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Pituitary Gland Mixed Acidophil-Basophil Carcinoma

MedGen UID:
87216
•Concept ID:
C0334313
•
Neoplastic Process
Synonym: Mixed acidophil-basophil carcinoma
SNOMED CT: Mixed acidophil-basophil carcinoma (23444003)

Definition

A malignant epithelial neoplasm of the anterior pituitary gland in which the neoplastic cells stain positive with acidic and basic dyes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPituitary Gland Mixed Acidophil-Basophil Carcinoma

Professional guidelines

PubMed

Treatment of pain of diffuse metastatic cancer by stereotactic chemical hypophysectomy: long term results and observations on mechanism of action.
Levin AB, Katz J, Benson RC, Jones AG
Neurosurgery 1980 Mar;6(3):258-62. doi: 10.1227/00006123-198003000-00006. PMID: 6991970

Recent clinical studies

Etiology

Bone demineralization and vertebral fractures in endogenous cortisol excess: role of disease etiology and gonadal status.
Tauchmanovà L, Pivonello R, Di Somma C, Rossi R, De Martino MC, Camera L, Klain M, Salvatore M, Lombardi G, Colao A
J Clin Endocrinol Metab 2006 May;91(5):1779-84. Epub 2006 Mar 7 doi: 10.1210/jc.2005-0582. PMID: 16522701
The pituitary uptake of (111)In-DTPA-D-Phe1-octreotide in the normal pituitary and in pituitary adenomas.
Colao A, Lastoria S, Ferone D, Varrella P, Marzullo P, Pivonello R, Cerbone G, Acampa W, Salvatore M, Lombardi G
J Endocrinol Invest 1999 Mar;22(3):176-83. doi: 10.1007/BF03343538. PMID: 10219884
Thyroid gland abnormalities in patients with the syndrome of spotty skin pigmentation, myxomas, endocrine overactivity, and schwannomas (Carney complex).
Stratakis CA, Courcoutsakis NA, Abati A, Filie A, Doppman JL, Carney JA, Shawker T
J Clin Endocrinol Metab 1997 Jul;82(7):2037-43. doi: 10.1210/jcem.82.7.4079. PMID: 9215269
Autoantibodies to adrenal medullary and thyroid calcitonin cells in type I diabetes mellitus--a prospective study.
Scherbaum WA, Mogel H, Boehm BO, Hedderich U, Glück M, Schernthaner G, Bottazzo GF, Pfeiffer EF
J Autoimmun 1988 Jun;1(3):219-30. doi: 10.1016/0896-8411(88)90028-5. PMID: 3251490
Treatment of pain of diffuse metastatic cancer by stereotactic chemical hypophysectomy: long term results and observations on mechanism of action.
Levin AB, Katz J, Benson RC, Jones AG
Neurosurgery 1980 Mar;6(3):258-62. doi: 10.1227/00006123-198003000-00006. PMID: 6991970

Diagnosis

Primary papillary epithelial tumour of the sella: expanding the spectrum of TTF-1-positive sellar lesions.
Roncaroli F, Chatterjee D, Giannini C, Pereira M, La Rosa S, Brouland JP, Gnanalingham K, Galli C, Fernandes B, Lania A, Radotra B
Neuropathol Appl Neurobiol 2020 Aug;46(5):493-505. Epub 2020 May 9 doi: 10.1111/nan.12622. PMID: 32311761
No evidence of somatic aryl hydrocarbon receptor interacting protein mutations in sporadic endocrine neoplasia.
Raitila A, Georgitsi M, Karhu A, Tuppurainen K, Mäkinen MJ, Birkenkamp-Demtröder K, Salmenkivi K, Orntoft TF, Arola J, Launonen V, Vahteristo P, Aaltonen LA
Endocr Relat Cancer 2007 Sep;14(3):901-6. doi: 10.1677/ERC-07-0025. PMID: 17914118
Mixed germ cell tumors with abundant sarcomatous component in the temporal lobe after radiochemotherapy of neurohypophyseal germinoma: a case report.
Kamitani H, Miyata H, Ishibashi M, Kurosaki M, Mizushima M, Akatsuka K, Ohama E, Watanabe T
Brain Tumor Pathol 2006 Oct;23(2):83-9. doi: 10.1007/s10014-006-0205-x. PMID: 18095124
Thyroid gland abnormalities in patients with the syndrome of spotty skin pigmentation, myxomas, endocrine overactivity, and schwannomas (Carney complex).
Stratakis CA, Courcoutsakis NA, Abati A, Filie A, Doppman JL, Carney JA, Shawker T
J Clin Endocrinol Metab 1997 Jul;82(7):2037-43. doi: 10.1210/jcem.82.7.4079. PMID: 9215269
Autoantibodies to adrenal medullary and thyroid calcitonin cells in type I diabetes mellitus--a prospective study.
Scherbaum WA, Mogel H, Boehm BO, Hedderich U, Glück M, Schernthaner G, Bottazzo GF, Pfeiffer EF
J Autoimmun 1988 Jun;1(3):219-30. doi: 10.1016/0896-8411(88)90028-5. PMID: 3251490

