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Metastatic Malignant Neoplasm in the Choroid

MedGen UID:
87569
•Concept ID:
C0347021
•
Neoplastic Process
Synonyms: Cancer metastatic to choroid; Metastasis to choroid; Metastatic malignant neoplasm of choroid; Metastatic malignant neoplasm to choroid; Metastatic Malignant Neoplasm to the Choroid; Metastatic Neoplasm to the Choroid; Metastatic Tumor to the Choroid; Secondary choroidal tumor; Secondary malignant neoplasm of choroid
SNOMED CT: Secondary choroidal tumor (94254004); Metastasis to choroid (94254004); Secondary malignant neoplasm of choroid (94254004); Metastatic malignant neoplasm to choroid (94254004); Cancer metastatic to choroid (94254004); Metastatic malignant neoplasm of choroid (94254004)

Definition

A malignant neoplasm that has spread to the choroid from another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Neoplasm in the Choroid

Professional guidelines

PubMed

Management of Uveal Melanoma: Updated Cancer Care Alberta Clinical Practice Guideline.
Weis E, Surgeoner B, Salopek TG, Cheng T, Hyrcza M, Kostaras X, Larocque M, McKinnon G, McWhae J, Menon G, Monzon J, Murtha AD, Walker J, Temple-Oberle C
Curr Oncol 2023 Dec 20;31(1):24-41. doi: 10.3390/curroncol31010002. PMID: 38275828Free PMC Article
Metastatic disease from uveal melanoma: treatment options and future prospects.
Carvajal RD, Schwartz GK, Tezel T, Marr B, Francis JH, Nathan PD
Br J Ophthalmol 2017 Jan;101(1):38-44. Epub 2016 Aug 29 doi: 10.1136/bjophthalmol-2016-309034. PMID: 27574175Free PMC Article
Uveal melanoma: From diagnosis to treatment and the science in between.
Chattopadhyay C, Kim DW, Gombos DS, Oba J, Qin Y, Williams MD, Esmaeli B, Grimm EA, Wargo JA, Woodman SE, Patel SP
Cancer 2016 Aug 1;122(15):2299-312. Epub 2016 Mar 15 doi: 10.1002/cncr.29727. PMID: 26991400Free PMC Article

Recent clinical studies

Etiology

Management of Uveal Melanoma: Updated Cancer Care Alberta Clinical Practice Guideline.
Weis E, Surgeoner B, Salopek TG, Cheng T, Hyrcza M, Kostaras X, Larocque M, McKinnon G, McWhae J, Menon G, Monzon J, Murtha AD, Walker J, Temple-Oberle C
Curr Oncol 2023 Dec 20;31(1):24-41. doi: 10.3390/curroncol31010002. PMID: 38275828Free PMC Article
Tumor-Associated Retinal Pigmentation in Choroidal Melanoma.
Wallace A, Krishna Y, Coupland SE, Heimann H, Diafas A, Hussain RN
Ophthalmology 2023 Oct;130(10):1046-1052. Epub 2023 May 13 doi: 10.1016/j.ophtha.2023.05.009. PMID: 37182744
Uveal melanoma: From diagnosis to treatment and the science in between.
Chattopadhyay C, Kim DW, Gombos DS, Oba J, Qin Y, Williams MD, Esmaeli B, Grimm EA, Wargo JA, Woodman SE, Patel SP
Cancer 2016 Aug 1;122(15):2299-312. Epub 2016 Mar 15 doi: 10.1002/cncr.29727. PMID: 26991400Free PMC Article
Ocular melanoma.
Laver NV, McLaughlin ME, Duker JS
Arch Pathol Lab Med 2010 Dec;134(12):1778-84. doi: 10.5858/2009-0441-RAR.1. PMID: 21128775
Understanding intraocular lymphomas.
Coupland SE, Damato B
Clin Exp Ophthalmol 2008 Aug;36(6):564-78. doi: 10.1111/j.1442-9071.2008.01843.x. PMID: 18954321

Diagnosis

Secondary ocular malignancies: A review.
Yeung AM, Wells JR, Grossniklaus HE
Clin Exp Ophthalmol 2021 Mar;49(2):161-168. Epub 2021 Jan 10 doi: 10.1111/ceo.13889. PMID: 33426794
New concepts in the diagnosis and management of choroidal metastases.
Mathis T, Jardel P, Loria O, Delaunay B, Nguyen AM, Lanza F, Mosci C, Caujolle JP, Kodjikian L, Thariat J
Prog Retin Eye Res 2019 Jan;68:144-176. Epub 2018 Sep 19 doi: 10.1016/j.preteyeres.2018.09.003. PMID: 30240895
Intraocular Metastases--A Review.
Konstantinidis L, Damato B
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):208-214. doi: 10.22608/APO.201712. PMID: 28399345
Choroidal osteoma.
Kadrmas EF, Weiter JJ
Int Ophthalmol Clin 1997 Fall;37(4):171-82. doi: 10.1097/00004397-199703740-00015. PMID: 9429940
Choroidal osteoma.
Shields CL, Shields JA, Augsburger JJ
Surv Ophthalmol 1988 Jul-Aug;33(1):17-27. doi: 10.1016/0039-6257(88)90069-0. PMID: 3051466

