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Tip Lesion Glomerulopathy

MedGen UID:
886189
•Concept ID:
C4053934
•
Disease or Syndrome

Definition

Segmental glomerulopathy of localized intracapillary foam cells with adjacent, often vacuolated glomerular epithelial cells confluent to the origin of the proximal tubule. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTip Lesion Glomerulopathy

Recent clinical studies

Etiology

Collapsing glomerulopathy is common in the setting of thrombotic microangiopathy of the native kidney.
Buob D, Decambron M, Gnemmi V, Frimat M, Hoffmann M, Azar R, Gheerbrant JD, Guincestre T, Noël C, Copin MC, Glowacki F
Kidney Int 2016 Dec;90(6):1321-1331. Epub 2016 Sep 17 doi: 10.1016/j.kint.2016.07.021. PMID: 27650730
Histologic variants of primary focal segmental glomerulosclerosis: presentation and outcome.
Arias LF, Jiménez CA, Arroyave MJ
J Bras Nefrol 2013 Apr-Jun;35(2):112-9. doi: 10.5935/0101-2800.20130019. PMID: 23812568
Signs and symptoms of thin basement membrane nephropathy: a prospective regional study on primary glomerular disease-The Limburg Renal Registry.
van Paassen P, van Breda Vriesman PJ, van Rie H, Tervaert JW
Kidney Int 2004 Sep;66(3):909-13. doi: 10.1111/j.1523-1755.2004.00835.x. PMID: 15327380

Diagnosis

Immunohistochemical expression of podocyte markers in the variants of focal segmental glomerulosclerosis.
Testagrossa L, Azevedo Neto R, Resende A, Woronik V, Malheiros D
Nephrol Dial Transplant 2013 Jan;28(1):91-8. Epub 2012 Aug 1 doi: 10.1093/ndt/gfs325. PMID: 22859792
Problems with 'focal segmental glomerulosclerosis'.
Howie AJ
Pediatr Nephrol 2011 Aug;26(8):1197-205. Epub 2010 Dec 2 doi: 10.1007/s00467-010-1701-0. PMID: 21125407
Is there an obesity-metabolic syndrome related glomerulopathy?
Ritz E, Koleganova N, Piecha G
Curr Opin Nephrol Hypertens 2011 Jan;20(1):44-9. doi: 10.1097/MNH.0b013e3283414ca1. PMID: 21088574
E pluribus unum: The riddle of focal segmental glomerulosclerosis.
Meyrier A
Semin Nephrol 2003 Mar;23(2):135-40. doi: 10.1053/snep.2003.50013. PMID: 12704573

Therapy

The glomerular tip lesion: a distinct entity or not?
Huppes W, Hené RJ, Kooiker CJ
J Pathol 1988 Feb;154(2):187-90. doi: 10.1002/path.1711540212. PMID: 3280767

Prognosis

Collapsing glomerulopathy is common in the setting of thrombotic microangiopathy of the native kidney.
Buob D, Decambron M, Gnemmi V, Frimat M, Hoffmann M, Azar R, Gheerbrant JD, Guincestre T, Noël C, Copin MC, Glowacki F
Kidney Int 2016 Dec;90(6):1321-1331. Epub 2016 Sep 17 doi: 10.1016/j.kint.2016.07.021. PMID: 27650730
Histologic variants of primary focal segmental glomerulosclerosis: presentation and outcome.
Arias LF, Jiménez CA, Arroyave MJ
J Bras Nefrol 2013 Apr-Jun;35(2):112-9. doi: 10.5935/0101-2800.20130019. PMID: 23812568
Is there an obesity-metabolic syndrome related glomerulopathy?
Ritz E, Koleganova N, Piecha G
Curr Opin Nephrol Hypertens 2011 Jan;20(1):44-9. doi: 10.1097/MNH.0b013e3283414ca1. PMID: 21088574
E pluribus unum: The riddle of focal segmental glomerulosclerosis.
Meyrier A
Semin Nephrol 2003 Mar;23(2):135-40. doi: 10.1053/snep.2003.50013. PMID: 12704573
The glomerular tip lesion: a distinct entity or not?
Huppes W, Hené RJ, Kooiker CJ
J Pathol 1988 Feb;154(2):187-90. doi: 10.1002/path.1711540212. PMID: 3280767

Clinical prediction guides

Is there an obesity-metabolic syndrome related glomerulopathy?
Ritz E, Koleganova N, Piecha G
Curr Opin Nephrol Hypertens 2011 Jan;20(1):44-9. doi: 10.1097/MNH.0b013e3283414ca1. PMID: 21088574
Signs and symptoms of thin basement membrane nephropathy: a prospective regional study on primary glomerular disease-The Limburg Renal Registry.
van Paassen P, van Breda Vriesman PJ, van Rie H, Tervaert JW
Kidney Int 2004 Sep;66(3):909-13. doi: 10.1111/j.1523-1755.2004.00835.x. PMID: 15327380
The glomerular tip lesion: a distinct entity or not?
Huppes W, Hené RJ, Kooiker CJ
J Pathol 1988 Feb;154(2):187-90. doi: 10.1002/path.1711540212. PMID: 3280767

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