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Abnormality of glycolysis

MedGen UID:
870873
•Concept ID:
C4025334
•
Finding
HPO: HP:0004366

Definition

An abnormality of glycolysis. [from HPO]

Professional guidelines

PubMed

Pyruvate kinase deficiency: the genotype-phenotype association.
Zanella A, Fermo E, Bianchi P, Chiarelli LR, Valentini G
Blood Rev 2007 Jul;21(4):217-31. Epub 2007 Mar 13 doi: 10.1016/j.blre.2007.01.001. PMID: 17360088

Recent clinical studies

Etiology

PPM1K-regulated impaired catabolism of branched-chain amino acids orchestrates polycystic ovary syndrome.
Mu L, Ye Z, Hu J, Zhang Y, Chen K, Sun H, Li R, Mao W, Long X, Zhang C, Lai Y, Liu J, Zhao Y, Qiao J
EBioMedicine 2023 Mar;89:104492. Epub 2023 Feb 28 doi: 10.1016/j.ebiom.2023.104492. PMID: 36863088Free PMC Article
Decorin promotes decidual M1-like macrophage polarization via mitochondrial dysfunction resulting in recurrent pregnancy loss.
Wang L, Wang H, Luo J, Xie T, Mor G, Liao A
Theranostics 2022;12(17):7216-7236. Epub 2022 Oct 17 doi: 10.7150/thno.78467. PMID: 36438479Free PMC Article
Metabolic Control of Autoimmunity and Tissue Inflammation in Rheumatoid Arthritis.
Qiu J, Wu B, Goodman SB, Berry GJ, Goronzy JJ, Weyand CM
Front Immunol 2021;12:652771. Epub 2021 Apr 2 doi: 10.3389/fimmu.2021.652771. PMID: 33868292Free PMC Article
Pulmonary arterial hypertension: pathogenesis and clinical management.
Thenappan T, Ormiston ML, Ryan JJ, Archer SL
BMJ 2018 Mar 14;360:j5492. doi: 10.1136/bmj.j5492. PMID: 29540357Free PMC Article
Evidence for brain glucose dysregulation in Alzheimer's disease.
An Y, Varma VR, Varma S, Casanova R, Dammer E, Pletnikova O, Chia CW, Egan JM, Ferrucci L, Troncoso J, Levey AI, Lah J, Seyfried NT, Legido-Quigley C, O'Brien R, Thambisetty M
Alzheimers Dement 2018 Mar;14(3):318-329. Epub 2017 Oct 19 doi: 10.1016/j.jalz.2017.09.011. PMID: 29055815Free PMC Article

Diagnosis

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
ROS/PI3K/Akt and Wnt/β-catenin signalings activate HIF-1α-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer.
Dong S, Liang S, Cheng Z, Zhang X, Luo L, Li L, Zhang W, Li S, Xu Q, Zhong M, Zhu J, Zhang G, Hu S
J Exp Clin Cancer Res 2022 Jan 8;41(1):15. doi: 10.1186/s13046-021-02229-6. PMID: 34998404Free PMC Article
Metabolic Reprogramming of Colorectal Cancer Cells and the Microenvironment: Implication for Therapy.
Nenkov M, Ma Y, Gaßler N, Chen Y
Int J Mol Sci 2021 Jun 10;22(12) doi: 10.3390/ijms22126262. PMID: 34200820Free PMC Article
International consensus guidelines for phosphoglucomutase 1 deficiency (PGM1-CDG): Diagnosis, follow-up, and management.
Altassan R, Radenkovic S, Edmondson AC, Barone R, Brasil S, Cechova A, Coman D, Donoghue S, Falkenstein K, Ferreira V, Ferreira C, Fiumara A, Francisco R, Freeze H, Grunewald S, Honzik T, Jaeken J, Krasnewich D, Lam C, Lee J, Lefeber D, Marques-da-Silva D, Pascoal C, Quelhas D, Raymond KM, Rymen D, Seroczynska M, Serrano M, Sykut-Cegielska J, Thiel C, Tort F, Vals MA, Videira P, Voermans N, Witters P, Morava E
J Inherit Metab Dis 2021 Jan;44(1):148-163. Epub 2020 Sep 15 doi: 10.1002/jimd.12286. PMID: 32681750Free PMC Article
Pulmonary arterial hypertension: pathogenesis and clinical management.
Thenappan T, Ormiston ML, Ryan JJ, Archer SL
BMJ 2018 Mar 14;360:j5492. doi: 10.1136/bmj.j5492. PMID: 29540357Free PMC Article

Therapy

PPM1K-regulated impaired catabolism of branched-chain amino acids orchestrates polycystic ovary syndrome.
Mu L, Ye Z, Hu J, Zhang Y, Chen K, Sun H, Li R, Mao W, Long X, Zhang C, Lai Y, Liu J, Zhao Y, Qiao J
EBioMedicine 2023 Mar;89:104492. Epub 2023 Feb 28 doi: 10.1016/j.ebiom.2023.104492. PMID: 36863088Free PMC Article
Current and future pharmacotherapy options for drug-resistant epilepsy.
Elkommos S, Mula M
Expert Opin Pharmacother 2022 Dec;23(18):2023-2034. Epub 2022 Sep 27 doi: 10.1080/14656566.2022.2128670. PMID: 36154780
ROS/PI3K/Akt and Wnt/β-catenin signalings activate HIF-1α-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer.
Dong S, Liang S, Cheng Z, Zhang X, Luo L, Li L, Zhang W, Li S, Xu Q, Zhong M, Zhu J, Zhang G, Hu S
J Exp Clin Cancer Res 2022 Jan 8;41(1):15. doi: 10.1186/s13046-021-02229-6. PMID: 34998404Free PMC Article
International consensus guidelines for phosphoglucomutase 1 deficiency (PGM1-CDG): Diagnosis, follow-up, and management.
Altassan R, Radenkovic S, Edmondson AC, Barone R, Brasil S, Cechova A, Coman D, Donoghue S, Falkenstein K, Ferreira V, Ferreira C, Fiumara A, Francisco R, Freeze H, Grunewald S, Honzik T, Jaeken J, Krasnewich D, Lam C, Lee J, Lefeber D, Marques-da-Silva D, Pascoal C, Quelhas D, Raymond KM, Rymen D, Seroczynska M, Serrano M, Sykut-Cegielska J, Thiel C, Tort F, Vals MA, Videira P, Voermans N, Witters P, Morava E
J Inherit Metab Dis 2021 Jan;44(1):148-163. Epub 2020 Sep 15 doi: 10.1002/jimd.12286. PMID: 32681750Free PMC Article
Glycolysis inhibition for anticancer treatment.
Pelicano H, Martin DS, Xu RH, Huang P
Oncogene 2006 Aug 7;25(34):4633-46. doi: 10.1038/sj.onc.1209597. PMID: 16892078

