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Focal Segmental Glomerulosclerosis Collapsing Variant

MedGen UID:
889144
•Concept ID:
C4054945
•
Disease or Syndrome

Definition

A variant of FSGS characterized by glomerular tuft collapse, which may result in scarring. (D''Agati VD, et al. ""Pathologic Classification of Focal Segmental Glomerulosclerosis: A Working Proposal."" Am J Kidney Dis 43.2 (2004): 368-82.) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFocal Segmental Glomerulosclerosis Collapsing Variant

Professional guidelines

PubMed

Acute kidney injury in patients with COVID-19: Epidemiology, pathogenesis and treatment.
Adamczak M, Surma S, Więcek A
Adv Clin Exp Med 2022 Mar;31(3):317-326. doi: 10.17219/acem/143542. PMID: 35077034
Utility of Columbia classification in focal segmental glomerulosclerosis: renal prognosis and treatment response among the pathological variants.
Tsuchimoto A, Matsukuma Y, Ueki K, Tanaka S, Masutani K, Nakagawa K, Mitsuiki K, Uesugi N, Katafuchi R, Tsuruya K, Nakano T, Kitazono T
Nephrol Dial Transplant 2020 Jul 1;35(7):1219-1227. doi: 10.1093/ndt/gfy374. PMID: 30649467
HIV-associated nephropathies: epidemiology, pathology, mechanisms and treatment.
Rosenberg AZ, Naicker S, Winkler CA, Kopp JB
Nat Rev Nephrol 2015 Mar;11(3):150-60. Epub 2015 Feb 17 doi: 10.1038/nrneph.2015.9. PMID: 25686569

Recent clinical studies

Etiology

Coincident idiopathic focal segmental glomerulosclerosis collapsing variant and diabetic nephropathy in an African American homozygous for MYH9 risk variants.
Gopalakrishnan I, Iskandar SS, Daeihagh P, Divers J, Langefeld CD, Bowden DW, Hicks PJ, Rocco MV, Freedman BI
Hum Pathol 2011 Feb;42(2):291-4. Epub 2010 Nov 13 doi: 10.1016/j.humpath.2010.07.016. PMID: 21074826Free PMC Article

Diagnosis

A case of recurrent focal segmental glomerulosclerosis after kidney transplantation associated with variant conversion in the Columbia classification.
Unagami K, Kawanishi K, Shimizu T, Kanzawa T, Toki D, Okumi M, Omoto K, Horita S, Koike J, Honda K, Nagashima Y, Ishida H, Tanabe K, Nitta K
Nephrology (Carlton) 2015 Jul;20 Suppl 2:96-100. doi: 10.1111/nep.12457. PMID: 26031598
Coincident idiopathic focal segmental glomerulosclerosis collapsing variant and diabetic nephropathy in an African American homozygous for MYH9 risk variants.
Gopalakrishnan I, Iskandar SS, Daeihagh P, Divers J, Langefeld CD, Bowden DW, Hicks PJ, Rocco MV, Freedman BI
Hum Pathol 2011 Feb;42(2):291-4. Epub 2010 Nov 13 doi: 10.1016/j.humpath.2010.07.016. PMID: 21074826Free PMC Article

Therapy

A case of recurrent focal segmental glomerulosclerosis after kidney transplantation associated with variant conversion in the Columbia classification.
Unagami K, Kawanishi K, Shimizu T, Kanzawa T, Toki D, Okumi M, Omoto K, Horita S, Koike J, Honda K, Nagashima Y, Ishida H, Tanabe K, Nitta K
Nephrology (Carlton) 2015 Jul;20 Suppl 2:96-100. doi: 10.1111/nep.12457. PMID: 26031598

Prognosis

A case of recurrent focal segmental glomerulosclerosis after kidney transplantation associated with variant conversion in the Columbia classification.
Unagami K, Kawanishi K, Shimizu T, Kanzawa T, Toki D, Okumi M, Omoto K, Horita S, Koike J, Honda K, Nagashima Y, Ishida H, Tanabe K, Nitta K
Nephrology (Carlton) 2015 Jul;20 Suppl 2:96-100. doi: 10.1111/nep.12457. PMID: 26031598

Clinical prediction guides

Coincident idiopathic focal segmental glomerulosclerosis collapsing variant and diabetic nephropathy in an African American homozygous for MYH9 risk variants.
Gopalakrishnan I, Iskandar SS, Daeihagh P, Divers J, Langefeld CD, Bowden DW, Hicks PJ, Rocco MV, Freedman BI
Hum Pathol 2011 Feb;42(2):291-4. Epub 2010 Nov 13 doi: 10.1016/j.humpath.2010.07.016. PMID: 21074826Free PMC Article

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