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Urethral atresia, male

MedGen UID:
871396
•Concept ID:
C4025894
•
Congenital Abnormality
HPO: HP:0000052

Definition

Congenital anomaly characterized by closure or failure to develop an opening in the urethra in males. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUrethral atresia, male

Professional guidelines

PubMed

Definition, diagnosis and management of fetal lower urinary tract obstruction: consensus of the ERKNet CAKUT-Obstructive Uropathy Work Group.
Capone V, Persico N, Berrettini A, Decramer S, De Marco EA, De Palma D, Familiari A, Feitz W, Herthelius M, Kazlauskas V, Liebau M, Manzoni G, Maternik M, Mosiello G, Schanstra JP, Vande Walle J, Wühl E, Ylinen E, Zurowska A, Schaefer F, Montini G
Nat Rev Urol 2022 May;19(5):295-303. Epub 2022 Feb 8 doi: 10.1038/s41585-022-00563-8. PMID: 35136187
The genetic factors contributing to hypospadias and their clinical utility in its diagnosis.
Joodi M, Amerizadeh F, Hassanian SM, Erfani M, Ghayour-Mobarhan M, Ferns GA, Khazaei M, Avan A
J Cell Physiol 2019 May;234(5):5519-5523. Epub 2018 Sep 21 doi: 10.1002/jcp.27350. PMID: 30238986
Dysuria: Evaluation and Differential Diagnosis in Adults.
Michels TC, Sands JE
Am Fam Physician 2015 Nov 1;92(9):778-86. PMID: 26554471

Recent clinical studies

Etiology

Spectrum and classification of megameatus anomalies.
Baky Fahmy MA, Shebl SE, Gad D, Othman D, Elsadek M
Int J Urol 2023 Jun;30(6):526-531. Epub 2023 Mar 5 doi: 10.1111/iju.15173. PMID: 36872075
Congenital anterior urethral valves and diverticula.
Rawat J, Singh S, Pandey A, Singh S
J Pediatr Surg 2023 Feb;58(2):263-265. Epub 2022 Oct 21 doi: 10.1016/j.jpedsurg.2022.10.036. PMID: 36376124
Recurrent chordee in 59 adolescents and young adults following childhood hypospadias repair.
Abosena W, Talab SS, Hanna MK
J Pediatr Urol 2020 Apr;16(2):162.e1-162.e5. Epub 2019 Dec 2 doi: 10.1016/j.jpurol.2019.11.013. PMID: 31974021
Syringocele: a retrospective study and review of the literature.
Sørensen FE, Skott M, Rawashdeh YF, Kirkeby HJ
Scand J Urol 2019 Oct;53(5):269-274. Epub 2019 Aug 14 doi: 10.1080/21681805.2019.1649719. PMID: 31411088
Hypospadias, all there is to know.
van der Horst HJ, de Wall LL
Eur J Pediatr 2017 Apr;176(4):435-441. Epub 2017 Feb 11 doi: 10.1007/s00431-017-2864-5. PMID: 28190103Free PMC Article

Diagnosis

Hypospadias.
Mole RJ, Nash S, MacKenzie DN
BMJ 2020 Jun 17;369:m2070. doi: 10.1136/bmj.m2070. PMID: 32554436
Hypospadias, all there is to know.
van der Horst HJ, de Wall LL
Eur J Pediatr 2017 Apr;176(4):435-441. Epub 2017 Feb 11 doi: 10.1007/s00431-017-2864-5. PMID: 28190103Free PMC Article
Posterior urethral valve.
Nasir AA, Ameh EA, Abdur-Rahman LO, Adeniran JO, Abraham MK
World J Pediatr 2011 Aug;7(3):205-16. Epub 2011 Aug 7 doi: 10.1007/s12519-011-0289-1. PMID: 21822988
Posterior urethral valves.
Hodges SJ, Patel B, McLorie G, Atala A
ScientificWorldJournal 2009 Oct 14;9:1119-26. doi: 10.1100/tsw.2009.127. PMID: 19838598Free PMC Article
Posterior urethral valves.
Manzoni C, Valentini AL
Rays 2002 Apr-Jun;27(2):131-4. PMID: 12696266

Therapy

Definition, diagnosis and management of fetal lower urinary tract obstruction: consensus of the ERKNet CAKUT-Obstructive Uropathy Work Group.
Capone V, Persico N, Berrettini A, Decramer S, De Marco EA, De Palma D, Familiari A, Feitz W, Herthelius M, Kazlauskas V, Liebau M, Manzoni G, Maternik M, Mosiello G, Schanstra JP, Vande Walle J, Wühl E, Ylinen E, Zurowska A, Schaefer F, Montini G
Nat Rev Urol 2022 May;19(5):295-303. Epub 2022 Feb 8 doi: 10.1038/s41585-022-00563-8. PMID: 35136187
Congenital urinary tract obstruction.
Cheung KW, Morris RK, Kilby MD
Best Pract Res Clin Obstet Gynaecol 2019 Jul;58:78-92. Epub 2019 Jan 11 doi: 10.1016/j.bpobgyn.2019.01.003. PMID: 30819578
Hypospadias.
Macedo A Jr, Rondon A, Ortiz V
Curr Opin Urol 2012 Nov;22(6):447-52. doi: 10.1097/MOU.0b013e328357bc62. PMID: 23026892
The vesical calculus.
Schwartz BF, Stoller ML
Urol Clin North Am 2000 May;27(2):333-46. doi: 10.1016/s0094-0143(05)70262-7. PMID: 10778475
Incontinence.
Edwards LE
Practitioner 1975 Jan;214(1279):46-55. PMID: 1096112

