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Malignant Fibrohistiocytic Neoplasm

MedGen UID:
886851
•Concept ID:
C4054579
•
Neoplastic Process
Synonym: Malignant fibrohistiocytic neoplasm
SNOMED CT: Malignant fibrohistiocytic neoplasm (1186901002)

Definition

A fibrohistiocytic neoplasm that metastasizes to other anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Fibrohistiocytic Neoplasm

Professional guidelines

PubMed

Top 10 Differential Diagnoses for Desmoplastic Melanoma.
Fernandez-Flores A, Singh R, Cassarino DS
Head Neck Pathol 2023 Mar;17(1):143-153. Epub 2023 Mar 16 doi: 10.1007/s12105-023-01536-y. PMID: 36928737Free PMC Article
Treatment Options for Multinucleate Cell Angiohistiocytoma: A Case Series and Review of the Literature.
Taibo A, Padin CP, Losada JDP, Fonseca E
J Cutan Med Surg 2023 May-Jun;27(3):219-225. Epub 2023 Mar 16 doi: 10.1177/12034754231163539. PMID: 36927096
Dermatofibrosarcoma protuberans in children: an update on the diagnosis and treatment.
Kornik RI, Muchard LK, Teng JM
Pediatr Dermatol 2012 Nov-Dec;29(6):707-13. Epub 2012 Jul 11 doi: 10.1111/j.1525-1470.2012.01767.x. PMID: 22780227

Recent clinical studies

Etiology

Giant Cell Tumor of Soft Tissue: A Rare Entity.
Mavrogenis AF, Tsukamoto S, Antoniadou T, Righi A, Errani C
Orthopedics 2019 Jul 1;42(4):e364-e369. doi: 10.3928/01477447-20190624-04. PMID: 31323108
Fibrohistiocytic Tumors.
Romano RC, Fritchie KJ
Clin Lab Med 2017 Sep;37(3):603-631. Epub 2017 Jun 15 doi: 10.1016/j.cll.2017.05.007. PMID: 28802503
Dermatofibrosarcoma protuberans in childhood.
Valdivielso-Ramos M, Hernanz JM
Actas Dermosifiliogr 2012 Dec;103(10):863-73. Epub 2012 Nov 13 doi: 10.1016/j.adengl.2011.12.002. PMID: 23154247
Fibrohistiocytic tumors and related neoplasms in children and adolescents.
Black J, Coffin CM, Dehner LP
Pediatr Dev Pathol 2012;15(1 Suppl):181-210. doi: 10.2350/11-03-1001-PB.1. PMID: 22420728
Malignant fibrous tumors.
Stadler FJ, Scott GA, Brown MD
Semin Cutan Med Surg 1998 Jun;17(2):141-52. doi: 10.1016/s1085-5629(98)80007-2. PMID: 9669607

Diagnosis

Hand Masses.
Teh J, Shahabpour M, Drape JL, Feydy A, Sudoł-Szopińska I, Vanhoenacker FM
Semin Musculoskelet Radiol 2021 Apr;25(2):216-231. Epub 2021 Jun 3 doi: 10.1055/s-0041-1724017. PMID: 34082448
Giant Cell Tumor of Soft Tissue: A Rare Entity.
Mavrogenis AF, Tsukamoto S, Antoniadou T, Righi A, Errani C
Orthopedics 2019 Jul 1;42(4):e364-e369. doi: 10.3928/01477447-20190624-04. PMID: 31323108
Fibrohistiocytic Tumors.
Romano RC, Fritchie KJ
Clin Lab Med 2017 Sep;37(3):603-631. Epub 2017 Jun 15 doi: 10.1016/j.cll.2017.05.007. PMID: 28802503
Fibrohistiocytic tumors and related neoplasms in children and adolescents.
Black J, Coffin CM, Dehner LP
Pediatr Dev Pathol 2012;15(1 Suppl):181-210. doi: 10.2350/11-03-1001-PB.1. PMID: 22420728
Malignant fibrous tumors.
Stadler FJ, Scott GA, Brown MD
Semin Cutan Med Surg 1998 Jun;17(2):141-52. doi: 10.1016/s1085-5629(98)80007-2. PMID: 9669607

Therapy

SOX10 commonly stains scar in Mohs sections.
Donaldson MR, Weber LA
Dermatol Online J 2020 Jan 15;26(1) PMID: 32155034
Histology of pediatric classic Hodgkin lymphoma: From diagnosis to prognostic stratification.
Pizzi M, Tazzoli S, Carraro E, Chaviano F, Massano D, Lovisa F, Mussolin L, Todesco A, Biffi A, d'Amore ES, Pillon M, Rugge M
Pediatr Blood Cancer 2020 May;67(5):e28230. Epub 2020 Mar 5 doi: 10.1002/pbc.28230. PMID: 32134194
Fibrous and fibrohistiocytic neoplasms: an update.
Clarke LE
Dermatol Clin 2012 Oct;30(4):643-56, vi. Epub 2012 Aug 11 doi: 10.1016/j.det.2012.06.005. PMID: 23021051
Occupational risk factors for sarcoma subtypes.
Hoppin JA, Tolbert PE, Flanders WD, Zhang RH, Daniels DS, Ragsdale BD, Brann EA
Epidemiology 1999 May;10(3):300-6. PMID: 10230842
HIV-associated Hodgkin's disease. Biologic and clinical aspects.
Levine AM
Hematol Oncol Clin North Am 1996 Oct;10(5):1135-48. doi: 10.1016/s0889-8588(05)70389-0. PMID: 8880201

