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Megaureter

MedGen UID:
888976
•Concept ID:
C4049615
•
Congenital Abnormality

Definition

Enlargement of the diameter of the ureter, which can be partial or complete. [from NCI]

Professional guidelines

PubMed

Primary non-refluxing megaureter: Natural history, follow-up and treatment.
Rivetti G, Marzuillo P, Guarino S, Di Sessa A, La Manna A, Caldamone AA, Papparella A, Noviello C
Eur J Pediatr 2024 May;183(5):2029-2036. Epub 2024 Mar 5 doi: 10.1007/s00431-024-05494-7. PMID: 38441661Free PMC Article
Sonographic differential diagnosis of duplex kidneys.
Deeg KH
Ultraschall Med 2022 Aug;43(4):332-353. Epub 2022 Apr 29 doi: 10.1055/a-1749-5136. PMID: 35488089
Megaureter: classification, pathophysiology, and management.
Simoni F, Vino L, Pizzini C, Benini D, Fanos V
Pediatr Med Chir 2000;22(1):15-24. PMID: 11387761

Recent clinical studies

Etiology

Primary non-refluxing megaureter: Natural history, follow-up and treatment.
Rivetti G, Marzuillo P, Guarino S, Di Sessa A, La Manna A, Caldamone AA, Papparella A, Noviello C
Eur J Pediatr 2024 May;183(5):2029-2036. Epub 2024 Mar 5 doi: 10.1007/s00431-024-05494-7. PMID: 38441661Free PMC Article
Update and Summary of the European Association of Urology/European Society of Paediatric Urology Paediatric Guidelines on Vesicoureteral Reflux in Children.
Gnech M, 't Hoen L, Zachou A, Bogaert G, Castagnetti M, O'Kelly F, Quaedackers J, Rawashdeh YF, Silay MS, Kennedy U, Skott M, van Uitert A, Yuan Y, Radmayr C, Burgu B
Eur Urol 2024 May;85(5):433-442. Epub 2024 Jan 5 doi: 10.1016/j.eururo.2023.12.005. PMID: 38182493
Peristalsis prevents ureteral dilation.
Kalayeh K, Fowlkes JB, Xie H, Schultz WW, Sack BS
Neurourol Urodyn 2024 Jan;43(1):258-266. Epub 2023 Nov 13 doi: 10.1002/nau.25332. PMID: 37961019
Non-surgical management in children with non-refluxing primary megaureter: a systematic review and meta-analysis.
Buder K, Opherk K, Mazzi S, Rohner K, Weitz M
Pediatr Nephrol 2023 Nov;38(11):3549-3558. Epub 2023 Mar 30 doi: 10.1007/s00467-023-05938-6. PMID: 36995462Free PMC Article
Continuous Antibiotic Prophylaxis in Pediatric Urology.
Storm DW, Braga LH, Cooper CS
Urol Clin North Am 2018 Nov;45(4):525-538. Epub 2018 Sep 7 doi: 10.1016/j.ucl.2018.06.001. PMID: 30316308

Diagnosis

Primary non-refluxing megaureter: Natural history, follow-up and treatment.
Rivetti G, Marzuillo P, Guarino S, Di Sessa A, La Manna A, Caldamone AA, Papparella A, Noviello C
Eur J Pediatr 2024 May;183(5):2029-2036. Epub 2024 Mar 5 doi: 10.1007/s00431-024-05494-7. PMID: 38441661Free PMC Article
Update and Summary of the European Association of Urology/European Society of Paediatric Urology Paediatric Guidelines on Vesicoureteral Reflux in Children.
Gnech M, 't Hoen L, Zachou A, Bogaert G, Castagnetti M, O'Kelly F, Quaedackers J, Rawashdeh YF, Silay MS, Kennedy U, Skott M, van Uitert A, Yuan Y, Radmayr C, Burgu B
Eur Urol 2024 May;85(5):433-442. Epub 2024 Jan 5 doi: 10.1016/j.eururo.2023.12.005. PMID: 38182493
Congenital Anomalies of the Upper Urinary Tract: A Comprehensive Review.
Houat AP, Guimarães CTS, Takahashi MS, Rodi GP, Gasparetto TPD, Blasbalg R, Velloni FG
Radiographics 2021 Mar-Apr;41(2):462-486. Epub 2021 Jan 29 doi: 10.1148/rg.2021200078. PMID: 33513074
Megaureter.
Hodges SJ, Werle D, McLorie G, Atala A
ScientificWorldJournal 2010 Apr 13;10:603-12. doi: 10.1100/tsw.2010.54. PMID: 20419273Free PMC Article
Megaureter.
Manzoni C
Rays 2002 Apr-Jun;27(2):83-5. PMID: 12696257

