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Abnormality of the knee

MedGen UID:
871199
Concept ID:
C4025676
Anatomical Abnormality
HPO: HP:0002815

Definition

An abnormality of the knee joint or surrounding structures. [from HPO]

Conditions with this feature

Popliteal cyst
MedGen UID:
10853
Concept ID:
C0032650
Anatomical Abnormality
A fluid-filled mass that is a distention of a preexisting bursa in the popliteal fossa, most commonly the gastrocnemio-semimembranosus bursa. This bursa is unique in that it communicates with the knee joint, unlike other periarticular bursae, via an opening in the joint capsule posterior to the medial femoral condyle.
Epiphyseal dysplasia, multiple, 6
MedGen UID:
436517
Concept ID:
C2675767
Disease or Syndrome
Autosomal dominant multiple epiphyseal dysplasia (MED) presents in early childhood, usually with pain in the hips and/or knees after exercise. Affected children complain of fatigue with long-distance walking. Waddling gait may be present. Adult height is either in the lower range of normal or mildly shortened. The limbs are relatively short in comparison to the trunk. Pain and joint deformity progress, resulting in early-onset osteoarthritis, particularly of the large weight-bearing joints.

Professional guidelines

PubMed

Ochi J, Nozaki T, Nimura A, Yamaguchi T, Kitamura N
Jpn J Radiol 2022 May;40(5):443-457. Epub 2021 Nov 29 doi: 10.1007/s11604-021-01224-3. PMID: 34843043Free PMC Article
Kushare I, Klingele K, Samora W
Orthop Clin North Am 2015 Oct;46(4):533-40. Epub 2015 Aug 6 doi: 10.1016/j.ocl.2015.06.007. PMID: 26410641
Dragoo JL, Johnson C, McConnell J
Sports Med 2012 Jan 1;42(1):51-67. doi: 10.2165/11595680-000000000-00000. PMID: 22149697

Recent clinical studies

Etiology

Aksoy T, Bakircioglu S, Ozdemir E, Ramazanov R, Aksoy MC, Yilmaz G
J Pediatr Orthop 2023 Aug 1;43(7):e567-e573. Epub 2023 May 10 doi: 10.1097/BPO.0000000000002429. PMID: 37168006
Boonjindasup W, Marchant JM, McElrea MS, Yerkovich ST, Thomas RJ, Masters IB, Chang AB
Respir Med 2022 Nov-Dec;204:107029. Epub 2022 Oct 29 doi: 10.1016/j.rmed.2022.107029. PMID: 36335911
Silva MS, Fernandes ARC, Cardoso FN, Longo CH, Aihara AY
Radiographics 2019 May-Jun;39(3):779-794. doi: 10.1148/rg.2019180101. PMID: 31059403
Sculco PK, Kahlenberg CA, Fragomen AT, Rozbruch SR
J Am Acad Orthop Surg 2019 Sep 15;27(18):e819-e830. doi: 10.5435/JAAOS-D-18-00361. PMID: 30624304
Dupuis CS, Westra SJ, Makris J, Wallace EC
Radiographics 2009 May-Jun;29(3):877-86. doi: 10.1148/rg.293085163. PMID: 19448122

Diagnosis

Davies WT, Myer GD, Read PJ
Sports Med 2020 Mar;50(3):485-495. doi: 10.1007/s40279-019-01221-7. PMID: 31745732Free PMC Article
Gorbachova T, Melenevsky Y, Cohen M, Cerniglia BW
Radiographics 2018 Sep-Oct;38(5):1478-1495. Epub 2018 Aug 17 doi: 10.1148/rg.2018180044. PMID: 30118392
Accadbled F, Vial J, Sales de Gauzy J
Orthop Traumatol Surg Res 2018 Feb;104(1S):S97-S105. Epub 2017 Nov 29 doi: 10.1016/j.otsr.2017.02.016. PMID: 29197636
Orth RC
Pediatr Radiol 2013 Mar;43 Suppl 1:S90-8. Epub 2013 Mar 12 doi: 10.1007/s00247-012-2601-1. PMID: 23478924
Peterfy CG, Guermazi A, Zaim S, Tirman PF, Miaux Y, White D, Kothari M, Lu Y, Fye K, Zhao S, Genant HK
Osteoarthritis Cartilage 2004 Mar;12(3):177-90. doi: 10.1016/j.joca.2003.11.003. PMID: 14972335