Prognosis

Cutaneous soft tissue tumors: diagnostically disorienting epithelioid tumors that are not epithelial, and other perplexing mesenchymal lesions.
Carter CS, Patel RM
Mod Pathol 2020 Jan;33(Suppl 1):66-82. Epub 2019 Nov 4 doi: 10.1038/s41379-019-0387-5. PMID: 31685962
Myxoinflammatory fibroblastic sarcoma: morphologic and genetic updates.
Ieremia E, Thway K
Arch Pathol Lab Med 2014 Oct;138(10):1406-11. doi: 10.5858/arpa.2013-0549-RS. PMID: 25268202
Fibrous and fibrohistiocytic neoplasms: an update.
Clarke LE
Dermatol Clin 2012 Oct;30(4):643-56, vi. Epub 2012 Aug 11 doi: 10.1016/j.det.2012.06.005. PMID: 23021051
Plexiform fibrohistiocytic tumor: a brief review.
Taher A, Pushpanathan C
Arch Pathol Lab Med 2007 Jul;131(7):1135-8. doi: 10.5858/2007-131-1135-PFTABR. PMID: 17617005
Malignant fibrous tumors.
Stadler FJ, Scott GA, Brown MD
Semin Cutan Med Surg 1998 Jun;17(2):141-52. doi: 10.1016/s1085-5629(98)80007-2. PMID: 9669607

Clinical prediction guides

Multiple dermatofibromas, associated clinical and histological characteristics: A systematic review.
Seifi G, Kalantari Y, Etesami I
J Dtsch Dermatol Ges 2022 Dec;20(12):1569-1579. Epub 2022 Dec 4 doi: 10.1111/ddg.14888. PMID: 36464809
Cutaneous soft tissue tumors: diagnostically disorienting epithelioid tumors that are not epithelial, and other perplexing mesenchymal lesions.
Carter CS, Patel RM
Mod Pathol 2020 Jan;33(Suppl 1):66-82. Epub 2019 Nov 4 doi: 10.1038/s41379-019-0387-5. PMID: 31685962
Cutaneous soft tissue tumors: how do we make sense of fibrous and "fibrohistiocytic" tumors with confusing names and similar appearances?
Hornick JL
Mod Pathol 2020 Jan;33(Suppl 1):56-65. Epub 2019 Oct 25 doi: 10.1038/s41379-019-0388-4. PMID: 31653978
Soft tissue tumours: imaging strategy.
Brisse HJ, Orbach D, Klijanienko J
Pediatr Radiol 2010 Jun;40(6):1019-28. Epub 2010 Apr 30 doi: 10.1007/s00247-010-1592-z. PMID: 20432021
Atrophic dermatofibroma.
Ohnishi T, Sasaki M, Nakai K, Watanabe S
J Eur Acad Dermatol Venereol 2004 Sep;18(5):580-3. doi: 10.1111/j.1468-3083.2004.00975.x. PMID: 15324399

Recent systematic reviews

Multiple dermatofibromas, associated clinical and histological characteristics: A systematic review.
Seifi G, Kalantari Y, Etesami I
J Dtsch Dermatol Ges 2022 Dec;20(12):1569-1579. Epub 2022 Dec 4 doi: 10.1111/ddg.14888. PMID: 36464809
Surgical excision margins for fibrohistiocytic tumors, including atypical fibroxanthoma and undifferentiated pleomorphic sarcoma: A probability model based on a systematic review.
Jibbe A, Worley B, Miller CH, Alam M
J Am Acad Dermatol 2022 Oct;87(4):833-840. Epub 2021 Sep 26 doi: 10.1016/j.jaad.2021.09.036. PMID: 34587553
Time to recurrence after surgical excision of atypical fibroxanthoma-updated systematic review and meta-analysis.
Phan K, Onggo J
Australas J Dermatol 2019 Aug;60(3):e220-e222. Epub 2019 Feb 21 doi: 10.1111/ajd.13010. PMID: 30793288
Generalized multinucleate cell angiohistiocytoma: case report and literature review.
Wang M, Abdul-Fattah B, Wang C, Zhao Y, Qu X, Al-Muriesh M, Wang X, Zhu L, Qian Y, Huang C, Chen S
J Cutan Pathol 2017 Feb;44(2):125-134. Epub 2016 Nov 28 doi: 10.1111/cup.12853. PMID: 27813137
Sarcomas other than Kaposi sarcoma occurring in immunodeficiency: interpretations from a systematic literature review.
Bhatia K, Shiels MS, Berg A, Engels EA
Curr Opin Oncol 2012 Sep;24(5):537-46. doi: 10.1097/CCO.0b013e328355e115. PMID: 22729152Free PMC Article

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