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Childhood Langerhans Cell Histiocytosis without Risk Organ Involvement

MedGen UID:
885003
Concept ID:
C4055245
Neoplastic Process

Definition

Langerhans cell histiocytosis that occurs during childhood and does not involve the bone marrow, spleen, liver, or lung. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood Langerhans Cell Histiocytosis without Risk Organ Involvement

Professional guidelines

PubMed

Lin HL, Zheng QQ, Huang RL, Hu R, Liu XD, Wang JY
Orphanet J Rare Dis 2024 Apr 23;19(1):174. doi: 10.1186/s13023-024-03151-8. PMID: 38654381Free PMC Article
Héritier S, Emile JF, Hélias-Rodzewicz Z, Donadieu J
Arch Pediatr 2019 Jul;26(5):301-307. Epub 2019 Jul 4 doi: 10.1016/j.arcped.2019.05.015. PMID: 31281037

Recent clinical studies

Etiology

Hélias-Rodzewicz Z, Donadieu J, Terrones N, Barkaoui MA, Lambilliotte A, Moshous D, Thomas C, Azarnoush S, Pasquet M, Mansuy L, Aladjidi N, Jeziorski E, Marec-Berard P, Gilibert-Yvert M, Spiegel A, Saultier P, Pellier I, Pagnier A, Pertuisel S, Poiree M, Bodet D, Millot F, Isfan F, Stephan JL, Leruste A, Rigaud C, Filhon B, Carausu L, Reguerre Y, Kieffer I, Brichard B, Ben Jannet R, Bakari M, Idbaih A, Bodemer C, Cohen-Aubart F, Haroche J, Tazi A, Boudjemaa S, Fraitag S, Emile JF, Heritier S; French Histiocytosis Study Group
Am J Hematol 2023 Jul;98(7):1058-1069. Epub 2023 Apr 28 doi: 10.1002/ajh.26938. PMID: 37115038
Wang DS, Lu MY, Yang YL, Lin DT, Lin KH, Chang HH, Jou ST
J Formos Med Assoc 2021 Jan;120(1 Pt 3):594-601. Epub 2020 Jul 30 doi: 10.1016/j.jfma.2019.12.019. PMID: 32741735
Le Louet S, Barkaoui MA, Miron J, Galambrun C, Aladjidi N, Chastagner P, Kebaili K, Armari-Alla C, Lambilliotte A, Lejeune J, Moshous D, Della Valle V, Sileo C, Ducou Le Pointe H, Chateil JF, Renolleau S, Piloquet JE, Portefaix A, Epaud R, Chiron R, Bugnet E, Lorillon G, Tazi A, Emile JF, Donadieu J, Héritier S
Orphanet J Rare Dis 2020 Sep 9;15(1):241. doi: 10.1186/s13023-020-01495-5. PMID: 32907615Free PMC Article
Leung AKC, Lam JM, Leong KF
World J Pediatr 2019 Dec;15(6):536-545. Epub 2019 Aug 28 doi: 10.1007/s12519-019-00304-9. PMID: 31456157
Héritier S, Emile JF, Hélias-Rodzewicz Z, Donadieu J
Arch Pediatr 2019 Jul;26(5):301-307. Epub 2019 Jul 4 doi: 10.1016/j.arcped.2019.05.015. PMID: 31281037

