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Benign Notochordal Cell Tumor

MedGen UID:
886843
Concept ID:
C4050147
Neoplastic Process
Synonym: Intraosseous Benign Notochordal Cell Tumor

Definition

An intraosseous benign tumor of notochord origin that arises in the bones of the base of the skull, vertebral bodies, sacrum or coccyx. It contains vacuolated tumor cells without atypia, but lacks myxoid matrix, necrosis, and lobular architecture, which are features that characterize its malignant counterpart, chordoma. Most lesions are incidental findings. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign Notochordal Cell Tumor

Recent clinical studies

Etiology

Veiceschi P, Arosio AD, Agosti E, Bignami M, Pistochini A, Cerati M, Castelnuovo P, Locatelli D
Acta Neurochir (Wien) 2021 Sep;163(9):2475-2486. Epub 2021 Apr 26 doi: 10.1007/s00701-021-04857-5. PMID: 33900480
Usher I, Flanagan AM, Choi D
World Neurosurg 2019 Oct;130:13-23. Epub 2019 Jun 14 doi: 10.1016/j.wneu.2019.06.009. PMID: 31421435
Ma X, Xia C, Liu D, Liu H, Wang C, Yu H
Int J Clin Exp Pathol 2014;7(7):3548-54. Epub 2014 Jun 15 PMID: 25120733Free PMC Article
Golden LD, Small JE
J Neuroimaging 2014 May-Jun;24(3):245-9. Epub 2013 Mar 6 doi: 10.1111/jon.12013. PMID: 23464492

Diagnosis

Murphey MD, Minn MJ, Contreras AL, Koeller KK, Shih RY, Inwards CY, Yamaguchi T
Skeletal Radiol 2023 Mar;52(3):349-363. Epub 2022 Sep 5 doi: 10.1007/s00256-022-04158-7. PMID: 36063190
Tirabosco R, O'Donnell P, Flanagan AM
Surg Pathol Clin 2021 Dec;14(4):619-643. Epub 2021 Jul 28 doi: 10.1016/j.path.2021.06.006. PMID: 34742484
Shintaku M, Kikuchi R
Pathol Int 2020 Nov;70(11):871-875. Epub 2020 Aug 22 doi: 10.1111/pin.13005. PMID: 32827236
Kreshak J, Larousserie F, Picci P, Boriani S, Mirra J, Merlino B, Brunocilla E, Vanel D
Cancer Imaging 2014 Apr 22;14(1):4. doi: 10.1186/1470-7330-14-4. PMID: 25609192Free PMC Article
Amer HZ, Hameed M
Arch Pathol Lab Med 2010 Feb;134(2):283-8. doi: 10.5858/134.2.283. PMID: 20121620

Prognosis

Murphey MD, Minn MJ, Contreras AL, Koeller KK, Shih RY, Inwards CY, Yamaguchi T
Skeletal Radiol 2023 Mar;52(3):349-363. Epub 2022 Sep 5 doi: 10.1007/s00256-022-04158-7. PMID: 36063190
Tirabosco R, O'Donnell P, Flanagan AM
Surg Pathol Clin 2021 Dec;14(4):619-643. Epub 2021 Jul 28 doi: 10.1016/j.path.2021.06.006. PMID: 34742484
Golden LD, Small JE
J Neuroimaging 2014 May-Jun;24(3):245-9. Epub 2013 Mar 6 doi: 10.1111/jon.12013. PMID: 23464492
Amer HZ, Hameed M
Arch Pathol Lab Med 2010 Feb;134(2):283-8. doi: 10.5858/134.2.283. PMID: 20121620
Yamaguchi T, Watanabe-Ishiiwa H, Suzuki S, Igarashi Y, Ueda Y
Mod Pathol 2005 Jul;18(7):1005-10. doi: 10.1038/modpathol.3800378. PMID: 15803192

Clinical prediction guides

Veiceschi P, Arosio AD, Agosti E, Bignami M, Pistochini A, Cerati M, Castelnuovo P, Locatelli D
Acta Neurochir (Wien) 2021 Sep;163(9):2475-2486. Epub 2021 Apr 26 doi: 10.1007/s00701-021-04857-5. PMID: 33900480
Carter JM, Wenger DE, Rose PS, Inwards CY
Am J Surg Pathol 2017 Jan;41(1):39-48. doi: 10.1097/PAS.0000000000000766. PMID: 27819871

Recent systematic reviews

Veiceschi P, Arosio AD, Agosti E, Bignami M, Pistochini A, Cerati M, Castelnuovo P, Locatelli D
Acta Neurochir (Wien) 2021 Sep;163(9):2475-2486. Epub 2021 Apr 26 doi: 10.1007/s00701-021-04857-5. PMID: 33900480
Usher I, Flanagan AM, Choi D
World Neurosurg 2019 Oct;130:13-23. Epub 2019 Jun 14 doi: 10.1016/j.wneu.2019.06.009. PMID: 31421435

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