Therapy

The pituitary uptake of (111)In-DTPA-D-Phe1-octreotide in the normal pituitary and in pituitary adenomas.
Colao A, Lastoria S, Ferone D, Varrella P, Marzullo P, Pivonello R, Cerbone G, Acampa W, Salvatore M, Lombardi G
J Endocrinol Invest 1999 Mar;22(3):176-83. doi: 10.1007/BF03343538. PMID: 10219884
Sipple's syndrome associated with a large prolactinoma.
Bertrand JH, Ritz P, Reznik Y, Grollier G, Potier JC, Evrad C, Mahoudeau JA
Clin Endocrinol (Oxf) 1987 Nov;27(5):607-14. doi: 10.1111/j.1365-2265.1987.tb01191.x. PMID: 2897262
Prolactin binding in minor salivary gland tumors.
Abbey LM, Witorsch RJ
Oral Surg Oral Med Oral Pathol 1985 Jul;60(1):44-9. doi: 10.1016/0030-4220(85)90214-2. PMID: 2993975

Prognosis

Mixed germ cell tumors with abundant sarcomatous component in the temporal lobe after radiochemotherapy of neurohypophyseal germinoma: a case report.
Kamitani H, Miyata H, Ishibashi M, Kurosaki M, Mizushima M, Akatsuka K, Ohama E, Watanabe T
Brain Tumor Pathol 2006 Oct;23(2):83-9. doi: 10.1007/s10014-006-0205-x. PMID: 18095124
Bone demineralization and vertebral fractures in endogenous cortisol excess: role of disease etiology and gonadal status.
Tauchmanovà L, Pivonello R, Di Somma C, Rossi R, De Martino MC, Camera L, Klain M, Salvatore M, Lombardi G, Colao A
J Clin Endocrinol Metab 2006 May;91(5):1779-84. Epub 2006 Mar 7 doi: 10.1210/jc.2005-0582. PMID: 16522701
The pituitary uptake of (111)In-DTPA-D-Phe1-octreotide in the normal pituitary and in pituitary adenomas.
Colao A, Lastoria S, Ferone D, Varrella P, Marzullo P, Pivonello R, Cerbone G, Acampa W, Salvatore M, Lombardi G
J Endocrinol Invest 1999 Mar;22(3):176-83. doi: 10.1007/BF03343538. PMID: 10219884

Clinical prediction guides

No evidence of somatic aryl hydrocarbon receptor interacting protein mutations in sporadic endocrine neoplasia.
Raitila A, Georgitsi M, Karhu A, Tuppurainen K, Mäkinen MJ, Birkenkamp-Demtröder K, Salmenkivi K, Orntoft TF, Arola J, Launonen V, Vahteristo P, Aaltonen LA
Endocr Relat Cancer 2007 Sep;14(3):901-6. doi: 10.1677/ERC-07-0025. PMID: 17914118
Bone demineralization and vertebral fractures in endogenous cortisol excess: role of disease etiology and gonadal status.
Tauchmanovà L, Pivonello R, Di Somma C, Rossi R, De Martino MC, Camera L, Klain M, Salvatore M, Lombardi G, Colao A
J Clin Endocrinol Metab 2006 May;91(5):1779-84. Epub 2006 Mar 7 doi: 10.1210/jc.2005-0582. PMID: 16522701
The pituitary uptake of (111)In-DTPA-D-Phe1-octreotide in the normal pituitary and in pituitary adenomas.
Colao A, Lastoria S, Ferone D, Varrella P, Marzullo P, Pivonello R, Cerbone G, Acampa W, Salvatore M, Lombardi G
J Endocrinol Invest 1999 Mar;22(3):176-83. doi: 10.1007/BF03343538. PMID: 10219884
Pituitary proliferative lesions in aging male Long-Evans rats. A model of mixed multiple endocrine neoplasia syndrome.
Lee AK, DeLellis RA, Blount M, Nunnemacher G, Wolfe HJ
Lab Invest 1982 Dec;47(6):595-602. PMID: 6128443
Treatment of pain of diffuse metastatic cancer by stereotactic chemical hypophysectomy: long term results and observations on mechanism of action.
Levin AB, Katz J, Benson RC, Jones AG
Neurosurgery 1980 Mar;6(3):258-62. doi: 10.1227/00006123-198003000-00006. PMID: 6991970

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