Mol Med 2021 May 26;27(1):51. doi: 10.1186/s10020-021-00312-4. PMID: 34039257Free PMC Article
Pulmonary arterial hypertension: pathogenesis and clinical management.
Thenappan T, Ormiston ML, Ryan JJ, Archer SL
BMJ 2018 Mar 14;360:j5492. doi: 10.1136/bmj.j5492. PMID: 29540357Free PMC Article

Diagnosis

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
ROS/PI3K/Akt and Wnt/β-catenin signalings activate HIF-1α-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer.
Dong S, Liang S, Cheng Z, Zhang X, Luo L, Li L, Zhang W, Li S, Xu Q, Zhong M, Zhu J, Zhang G, Hu S
J Exp Clin Cancer Res 2022 Jan 8;41(1):15. doi: 10.1186/s13046-021-02229-6. PMID: 34998404Free PMC Article
Metabolic Reprogramming of Colorectal Cancer Cells and the Microenvironment: Implication for Therapy.
Nenkov M, Ma Y, Gaßler N, Chen Y
Int J Mol Sci 2021 Jun 10;22(12) doi: 10.3390/ijms22126262. PMID: 34200820Free PMC Article
Role of long noncoding RNA taurine-upregulated gene 1 in cancers.
Da M, Zhuang J, Zhou Y, Qi Q, Han S
Mol Med 2021 May 26;27(1):51. doi: 10.1186/s10020-021-00312-4. PMID: 34039257Free PMC Article
Pulmonary arterial hypertension: pathogenesis and clinical management.
Thenappan T, Ormiston ML, Ryan JJ, Archer SL
BMJ 2018 Mar 14;360:j5492. doi: 10.1136/bmj.j5492. PMID: 29540357Free PMC Article

Therapy

PPM1K-regulated impaired catabolism of branched-chain amino acids orchestrates polycystic ovary syndrome.
Mu L, Ye Z, Hu J, Zhang Y, Chen K, Sun H, Li R, Mao W, Long X, Zhang C, Lai Y, Liu J, Zhao Y, Qiao J
EBioMedicine 2023 Mar;89:104492. Epub 2023 Feb 28 doi: 10.1016/j.ebiom.2023.104492. PMID: 36863088Free PMC Article
Current and future pharmacotherapy options for drug-resistant epilepsy.
Elkommos S, Mula M
Expert Opin Pharmacother 2022 Dec;23(18):2023-2034. Epub 2022 Sep 27 doi: 10.1080/14656566.2022.2128670. PMID: 36154780
ROS/PI3K/Akt and Wnt/β-catenin signalings activate HIF-1α-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer.
Dong S, Liang S, Cheng Z, Zhang X, Luo L, Li L, Zhang W, Li S, Xu Q, Zhong M, Zhu J, Zhang G, Hu S
J Exp Clin Cancer Res 2022 Jan 8;41(1):15. doi: 10.1186/s13046-021-02229-6. PMID: 34998404Free PMC Article
International consensus guidelines for phosphoglucomutase 1 deficiency (PGM1-CDG): Diagnosis, follow-up, and management.
Altassan R, Radenkovic S, Edmondson AC, Barone R, Brasil S, Cechova A, Coman D, Donoghue S, Falkenstein K, Ferreira V, Ferreira C, Fiumara A, Francisco R, Freeze H, Grunewald S, Honzik T, Jaeken J, Krasnewich D, Lam C, Lee J, Lefeber D, Marques-da-Silva D, Pascoal C, Quelhas D, Raymond KM, Rymen D, Seroczynska M, Serrano M, Sykut-Cegielska J, Thiel C, Tort F, Vals MA, Videira P, Voermans N, Witters P, Morava E
J Inherit Metab Dis 2021 Jan;44(1):148-163. Epub 2020 Sep 15 doi: 10.1002/jimd.12286. PMID: 32681750Free PMC Article
Metabolic Reprogramming in Autosomal Dominant Polycystic Kidney Disease: Evidence and Therapeutic Potential.
Nowak KL, Hopp K
Clin J Am Soc Nephrol 2020 Apr 7;15(4):577-584. Epub 2020 Feb 21 doi: 10.2215/CJN.13291019. PMID: 32086281Free PMC Article