Diagnosis

Wang DS, Lu MY, Yang YL, Lin DT, Lin KH, Chang HH, Jou ST
J Formos Med Assoc 2021 Jan;120(1 Pt 3):594-601. Epub 2020 Jul 30 doi: 10.1016/j.jfma.2019.12.019. PMID: 32741735
Le Louet S, Barkaoui MA, Miron J, Galambrun C, Aladjidi N, Chastagner P, Kebaili K, Armari-Alla C, Lambilliotte A, Lejeune J, Moshous D, Della Valle V, Sileo C, Ducou Le Pointe H, Chateil JF, Renolleau S, Piloquet JE, Portefaix A, Epaud R, Chiron R, Bugnet E, Lorillon G, Tazi A, Emile JF, Donadieu J, Héritier S
Orphanet J Rare Dis 2020 Sep 9;15(1):241. doi: 10.1186/s13023-020-01495-5. PMID: 32907615Free PMC Article
Donadieu J, Larabi IA, Tardieu M, Visser J, Hutter C, Sieni E, Kabbara N, Barkaoui M, Miron J, Chalard F, Milne P, Haroche J, Cohen F, Hélias-Rodzewicz Z, Simon N, Jehanne M, Kolenova A, Pagnier A, Aladjidi N, Schneider P, Plat G, Lutun A, Sonntagbauer A, Lehrnbecher T, Ferster A, Efremova V, Ahlmann M, Blanc L, Nicholson J, Lambilliote A, Boudiaf H, Lissat A, Svojgr K, Bernard F, Elitzur S, Golan M, Evseev D, Maschan M, Idbaih A, Slater O, Minkov M, Taly V, Collin M, Alvarez JC, Emile JF, Héritier S
J Clin Oncol 2019 Nov 1;37(31):2857-2865. Epub 2019 Sep 12 doi: 10.1200/JCO.19.00456. PMID: 31513482Free PMC Article
Leung AKC, Lam JM, Leong KF
World J Pediatr 2019 Dec;15(6):536-545. Epub 2019 Aug 28 doi: 10.1007/s12519-019-00304-9. PMID: 31456157
Héritier S, Emile JF, Hélias-Rodzewicz Z, Donadieu J
Arch Pediatr 2019 Jul;26(5):301-307. Epub 2019 Jul 4 doi: 10.1016/j.arcped.2019.05.015. PMID: 31281037

Therapy

Barkaoui MA, Queheille E, Aladjidi N, Plat G, Jeziorski E, Moshous D, Lambilliotte A, Kebaili K, Pacquement H, Leverger G, Mansuy L, Entz-Werlé N, Bodet D, Schneider P, Pagnier A, Lutun A, Gillibert-Yvert M, Millot F, Toutain F, Reguerre Y, Thomas C, Tazi A, Emile JF, Donadieu J, Héritier S
Br J Haematol 2020 Dec;191(5):825-834. Epub 2020 Jul 22 doi: 10.1111/bjh.16944. PMID: 32700439
Donadieu J, Larabi IA, Tardieu M, Visser J, Hutter C, Sieni E, Kabbara N, Barkaoui M, Miron J, Chalard F, Milne P, Haroche J, Cohen F, Hélias-Rodzewicz Z, Simon N, Jehanne M, Kolenova A, Pagnier A, Aladjidi N, Schneider P, Plat G, Lutun A, Sonntagbauer A, Lehrnbecher T, Ferster A, Efremova V, Ahlmann M, Blanc L, Nicholson J, Lambilliote A, Boudiaf H, Lissat A, Svojgr K, Bernard F, Elitzur S, Golan M, Evseev D, Maschan M, Idbaih A, Slater O, Minkov M, Taly V, Collin M, Alvarez JC, Emile JF, Héritier S
J Clin Oncol 2019 Nov 1;37(31):2857-2865. Epub 2019 Sep 12 doi: 10.1200/JCO.19.00456. PMID: 31513482Free PMC Article
Leung AKC, Lam JM, Leong KF
World J Pediatr 2019 Dec;15(6):536-545. Epub 2019 Aug 28 doi: 10.1007/s12519-019-00304-9. PMID: 31456157
Héritier S, Emile JF, Hélias-Rodzewicz Z, Donadieu J
Arch Pediatr 2019 Jul;26(5):301-307. Epub 2019 Jul 4 doi: 10.1016/j.arcped.2019.05.015. PMID: 31281037
Minkov M, Prosch H, Steiner M, Grois N, Pötschger U, Kaatsch P, Janka-Schaub G, Gadner H
Pediatr Blood Cancer 2005 Nov;45(6):802-7. doi: 10.1002/pbc.20362. PMID: 15770639