Therapy

Update and Summary of the European Association of Urology/European Society of Paediatric Urology Paediatric Guidelines on Vesicoureteral Reflux in Children.
Gnech M, 't Hoen L, Zachou A, Bogaert G, Castagnetti M, O'Kelly F, Quaedackers J, Rawashdeh YF, Silay MS, Kennedy U, Skott M, van Uitert A, Yuan Y, Radmayr C, Burgu B
Eur Urol 2024 May;85(5):433-442. Epub 2024 Jan 5 doi: 10.1016/j.eururo.2023.12.005. PMID: 38182493
Non-surgical management in children with non-refluxing primary megaureter: a systematic review and meta-analysis.
Buder K, Opherk K, Mazzi S, Rohner K, Weitz M
Pediatr Nephrol 2023 Nov;38(11):3549-3558. Epub 2023 Mar 30 doi: 10.1007/s00467-023-05938-6. PMID: 36995462Free PMC Article
Laparoscopic Extravesical Reimplantation in Children with Primary Obstructive Megaureter.
Lopez M, Perez-Etchepare E, Bustangi N, Godik O, Juricic M, Varlet F, Gutierrez R, Gomez Culebras M, Gander R, Royo G, Asensio M
J Laparoendosc Adv Surg Tech A 2023 Jul;33(7):713-718. Epub 2020 Mar 26 doi: 10.1089/lap.2019.0396. PMID: 32212997
Endoscopic management of primary obstructive megaureter in pediatrics.
Teklali Y, Robert Y, Boillot B, Overs C, Piolat C, Rabattu PY
J Pediatr Urol 2018 Oct;14(5):382-387. Epub 2018 Jun 28 doi: 10.1016/j.jpurol.2018.05.027. PMID: 30006257
Primary neonatal MRSA pyonephrosis.
Patel R, Nwokoma N, Ninan GK
Int Urol Nephrol 2013 Aug;45(4):939-42. Epub 2012 Aug 21 doi: 10.1007/s11255-012-0260-7. PMID: 22907630

Prognosis

Primary non-refluxing megaureter: Natural history, follow-up and treatment.
Rivetti G, Marzuillo P, Guarino S, Di Sessa A, La Manna A, Caldamone AA, Papparella A, Noviello C
Eur J Pediatr 2024 May;183(5):2029-2036. Epub 2024 Mar 5 doi: 10.1007/s00431-024-05494-7. PMID: 38441661Free PMC Article
Spontaneous resolution and the role of endoscopic surgery in the treatment of primary obstructive megaureter: a review of the literature.
Isac GV, Danila GM, Ionescu SN
Pediatr Med Chir 2023 Dec 19;45(2) doi: 10.4081/pmc.2023.327. PMID: 38112615
Megaureter.
Hodges SJ, Werle D, McLorie G, Atala A
ScientificWorldJournal 2010 Apr 13;10:603-12. doi: 10.1100/tsw.2010.54. PMID: 20419273Free PMC Article
Urological manifestations of Down syndrome.
Mercer ES, Broecker B, Smith EA, Kirsch AJ, Scherz HC, A Massad C
J Urol 2004 Mar;171(3):1250-3. doi: 10.1097/01.ju.0000112915.69436.91. PMID: 14767322
Congenital megaureter.
Lockhart JL, Singer AM, Glenn JF
J Urol 1979 Sep;122(3):310-4. doi: 10.1016/s0022-5347(17)56380-6. PMID: 470000

Clinical prediction guides

Advancements in Surgical Management of Megaureters.
Boswell TC
Curr Urol Rep 2024 Sep;25(9):215-223. Epub 2024 Jul 2 doi: 10.1007/s11934-024-01214-8. PMID: 38954357Free PMC Article
Primary non-refluxing megaureter: Natural history, follow-up and treatment.
Rivetti G, Marzuillo P, Guarino S, Di Sessa A, La Manna A, Caldamone AA, Papparella A, Noviello C
Eur J Pediatr 2024 May;183(5):2029-2036. Epub 2024 Mar 5 doi: 10.1007/s00431-024-05494-7. PMID: 38441661Free PMC Article
Peristalsis prevents ureteral dilation.
Kalayeh K, Fowlkes JB, Xie H, Schultz WW, Sack BS
Neurourol Urodyn 2024 Jan;43(1):258-266. Epub 2023 Nov 13 doi: 10.1002/nau.25332. PMID: 37961019
Megaureter.
Hodges SJ, Werle D, McLorie G, Atala A
ScientificWorldJournal 2010 Apr 13;10:603-12. doi: 10.1100/tsw.2010.54. PMID: 20419273Free PMC Article
Megaureter: classification, pathophysiology, and management.
Simoni F, Vino L, Pizzini C, Benini D, Fanos V
Pediatr Med Chir 2000;22(1):15-24. PMID: 11387761

Recent systematic reviews

Endoscopic dilatation/incision of primary obstructive megaureter. A systematic review. On behalf of the EAU paediatric urology guidelines panel.
Skott M, Gnech M, Hoen LA', Kennedy U, Van Uitert A, Zachou A, Yuan Y, Quaedackers J, Silay MS, Rawashdeh YF, Burgu B, Castagnetti M, O'Kelly F, Bogaert G, Radmayr C
J Pediatr Urol 2024 Feb;20(1):47-56. Epub 2023 Sep 13 doi: 10.1016/j.jpurol.2023.09.005. PMID: 37758534
Non-surgical management in children with non-refluxing primary megaureter: a systematic review and meta-analysis.
Buder K, Opherk K, Mazzi S, Rohner K, Weitz M
Pediatr Nephrol 2023 Nov;38(11):3549-3558. Epub 2023 Mar 30 doi: 10.1007/s00467-023-05938-6. PMID: 36995462Free PMC Article
High-pressure balloon dilatation of primary obstructive megaureter in children: a systematic review.
Ripatti L, Viljamaa HR, Suihko A, Pakkasjärvi N
BMC Urol 2023 Mar 3;23(1):30. doi: 10.1186/s12894-023-01199-5. PMID: 36869342Free PMC Article
Febrile Urinary Tract Infections in Children with Primary Non-Refluxing Megaureter: A Systematic Review and Meta-Analysis.
Rohner K, Mazzi S, Buder K, Weitz M
Klin Padiatr 2022 Jan;234(1):5-13. Epub 2020 Dec 17 doi: 10.1055/a-1303-4695. PMID: 33336329
Endoscopic Management of Primary Obstructive Megaureter: A Systematic Review.
Doudt AD, Pusateri CR, Christman MS
J Endourol 2018 Jun;32(6):482-487. doi: 10.1089/end.2017.0434. PMID: 29676162

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