Prognosis

Glucose metabolism impairment in Parkinson's disease.
Dai C, Tan C, Zhao L, Liang Y, Liu G, Liu H, Zhong Y, Liu Z, Mo L, Liu X, Chen L
Brain Res Bull 2023 Jul;199:110672. Epub 2023 May 18 doi: 10.1016/j.brainresbull.2023.110672. PMID: 37210012
Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma.
Tong Y, Sun M, Chen L, Wang Y, Li Y, Li L, Zhang X, Cai Y, Qie J, Pang Y, Xu Z, Zhao J, Zhang X, Liu Y, Tian S, Qin Z, Feng J, Zhang F, Zhu J, Xu Y, Lou W, Ji Y, Zhao J, He F, Hou Y, Ding C
J Hematol Oncol 2022 Nov 25;15(1):168. doi: 10.1186/s13045-022-01384-3. PMID: 36434634Free PMC Article
Effects of Glucose Metabolism, Lipid Metabolism, and Glutamine Metabolism on Tumor Microenvironment and Clinical Implications.
Zhu L, Zhu X, Wu Y
Biomolecules 2022 Apr 14;12(4) doi: 10.3390/biom12040580. PMID: 35454171Free PMC Article
ROS/PI3K/Akt and Wnt/β-catenin signalings activate HIF-1α-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer.
Dong S, Liang S, Cheng Z, Zhang X, Luo L, Li L, Zhang W, Li S, Xu Q, Zhong M, Zhu J, Zhang G, Hu S
J Exp Clin Cancer Res 2022 Jan 8;41(1):15. doi: 10.1186/s13046-021-02229-6. PMID: 34998404Free PMC Article
BZW1 Facilitates Glycolysis and Promotes Tumor Growth in Pancreatic Ductal Adenocarcinoma Through Potentiating eIF2α Phosphorylation.
Li Z, Ge Y, Dong J, Wang H, Zhao T, Wang X, Liu J, Gao S, Shi L, Yang S, Huang C, Hao J
Gastroenterology 2022 Apr;162(4):1256-1271.e14. Epub 2021 Dec 21 doi: 10.1053/j.gastro.2021.12.249. PMID: 34951995Free PMC Article

Clinical prediction guides

Umbilical cord pH, blood gases, and lactate at birth: normal values, interpretation, and clinical utility.
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Decorin promotes decidual M1-like macrophage polarization via mitochondrial dysfunction resulting in recurrent pregnancy loss.
Wang L, Wang H, Luo J, Xie T, Mor G, Liao A
Theranostics 2022;12(17):7216-7236. Epub 2022 Oct 17 doi: 10.7150/thno.78467. PMID: 36438479Free PMC Article
Revisited Metabolic Control and Reprogramming Cancers by Means of the Warburg Effect in Tumor Cells.
Fukushi A, Kim HD, Chang YC, Kim CH
Int J Mol Sci 2022 Sep 2;23(17) doi: 10.3390/ijms231710037. PMID: 36077431Free PMC Article
Endothelium-derived lactate is required for pericyte function and blood-brain barrier maintenance.
Lee HW, Xu Y, Zhu X, Jang C, Choi W, Bae H, Wang W, He L, Jin SW, Arany Z, Simons M
EMBO J 2022 May 2;41(9):e109890. Epub 2022 Mar 3 doi: 10.15252/embj.2021109890. PMID: 35243676Free PMC Article
Low chorionic villous succinate accumulation associates with recurrent spontaneous abortion risk.
Wang XH, Xu S, Zhou XY, Zhao R, Lin Y, Cao J, Zang WD, Tao H, Xu W, Li MQ, Zhao SM, Jin LP, Zhao JY
Nat Commun 2021 Jun 8;12(1):3428. doi: 10.1038/s41467-021-23827-0. PMID: 34103526Free PMC Article

Recent systematic reviews

Brain lactate and pH in schizophrenia and bipolar disorder: a systematic review of findings from magnetic resonance studies.
Dogan AE, Yuksel C, Du F, Chouinard VA, Öngür D
Neuropsychopharmacology 2018 Jul;43(8):1681-1690. Epub 2018 Mar 14 doi: 10.1038/s41386-018-0041-9. PMID: 29581538Free PMC Article
The prognostic value of GLUT1 in cancers: a systematic review and meta-analysis.
Yu M, Yongzhi H, Chen S, Luo X, Lin Y, Zhou Y, Jin H, Hou B, Deng Y, Tu L, Jian Z
Oncotarget 2017 Jun 27;8(26):43356-43367. doi: 10.18632/oncotarget.17445. PMID: 28498810Free PMC Article

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