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t(7;12)(q36;p13)

MedGen UID:: 885829
•Concept ID:: C4053813
•: Cell or Molecular Dysfunction

Definition

A chromosomal translocation involving the ETV6 gene on chromosome 12p13 and HLXB9 gene on chromosome 7q36. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVt(7;12)(q36;p13)

Molecular Abnormality
- Cytogenetic Abnormality
  - Chromosomal Rearrangement
    - Chromosomal translocation
      - t(7;12)(q36;p13)

Professional guidelines

PubMed

Mechanisms associated with t(7;12) acute myeloid leukaemia: from genetics to potential treatment targets.

Ragusa D, Dijkhuis L, Pina C, Tosi S
Biosci Rep 2023 Jan 31;43(1) doi: 10.1042/BSR20220489. PMID: 36622782 Free PMC Article

Recent clinical studies

Diagnosis

Acute myeloid leukemia (AML) with t(7;12)(q36;p13) is associated with infancy and trisomy 19: Data from Nordic Society for Pediatric Hematology and Oncology (NOPHO-AML) and review of the literature.

Espersen ADL, Noren-Nyström U, Abrahamsson J, Ha SY, Pronk CJ, Jahnukainen K, Jónsson ÓG, Lausen B, Palle J, Zeller B, Palmqvist L, Hasle H
Genes Chromosomes Cancer 2018 Jul;57(7):359-365. Epub 2018 Apr 30 doi: 10.1002/gcc.22538. PMID: 29569294

Prognosis

Acute myeloid leukemia (AML) with t(7;12)(q36;p13) is associated with infancy and trisomy 19: Data from Nordic Society for Pediatric Hematology and Oncology (NOPHO-AML) and review of the literature.

Espersen ADL, Noren-Nyström U, Abrahamsson J, Ha SY, Pronk CJ, Jahnukainen K, Jónsson ÓG, Lausen B, Palle J, Zeller B, Palmqvist L, Hasle H
Genes Chromosomes Cancer 2018 Jul;57(7):359-365. Epub 2018 Apr 30 doi: 10.1002/gcc.22538. PMID: 29569294

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Practice guidelines

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