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Bullous dermatosis

MedGen UID:
88485
•Concept ID:
C0085932
•
Disease or Syndrome
Synonyms: Bullous Dermatoses; Bullous Skin Disease; Bullous Skin Diseases; Dermatoses, Bullous; Skin Disease, Bullous; Skin Diseases, Bullous
SNOMED CT: Bullous dermatosis (7231009); Bullous dermatitis (7231009); Bullous dermatoses (7231009)

Definition

Inflammation of the skin characterized by the presence of bullae which are filled with fluid. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBullous dermatosis

Professional guidelines

PubMed

Advancing Treatment in Bullous Pemphigoid: A Comprehensive Review of Novel Therapeutic Targets and Approaches.
Chen HC, Wang CW, Toh WH, Lee HE, Chung WH, Chen CB
Clin Rev Allergy Immunol 2023 Dec;65(3):331-353. Epub 2023 Oct 28 doi: 10.1007/s12016-023-08973-1. PMID: 37897588
Updates in the Diagnosis and Management of Linear IgA Disease: A Systematic Review.
Shin L, Gardner JT 2nd, Dao H Jr
Medicina (Kaunas) 2021 Aug 12;57(8) doi: 10.3390/medicina57080818. PMID: 34441024Free PMC Article
Clinical, pathologic, and immunologic features of pemphigus herpetiformis: a literature review and proposed diagnostic criteria.
Costa LMC, Cappel MA, Keeling JH
Int J Dermatol 2019 Sep;58(9):997-1007. Epub 2019 Mar 22 doi: 10.1111/ijd.14395. PMID: 30900757

Recent clinical studies

Etiology

Linear IgA bullous dermatosis of childhood: Retrospective single-center cohort.
Wang KL, Lehman JS, Davis DMR
Pediatr Dermatol 2024 May-Jun;41(3):461-464. Epub 2024 Feb 20 doi: 10.1111/pde.15567. PMID: 38378007
Histopathology of autoimmune bullous dermatoses: what's new?
Tekin B, Johnson EF, Wieland CN, Gibson LE, Camilleri MJ, Kalaaji AN, Comfere NI, Peters MS, Lehman JS
Hum Pathol 2022 Oct;128:69-89. Epub 2022 Jun 25 doi: 10.1016/j.humpath.2022.06.021. PMID: 35764145
Subepithelial autoimmune blistering dermatoses: Clinical features and diagnosis.
Montagnon CM, Tolkachjov SN, Murrell DF, Camilleri MJ, Lehman JS
J Am Acad Dermatol 2021 Jul;85(1):1-14. Epub 2021 Mar 5 doi: 10.1016/j.jaad.2020.11.076. PMID: 33684496
Subepithelial autoimmune bullous dermatoses disease activity assessment and therapy.
Montagnon CM, Lehman JS, Murrell DF, Camilleri MJ, Tolkachjov SN
J Am Acad Dermatol 2021 Jul;85(1):18-27. Epub 2021 Mar 5 doi: 10.1016/j.jaad.2020.05.161. PMID: 33684494
Spectrum of orocutaneous disease associations: Immune-mediated conditions.
Cizenski JD, Michel P, Watson IT, Frieder J, Wilder EG, Wright JM, Menter MA
J Am Acad Dermatol 2017 Nov;77(5):795-806. doi: 10.1016/j.jaad.2017.02.019. PMID: 29029901

Diagnosis

Histopathology of autoimmune bullous dermatoses: what's new?
Tekin B, Johnson EF, Wieland CN, Gibson LE, Camilleri MJ, Kalaaji AN, Comfere NI, Peters MS, Lehman JS
Hum Pathol 2022 Oct;128:69-89. Epub 2022 Jun 25 doi: 10.1016/j.humpath.2022.06.021. PMID: 35764145
Vancomycin-induced linear IgA bullous dermatosis.
Navarro-Bielsa A, Abadías-Granado I, Gomez-Mateo MC, Gilaberte Y
Med Clin (Barc) 2022 Jul 22;159(2):107. Epub 2022 Jun 2 doi: 10.1016/j.medcli.2022.01.012. PMID: 35660288
Linear IgA Bullous Dermatosis.
Nogueira BL, Heck R
J Cutan Med Surg 2022 Nov-Dec;26(6):640. Epub 2022 Mar 23 doi: 10.1177/12034754221088563. PMID: 35321585
Subepithelial autoimmune blistering dermatoses: Clinical features and diagnosis.
Montagnon CM, Tolkachjov SN, Murrell DF, Camilleri MJ, Lehman JS
J Am Acad Dermatol 2021 Jul;85(1):1-14. Epub 2021 Mar 5 doi: 10.1016/j.jaad.2020.11.076. PMID: 33684496
Subepithelial autoimmune bullous dermatoses disease activity assessment and therapy.
Montagnon CM, Lehman JS, Murrell DF, Camilleri MJ, Tolkachjov SN
J Am Acad Dermatol 2021 Jul;85(1):18-27. Epub 2021 Mar 5 doi: 10.1016/j.jaad.2020.05.161. PMID: 33684494

