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Fibrohistiocytic Neoplasm

MedGen UID:
1751405
•Concept ID:
C5399794
•
Neoplastic Process
Synonyms: Fibrohistiocytic neoplasm; Fibrohistiocytic Tumor
SNOMED CT: Fibrohistiocytic neoplasm (1186902009)

Definition

A benign, intermediate, or malignant mesenchymal neoplasm composed of fibrohistiocytic cells, spindle fibroblastic cells, and histiocytes, in a storiform pattern. [from NCI]

Professional guidelines

PubMed

Top 10 Differential Diagnoses for Desmoplastic Melanoma.
Fernandez-Flores A, Singh R, Cassarino DS
Head Neck Pathol 2023 Mar;17(1):143-153. Epub 2023 Mar 16 doi: 10.1007/s12105-023-01536-y. PMID: 36928737Free PMC Article
Treatment Options for Multinucleate Cell Angiohistiocytoma: A Case Series and Review of the Literature.
Taibo A, Padin CP, Losada JDP, Fonseca E
J Cutan Med Surg 2023 May-Jun;27(3):219-225. Epub 2023 Mar 16 doi: 10.1177/12034754231163539. PMID: 36927096
Dermatofibrosarcoma protuberans in children: an update on the diagnosis and treatment.
Kornik RI, Muchard LK, Teng JM
Pediatr Dermatol 2012 Nov-Dec;29(6):707-13. Epub 2012 Jul 11 doi: 10.1111/j.1525-1470.2012.01767.x. PMID: 22780227

Recent clinical studies

Etiology

Immunohistochemical analysis of S100-positive epidermal Langerhans cells in dermatofibroma.
Hussein MRA
An Bras Dermatol 2020 Sep-Oct;95(5):627-630. Epub 2020 Jul 12 doi: 10.1016/j.abd.2020.04.006. PMID: 32711930Free PMC Article
Atypical fibroxanthoma: DNA ploidy analysis of 14 cases with possible histogenetic implications.
Worrell JT, Ansari MQ, Ansari SJ, Cockerell CJ
J Cutan Pathol 1993 Jun;20(3):211-5. doi: 10.1111/j.1600-0560.1993.tb00645.x. PMID: 8396160

Diagnosis

Giant cell tumor of soft tissue: FNA cytopathology of 4 cases, review of the literature, and comparison with giant cell tumor of bone.
Wakely PE Jr
Cancer Cytopathol 2022 Feb;130(2):120-127. Epub 2021 Oct 7 doi: 10.1002/cncy.22517. PMID: 34618411
Cytopathology of myxoinflammatory fibroblastic sarcoma: a series of eight cases and review of the literature.
Wangsiricharoen S, Ali SZ, Wakely PE Jr
J Am Soc Cytopathol 2021 May-Jun;10(3):310-320. Epub 2021 Jan 9 doi: 10.1016/j.jasc.2020.12.004. PMID: 33431307
Cellular neurothekeoma of the eyelid: a unique internal palpebral presentation.
Lefebvre DR, Robinson-Bostom L, Migliori ME
Ophthalmic Plast Reconstr Surg 2014 Jul-Aug;30(4):e91-2. doi: 10.1097/IOP.0b013e3182a22aea. PMID: 24195988
Benign fibrous histiocytoma of the tongue.
Priya NS, Rao K, Umadevi HS, Smitha T
Indian J Dent Res 2013 Sep-Oct;24(5):635-8. doi: 10.4103/0970-9290.123419. PMID: 24355969
Cutaneous metastasis of signet-ring gastric adenocarcinoma to the breast with unusual clinicopathological features.
Avgerinou G, Flessas I, Hatziolou E, Zografos G, Nitsios I, Zagouri F, Katsambas A, Kanitakis J
Anticancer Res 2011 Jun;31(6):2373-8. PMID: 21737667

Therapy

Epithelioid histiocytic infiltrate caused by Mycobacterium scrofulaceum infection: a potential mimic of various neoplastic entities.
Lai J, Abbey BV, Jakubovic HR
Am J Dermatopathol 2013 Apr;35(2):266-9. doi: 10.1097/DAD.0b013e31826b4aa0. PMID: 22935892

Clinical prediction guides

Immunohistochemical analysis of S100-positive epidermal Langerhans cells in dermatofibroma.
Hussein MRA
An Bras Dermatol 2020 Sep-Oct;95(5):627-630. Epub 2020 Jul 12 doi: 10.1016/j.abd.2020.04.006. PMID: 32711930Free PMC Article
Atypical fibroxanthoma with osteoclast-like multinucleated giant cells.
Ferrara N, Baldi G, Di Marino MP, Bellucci G, Baldi A
In Vivo 2000 Jan-Feb;14(1):105-7. PMID: 10757066
Atypical fibroxanthoma with osteoclast-like multinucleated giant cells.
Khan ZM, Cockerell CJ
Am J Dermatopathol 1997 Apr;19(2):174-9. doi: 10.1097/00000372-199704000-00012. PMID: 9129703

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