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Fat necrosis

MedGen UID:
8792
•Concept ID:
C0015668
•
Pathologic Function
Synonyms: Fat Necroses; Fat Necrosis; Necrosis, Fat; Steatonecroses; Steatonecrosis
SNOMED CT: Fat necrosis (79682009); Cytosteatonecrosis (79682009); Steatonecrosis (79682009); Fat necrosis (238888007)

Definition

Destruction of adipose tissue caused by the activity of lipase on damaged fat cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFat necrosis

Professional guidelines

PubMed

The treatment of symptomatic fat necrosis: A review and introduction of a new treatment algorithm.
Janssen TJ, Wigley CH, Adegbie D, Zoller F, Mosahebi A
J Plast Reconstr Aesthet Surg 2023 Feb;77:87-93. Epub 2022 Nov 24 doi: 10.1016/j.bjps.2022.11.045. PMID: 36563639
Rapid cytologic diagnosis of subcutaneous fat necrosis of the newborn.
Harview CL, Chen A, Stone M, Fairley J
Pediatr Dermatol 2023 Mar;40(2):387-388. Epub 2022 Nov 21 doi: 10.1111/pde.15194. PMID: 36411587
Breast Surgery: Management of Postoperative Complications Following Operations for Breast Cancer.
Al-Hilli Z, Wilkerson A
Surg Clin North Am 2021 Oct;101(5):845-863. Epub 2021 Aug 7 doi: 10.1016/j.suc.2021.06.014. PMID: 34537147

Recent clinical studies

Etiology

Right Epipericardial Fat Necrosis After Thymectomy.
Utsumi T, Saito T, Honda O, Ishida M, Maru N, Matsui H, Taniguchi Y, Hino H, Murakawa T
Ann Thorac Surg 2022 Apr;113(4):e259-e261. Epub 2021 Jun 29 doi: 10.1016/j.athoracsur.2021.06.013. PMID: 34214546
Cutaneous paraneoplastic syndromes.
Wick MR, Patterson JW
Semin Diagn Pathol 2019 Jul;36(4):211-228. Epub 2019 Jan 31 doi: 10.1053/j.semdp.2019.01.001. PMID: 30736994
Neutrophil-rich subcutaneous fat necrosis of the newborn: A potential mimic of infection.
Ricardo-Gonzalez RR, Lin JR, Mathes EF, McCalmont TH, Pincus LB
J Am Acad Dermatol 2016 Jul;75(1):177-185.e17. Epub 2016 May 4 doi: 10.1016/j.jaad.2016.02.1151. PMID: 27157147
Mesenteric panniculitis: an update.
Hussein MR, Abdelwahed SR
Expert Rev Gastroenterol Hepatol 2015 Jan;9(1):67-78. Epub 2014 Sep 14 doi: 10.1586/17474124.2014.939632. PMID: 25220299
Epipericardial fat necrosis.
Mazzamuto G, Ghaye B
JBR-BTR 2012 May-Jun;95(3):154-5. doi: 10.5334/jbr-btr.598. PMID: 22880517

Diagnosis

Mediastinal Fat Necrosis.
Moreira BL, Libânio BB, Pinheiro Santana PR, Marchiori E
J Pediatr 2020 Jul;222:250-252. Epub 2020 May 13 doi: 10.1016/j.jpeds.2020.03.012. PMID: 32417085
Epipericardial Fat Necrosis.
Friedman YE, Gayer G, Livne Margolin M, Kneller A, Mouallem M
Isr Med Assoc J 2018 May;20(5):327-328. PMID: 29761683
Panniculitis: A summary.
Wick MR
Semin Diagn Pathol 2017 May;34(3):261-272. Epub 2016 Dec 27 doi: 10.1053/j.semdp.2016.12.004. PMID: 28129926
Benign breast disease.
Amin AL, Purdy AC, Mattingly JD, Kong AL, Termuhlen PM
Surg Clin North Am 2013 Apr;93(2):299-308. Epub 2013 Feb 8 doi: 10.1016/j.suc.2013.01.001. PMID: 23464687
Cold panniculitis.
Quesada-Cortés A, Campos-Muñoz L, Díaz-Díaz RM, Casado-Jiménez M
Dermatol Clin 2008 Oct;26(4):485-9, vii. doi: 10.1016/j.det.2008.05.015. PMID: 18793981

Therapy

Right Epipericardial Fat Necrosis After Thymectomy.
Utsumi T, Saito T, Honda O, Ishida M, Maru N, Matsui H, Taniguchi Y, Hino H, Murakawa T
Ann Thorac Surg 2022 Apr;113(4):e259-e261. Epub 2021 Jun 29 doi: 10.1016/j.athoracsur.2021.06.013. PMID: 34214546
Breast Surgery: Management of Postoperative Complications Following Operations for Breast Cancer.
Al-Hilli Z, Wilkerson A
Surg Clin North Am 2021 Oct;101(5):845-863. Epub 2021 Aug 7 doi: 10.1016/j.suc.2021.06.014. PMID: 34537147
Mesotherapy for local fat reduction.
Jayasinghe S, Guillot T, Bissoon L, Greenway F
Obes Rev 2013 Oct;14(10):780-91. Epub 2013 Jun 25 doi: 10.1111/obr.12049. PMID: 23800269
Epipericardial fat necrosis.
Mazzamuto G, Ghaye B
JBR-BTR 2012 May-Jun;95(3):154-5. doi: 10.5334/jbr-btr.598. PMID: 22880517
Cold panniculitis.
Quesada-Cortés A, Campos-Muñoz L, Díaz-Díaz RM, Casado-Jiménez M
Dermatol Clin 2008 Oct;26(4):485-9, vii. doi: 10.1016/j.det.2008.05.015. PMID: 18793981