Therapy

Vancomycin-induced linear IgA bullous dermatosis.
Navarro-Bielsa A, Abadías-Granado I, Gomez-Mateo MC, Gilaberte Y
Med Clin (Barc) 2022 Jul 22;159(2):107. Epub 2022 Jun 2 doi: 10.1016/j.medcli.2022.01.012. PMID: 35660288
Enoxaparin-induced distal haemorrhagic bullous dermatosis.
Rodríguez-Villa Lario A, Piteiro-Bermejo AB, Bèa-Ardébol S
Rev Clin Esp (Barc) 2021 Feb;221(2):125-126. Epub 2020 Dec 4 doi: 10.1016/j.rceng.2019.11.016. PMID: 33998488
Linear Immunoglobulin-A Bullous Dermatosis.
Pagliarello C, Feliciani C, Girardelli CR
JAMA Dermatol 2021 Feb 1;157(2):221. doi: 10.1001/jamadermatol.2020.4006. PMID: 33325993
Pemphigus vulgaris.
Porro AM, Seque CA, Ferreira MCC, Enokihara MMSES
An Bras Dermatol 2019 Jul 29;94(3):264-278. doi: 10.1590/abd1806-4841.20199011. PMID: 31365654Free PMC Article
Linear IgA bullous dermatosis.
Egan CA, Zone JJ
Int J Dermatol 1999 Nov;38(11):818-27. doi: 10.1046/j.1365-4362.1999.00813.x. PMID: 10583613

Prognosis

Blistering diseases in the mature patient.
Lakoš Jukić I, Jerković Gulin S, Marinović B
Clin Dermatol 2018 Mar-Apr;36(2):231-238. Epub 2017 Oct 3 doi: 10.1016/j.clindermatol.2017.10.014. PMID: 29566927
A polymorphous bullous dermatosis.
Drahy F, Hotz C, Ortonne N, Ghoufi L, Grootenboer-Mignot S, Massard C, Perrin MP, Chosidow O, Ingen-Housz-Oro S
Lancet Oncol 2017 Dec;18(12):e776. doi: 10.1016/S1470-2045(17)30461-8. PMID: 29208443
Spectrum of orocutaneous disease associations: Immune-mediated conditions.
Cizenski JD, Michel P, Watson IT, Frieder J, Wilder EG, Wright JM, Menter MA
J Am Acad Dermatol 2017 Nov;77(5):795-806. doi: 10.1016/j.jaad.2017.02.019. PMID: 29029901
Cutaneous manifestations in patients with chronic renal failure on hemodialysis.
Specchio F, Carboni I, Chimenti S, Tamburi F, Nistico' S
Int J Immunopathol Pharmacol 2014 Jan-Mar;27(1):1-4. doi: 10.1177/039463201402700101. PMID: 24674672
Drug-induced linear IgA bullous dermatosis.
Onodera H, Mihm MC Jr, Yoshida A, Akasaka T
J Dermatol 2005 Sep;32(9):759-64. doi: 10.1111/j.1346-8138.2005.tb00839.x. PMID: 16361722

Clinical prediction guides

Patients suffering from dystrophic epidermolysis bullosa are prone to developing autoantibodies against skin proteins: A longitudinal confirmational study.
Bremer J, Pas HH, Diercks GFH, Meijer HJ, van der Molen SM, Nijenhuis AM, van Nijen-Vos LL, Morandé P, Yubero MJ, Palisson F, Fuentes I, Pasmooij AMG
Exp Dermatol 2024 Feb;33(2):e15035. doi: 10.1111/exd.15035. PMID: 38389191
Subepithelial autoimmune bullous dermatoses disease activity assessment and therapy.
Montagnon CM, Lehman JS, Murrell DF, Camilleri MJ, Tolkachjov SN
J Am Acad Dermatol 2021 Jul;85(1):18-27. Epub 2021 Mar 5 doi: 10.1016/j.jaad.2020.05.161. PMID: 33684494
A Case of Linear IgA Bullous Dermatosis Induced by Aspirin Therapy.
Nabavi M, Rezaeifar A, Sadeghinia A, Arshi S, Bahrami S, Bemanian MH, Fallahpour M, Shokri S, Vakilazad Z
Iran J Allergy Asthma Immunol 2020 Oct 18;19(5):550-554. doi: 10.18502/ijaai.v19i5.4473. PMID: 33463124
Vancomycin Mediates IgA Autoreactivity in Drug-Induced Linear IgA Bullous Dermatosis.
Yamagami J, Nakamura Y, Nagao K, Funakoshi T, Takahashi H, Tanikawa A, Hachiya T, Yamamoto T, Ishida-Yamamoto A, Tanaka T, Fujimoto N, Nishigori C, Yoshida T, Ishii N, Hashimoto T, Amagai M
J Invest Dermatol 2018 Jul;138(7):1473-1480. Epub 2018 Feb 2 doi: 10.1016/j.jid.2017.12.035. PMID: 29410066Free PMC Article
Juvenile dermatitis herpetiformis.
Diaz LA, Lamkin BC, Dubin HV
Arch Dermatol 1979 May;115(5):584-6. PMID: 375840

Recent systematic reviews

Clinical features of chronic bullous dermatosis of childhood.
Wilson A, Murrell DF
Clin Exp Dermatol 2022 May;47(5):873-881. Epub 2022 Jan 2 doi: 10.1111/ced.15059. PMID: 34919291
Updates in the Diagnosis and Management of Linear IgA Disease: A Systematic Review.
Shin L, Gardner JT 2nd, Dao H Jr
Medicina (Kaunas) 2021 Aug 12;57(8) doi: 10.3390/medicina57080818. PMID: 34441024Free PMC Article
Immune-mediated reactions to vancomycin: A systematic case review and analysis.
Minhas JS, Wickner PG, Long AA, Banerji A, Blumenthal KG
Ann Allergy Asthma Immunol 2016 Jun;116(6):544-53. Epub 2016 May 4 doi: 10.1016/j.anai.2016.03.030. PMID: 27156746Free PMC Article
Neonatal Autoimmune Blistering Disease: A Systematic Review.
Zhao CY, Chiang YZ, Murrell DF
Pediatr Dermatol 2016 Jul;33(4):367-74. Epub 2016 Apr 18 doi: 10.1111/pde.12859. PMID: 27086740

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