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Fat necrosis

MedGen UID:
8792
•Concept ID:
C0015668
•
Pathologic Function
Synonyms: Fat Necroses; Fat Necrosis; Necrosis, Fat; Steatonecroses; Steatonecrosis
SNOMED CT: Fat necrosis (79682009); Cytosteatonecrosis (79682009); Steatonecrosis (79682009); Fat necrosis (238888007)

Definition

Destruction of adipose tissue caused by the activity of lipase on damaged fat cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFat necrosis

Professional guidelines

PubMed

The treatment of symptomatic fat necrosis: A review and introduction of a new treatment algorithm.
Janssen TJ, Wigley CH, Adegbie D, Zoller F, Mosahebi A
J Plast Reconstr Aesthet Surg 2023 Feb;77:87-93. Epub 2022 Nov 24 doi: 10.1016/j.bjps.2022.11.045. PMID: 36563639
Rapid cytologic diagnosis of subcutaneous fat necrosis of the newborn.
Harview CL, Chen A, Stone M, Fairley J
Pediatr Dermatol 2023 Mar;40(2):387-388. Epub 2022 Nov 21 doi: 10.1111/pde.15194. PMID: 36411587
Breast Surgery: Management of Postoperative Complications Following Operations for Breast Cancer.
Al-Hilli Z, Wilkerson A
Surg Clin North Am 2021 Oct;101(5):845-863. Epub 2021 Aug 7 doi: 10.1016/j.suc.2021.06.014. PMID: 34537147

Recent clinical studies

Etiology

Large-Volume Fat Grafting: Identifying Risk Factors for Fat Necrosis.
Chang CS, Lanni MA, Mirzabeigi MN, Bucky LP
Plast Reconstr Surg 2022 Nov 1;150(5):941e-949e. Epub 2022 Aug 22 doi: 10.1097/PRS.0000000000009655. PMID: 35993869
Cutaneous paraneoplastic syndromes.
Wick MR, Patterson JW
Semin Diagn Pathol 2019 Jul;36(4):211-228. Epub 2019 Jan 31 doi: 10.1053/j.semdp.2019.01.001. PMID: 30736994
Mesenteric panniculitis: an update.
Hussein MR, Abdelwahed SR
Expert Rev Gastroenterol Hepatol 2015 Jan;9(1):67-78. Epub 2014 Sep 14 doi: 10.1586/17474124.2014.939632. PMID: 25220299
Panniculitis in children.
Grassi S, Borroni RG, Brazzelli V
G Ital Dermatol Venereol 2013 Aug;148(4):371-85. PMID: 23900159
Pancreatic panniculitis.
Dahl PR, Su WP, Cullimore KC, Dicken CH
J Am Acad Dermatol 1995 Sep;33(3):413-7. doi: 10.1016/0190-9622(95)91385-8. PMID: 7657863

Diagnosis

Mediastinal Fat Necrosis.
Moreira BL, Libânio BB, Pinheiro Santana PR, Marchiori E
J Pediatr 2020 Jul;222:250-252. Epub 2020 May 13 doi: 10.1016/j.jpeds.2020.03.012. PMID: 32417085
Panniculitis: A summary.
Wick MR
Semin Diagn Pathol 2017 May;34(3):261-272. Epub 2016 Dec 27 doi: 10.1053/j.semdp.2016.12.004. PMID: 28129926
Pancreatic panniculitis.
Rongioletti F, Caputo V
G Ital Dermatol Venereol 2013 Aug;148(4):419-25. PMID: 23900163
Cold panniculitis.
Quesada-Cortés A, Campos-Muñoz L, Díaz-Díaz RM, Casado-Jiménez M
Dermatol Clin 2008 Oct;26(4):485-9, vii. doi: 10.1016/j.det.2008.05.015. PMID: 18793981
Pancreatic panniculitis.
Dahl PR, Su WP, Cullimore KC, Dicken CH
J Am Acad Dermatol 1995 Sep;33(3):413-7. doi: 10.1016/0190-9622(95)91385-8. PMID: 7657863

