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Nasal mucosa telangiectasia

MedGen UID:
871359
Concept ID:
C4025853
Finding
Synonyms: Angioectasia of mucosa of nose; Angioectasia of mucous membrane of nose; Angioectasia of nasal mucous membrane; Nasal mucous membrane telangiectasia; Spider veins of mucosa of nose; Spider veins of mucous membrane of nose; Spider veins of nasal mucous membrane; Telangiectasia of mucosa of nose; Telangiectasia of mucous membrane of nose; Telangiectasia of nasal mucous membrane
 
HPO: HP:0000434

Definition

Telangiectasia of the nasal mucosa. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNasal mucosa telangiectasia

Conditions with this feature

Telangiectasia, hereditary hemorrhagic, type 2
MedGen UID:
324960
Concept ID:
C1838163
Disease or Syndrome
Hereditary hemorrhagic telangiectasia (HHT) is characterized by the presence of multiple arteriovenous malformations (AVMs) that lack intervening capillaries and result in direct connections between arteries and veins. The most common clinical manifestation is spontaneous and recurrent nosebleeds (epistaxis) beginning on average at age 12 years. Telangiectases (small AVMs) are characteristically found on the lips, tongue, buccal and gastrointestinal (GI) mucosa, face, and fingers. The appearance of telangiectases is generally later than epistaxis but may be during childhood. Large AVMs occur most often in the lungs, liver, or brain; complications from bleeding or shunting may be sudden and catastrophic. A minority of individuals with HHT have GI bleeding, which is rarely seen before age 50 years.
Hereditary hemorrhagic telangiectasia type 4
MedGen UID:
341824
Concept ID:
C1857688
Disease or Syndrome
Hereditary hemorrhagic telangiectasia (HHT) is characterized by the presence of multiple arteriovenous malformations (AVMs) that lack intervening capillaries and result in direct connections between arteries and veins. The most common clinical manifestation is spontaneous and recurrent nosebleeds (epistaxis) beginning on average at age 12 years. Telangiectases (small AVMs) are characteristically found on the lips, tongue, buccal and gastrointestinal (GI) mucosa, face, and fingers. The appearance of telangiectases is generally later than epistaxis but may be during childhood. Large AVMs occur most often in the lungs, liver, or brain; complications from bleeding or shunting may be sudden and catastrophic. A minority of individuals with HHT have GI bleeding, which is rarely seen before age 50 years.
Telangiectasia, hereditary hemorrhagic, type 1
MedGen UID:
1643786
Concept ID:
C4551861
Disease or Syndrome
Hereditary hemorrhagic telangiectasia (HHT) is characterized by the presence of multiple arteriovenous malformations (AVMs) that lack intervening capillaries and result in direct connections between arteries and veins. The most common clinical manifestation is spontaneous and recurrent nosebleeds (epistaxis) beginning on average at age 12 years. Telangiectases (small AVMs) are characteristically found on the lips, tongue, buccal and gastrointestinal (GI) mucosa, face, and fingers. The appearance of telangiectases is generally later than epistaxis but may be during childhood. Large AVMs occur most often in the lungs, liver, or brain; complications from bleeding or shunting may be sudden and catastrophic. A minority of individuals with HHT have GI bleeding, which is rarely seen before age 50 years.

Professional guidelines

PubMed

Krajina A, Chrobok V
Cardiovasc Intervent Radiol 2014 Feb;37(1):26-36. doi: 10.1007/s00270-013-0776-y. PMID: 24232035Free PMC Article
McDonald J, Bayrak-Toydemir P, Pyeritz RE
Genet Med 2011 Jul;13(7):607-16. doi: 10.1097/GIM.0b013e3182136d32. PMID: 21546842
Zarrabeitia R, Albiñana V, Salcedo M, Señaris-Gonzalez B, Fernandez-Forcelledo JL, Botella LM
Curr Vasc Pharmacol 2010 Jul;8(4):473-81. doi: 10.2174/157016110791330771. PMID: 19485912

Recent clinical studies

Etiology

Gonzalez J, Bryant S, Hermes-DeSantis ER
Am J Health Syst Pharm 2018 May 1;75(9):e177-e183. doi: 10.2146/ajhp170241. PMID: 29691259
Eivazi B, Werner JA, Roessler M, Negm H, Teymoortash A
Acta Otolaryngol 2012 Jan;132(1):86-9. Epub 2011 Nov 6 doi: 10.3109/00016489.2011.621145. PMID: 22185213
Zarrabeitia R, Albiñana V, Salcedo M, Señaris-Gonzalez B, Fernandez-Forcelledo JL, Botella LM
Curr Vasc Pharmacol 2010 Jul;8(4):473-81. doi: 10.2174/157016110791330771. PMID: 19485912
Folz BJ, Wollstein AC, Lippert BM, Werner JA
Am J Rhinol 2005 Jan-Feb;19(1):65-70. PMID: 15794077
Sadick H, Naim R, Oulmi J, Hörmann K, Bergler W
Otolaryngol Head Neck Surg 2003 Sep;129(3):233-8. doi: 10.1016/S0194-5998(03)00361-9. PMID: 12958572