Therapy

Determinants of Long-Term Survival in Metastatic Choroidal and Ciliary Body Melanoma.
Rantala ES, Parrozzani R, Hernberg MM, Chiarion-Sileni V, Kivelä TT, Midena E
Am J Ophthalmol 2023 Feb;246:258-272. Epub 2022 Nov 1 doi: 10.1016/j.ajo.2022.10.017. PMID: 36328199
New concepts in the diagnosis and management of choroidal metastases.
Mathis T, Jardel P, Loria O, Delaunay B, Nguyen AM, Lanza F, Mosci C, Caujolle JP, Kodjikian L, Thariat J
Prog Retin Eye Res 2019 Jan;68:144-176. Epub 2018 Sep 19 doi: 10.1016/j.preteyeres.2018.09.003. PMID: 30240895
Ocular oncology: advances in retinoblastoma, uveal melanoma and conjunctival melanoma.
Vasalaki M, Fabian ID, Reddy MA, Cohen VM, Sagoo MS
Br Med Bull 2017 Jan 1;121(1):107-119. doi: 10.1093/bmb/ldw053. PMID: 28069617
Intra-axial brain tumors.
Rapalino O, Batchelor T, González RG
Handb Clin Neurol 2016;135:253-274. doi: 10.1016/B978-0-444-53485-9.00014-3. PMID: 27432670
Breast cancer (metastatic).
Stebbing J, Ngan S
BMJ Clin Evid 2010 Sep 8;2010 PMID: 21418674Free PMC Article

Prognosis

Intraocular Metastases--A Review.
Konstantinidis L, Damato B
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):208-214. doi: 10.22608/APO.201712. PMID: 28399345
Metastatic disease from uveal melanoma: treatment options and future prospects.
Carvajal RD, Schwartz GK, Tezel T, Marr B, Francis JH, Nathan PD
Br J Ophthalmol 2017 Jan;101(1):38-44. Epub 2016 Aug 29 doi: 10.1136/bjophthalmol-2016-309034. PMID: 27574175Free PMC Article
Ocular melanoma.
Laver NV, McLaughlin ME, Duker JS
Arch Pathol Lab Med 2010 Dec;134(12):1778-84. doi: 10.5858/2009-0441-RAR.1. PMID: 21128775
Intraocular lymphoma.
Chan CC, Buggage RR, Nussenblatt RB
Curr Opin Ophthalmol 2002 Dec;13(6):411-8. doi: 10.1097/00055735-200212000-00012. PMID: 12441846
Choroidal osteoma.
Shields CL, Shields JA, Augsburger JJ
Surv Ophthalmol 1988 Jul-Aug;33(1):17-27. doi: 10.1016/0039-6257(88)90069-0. PMID: 3051466

Clinical prediction guides

Tumor-Associated Retinal Pigmentation in Choroidal Melanoma.
Wallace A, Krishna Y, Coupland SE, Heimann H, Diafas A, Hussain RN
Ophthalmology 2023 Oct;130(10):1046-1052. Epub 2023 May 13 doi: 10.1016/j.ophtha.2023.05.009. PMID: 37182744
Cancers of the eye.
Maheshwari A, Finger PT
Cancer Metastasis Rev 2018 Dec;37(4):677-690. doi: 10.1007/s10555-018-9762-9. PMID: 30203109
Uveal Melanoma Treatment and Prognostication.
Dogrusöz M, Jager MJ, Damato B
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):186-196. doi: 10.22608/APO.201734. PMID: 28399342
Complement Component 3 Adapts the Cerebrospinal Fluid for Leptomeningeal Metastasis.
Boire A, Zou Y, Shieh J, Macalinao DG, Pentsova E, Massagué J
Cell 2017 Mar 9;168(6):1101-1113.e13. doi: 10.1016/j.cell.2017.02.025. PMID: 28283064Free PMC Article
Breast cancer (metastatic).
Stebbing J, Ngan S
BMJ Clin Evid 2010 Sep 8;2010 PMID: 21418674Free PMC Article

Recent systematic reviews

Vitreoretinal Surgery in the Prevention and Treatment of Toxic Tumour Syndrome in Uveal Melanoma: A Systematic Review.
Romano MR, Catania F, Confalonieri F, Zollet P, Allegrini D, Sergenti J, Lanza FB, Ferrara M, Angi M
Int J Mol Sci 2021 Sep 17;22(18) doi: 10.3390/ijms221810066. PMID: 34576231Free PMC Article
Combination of intravitreal bevacizumab and systemic therapy for choroidal metastases from lung cancer: report of two cases and a systematic review of literature.
Maturu VN, Singh N, Bansal P, Rai Mittal B, Gupta N, Behera D, Gupta A
Med Oncol 2014 Apr;31(4):901. Epub 2014 Mar 7 doi: 10.1007/s12032-014-0901-z. PMID: 24604338
Choroidal metastasis as a presenting manifestation of lung cancer: a report of 3 cases and systematic review of the literature.
Singh N, Kulkarni P, Aggarwal AN, Mittal BR, Gupta N, Behera D, Gupta A
Medicine (Baltimore) 2012 Jul;91(4):179-194. doi: 10.1097/MD.0b013e3182574a0b. PMID: 22732948
Breast cancer (metastatic).
Stebbing J, Ngan S
BMJ Clin Evid 2010 Sep 8;2010 PMID: 21418674Free PMC Article
Breast cancer (metastatic).
Stebbing J, Slater S, Slevin M
BMJ Clin Evid 2007 Feb 1;2007 PMID: 19454050Free PMC Article

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