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Anaplastic Embryonal Rhabdomyosarcoma

MedGen UID:
882144
•Concept ID:
C4055470
•
Neoplastic Process

Definition

A morphologic variant of embryonal rhabdomyosarcoma. It is characterized by the presence of large hyperchromatic and anaplastic cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnaplastic Embryonal Rhabdomyosarcoma

Professional guidelines

PubMed

The Presence of ALK Alterations and Clinical Relevance of Crizotinib Treatment in Pediatric Solid Tumors.
Felkai L, Bánusz R, Kovalszky I, Sápi Z, Garami M, Papp G, Karászi K, Varga E, Csóka M
Pathol Oncol Res 2019 Jan;25(1):217-224. Epub 2017 Oct 28 doi: 10.1007/s12253-017-0332-1. PMID: 29081033
Risk-based management: current concepts of treating malignant solid tumors of childhood.
Grosfeld JL
J Am Coll Surg 1999 Oct;189(4):407-25. doi: 10.1016/s1072-7515(99)00167-2. PMID: 10509467
Polysialylated neural cell adhesion molecule as a marker for differential diagnosis in pediatric tumors.
Glüer S, Schelp C, Gerardy-Schahn R, von Schweinitz D
J Pediatr Surg 1998 Oct;33(10):1516-20. doi: 10.1016/s0022-3468(98)90488-2. PMID: 9802804

Recent clinical studies

Etiology

Pediatric radical abdominal trachelectomy for anaplastic embryonal rhabdomyosarcoma of the uterine cervix: an alternative to radical hysterectomy.
Kayton ML, Wexler LH, Lewin SN, Park KJ, La Quaglia MP, Abu-Rustum NR
J Pediatr Surg 2009 Apr;44(4):862-7. doi: 10.1016/j.jpedsurg.2008.11.038. PMID: 19361657Free PMC Article

Diagnosis

Distinct clonal evolution in a case with anaplastic embryonal rhabdomyosarcoma.
Kato K, Yoshimi A, Noda A, Otani H, Hojo H, Tanaka M, Tanaka Y, Ito Y, Nishimura R, Takita J, Yanai T, Koike K, Tsuchida M
Pediatr Int 2021 Jul;63(7):782-789. Epub 2021 Jun 24 doi: 10.1111/ped.14499. PMID: 33021000
Pediatric radical abdominal trachelectomy for anaplastic embryonal rhabdomyosarcoma of the uterine cervix: an alternative to radical hysterectomy.
Kayton ML, Wexler LH, Lewin SN, Park KJ, La Quaglia MP, Abu-Rustum NR
J Pediatr Surg 2009 Apr;44(4):862-7. doi: 10.1016/j.jpedsurg.2008.11.038. PMID: 19361657Free PMC Article

Therapy

Rhabdomyosarcoma-associated renal cell carcinoma: a link with constitutional Tp53 mutation.
Curry S, Ibrahim F, Grehan D, McDermott M, Capra M, Betts D, O'Sullivan M
Pediatr Dev Pathol 2011 May-Jun;14(3):248-51. Epub 2010 Nov 5 doi: 10.2350/10-07-0871-CR.1. PMID: 21054160
Pediatric radical abdominal trachelectomy for anaplastic embryonal rhabdomyosarcoma of the uterine cervix: an alternative to radical hysterectomy.
Kayton ML, Wexler LH, Lewin SN, Park KJ, La Quaglia MP, Abu-Rustum NR
J Pediatr Surg 2009 Apr;44(4):862-7. doi: 10.1016/j.jpedsurg.2008.11.038. PMID: 19361657Free PMC Article

Prognosis

Pediatric radical abdominal trachelectomy for anaplastic embryonal rhabdomyosarcoma of the uterine cervix: an alternative to radical hysterectomy.
Kayton ML, Wexler LH, Lewin SN, Park KJ, La Quaglia MP, Abu-Rustum NR
J Pediatr Surg 2009 Apr;44(4):862-7. doi: 10.1016/j.jpedsurg.2008.11.038. PMID: 19361657Free PMC Article

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    Practice guidelines

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