Prognosis

Identification of subclusters and prognostic genes based on glycolysis/gluconeogenesis in hepatocellular carcinoma.
Chen D, Aierken A, Li H, Chen R, Ren L, Wang K
Front Immunol 2023;14:1232390. Epub 2023 Oct 10 doi: 10.3389/fimmu.2023.1232390. PMID: 37881434Free PMC Article
Glucose metabolism impairment in Parkinson's disease.
Dai C, Tan C, Zhao L, Liang Y, Liu G, Liu H, Zhong Y, Liu Z, Mo L, Liu X, Chen L
Brain Res Bull 2023 Jul;199:110672. Epub 2023 May 18 doi: 10.1016/j.brainresbull.2023.110672. PMID: 37210012
Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma.
Tong Y, Sun M, Chen L, Wang Y, Li Y, Li L, Zhang X, Cai Y, Qie J, Pang Y, Xu Z, Zhao J, Zhang X, Liu Y, Tian S, Qin Z, Feng J, Zhang F, Zhu J, Xu Y, Lou W, Ji Y, Zhao J, He F, Hou Y, Ding C
J Hematol Oncol 2022 Nov 25;15(1):168. doi: 10.1186/s13045-022-01384-3. PMID: 36434634Free PMC Article
Effects of Glucose Metabolism, Lipid Metabolism, and Glutamine Metabolism on Tumor Microenvironment and Clinical Implications.
Zhu L, Zhu X, Wu Y
Biomolecules 2022 Apr 14;12(4) doi: 10.3390/biom12040580. PMID: 35454171Free PMC Article
ROS/PI3K/Akt and Wnt/β-catenin signalings activate HIF-1α-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer.
Dong S, Liang S, Cheng Z, Zhang X, Luo L, Li L, Zhang W, Li S, Xu Q, Zhong M, Zhu J, Zhang G, Hu S
J Exp Clin Cancer Res 2022 Jan 8;41(1):15. doi: 10.1186/s13046-021-02229-6. PMID: 34998404Free PMC Article

Clinical prediction guides

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Decorin promotes decidual M1-like macrophage polarization via mitochondrial dysfunction resulting in recurrent pregnancy loss.
Wang L, Wang H, Luo J, Xie T, Mor G, Liao A
Theranostics 2022;12(17):7216-7236. Epub 2022 Oct 17 doi: 10.7150/thno.78467. PMID: 36438479Free PMC Article
Revisited Metabolic Control and Reprogramming Cancers by Means of the Warburg Effect in Tumor Cells.
Fukushi A, Kim HD, Chang YC, Kim CH
Int J Mol Sci 2022 Sep 2;23(17) doi: 10.3390/ijms231710037. PMID: 36077431Free PMC Article
Dysfunctional Glucose Metabolism in Alzheimer's Disease Onset and Potential Pharmacological Interventions.
Kumar V, Kim SH, Bishayee K
Int J Mol Sci 2022 Aug 23;23(17) doi: 10.3390/ijms23179540. PMID: 36076944Free PMC Article
Transketolase: observations in alcohol-related brain damage research.
Alexander-Kaufman K, Harper C
Int J Biochem Cell Biol 2009 Apr;41(4):717-20. Epub 2008 Apr 8 doi: 10.1016/j.biocel.2008.04.005. PMID: 18490188

Recent systematic reviews

Brain lactate and pH in schizophrenia and bipolar disorder: a systematic review of findings from magnetic resonance studies.
Dogan AE, Yuksel C, Du F, Chouinard VA, Öngür D
Neuropsychopharmacology 2018 Jul;43(8):1681-1690. Epub 2018 Mar 14 doi: 10.1038/s41386-018-0041-9. PMID: 29581538Free PMC Article
The prognostic value of GLUT1 in cancers: a systematic review and meta-analysis.
Yu M, Yongzhi H, Chen S, Luo X, Lin Y, Zhou Y, Jin H, Hou B, Deng Y, Tu L, Jian Z
Oncotarget 2017 Jun 27;8(26):43356-43367. doi: 10.18632/oncotarget.17445. PMID: 28498810Free PMC Article

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