Therapy

Ghazi Zadeh L, Chevrier A, Farr J, Rodeo SA, Buschmann MD
J Knee Surg 2018 Jan;31(1):99-116. Epub 2017 May 2 doi: 10.1055/s-0037-1602247. PMID: 28464195
Uquillas C, Rossy W, Strauss E
Bull Hosp Jt Dis (2013) 2017 Jan;75(1):81-87. PMID: 28236624
Kan SL, Li Y, Ning GZ, Yuan ZF, Chen LX, Bi MC, Sun JC, Feng SQ
PLoS One 2016;11(6):e0157105. Epub 2016 Jun 13 doi: 10.1371/journal.pone.0157105. PMID: 27294371Free PMC Article
Scott D, Kowalczyk A
BMJ Clin Evid 2007 Sep 1;2007 PMID: 19450299Free PMC Article
Zizic TM
Curr Opin Rheumatol 1991 Jun;3(3):481-9. doi: 10.1097/00002281-199106000-00023. PMID: 1883703

Prognosis

Aksoy T, Bakircioglu S, Ozdemir E, Ramazanov R, Aksoy MC, Yilmaz G
J Pediatr Orthop 2023 Aug 1;43(7):e567-e573. Epub 2023 May 10 doi: 10.1097/BPO.0000000000002429. PMID: 37168006
Russo A, Capasso R, Varelli C, Laporta A, Carbone M, D'Agosto G, Giovine S, Zappia M, Reginelli A
Musculoskelet Surg 2017 Mar;101(Suppl 1):37-42. Epub 2017 Feb 16 doi: 10.1007/s12306-017-0454-3. PMID: 28210945
Duthon VB
Orthop Traumatol Surg Res 2015 Feb;101(1 Suppl):S59-67. Epub 2015 Jan 12 doi: 10.1016/j.otsr.2014.12.001. PMID: 25592052
Hang JF, Chen PC
Arch Pathol Lab Med 2014 May;138(5):694-9. doi: 10.5858/arpa.2013-0030-RS. PMID: 24786129
Zizic TM
Curr Opin Rheumatol 1991 Jun;3(3):481-9. doi: 10.1097/00002281-199106000-00023. PMID: 1883703

Clinical prediction guides

Boonjindasup W, Marchant JM, McElrea MS, Yerkovich ST, Thomas RJ, Masters IB, Chang AB
Pediatr Pulmonol 2022 Oct;57(10):2437-2444. Epub 2022 Jul 18 doi: 10.1002/ppul.26054. PMID: 35785487Free PMC Article
Shen QJ, Zhang JL, Xing GS, Liu ZY, Li EQ, Zhao BC, Zheng YC, Cao Q, Zhang T
Orthop Surg 2019 Dec;11(6):1029-1038. Epub 2019 Nov 6 doi: 10.1111/os.12544. PMID: 31693310Free PMC Article
Russo A, Capasso R, Varelli C, Laporta A, Carbone M, D'Agosto G, Giovine S, Zappia M, Reginelli A
Musculoskelet Surg 2017 Mar;101(Suppl 1):37-42. Epub 2017 Feb 16 doi: 10.1007/s12306-017-0454-3. PMID: 28210945
Faruch Bilfeld M, Lapègue F, Brun C, Bakouche S, Cambon Z, Brucher N, Chiavassa Gandois H, Larbi A, Sans N
Diagn Interv Imaging 2016 Jul-Aug;97(7-8):779-88. Epub 2016 Mar 24 doi: 10.1016/j.diii.2016.02.011. PMID: 27017094
Peterfy CG, Guermazi A, Zaim S, Tirman PF, Miaux Y, White D, Kothari M, Lu Y, Fye K, Zhao S, Genant HK
Osteoarthritis Cartilage 2004 Mar;12(3):177-90. doi: 10.1016/j.joca.2003.11.003. PMID: 14972335

Recent systematic reviews

Dwan K, Kirkham J, Paton RW, Morley E, Newton AW, Perry DC
Cochrane Database Syst Rev 2022 Oct 10;10(10):CD012717. doi: 10.1002/14651858.CD012717.pub2. PMID: 36214650Free PMC Article
Burssens A, De Roos D, Barg A, Welck MJ, Krähenbühl N, Saltzman CL, Victor J
Bone Joint J 2021 Jan;103-B(1):87-97. doi: 10.1302/0301-620X.103B1.BJJ-2020-0143.R1. PMID: 33380206
Shabtai L, Herzenberg JE
J Am Acad Orthop Surg 2016 Oct;24(10):691-701. doi: 10.5435/JAAOS-D-14-00234. PMID: 27564792
Papalia R, Franceschi F, Zampogna B, Tecame A, Maffulli N, Denaro V
Knee Surg Sports Traumatol Arthrosc 2014 Jan;22(1):154-65. Epub 2012 Dec 23 doi: 10.1007/s00167-012-2339-1. PMID: 23263259
Scott D, Kowalczyk A
BMJ Clin Evid 2007 Sep 1;2007 PMID: 19450299Free PMC Article

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