Prognosis

Minkov M, Pötschger U, Thacker N, Astigarraga I, Braier J, Donadieu J, Henter JI, Lehrnbecher T, Rodriguez-Galindo C, Sieni E, Nanduri V, van den Bos C, Abla O; LCH Study Group of the Histiocyte Society
J Pediatr 2021 Oct;237:65-70.e3. Epub 2021 Jun 17 doi: 10.1016/j.jpeds.2021.06.016. PMID: 34146548
Wang DS, Lu MY, Yang YL, Lin DT, Lin KH, Chang HH, Jou ST
J Formos Med Assoc 2021 Jan;120(1 Pt 3):594-601. Epub 2020 Jul 30 doi: 10.1016/j.jfma.2019.12.019. PMID: 32741735
Barkaoui MA, Queheille E, Aladjidi N, Plat G, Jeziorski E, Moshous D, Lambilliotte A, Kebaili K, Pacquement H, Leverger G, Mansuy L, Entz-Werlé N, Bodet D, Schneider P, Pagnier A, Lutun A, Gillibert-Yvert M, Millot F, Toutain F, Reguerre Y, Thomas C, Tazi A, Emile JF, Donadieu J, Héritier S
Br J Haematol 2020 Dec;191(5):825-834. Epub 2020 Jul 22 doi: 10.1111/bjh.16944. PMID: 32700439
Karpinsky G, Fatyga A, Krawczyk MA, Chamera M, Sande N, Szmyd D, Izycka-Swieszewska E, Bien E
Biomark Med 2017 Apr;11(4):389-402. Epub 2017 Mar 14 doi: 10.2217/bmm-2016-0308. PMID: 28326824
Minkov M, Prosch H, Steiner M, Grois N, Pötschger U, Kaatsch P, Janka-Schaub G, Gadner H
Pediatr Blood Cancer 2005 Nov;45(6):802-7. doi: 10.1002/pbc.20362. PMID: 15770639

Clinical prediction guides

Le Louet S, Barkaoui MA, Miron J, Galambrun C, Aladjidi N, Chastagner P, Kebaili K, Armari-Alla C, Lambilliotte A, Lejeune J, Moshous D, Della Valle V, Sileo C, Ducou Le Pointe H, Chateil JF, Renolleau S, Piloquet JE, Portefaix A, Epaud R, Chiron R, Bugnet E, Lorillon G, Tazi A, Emile JF, Donadieu J, Héritier S
Orphanet J Rare Dis 2020 Sep 9;15(1):241. doi: 10.1186/s13023-020-01495-5. PMID: 32907615Free PMC Article
Barkaoui MA, Queheille E, Aladjidi N, Plat G, Jeziorski E, Moshous D, Lambilliotte A, Kebaili K, Pacquement H, Leverger G, Mansuy L, Entz-Werlé N, Bodet D, Schneider P, Pagnier A, Lutun A, Gillibert-Yvert M, Millot F, Toutain F, Reguerre Y, Thomas C, Tazi A, Emile JF, Donadieu J, Héritier S
Br J Haematol 2020 Dec;191(5):825-834. Epub 2020 Jul 22 doi: 10.1111/bjh.16944. PMID: 32700439
Donadieu J, Larabi IA, Tardieu M, Visser J, Hutter C, Sieni E, Kabbara N, Barkaoui M, Miron J, Chalard F, Milne P, Haroche J, Cohen F, Hélias-Rodzewicz Z, Simon N, Jehanne M, Kolenova A, Pagnier A, Aladjidi N, Schneider P, Plat G, Lutun A, Sonntagbauer A, Lehrnbecher T, Ferster A, Efremova V, Ahlmann M, Blanc L, Nicholson J, Lambilliote A, Boudiaf H, Lissat A, Svojgr K, Bernard F, Elitzur S, Golan M, Evseev D, Maschan M, Idbaih A, Slater O, Minkov M, Taly V, Collin M, Alvarez JC, Emile JF, Héritier S
J Clin Oncol 2019 Nov 1;37(31):2857-2865. Epub 2019 Sep 12 doi: 10.1200/JCO.19.00456. PMID: 31513482Free PMC Article
Leung AKC, Lam JM, Leong KF
World J Pediatr 2019 Dec;15(6):536-545. Epub 2019 Aug 28 doi: 10.1007/s12519-019-00304-9. PMID: 31456157
Héritier S, Emile JF, Hélias-Rodzewicz Z, Donadieu J
Arch Pediatr 2019 Jul;26(5):301-307. Epub 2019 Jul 4 doi: 10.1016/j.arcped.2019.05.015. PMID: 31281037

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