Diagnosis

Hetts SW, Shieh JT, Ohliger MA, Conrad MB
Radiology 2021 Jul;300(1):17-30. Epub 2021 May 11 doi: 10.1148/radiol.2021203487. PMID: 33973836
Krajina A, Chrobok V
Cardiovasc Intervent Radiol 2014 Feb;37(1):26-36. doi: 10.1007/s00270-013-0776-y. PMID: 24232035Free PMC Article
Ozcan KM, Ozdaş T, Baran H, Ozdogan F, Dere H
Int J Pediatr Otorhinolaryngol 2013 Jan;77(1):137-8. Epub 2012 Oct 4 doi: 10.1016/j.ijporl.2012.09.020. PMID: 23040961
McDonald J, Bayrak-Toydemir P, Pyeritz RE
Genet Med 2011 Jul;13(7):607-16. doi: 10.1097/GIM.0b013e3182136d32. PMID: 21546842
Sharathkumar AA, Shapiro A
Haemophilia 2008 Nov;14(6):1269-80. doi: 10.1111/j.1365-2516.2008.01774.x. PMID: 19141168

Therapy

Krezdorn N, Lian CG, Wells M, Wo L, Tasigiorgos S, Xu S, Borges TJ, Frierson RM, Stanek E, Riella LV, Pomahac B, Murphy GF
Am J Transplant 2019 Apr;19(4):1168-1177. Epub 2018 Nov 10 doi: 10.1111/ajt.15143. PMID: 30312535Free PMC Article
Gonzalez J, Bryant S, Hermes-DeSantis ER
Am J Health Syst Pharm 2018 May 1;75(9):e177-e183. doi: 10.2146/ajhp170241. PMID: 29691259
Eivazi B, Werner JA, Roessler M, Negm H, Teymoortash A
Acta Otolaryngol 2012 Jan;132(1):86-9. Epub 2011 Nov 6 doi: 10.3109/00016489.2011.621145. PMID: 22185213
Davidson TM, Olitsky SE, Wei JL
Laryngoscope 2010 Feb;120(2):432-5. doi: 10.1002/lary.20757. PMID: 19998344
Sadick H, Naim R, Oulmi J, Hörmann K, Bergler W
Otolaryngol Head Neck Surg 2003 Sep;129(3):233-8. doi: 10.1016/S0194-5998(03)00361-9. PMID: 12958572

Prognosis

Al Kadah B, Papaspyrou G, Schneider M, Schick B
Eur Arch Otorhinolaryngol 2015 Jan;272(1):117-22. Epub 2014 May 23 doi: 10.1007/s00405-014-3086-3. PMID: 24854232
Stoddard T, Loehrl TA, Hunt BC, Poetker DM
JAMA Otolaryngol Head Neck Surg 2014 Feb;140(2):160-3. doi: 10.1001/jamaoto.2013.5991. PMID: 24337437
Eivazi B, Werner JA, Roessler M, Negm H, Teymoortash A
Acta Otolaryngol 2012 Jan;132(1):86-9. Epub 2011 Nov 6 doi: 10.3109/00016489.2011.621145. PMID: 22185213
Folz BJ, Wollstein AC, Lippert BM, Werner JA
Am J Rhinol 2005 Jan-Feb;19(1):65-70. PMID: 15794077
Sadick H, Naim R, Oulmi J, Hörmann K, Bergler W
Otolaryngol Head Neck Surg 2003 Sep;129(3):233-8. doi: 10.1016/S0194-5998(03)00361-9. PMID: 12958572

Clinical prediction guides

Gallardo-Vara E, Ruiz-Llorente L, Casado-Vela J, Ruiz-Rodríguez MJ, López-Andrés N, Pattnaik AK, Quintanilla M, Bernabeu C
Cells 2019 Sep 13;8(9) doi: 10.3390/cells8091082. PMID: 31540324Free PMC Article
Chao C, Tong L
Optom Vis Sci 2018 Oct;95(10):930-936. doi: 10.1097/OPX.0000000000001285. PMID: 30234832
Stoddard T, Loehrl TA, Hunt BC, Poetker DM
JAMA Otolaryngol Head Neck Surg 2014 Feb;140(2):160-3. doi: 10.1001/jamaoto.2013.5991. PMID: 24337437
Eivazi B, Werner JA, Roessler M, Negm H, Teymoortash A
Acta Otolaryngol 2012 Jan;132(1):86-9. Epub 2011 Nov 6 doi: 10.3109/00016489.2011.621145. PMID: 22185213
Sadick H, Naim R, Oulmi J, Hörmann K, Bergler W
Otolaryngol Head Neck Surg 2003 Sep;129(3):233-8. doi: 10.1016/S0194-5998(03)00361-9. PMID: 12958572

Recent systematic reviews

Zarrabeitia R, Albiñana V, Salcedo M, Señaris-Gonzalez B, Fernandez-Forcelledo JL, Botella LM
Curr Vasc Pharmacol 2010 Jul;8(4):473-81. doi: 10.2174/157016110791330771. PMID: 19485912

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