Prognosis

Neutrophil-rich subcutaneous fat necrosis of the newborn: A potential mimic of infection.
Ricardo-Gonzalez RR, Lin JR, Mathes EF, McCalmont TH, Pincus LB
J Am Acad Dermatol 2016 Jul;75(1):177-185.e17. Epub 2016 May 4 doi: 10.1016/j.jaad.2016.02.1151. PMID: 27157147
Mesenteric panniculitis: an update.
Hussein MR, Abdelwahed SR
Expert Rev Gastroenterol Hepatol 2015 Jan;9(1):67-78. Epub 2014 Sep 14 doi: 10.1586/17474124.2014.939632. PMID: 25220299
Epipericardial fat necrosis.
Mazzamuto G, Ghaye B
JBR-BTR 2012 May-Jun;95(3):154-5. doi: 10.5334/jbr-btr.598. PMID: 22880517
Pancreatic panniculitis.
García-Romero D, Vanaclocha F
Dermatol Clin 2008 Oct;26(4):465-70, vi. doi: 10.1016/j.det.2008.05.009. PMID: 18793978
Horse bite injury.
Vidal S, Barcala L, Tovar JA
Eur J Dermatol 1998 Sep;8(6):437-8. PMID: 9729060

Clinical prediction guides

Subcutaneous Panniculitis-Like T-Cell Lymphoma Revealed By Immunophenotyping of Necrosis.
Bellahsen-Harrar Y, Badrignans M, Cherif K, Papouin B, Ingen-Housz-Oro S, Ortonne N
Am J Dermatopathol 2022 Sep 1;44(9):675-676. Epub 2022 Apr 11 doi: 10.1097/DAD.0000000000002203. PMID: 35475979
Thoracolithiasis-Computed Tomography Findings of Intrapleural Loose Bodies.
Gayer G
Semin Ultrasound CT MR 2017 Dec;38(6):634-640. Epub 2017 Aug 24 doi: 10.1053/j.sult.2017.08.004. PMID: 29179903
Mesenteric panniculitis: an update.
Hussein MR, Abdelwahed SR
Expert Rev Gastroenterol Hepatol 2015 Jan;9(1):67-78. Epub 2014 Sep 14 doi: 10.1586/17474124.2014.939632. PMID: 25220299
Mesotherapy for local fat reduction.
Jayasinghe S, Guillot T, Bissoon L, Greenway F
Obes Rev 2013 Oct;14(10):780-91. Epub 2013 Jun 25 doi: 10.1111/obr.12049. PMID: 23800269
Lipomembranous fat necrosis of the subcutaneous tissue.
Segura S, Pujol RM
Dermatol Clin 2008 Oct;26(4):509-17, viii. doi: 10.1016/j.det.2008.05.002. PMID: 18793985

Recent systematic reviews

Evaluating the utility of robotic axillary lymph node dissection in patients with invasive breast cancer: a systematic review.
Thornton R, Davey MG, Kerin MJ
Ir J Med Sci 2024 Jun;193(3):1163-1170. Epub 2023 Nov 16 doi: 10.1007/s11845-023-03561-w. PMID: 37971673
A comparative study for the rate of adverse outcomes in unilateral and bilateral abdominal flap breast reconstruction: A meta-analysis.
Cao Z, Cao J, Pang X, Du W, Wu P
Medicine (Baltimore) 2020 Sep 11;99(37):e22096. doi: 10.1097/MD.0000000000022096. PMID: 32925752Free PMC Article
Breast cancer and fat grafting: efficacy, safety and complications-a systematic review.
De Decker M, De Schrijver L, Thiessen F, Tondu T, Van Goethem M, Tjalma WA
Eur J Obstet Gynecol Reprod Biol 2016 Dec;207:100-108. Epub 2016 Oct 28 doi: 10.1016/j.ejogrb.2016.10.032. PMID: 27835828
Improving wound healing and preventing surgical site complications of closed surgical incisions: a possible role of Incisional Negative Pressure Wound Therapy. A systematic review of the literature.
Scalise A, Calamita R, Tartaglione C, Pierangeli M, Bolletta E, Gioacchini M, Gesuita R, Di Benedetto G
Int Wound J 2016 Dec;13(6):1260-1281. Epub 2015 Oct 1 doi: 10.1111/iwj.12492. PMID: 26424609Free PMC Article
Fat necrosis in autologous abdomen-based breast reconstruction: a systematic review.
Khansa I, Momoh AO, Patel PP, Nguyen JT, Miller MJ, Lee BT
Plast Reconstr Surg 2013 Mar;131(3):443-452. doi: 10.1097/PRS.0b013e31827c6dc2. PMID: 23446559

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