Therapy

Large-Volume Fat Grafting: Identifying Risk Factors for Fat Necrosis.
Chang CS, Lanni MA, Mirzabeigi MN, Bucky LP
Plast Reconstr Surg 2022 Nov 1;150(5):941e-949e. Epub 2022 Aug 22 doi: 10.1097/PRS.0000000000009655. PMID: 35993869
Breast Surgery: Management of Postoperative Complications Following Operations for Breast Cancer.
Al-Hilli Z, Wilkerson A
Surg Clin North Am 2021 Oct;101(5):845-863. Epub 2021 Aug 7 doi: 10.1016/j.suc.2021.06.014. PMID: 34537147
Panniculitis in children.
Grassi S, Borroni RG, Brazzelli V
G Ital Dermatol Venereol 2013 Aug;148(4):371-85. PMID: 23900159
Mesotherapy for local fat reduction.
Jayasinghe S, Guillot T, Bissoon L, Greenway F
Obes Rev 2013 Oct;14(10):780-91. Epub 2013 Jun 25 doi: 10.1111/obr.12049. PMID: 23800269
Cold panniculitis.
Quesada-Cortés A, Campos-Muñoz L, Díaz-Díaz RM, Casado-Jiménez M
Dermatol Clin 2008 Oct;26(4):485-9, vii. doi: 10.1016/j.det.2008.05.015. PMID: 18793981

Prognosis

Sclerosing Mesenteritis.
Danford CJ, Lin SC, Wolf JL
Am J Gastroenterol 2019 Jun;114(6):867-873. doi: 10.14309/ajg.0000000000000167. PMID: 30829677
Infectious and Inflammatory Breast Disease.
Faguy K
Radiol Technol 2018 Jan;89(3):279M-295M. PMID: 29298955
Mesenteric panniculitis: an update.
Hussein MR, Abdelwahed SR
Expert Rev Gastroenterol Hepatol 2015 Jan;9(1):67-78. Epub 2014 Sep 14 doi: 10.1586/17474124.2014.939632. PMID: 25220299
Pancreatic panniculitis.
García-Romero D, Vanaclocha F
Dermatol Clin 2008 Oct;26(4):465-70, vi. doi: 10.1016/j.det.2008.05.009. PMID: 18793978
Acute pancreatitis.
Klöppel G
Semin Diagn Pathol 2004 Nov;21(4):221-6. doi: 10.1053/j.semdp.2005.07.001. PMID: 16273940

Clinical prediction guides

Subcutaneous Fat Necrosis of the Newborn.
Soua Y, Hamouda H, Njima M, Ghanmi S, Soua H, Zili J
Skinmed 2021;19(5):392-394. Epub 2021 Oct 1 PMID: 34861924
Mesenteric panniculitis: an update.
Hussein MR, Abdelwahed SR
Expert Rev Gastroenterol Hepatol 2015 Jan;9(1):67-78. Epub 2014 Sep 14 doi: 10.1586/17474124.2014.939632. PMID: 25220299
Panniculitides, an algorithmic approach.
Zelger B
G Ital Dermatol Venereol 2013 Aug;148(4):351-70. PMID: 23900158
Mesotherapy for local fat reduction.
Jayasinghe S, Guillot T, Bissoon L, Greenway F
Obes Rev 2013 Oct;14(10):780-91. Epub 2013 Jun 25 doi: 10.1111/obr.12049. PMID: 23800269
Acute pancreatitis.
Geokas MC, Baltaxe HA, Banks PA, Silva J Jr, Frey CF
Ann Intern Med 1985 Jul;103(1):86-100. doi: 10.7326/0003-4819-103-1-86. PMID: 3890660

Recent systematic reviews

Fat necrosis in the Breast: A systematic review of clinical.
Vasei N, Shishegar A, Ghalkhani F, Darvishi M
Lipids Health Dis 2019 Jun 11;18(1):139. doi: 10.1186/s12944-019-1078-4. PMID: 31185981Free PMC Article
Breast cancer and fat grafting: efficacy, safety and complications-a systematic review.
De Decker M, De Schrijver L, Thiessen F, Tondu T, Van Goethem M, Tjalma WA
Eur J Obstet Gynecol Reprod Biol 2016 Dec;207:100-108. Epub 2016 Oct 28 doi: 10.1016/j.ejogrb.2016.10.032. PMID: 27835828
Improving wound healing and preventing surgical site complications of closed surgical incisions: a possible role of Incisional Negative Pressure Wound Therapy. A systematic review of the literature.
Scalise A, Calamita R, Tartaglione C, Pierangeli M, Bolletta E, Gioacchini M, Gesuita R, Di Benedetto G
Int Wound J 2016 Dec;13(6):1260-1281. Epub 2015 Oct 1 doi: 10.1111/iwj.12492. PMID: 26424609Free PMC Article
Defining fat necrosis in plastic surgery.
Rao A, Saadeh PB
Plast Reconstr Surg 2014 Dec;134(6):1202-1212. doi: 10.1097/PRS.0000000000000700. PMID: 25415090
Fat necrosis in autologous abdomen-based breast reconstruction: a systematic review.
Khansa I, Momoh AO, Patel PP, Nguyen JT, Miller MJ, Lee BT
Plast Reconstr Surg 2013 Mar;131(3):443-452. doi: 10.1097/PRS.0b013e31827c6dc2. PMID: 23446559

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