Prognosis

Caudal duplication syndrome: 10-year experiences with a comprehensive literature review.
Wang K, Yang L, Peng C, Pang W, Wang Z, Zhang D, Wu D, Chen Y
Pediatr Surg Int 2022 Sep;38(9):1283-1289. Epub 2022 Jul 3 doi: 10.1007/s00383-022-05159-2. PMID: 35780394
Posterior urethral valve.
Nasir AA, Ameh EA, Abdur-Rahman LO, Adeniran JO, Abraham MK
World J Pediatr 2011 Aug;7(3):205-16. Epub 2011 Aug 7 doi: 10.1007/s12519-011-0289-1. PMID: 21822988
Posterior urethral valves.
Hodges SJ, Patel B, McLorie G, Atala A
ScientificWorldJournal 2009 Oct 14;9:1119-26. doi: 10.1100/tsw.2009.127. PMID: 19838598Free PMC Article
Hypospadias: an update.
Leung AK, Robson WL
Asian J Androl 2007 Jan;9(1):16-22. doi: 10.1111/j.1745-7262.2007.00243.x. PMID: 17187155
Anorectal malformations.
Peña A
Semin Pediatr Surg 1995 Feb;4(1):35-47. PMID: 7728507

Clinical prediction guides

An objective hypospadias classification system.
Abbas TO
J Pediatr Urol 2022 Aug;18(4):481.e1-481.e8. Epub 2022 May 11 doi: 10.1016/j.jpurol.2022.05.001. PMID: 35644790
Ontogeny of estrogen receptors in human male and female fetal reproductive tracts.
Cunha GR, Li Y, Mei C, Derpinghaus A, Baskin LS
Differentiation 2021 Mar-Apr;118:107-131. Epub 2020 Oct 17 doi: 10.1016/j.diff.2020.10.001. PMID: 33176961Free PMC Article
Fetal bladder outflow obstruction: Interventions, outcomes and management uncertainties.
Farrugia MK
Early Hum Dev 2020 Nov;150:105189. Epub 2020 Sep 10 doi: 10.1016/j.earlhumdev.2020.105189. PMID: 32978001
MRI of the Male Pelvic Floor.
Lakhoo J, Khatri G, Elsayed RF, Chernyak V, Olpin J, Steiner A, Tammisetti VS, Sundaram KM, Arora SS
Radiographics 2019 Nov-Dec;39(7):2003-2022. doi: 10.1148/rg.2019190064. PMID: 31697623
Congenital urinary tract obstruction.
Cheung KW, Morris RK, Kilby MD
Best Pract Res Clin Obstet Gynaecol 2019 Jul;58:78-92. Epub 2019 Jan 11 doi: 10.1016/j.bpobgyn.2019.01.003. PMID: 30819578

Recent systematic reviews

Congenital anterior urethrocutaneous fistula: A systematic review.
Lin Y, Deng C, Peng Q
Afr J Paediatr Surg 2018 Apr-Jun;15(2):63-68. doi: 10.4103/ajps.AJPS_97_17. PMID: 31290465Free PMC Article
Fetal megacystis: A systematic review.
Taghavi K, Sharpe C, Stringer MD
J Pediatr Urol 2017 Feb;13(1):7-15. Epub 2016 Oct 8 doi: 10.1016/j.jpurol.2016.09.003. PMID: 27889224
Algorithm for Optimal Urethral Coverage in Hypospadias and Fistula Repair: A Systematic Review.
Fahmy O, Khairul-Asri MG, Schwentner C, Schubert T, Stenzl A, Zahran MH, Gakis G
Eur Urol 2016 Aug;70(2):293-8. Epub 2016 Jan 15 doi: 10.1016/j.eururo.2015.12.047. PMID: 26776935
Prenatal Diagnosis and Perinatal Outcomes of Congenital Megalourethra: A Multicenter Cohort Study and Systematic Review of the Literature.
Moaddab A, Sananes N, Hernandez-Ruano S, Werneck Britto IS, Blumenfeld Y, Stoll F, Favre R, Ruano R
J Ultrasound Med 2015 Nov;34(11):2057-64. Epub 2015 Oct 7 doi: 10.7863/ultra.14.12064. PMID: 26446816
Predicting renal outcomes in children with anterior urethral valves: a systematic review.
Routh JC, McGee SM, Ashley RA, Reinberg Y, Vandersteen DR
J Urol 2010 Oct;184(4 Suppl):1615-9. Epub 2010 Aug 21 doi: 10.1016/j.juro.2010.03.119. PMID: 20728183

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